WO2006120426A1 - Sensor - Google Patents

Sensor Download PDF

Info

Publication number
WO2006120426A1
WO2006120426A1 PCT/GB2006/001691 GB2006001691W WO2006120426A1 WO 2006120426 A1 WO2006120426 A1 WO 2006120426A1 GB 2006001691 W GB2006001691 W GB 2006001691W WO 2006120426 A1 WO2006120426 A1 WO 2006120426A1
Authority
WO
WIPO (PCT)
Prior art keywords
sensor according
hologram
polymer
sensor
medium
Prior art date
Application number
PCT/GB2006/001691
Other languages
French (fr)
Inventor
Satyamoorthy Kabilan
Jeffrey Blyth
Original Assignee
Cambridge Enterprise Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Enterprise Limited filed Critical Cambridge Enterprise Limited
Publication of WO2006120426A1 publication Critical patent/WO2006120426A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4788—Diffraction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N2021/758—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated using reversible reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N2021/7706—Reagent provision
    • G01N2021/7723—Swelling part, also for adsorption sensor, i.e. without chemical reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N2021/7706—Reagent provision
    • G01N2021/773—Porous polymer jacket; Polymer matrix with indicator
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/0005—Adaptation of holography to specific applications
    • G03H2001/0033—Adaptation of holography to specific applications in hologrammetry for measuring or analysing
    • G03H2001/0044—Adaptation of holography to specific applications in hologrammetry for measuring or analysing holographic fringes deformations; holographic sensors
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H2260/00—Recording materials or recording processes
    • G03H2260/12—Photopolymer

