WO2006119736A3 - Modulatoren der pdz-domäne - Google Patents

Modulatoren der pdz-domäne Download PDF

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Publication number
WO2006119736A3
WO2006119736A3 PCT/DE2006/000779 DE2006000779W WO2006119736A3 WO 2006119736 A3 WO2006119736 A3 WO 2006119736A3 DE 2006000779 W DE2006000779 W DE 2006000779W WO 2006119736 A3 WO2006119736 A3 WO 2006119736A3
Authority
WO
WIPO (PCT)
Prior art keywords
pdz
domain modulators
compounds
modulators
domain
Prior art date
Application number
PCT/DE2006/000779
Other languages
English (en)
French (fr)
Other versions
WO2006119736A2 (de
Inventor
Mangesh Joshi
Hartmut Oschkinat
Markus Schade
Carolyn Vargas
Original Assignee
Combinature Biopharm Ag
Mangesh Joshi
Hartmut Oschkinat
Markus Schade
Carolyn Vargas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Combinature Biopharm Ag, Mangesh Joshi, Hartmut Oschkinat, Markus Schade, Carolyn Vargas filed Critical Combinature Biopharm Ag
Priority to US11/920,335 priority Critical patent/US20090204336A1/en
Priority to EP06722837A priority patent/EP1893199A2/de
Publication of WO2006119736A2 publication Critical patent/WO2006119736A2/de
Publication of WO2006119736A3 publication Critical patent/WO2006119736A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Die Erfindung betrifft Verbindungen, welche an die PDZ-Domäne von Proteinen mit PDZ-Domänen binden, Verwendungen solcher Verbindungen sowie Screening Verfahren zur Identifizierung solcher Verbindungen.
PCT/DE2006/000779 2005-05-09 2006-04-28 Modulatoren der pdz-domäne WO2006119736A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US11/920,335 US20090204336A1 (en) 2005-05-09 2006-04-28 PDZ-Domain Modulators
EP06722837A EP1893199A2 (de) 2005-05-09 2006-04-28 Modulatoren der pdz-domäne

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005022182A DE102005022182A1 (de) 2005-05-09 2005-05-09 Modulatoren der PDZ-Domäne
DE102005022182.3 2005-05-09

Publications (2)

Publication Number Publication Date
WO2006119736A2 WO2006119736A2 (de) 2006-11-16
WO2006119736A3 true WO2006119736A3 (de) 2007-09-20

Family

ID=36649661

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2006/000779 WO2006119736A2 (de) 2005-05-09 2006-04-28 Modulatoren der pdz-domäne

Country Status (4)

Country Link
US (1) US20090204336A1 (de)
EP (1) EP1893199A2 (de)
DE (1) DE102005022182A1 (de)
WO (1) WO2006119736A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008148747A2 (en) * 2007-06-08 2008-12-11 University Of Copenhagen Pdz domain modulators
CN102741758A (zh) * 2010-02-26 2012-10-17 保土谷化学工业株式会社 电荷控制剂以及使用该电荷控制剂的调色剂
CN103201684A (zh) * 2010-11-29 2013-07-10 保土谷化学工业株式会社 电荷控制剂以及使用该电荷控制剂的调色剂
CN107382996B (zh) * 2017-06-30 2020-11-06 中国农业大学 一种特异性抑制植物质膜H+-ATPase的化合物及其制备方法和应用
CN114945569A (zh) * 2019-12-26 2022-08-26 延世大学校产学协力团 吡咯烷衍生物，以及包含其的用于预防或治疗β-淀粉样蛋白或Tau蛋白相关疾病的药物组合物

