WO2006111296A3 - Darreichungsformen und kombinationsprärate von pyrimidinbiosyntheseinhibitoren zur erzielung zusätzlicher wirkungen auf das immunsystem - Google Patents
Darreichungsformen und kombinationsprärate von pyrimidinbiosyntheseinhibitoren zur erzielung zusätzlicher wirkungen auf das immunsystem Download PDFInfo
- Publication number
- WO2006111296A3 WO2006111296A3 PCT/EP2006/003291 EP2006003291W WO2006111296A3 WO 2006111296 A3 WO2006111296 A3 WO 2006111296A3 EP 2006003291 W EP2006003291 W EP 2006003291W WO 2006111296 A3 WO2006111296 A3 WO 2006111296A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dosage forms
- immune system
- biosynthesis inhibitors
- additional effects
- combined preparations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Die Erfindung betrifft ein pharmazeutisches Präparat, enthaltend mindestens einen Pyrimidinsyntheseinhibitor wie Leflunomide, wobei der Pyrimidinsyntheseinhibitor nach oraler Applikation beim Menschen innerhalb von einer Stunde eine Blutplasmaspiegelerhöhung von 1,1 mg/Liter bis 5 mg/Liter erzeugt.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005017592.9 | 2005-04-16 | ||
DE102005017592A DE102005017592A1 (de) | 2005-04-16 | 2005-04-16 | Darreichungsformen und Kombinationspräparate von Pyrimidinbiosyntheseinhibitoren zur Erzielung zusätzlicher Wirkungen auf das Immunsystem |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006111296A2 WO2006111296A2 (de) | 2006-10-26 |
WO2006111296A3 true WO2006111296A3 (de) | 2007-04-19 |
Family
ID=36741320
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2006/003291 WO2006111296A2 (de) | 2005-04-16 | 2006-04-11 | Darreichungsformen und kombinationsprärate von pyrimidinbiosyntheseinhibitoren zur erzielung zusätzlicher wirkungen auf das immunsystem |
Country Status (2)
Country | Link |
---|---|
DE (1) | DE102005017592A1 (de) |
WO (1) | WO2006111296A2 (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2899746A1 (en) * | 2013-01-31 | 2014-06-26 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Pharmaceutical composition comprising leflunomide |
WO2014170435A2 (en) * | 2013-04-18 | 2014-10-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for inhibiting lymphocyte proliferation in a subject in need thereof |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0529500A1 (de) * | 1991-08-22 | 1993-03-03 | Hoechst Aktiengesellschaft | Arzneimittel zur Behandlung von Abstossungsreaktionen bei Organverpflanzungen |
EP0538783A1 (de) * | 1991-10-23 | 1993-04-28 | Hoechst Aktiengesellschaft | N-phenyl-2-cyano-3-hydroxycrotonsäureamidderivate und deren Verwendung als Arzneimittel mit immunmodulatorischer Eigenschaft |
EP0551230A1 (de) * | 1992-01-08 | 1993-07-14 | Roussel Uclaf | Cyano-2-Hydroxy-3-Enamid-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel, diese enthaltende pharmazeutische Zusammensetzungen und erhaltene Zwischenprodukte |
DE19857009A1 (de) * | 1998-12-10 | 2000-06-15 | Aventis Pharma Gmbh | Zubereitung mit verbesserter therapeutischer Breite, enthaltend Nukleotidsyntheseinhibitoren |
WO2001043738A1 (de) * | 1999-12-15 | 2001-06-21 | Aventis Pharma Deutschland Gmbh | Verfahren zur auffindung von nukleotidsyntheseinhibitoren mit weniger nebenwirkungen |
US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
US20020022646A1 (en) * | 2000-02-15 | 2002-02-21 | Ilya Avrutov | Method for systhesizing leflunomide |
US20020077485A1 (en) * | 2000-08-14 | 2002-06-20 | Ilya Avrutov | Micronized leflunomide |
-
2005
- 2005-04-16 DE DE102005017592A patent/DE102005017592A1/de not_active Withdrawn
-
2006
- 2006-04-11 WO PCT/EP2006/003291 patent/WO2006111296A2/de active Application Filing
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0529500A1 (de) * | 1991-08-22 | 1993-03-03 | Hoechst Aktiengesellschaft | Arzneimittel zur Behandlung von Abstossungsreaktionen bei Organverpflanzungen |
EP0538783A1 (de) * | 1991-10-23 | 1993-04-28 | Hoechst Aktiengesellschaft | N-phenyl-2-cyano-3-hydroxycrotonsäureamidderivate und deren Verwendung als Arzneimittel mit immunmodulatorischer Eigenschaft |
EP0551230A1 (de) * | 1992-01-08 | 1993-07-14 | Roussel Uclaf | Cyano-2-Hydroxy-3-Enamid-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel, diese enthaltende pharmazeutische Zusammensetzungen und erhaltene Zwischenprodukte |
DE19857009A1 (de) * | 1998-12-10 | 2000-06-15 | Aventis Pharma Gmbh | Zubereitung mit verbesserter therapeutischer Breite, enthaltend Nukleotidsyntheseinhibitoren |
US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
WO2001043738A1 (de) * | 1999-12-15 | 2001-06-21 | Aventis Pharma Deutschland Gmbh | Verfahren zur auffindung von nukleotidsyntheseinhibitoren mit weniger nebenwirkungen |
US20020022646A1 (en) * | 2000-02-15 | 2002-02-21 | Ilya Avrutov | Method for systhesizing leflunomide |
US20020077485A1 (en) * | 2000-08-14 | 2002-06-20 | Ilya Avrutov | Micronized leflunomide |
Non-Patent Citations (5)
Title |
---|
BRUSA PAOLA ET AL: "Pharmacokinetic monitoring of mycophenolate mofetil in kidney transplanted patients", FARMACO (LAUSANNE), vol. 55, no. 4, April 2000 (2000-04-01), pages 270 - 275, XP002407623, ISSN: 0014-827X * |
DATABASE SCISEARCH [online] SUGIOKA N (REPRINT) ET AL: "Protein binding study of mycophenolate mofetil, a new immunosuppressant, in human plasma and pharmacokinetics in renal transplant patients", XP002407627, retrieved from STN Database accession no. 1997:584713 * |
DIMITROVA PETYA ET AL: "Restriction of de novo pyrimidine biosynthesis inhibits Th1 cell activation and promotes Th2 cell differentiation", JOURNAL OF IMMUNOLOGY, vol. 169, no. 6, 15 September 2002 (2002-09-15), pages 3392 - 3399, XP002407624, ISSN: 0022-1767 * |
JAPANESE JOURNAL OF TRANSPLANTATION, VOL. 32, NO. 1, PP. 33-42. ISSN: 0578-7947. PB - JAPANESE SOC TRANSPLANTATION, C/O DR KIKUO NOMOTO, NIHON GAKKAI JIMU CENTER, 5-16-9 HONKOMAGOME, BUNKYO-KU, TOKYO 131, JAPAN., 1997 * |
LI JUN ET AL: "Pharmacokinetics of leflunomide in Chinese healthy volunteers", ACTA PHARMACOLOGICA SINICA, vol. 23, no. 6, June 2002 (2002-06-01), pages 551 - 555, XP002407622, ISSN: 1671-4083 * |
Also Published As
Publication number | Publication date |
---|---|
DE102005017592A1 (de) | 2006-10-19 |
WO2006111296A2 (de) | 2006-10-26 |
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