Definitions

  • This invention relates to a holographic sensor. Background to the Invention
  • WO95/26499 discloses a holographic sensor.
  • the sensor comprises a holographic support medium and, disposed throughout its volume, a hologram.
  • the support medium interacts with an analyte, resulting in a variation of a physical property of the medium.
  • This variation induces a change in an optical characteristic of the holographic element, such as its polarisability, reflectance, refractance or absorbance. If any change occurs whilst the hologram is being replayed (e.g. using incident broad band, non-ionising electromagnetic radiation), then a colour change, for example, may be observed using an optical detector.
  • the optical detector may be a spectrometer or simply the human eye.
  • WO99/63408 describes an alternative method of producing a holographic sensor.
  • a sequential treatment technique is used, wherein the polymer film is made first and sensitive silver halide particles are added subsequently. These particles are introduced by diffusing soluble salts into the polymer matrix where they are subsequently reacted to form an insoluble light-sensitive precipitate. The holographic image is then recorded.
  • WO04/081676 describes a "silverless" holographic sensor, in which the holographic fringes are defined by different degrees of swellability in a liquid.
  • the holographic image is recorded by selective (de)polymerisation of the support medium, wherein the medium is in a swellable state during the recording.
  • a particular procedure involves two polymerisation steps, the first forming a sensitive polymeric matrix and the second forming, in selected parts of the matrix, a different degree or type-of polymerisation, thereby forming a holographic image.
  • the second step may involve furthercross-linking of the matrix, or the formation of an interpenetrating polymer.
  • holographic sensors are normally produced by recording a hologram in an analyte-sensitive polymeric medium.
  • Polymers are normally selected on the basis of their sensitivity for a particular analyte, often at the expense to the quality of the resulting hologram.
  • an acrylamide-based medium comprising pendant phenylboronic acid groups can be used to detect glucose, but generally will not give a hologram as bright as one recorded in a gelatin-based medium.
  • a gelatin- based medium gives a bright hologram, but cannot be used to detect glucose.
  • the present invention is based on a realisation that the versatility of conventional sensors is often limited because a single polymer is used to provide both the analyte sensitivity and the holographic recording.
  • the hologram is recorded in a first polymer and the sensitivity is provided by a second, interpenetrating polymer.
  • a bright hologram can be recorded in gelatin, with the analyte sensitivity provided by a different, interpenetrating polymer.
  • the use of an interpreting network of polymers can result in improved handling and mechanical properties with respect to conventional recording media.
  • a first aspect of the invention is a sensor for the detection of an analyte, which comprises a medium and, disposed therein, a hologram, wherein an optical characteristic of the medium changes as a result of a variation of a physical property of the medium, wherein the medium comprises a first polymer interpenetrated by a second, different polymer, and wherein the hologram is recorded in the first polymer and said variation arises as a result of interaction between the second polymer and the analyte.
  • a second aspect of the invention is a method of detection of an analyte in a sample, which comprises contacting the sample with the medium of a sensor of the invention, and detecting any change of the optical characteristic.
  • a holographic sensor of the type used in this invention generally comprises a support medium and, disposed throughout the volume of the medium, a hologram.
  • the support medium interacts with an analyte resulting in a variation of a physical property of the medium. This variation induces a change in an optical characteristic of the holographic element, such as its polarisability, reflectance, ref ractance or absorbance. If any change occurs whilst the hologram is being replayed by incident broad band, non-ionising electromagnetic radiation, then a colour change may be observed.
  • the physical property that varies is preferably the size of the holographic element. This variation may be achieved by incorporating specific groups into the support matrix, where these groups undergo a conformational change upon interaction with the analyte, and cause an expansion or contraction of the support medium. Such a group is preferably the specific binding conjugate of an analyte species. Another way of changing the physical property to change the active water content of the support medium. The interaction may be a reaction and may be reversible, as described in WO03/087899.
  • a holographic sensor may be used for detection of a variety of analytes, simply by modifying the composition of the support medium.
  • the medium is formed from a first polymer, in which the hologram is to be recorded, and a second, interpenetrating polymer, which is analyte-sensitive.
  • the first polymer is preferably gelatin, which allows for a bright hologram.
  • the second polymer may be of the type described in WO95/26499 and WO99/63408, the contents of which are incorporated herein by reference.
  • a "smart" polymer is preferred, i.e. a material that responds to the presence of one or more specific analytes in its environment by, say, a change in volume.
