WO2006102933A8 - Preparation of autologous haematopoietic stem cells, the methods of production, cyropreservation and use for therapy of traumatic diseases of the central nervous system - Google Patents

Preparation of autologous haematopoietic stem cells, the methods of production, cyropreservation and use for therapy of traumatic diseases of the central nervous system

Info

Publication number
WO2006102933A8
WO2006102933A8 PCT/EP2005/008527 EP2005008527W WO2006102933A8 WO 2006102933 A8 WO2006102933 A8 WO 2006102933A8 EP 2005008527 W EP2005008527 W EP 2005008527W WO 2006102933 A8 WO2006102933 A8 WO 2006102933A8
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
production
central nervous
nervous system
stem cells
Prior art date
Application number
PCT/EP2005/008527
Other languages
French (fr)
Other versions
WO2006102933A1 (en
Inventor
Andrei Stepanov Bryukhovetskiy
Georgiy Ludomirovic Mentkevich
Deimuri Melitonovich Mkheidze
Vladimir Nikitich Yarygin
Andrei Yuryevich Zaitsev
Olga Palumbo
Original Assignee
Meditech Ind Llc
Andrei Stepanov Bryukhovetskiy
Georgiy Ludomirovic Mentkevich
Deimuri Melitonovich Mkheidze
Vladimir Nikitich Yarygin
Andrei Yuryevich Zaitsev
Olga Palumbo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meditech Ind Llc, Andrei Stepanov Bryukhovetskiy, Georgiy Ludomirovic Mentkevich, Deimuri Melitonovich Mkheidze, Vladimir Nikitich Yarygin, Andrei Yuryevich Zaitsev, Olga Palumbo filed Critical Meditech Ind Llc
Priority to JP2008503377A priority Critical patent/JP2008534529A/en
Priority to AU2005329886A priority patent/AU2005329886A1/en
Priority to CA002601679A priority patent/CA2601679A1/en
Priority to EP05770085A priority patent/EP1863903A1/en
Publication of WO2006102933A1 publication Critical patent/WO2006102933A1/en
Priority to IL186228A priority patent/IL186228A0/en
Publication of WO2006102933A8 publication Critical patent/WO2006102933A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention applies to the field of cell transplantology and neurology and can be used to treat wound dystrophy of the central nervous system. The main idea of the invention is a preparation of haematopoietic stem cells (HSC), which is autologous HSC extracted from patient's peripheral blood enriched with cells containing CD34 antigen, in the final concentration of (40-100)x106 cells/ml. Enriching the blood is performed using intermittent administration of the preparation of the granulocyte colony-stimulating factor (G-CSF) - for example, Neilogen in the glucose solution, according to a certain scheme. Also, the method of production, cryoconservation of the preparation and the method of treating traumatic diseases in the brain and spinal cord, using the new preparation. The developed system allows patients to be helped with neurological diseases efficiently and suffering minimum injuries.
PCT/EP2005/008527 2005-03-29 2005-08-05 Preparation of autologous haematopoietic stem cells, the methods of production, cyropreservation and use for therapy of traumatic diseases of the central nervous system WO2006102933A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2008503377A JP2008534529A (en) 2005-03-29 2005-08-05 Autologous hematopoietic stem cell preparation, method for producing the same, cryopreservation method, and use for treatment of traumatic diseases of the central nervous system
AU2005329886A AU2005329886A1 (en) 2005-03-29 2005-08-05 Preparation of autologous haematopoietic stem cells, the methods of production, cyropreservation and use for therapy of traumatic diseases of the central nervous system
CA002601679A CA2601679A1 (en) 2005-03-29 2005-08-05 Preparation of autologous haematopoietic stem cells, the methods of production, cyropreservation and use for therapy of traumatic diseases of the central nervous system
EP05770085A EP1863903A1 (en) 2005-03-29 2005-08-05 Preparation of autologous haematopoietic stem cells, the methods of production, cyropreservation and use for therapy of traumatic diseases of the central nervous system
IL186228A IL186228A0 (en) 2005-03-29 2007-09-24 Preparation of autologous haematopoietic stem cells, the methods of production, cryopreservation and use for therapy of traumatic diseases of the central nervous system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2005108721/15A RU2283119C1 (en) 2005-03-29 2005-03-29 Autologic hemopoietic stem cells preparation and method for producing, cryogenic preserving and applying it in treating traumatic nervous system disease cases
RU2005108721 2005-03-29