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0587377A2 (de) * 1992-09-10 1994-03-16 Eli Lilly And Company Thiazolidinone Derivate als hypoglykämisches Mittel und für die Behandlung der Alzheimer Krankheit
WO1999003974A1 (en) * 1997-07-15 1999-01-28 The Regents Of The University Of California Compositions and methods for identifying modulators of transducisomes, a new class of therapeutic targets
WO2000018748A1 (en) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Rhodanine derivatives for the treatment and prevention of metabolic bone disorders
WO2000031124A2 (en) * 1998-11-20 2000-06-02 Mount Sinai Hospital Peptides that modulate the interaction of b class ephrins and pdz domains
WO2002007751A1 (en) * 2000-07-25 2002-01-31 Axcell Biosciences Corporation Identification and isolation of novel polypeptides having pdz domains and methods of using same
WO2002066954A2 (en) * 2001-02-16 2002-08-29 Arbor Vita Corporation Pdz domain interactions and lipid rafts
EP1284291A1 (de) * 2000-05-25 2003-02-19 Yamanouchi Pharmaceutical Co. Ltd. Humaner pgc-1 promotor
WO2003014303A2 (en) * 2001-08-03 2003-02-20 Arbor Vita Corporation Molecular interactions in cells
WO2004056347A2 (en) * 2002-12-20 2004-07-08 Novo Nordisk A/S Pharmaceutical compositions comprising insulin and legends of insulin hexamer
WO2004080480A1 (en) * 2003-03-11 2004-09-23 Novo Nordisk A/S Pharmaceutical preparations comprising acid-stabilised insulin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141600B2 (en) * 2003-04-15 2006-11-28 The Regents Of The University Of California Small molecule inhibition of a PDZ-domain interaction

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0587377A2 (de) * 1992-09-10 1994-03-16 Eli Lilly And Company Thiazolidinone Derivate als hypoglykämisches Mittel und für die Behandlung der Alzheimer Krankheit
WO1999003974A1 (en) * 1997-07-15 1999-01-28 The Regents Of The University Of California Compositions and methods for identifying modulators of transducisomes, a new class of therapeutic targets
WO2000018748A1 (en) * 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Rhodanine derivatives for the treatment and prevention of metabolic bone disorders
WO2000031124A2 (en) * 1998-11-20 2000-06-02 Mount Sinai Hospital Peptides that modulate the interaction of b class ephrins and pdz domains
US20020147306A1 (en) * 1998-11-20 2002-10-10 Danny Lin Peptides that modulate the interaction of B class ephrins and PDZ domains
EP1284291A1 (de) * 2000-05-25 2003-02-19 Yamanouchi Pharmaceutical Co. Ltd. Humaner pgc-1 promotor
WO2002007751A1 (en) * 2000-07-25 2002-01-31 Axcell Biosciences Corporation Identification and isolation of novel polypeptides having pdz domains and methods of using same
WO2002066954A2 (en) * 2001-02-16 2002-08-29 Arbor Vita Corporation Pdz domain interactions and lipid rafts
US20030049695A1 (en) * 2001-02-16 2003-03-13 Lu Peter S. PDZ domain interactions and lipid rafts
WO2003014303A2 (en) * 2001-08-03 2003-02-20 Arbor Vita Corporation Molecular interactions in cells
WO2004056347A2 (en) * 2002-12-20 2004-07-08 Novo Nordisk A/S Pharmaceutical compositions comprising insulin and legends of insulin hexamer
WO2004080480A1 (en) * 2003-03-11 2004-09-23 Novo Nordisk A/S Pharmaceutical preparations comprising acid-stabilised insulin

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CROXALL, W. J. ET AL: "3-Trichloromethanesulfenyloxazolidine- and thiazolidine-2,4-diones", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY , 75, 5419-21 CODEN: JACSAT; ISSN: 0002-7863, 1953, XP008077284 *
GILES R G ET AL: "Regiospecific Reduction of 5-Benzylidene-2,4-Thiazolidinediones and 4-Oxo-2-thiazolidinethiones using Lithium Borohydride in Pyridine and Tetrahydrofuran", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 56, no. 26, June 2000 (2000-06-01), pages 4531 - 4537, XP004202146, ISSN: 0040-4020 *
JOSHI, MANGESH ET AL: "Discovery of low-molecular-weight ligands for the AF6 PDZ domain", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION , 45(23), 3790-3795 CODEN: ACIEF5; ISSN: 1433-7851, 2006, XP008077285 *
SAMBASIVARAO ET AL: "Quantitative structure-activity analysis of 5-arylidene-2,4-thiazolid inediones as aldose reductase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 16, no. 3, 1 February 2006 (2006-02-01), pages 512 - 520, XP005222743, ISSN: 0960-894X *

Also Published As

Publication number Publication date
DE102005022182A1 (de) 2006-11-16
WO2006119736A2 (de) 2006-11-16
US20090204336A1 (en) 2009-08-13
EP1893199A2 (de) 2008-03-05

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