  • the first polymer may also be sensitive to, for example, a different analyte.
  • the sensor may be prepared according to the methods described in WO95/26499, WO99/63408 and WO04/081676.
  • the property of the holographic element which varies may be its charge density, volume, shape, density, viscosity, strength, hardness, charge, hydrophobicity, swellability, integrity, cross-link density or any other physical property. Variation of the or each physical property, in turn, causes a variation of an optical characteristic, such as polarisability, reflectance, refractance or absorbance of the holographic element.
  • the interaction can be detected remotely, using non-ionising radiation.
  • the extent of interaction between the holographic medium and the analyte species is reflected in the degree of change of the physical property, which is detected as a variation in an optical characteristic, preferably a shift in wavelength of non-ionising radiation.
  • the holographic effect may be exhibited by illumination (e.g. under white light, UV or infra-red radiation), specific temperature, magnetic or pressure conditions, or particular chemical, biochemical or biological stimuli.
  • the hologram may be an image of an object or a 2- or 3-dimensional effect, and may be in the form of a pattern which is only visible under magnification.
  • Sensors of the invention may be used to authenticate an article.
  • the sensor may be applied to an article using a transferable holographic film which is, for example, provided on a hot stamping tape.
  • the article may be a transaction card, banknote, passport, identification card, smart card, driving licence, share certificate, bond, cheque, cheque card, tax banderole, gift voucher, postage stamp, rail or airticket, telephone card, lottery card, event ticket, credit or debit card, business card, or an item used in consumer, brand and product protection for the purpose of distinguishing genuine products from counterfeit products and identifying stolen products.
  • the sensors may be used to provide product and pack information for intelligent packaging applications.
  • Intelligent packaging refers to a system that comprises part of, or an attachment to, a container, wrapper or enclosure, to monitor, indicate or test product information or quality or environmental conditions that will affect product quality, shelf life or safety and typical applications, such as indicators showing time-temperature, freshness, moisture, alcohol, gas, physical damage and the like.
  • the sensors can be applied to products with a decorative element or application such as any industrial or handicraft item including but not limited to items of jewellery, items of clothing (including footwear), fabric, furniture, toys, gifts, household items (including crockery and glassware), architecture (including glass, tile, paint, metals, bricks, ceramics, wood, plastics, waxes and other internal and external installations), art (including pictures, sculpture, pottery and light installations), stationery (including greetings cards, letterheads and promotional material) and sporting goods.
  • a decorative element or application such as any industrial or handicraft item including but not limited to items of jewellery, items of clothing (including footwear), fabric, furniture, toys, gifts, household items (including crockery and glassware), architecture (including glass, tile, paint, metals, bricks, ceramics, wood, plastics, waxes and other internal and external installations), art (including pictures, sculpture, pottery and light installations), stationery (including greetings cards, letterheads and promotional material) and sporting goods.
  • the invention is particularly relevant to a diagnostic device such as a test strip, chip, cartridge, swab, tube, pipette or any form of liquid sampling or testing device, and products or processes relating to human or veterinary prognostics, theranostics, diagnostics or medicines.
  • the sensors may be used in a contact lens, sub-conjuctival implant, sub-dermal implant, test strip, chip, cartridge, swab, tube, breathalyser, catheter, any form or blood, urine or body fluid sampling or analysis device.
  • the sensors may also be used in a product or process relating to petrochemical and chemical analysis and testing, for example in a testing device such as a test strip, chip, cartridge, swab, tube, pipette or any form of liquid sampling or analysis device.
  • a testing device such as a test strip, chip, cartridge, swab, tube, pipette or any form of liquid sampling or analysis device.
  • Example 1 illustrates the invention.
  • a hologram is recorded in a conventional, commercial gelatine film. Once bleached, this produces a bright image that responds to a wide range of stimuli, as gelatine is an amorphous polymer containing a variety of chemical groups.
  • gelatine is an amorphous polymer containing a variety of chemical groups.
  • a mixture of acrylic acid and a cross-linker such as bis-acryolyl piperazine (BAP) is then diffused into the hologram in a suitable solvent such as water.
  • a free radical initiator is also mixed in with the solvent and monomers.
  • the gelatine layer containing the monomers is then exposed to UV light, and this causes the monomers to polymerise and contract the gelatine film.
  • this new film primarily responds to pH change and will expand at high pH when the acrylic groups are ionized.
  • the presence of the hologram in the gelatine film provides a very bright, visually perceivable hologram which would not normally be possible using just the acrylic acid co-polymer.