Publications (2)

Publication Number Publication Date
WO2006102933A1 WO2006102933A1 (en) 2006-10-05
WO2006102933A8 true WO2006102933A8 (en) 2007-11-08

Family

ID=35539372

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/008527 WO2006102933A1 (en) 2005-03-29 2005-08-05 Preparation of autologous haematopoietic stem cells, the methods of production, cyropreservation and use for therapy of traumatic diseases of the central nervous system

Country Status (7)

Country Link
EP (1) EP1863903A1 (en)
JP (1) JP2008534529A (en)
AU (1) AU2005329886A1 (en)
CA (1) CA2601679A1 (en)
IL (1) IL186228A0 (en)
RU (1) RU2283119C1 (en)
WO (1) WO2006102933A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008031448A1 (en) * 2006-09-15 2008-03-20 Meditech Industries Llc Preparation of autologous non-hematopoietic progenitor stem cells, method of preparation and use thereof
RU2394593C2 (en) 2008-09-25 2010-07-20 Андрей Степанович БРЮХОВЕЦКИЙ Implanted neuroendoprosthetic system, method of obtaining it and method of carrying out reconstructive neurosurgical operation
RU2428475C2 (en) 2008-12-30 2011-09-10 Андрей Степанович БРЮХОВЕЦКИЙ Stem cell preparation with reprogrammed cell signalling, method for making this preparation and application thereof
RU2521225C2 (en) * 2013-01-09 2014-06-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Казанский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО Казанский ГМУ Министерства здравоохранения Российской Федерации) Method for stimulating spinal cord regeneration with genetically modified human umbilical cord blood cells
WO2016147675A1 (en) * 2015-03-18 2016-09-22 公益財団法人先端医療振興財団 Medicine for treatment and/or prevention of ischemic diseases, method for improving angiogenesis-promoting activity of cells, or method for producing medicine
CA3040687A1 (en) 2016-10-14 2018-04-19 Childrens' Medical Center Corporation Compositions and methods for treating diseases and disorders of the central nervous system
EP3570670B1 (en) 2017-01-17 2024-03-06 Children's Medical Center Corporation Compositions and methods for treating lysosomal storage diseases and disorders
WO2018136434A1 (en) 2017-01-17 2018-07-26 Children's Medical Center Corporation Compositions and methods for diagnosing and treating peroxisomal diseases
RU2647429C1 (en) * 2017-02-06 2018-03-15 Федеральное государственное автономное образовательное учреждение высшего образования "Дальневосточный федеральный университет" (ДВФУ) Biomedical cell preparation
RU2741769C2 (en) * 2018-12-21 2021-01-28 Андрей Степанович БРЮХОВЕЦКИЙ Biomedical cell product, method for its production and application
RU2720002C1 (en) * 2018-12-28 2020-04-23 Андрей Степанович БРЮХОВЕЦКИЙ Biomedical cell product for treating nervous diseases and mental disorders, method for production thereof and use thereof
RU2757812C2 (en) * 2018-12-28 2021-10-21 Андрей Степанович БРЮХОВЕЦКИЙ Antitumor target cell product, method for its production and its application
RU2716013C2 (en) * 2019-05-27 2020-03-05 Федеральное государственное бюджетное образовательное учреждение высшего образования "Казанский Государственный медицинский университет" Министерства здравоохранения Российской Федерации Method for preparing a cell-mediated gene therapy agent and a cell-mediated gene therapy agent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020142462A1 (en) * 1997-11-26 2002-10-03 Ildstad Suzanne T. Methods for mobilizing hematopoietic facilitating cells and hematopoietic stem cells into the peripheral blood
GB9904281D0 (en) * 1999-02-24 1999-04-21 Reneuron Ltd Transplantation
US7811557B1 (en) * 2000-10-27 2010-10-12 Viacell, Inc. Methods for improving central nervous system functioning

Also Published As

Publication number Publication date
JP2008534529A (en) 2008-08-28
EP1863903A1 (en) 2007-12-12
AU2005329886A1 (en) 2006-10-05
CA2601679A1 (en) 2006-10-05
WO2006102933A1 (en) 2006-10-05
IL186228A0 (en) 2008-01-20
RU2283119C1 (en) 2006-09-10

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