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Engineering & Computer Science (AREA)
  • Holo Graphy (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

A sensor for the detection of an analyte, comprises a medium and, disposed therein, a hologram, wherein an optical characteristic of the medium changes as a result of a variation of a physical property of the medium, wherein the medium comprises a first polymer interpenetrated by a second, different polymer, and wherein the hologram is recorded in the first polymer and said variation arises as a result of interaction between the second polymer and the analyte.

Description

HOLOGRAPHIC SENSOR
Field of the Invention
This invention relates to a holographic sensor. Background to the Invention
WO95/26499 discloses a holographic sensor. The sensor comprises a holographic support medium and, disposed throughout its volume, a hologram. The support medium interacts with an analyte, resulting in a variation of a physical property of the medium. This variation induces a change in an optical characteristic of the holographic element, such as its polarisability, reflectance, refractance or absorbance. If any change occurs whilst the hologram is being replayed (e.g. using incident broad band, non-ionising electromagnetic radiation), then a colour change, for example, may be observed using an optical detector. The optical detector may be a spectrometer or simply the human eye.
WO99/63408 describes an alternative method of producing a holographic sensor. A sequential treatment technique is used, wherein the polymer film is made first and sensitive silver halide particles are added subsequently. These particles are introduced by diffusing soluble salts into the polymer matrix where they are subsequently reacted to form an insoluble light-sensitive precipitate. The holographic image is then recorded.
WO04/081676 describes a "silverless" holographic sensor, in which the holographic fringes are defined by different degrees of swellability in a liquid. The holographic image is recorded by selective (de)polymerisation of the support medium, wherein the medium is in a swellable state during the recording. A particular procedure involves two polymerisation steps, the first forming a sensitive polymeric matrix and the second forming, in selected parts of the matrix, a different degree or type-of polymerisation, thereby forming a holographic image. The second step may involve furthercross-linking of the matrix, or the formation of an interpenetrating polymer.
Conventional holographic sensors are normally produced by recording a hologram in an analyte-sensitive polymeric medium. Polymers are normally selected on the basis of their sensitivity for a particular analyte, often at the expense to the quality of the resulting hologram. Thus, for example, an acrylamide-based medium comprising pendant phenylboronic acid groups can be used to detect glucose, but generally will not give a hologram as bright as one recorded in a gelatin-based medium. Converβely, a gelatin- based medium gives a bright hologram, but cannot be used to detect glucose. There remains a need for sensors which are not only capable of detecting a wide range of analytes, but which comprise a high-quality hologram. Summary of the Invention
The present invention is based on a realisation that the versatility of conventional sensors is often limited because a single polymer is used to provide both the analyte sensitivity and the holographic recording. According to the present invention, the hologram is recorded in a first polymer and the sensitivity is provided by a second, interpenetrating polymer. Thus, for example, a bright hologram can be recorded in gelatin, with the analyte sensitivity provided by a different, interpenetrating polymer. In addition, the use of an interpreting network of polymers can result in improved handling and mechanical properties with respect to conventional recording media. A first aspect of the invention is a sensor for the detection of an analyte, which comprises a medium and, disposed therein, a hologram, wherein an optical characteristic of the medium changes as a result of a variation of a physical property of the medium, wherein the medium comprises a first polymer interpenetrated by a second, different polymer, and wherein the hologram is recorded in the first polymer and said variation arises as a result of interaction between the second polymer and the analyte.
A second aspect of the invention is a method of detection of an analyte in a sample, which comprises contacting the sample with the medium of a sensor of the invention, and detecting any change of the optical characteristic. Description of Preferred Embodiments A holographic sensor of the type used in this invention generally comprises a support medium and, disposed throughout the volume of the medium, a hologram. The support medium interacts with an analyte resulting in a variation of a physical property of the medium. This variation induces a change in an optical characteristic of the holographic element, such as its polarisability, reflectance, ref ractance or absorbance. If any change occurs whilst the hologram is being replayed by incident broad band, non-ionising electromagnetic radiation, then a colour change may be observed.
There are a number of basic ways to change a physical property, and thus vary an optical characteristic. The physical property that varies is preferably the size of the holographic element. This variation may be achieved by incorporating specific groups into the support matrix, where these groups undergo a conformational change upon interaction with the analyte, and cause an expansion or contraction of the support medium. Such a group is preferably the specific binding conjugate of an analyte species. Another way of changing the physical property to change the active water content of the support medium. The interaction may be a reaction and may be reversible, as described in WO03/087899.
A holographic sensor may be used for detection of a variety of analytes, simply by modifying the composition of the support medium. The medium is formed from a first polymer, in which the hologram is to be recorded, and a second, interpenetrating polymer, which is analyte-sensitive. The first polymer is preferably gelatin, which allows for a bright hologram. The second polymer may be of the type described in WO95/26499 and WO99/63408, the contents of which are incorporated herein by reference. A "smart" polymer is preferred, i.e. a material that responds to the presence of one or more specific analytes in its environment by, say, a change in volume. The first polymer may also be sensitive to, for example, a different analyte. The sensor may be prepared according to the methods described in WO95/26499, WO99/63408 and WO04/081676.
The property of the holographic element which varies may be its charge density, volume, shape, density, viscosity, strength, hardness, charge, hydrophobicity, swellability, integrity, cross-link density or any other physical property. Variation of the or each physical property, in turn, causes a variation of an optical characteristic, such as polarisability, reflectance, refractance or absorbance of the holographic element.
The interaction can be detected remotely, using non-ionising radiation. The extent of interaction between the holographic medium and the analyte species is reflected in the degree of change of the physical property, which is detected as a variation in an optical characteristic, preferably a shift in wavelength of non-ionising radiation.
The holographic effect may be exhibited by illumination (e.g. under white light, UV or infra-red radiation), specific temperature, magnetic or pressure conditions, or particular chemical, biochemical or biological stimuli. The hologram may be an image of an object or a 2- or 3-dimensional effect, and may be in the form of a pattern which is only visible under magnification.
Sensors of the invention may be used to authenticate an article. The sensor may be applied to an article using a transferable holographic film which is, for example, provided on a hot stamping tape. The article may be a transaction card, banknote, passport, identification card, smart card, driving licence, share certificate, bond, cheque, cheque card, tax banderole, gift voucher, postage stamp, rail or airticket, telephone card, lottery card, event ticket, credit or debit card, business card, or an item used in consumer, brand and product protection for the purpose of distinguishing genuine products from counterfeit products and identifying stolen products. The sensors may be used to provide product and pack information for intelligent packaging applications. "Intelligent packaging" refers to a system that comprises part of, or an attachment to, a container, wrapper or enclosure, to monitor, indicate or test product information or quality or environmental conditions that will affect product quality, shelf life or safety and typical applications, such as indicators showing time-temperature, freshness, moisture, alcohol, gas, physical damage and the like. Alternatively, the sensors can be applied to products with a decorative element or application such as any industrial or handicraft item including but not limited to items of jewellery, items of clothing (including footwear), fabric, furniture, toys, gifts, household items (including crockery and glassware), architecture (including glass, tile, paint, metals, bricks, ceramics, wood, plastics, waxes and other internal and external installations), art (including pictures, sculpture, pottery and light installations), stationery (including greetings cards, letterheads and promotional material) and sporting goods.
The invention is particularly relevant to a diagnostic device such as a test strip, chip, cartridge, swab, tube, pipette or any form of liquid sampling or testing device, and products or processes relating to human or veterinary prognostics, theranostics, diagnostics or medicines. The sensors may be used in a contact lens, sub-conjuctival implant, sub-dermal implant, test strip, chip, cartridge, swab, tube, breathalyser, catheter, any form or blood, urine or body fluid sampling or analysis device. The sensors may also be used in a product or process relating to petrochemical and chemical analysis and testing, for example in a testing device such as a test strip, chip, cartridge, swab, tube, pipette or any form of liquid sampling or analysis device.
The following Example illustrates the invention. Example
A hologram is recorded in a conventional, commercial gelatine film. Once bleached, this produces a bright image that responds to a wide range of stimuli, as gelatine is an amorphous polymer containing a variety of chemical groups. A mixture of acrylic acid and a cross-linker such as bis-acryolyl piperazine (BAP) is then diffused into the hologram in a suitable solvent such as water. A free radical initiator is also mixed in with the solvent and monomers. The gelatine layer containing the monomers is then exposed to UV light, and this causes the monomers to polymerise and contract the gelatine film. As there are now a large number of acrylic acid groups in the new interpenetrating co-polymer, this new film primarily responds to pH change and will expand at high pH when the acrylic groups are ionized. The presence of the hologram in the gelatine film provides a very bright, visually perceivable hologram which would not normally be possible using just the acrylic acid co-polymer.

Claims

1. A sensor for the detection of an analyte, which comprises a medium and, disposed therein, a hologram, wherein an optical characteristic of the medium changes as a result of a variation of a physical property of the medium, wherein the medium comprises a first polymer interpenetrated by a second, different polymer, and wherein the hologram is recorded in the first polymer and said variation arises as a result of interaction between the second polymer and the analyte.
2. A sensor according to claim 1 , wherein the first polymer is gelatin.
3. A sensor according to claim 1 or claim 2, wherein the fringes of the hologram are formed by silver grains.
4. A sensor according to any preceding claim, wherein the interaction is a reaction.
5. A sensor according to any preceding claim, wherein the first polymer is sensitive to a second analyte.
6. A sensor according to any preceding claim, wherein the hologram is generated by the diffraction of light.
7. A sensor according to any preceding claim, wherein the hologram is only visible under magnification.
8. A sensor according to any preceding claim, wherein the holographic image is of an object or is a 2- or 3-dimensional effect.
9. A sensor according to any preceding claim, further comprising means for producing an interference effect when illuminated with laser light.
10. A sensor according to claim 9, wherein the means comprises a depolarising layer.
11. A sensor according to any preceding claim, wherein the hologram is viewable under white light, UV light or infra-red radiation.
12. A sensor according to any of claims 1 to 10, wherein the hologram is viewable under specific temperature, magnetism or pressure conditions.
13. A sensor according to any preceding claim, wherein the analyte is a chemical, biochemical or biological species.
14. A method of detection of an analyte in a sample, which comprises contacting the sample with the medium of a sensor according to any preceding claim, and detecting any change of the optical characteristic.
15. An article comprising a sensor according to any of claims 1 to 13.
16. An article according to claim 15, which is a transaction card, banknote, passport, identification card, smart card, driving licence, share certificate, bond, -cheque, cheque card, tax banderole, gift voucher, postage stamp, rail or air ticket, telephone card, lottery card, event ticket, credit or debit card, business card, or an item used in consumer, brand or product protection for the purpose of distinguishing genuine products from counterfeit products or identifying stolen products.
17. An article according to claim 15, which is an item of intelligent packaging as defined herein.
18. An article according to claim 15, which is an industrial or handicraft item comprising a decorative element, selected from items of jewellery, items of clothing
(including footwear), fabric, furniture, toys, gifts, household items (including crockery and glassware), architecture (including glass, tile, paint, metals, bricks, ceramics, wood, plastics, waxes and other internal and external installations), art (including pictures, sculpture, pottery and light installations), stationery (including greetings cards, letterheads and promotional material) and sporting goods.
19. An article according to claim 15, which is a product or device for use in agricultural studies, environmental studies, human or veterinary prognostics, theranostics, diagnostics, therapy or chemical analysis.
20. An article according to claim 19, which is a test strip, chip, cartridge, swab, tube, pipette, contact lens, sub-conjuctival implant, sub-dermal implant, breathalyser, catheter or a fluid sampling or analysis device.
21. A transferable holographic film comprising a sensor according to any of claims 1 to 13.
22. A film according to claim 21 , which is present on a hot stamping tape.
23. A method of enhancing the security of an article, which comprises transferring onto the article the sensor from a film according to claim 21 or claim 22.
24. A product comprising a sensor of any of claims 1 to 13, which is capable of generating data from said sensor.
25. A system which uses data generated by a product of claim 24, for data storage, control, transmission, reporting and/or modelling.
PCT/GB2006/001691 2005-05-09 2006-05-09 Sensor WO2006120426A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0509434.7A GB0509434D0 (en) 2005-05-09 2005-05-09 Sensor
GB0509434.7 2005-05-09

Publications (1)

Publication Number Publication Date
WO2006120426A1 true WO2006120426A1 (en) 2006-11-16

Family

ID=34685310

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2006/001691 WO2006120426A1 (en) 2005-05-09 2006-05-09 Sensor

Country Status (3)

Country Link
GB (1) GB0509434D0 (en)
TW (1) TW200700714A (en)
WO (1) WO2006120426A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999063408A1 (en) * 1998-05-29 1999-12-09 Cambridge University Technical Services Ltd. Holographic sensors and their production
WO2003087899A1 (en) * 2002-04-05 2003-10-23 Smart Holograms Limited Method of detecting an analyte in a fluid
WO2004081676A1 (en) * 2003-03-11 2004-09-23 Cambridge University Technical Services Limited Holographic sensors and their production
WO2006008524A1 (en) * 2004-07-19 2006-01-26 Cambridge Enterprise Limited Holographic sensor having heterogeneous properties
WO2006027575A1 (en) * 2004-09-07 2006-03-16 Cambridge Enterprise Limited . Holographic sensor

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999063408A1 (en) * 1998-05-29 1999-12-09 Cambridge University Technical Services Ltd. Holographic sensors and their production
WO2003087899A1 (en) * 2002-04-05 2003-10-23 Smart Holograms Limited Method of detecting an analyte in a fluid
WO2004081676A1 (en) * 2003-03-11 2004-09-23 Cambridge University Technical Services Limited Holographic sensors and their production
WO2006008524A1 (en) * 2004-07-19 2006-01-26 Cambridge Enterprise Limited Holographic sensor having heterogeneous properties
WO2006027575A1 (en) * 2004-09-07 2006-03-16 Cambridge Enterprise Limited . Holographic sensor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
LEE M-C ET AL: "GLUCOSE-SENSITIVE HOLOGRAPHIC SENSORS FOR MONITORING BACTERIAL GROWTH", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 76, no. 19, 1 October 2004 (2004-10-01), pages 5748 - 5755, XP001209666, ISSN: 0003-2700 *
MARSHALL A J ET AL: "Holographic sensors for the determination of ionic strength", ANALYTICA CHIMICA ACTA, ELSEVIER, AMSTERDAM, NL, vol. 527, no. 1, 29 November 2004 (2004-11-29), pages 13 - 20, XP004640286, ISSN: 0003-2670 *
MARSHALL A J ET AL: "PH-SENSITIVE HOLOGRAPHIC SENSORS", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 75, no. 17, 1 September 2003 (2003-09-01), pages 4423 - 4431, XP001176003, ISSN: 0003-2700 *

Also Published As

Publication number Publication date
GB0509434D0 (en) 2005-06-15
TW200700714A (en) 2007-01-01

Similar Documents

Publication Publication Date Title
US20070171491A1 (en) Holographic or diffraction devices
AU2006313586A1 (en) Novel boronate complex and its use in a glucose sensor
US7998639B2 (en) Holographic sensor
US7923678B2 (en) Sensing method including interrogation of a holographic sensor
US7978333B2 (en) Holographic sensor having heterogeneous properties
US20100143827A1 (en) Methods of Making Holographic Devices
US7968349B2 (en) Use of holographic sensor
US20080213675A1 (en) Interrogation of a Light-Sensitive Sensor
WO2006120426A1 (en) Sensor
US20100188715A1 (en) Method of Making Holograms Having at Least Two Replay Colours
AU2006271429A1 (en) Interrogation of a light-sensitive sensor
US20080030820A1 (en) Method of Recording a Hologram
WO2009027739A1 (en) Method of making multicoloured holograms

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Country of ref document: DE

NENP Non-entry into the national phase

Ref country code: RU

WWW Wipo information: withdrawn in national office

Country of ref document: RU

122 Ep: pct application non-entry in european phase

Ref document number: 06727054

Country of ref document: EP

Kind code of ref document: A1