WO2006092032A3 - PHARMACEUTICAL COMPOSITIONS CONTAINING 1-METHYL-3,6,7,8-TETRAHYDROPIRAZOLO[3,4-b]PIRROLO[4,3-d]PYRIDINE-6,8-DIONE DERIVATIVES, USE, AND PROCESS FOR PREPARING THEM - Google Patents

PHARMACEUTICAL COMPOSITIONS CONTAINING 1-METHYL-3,6,7,8-TETRAHYDROPIRAZOLO[3,4-b]PIRROLO[4,3-d]PYRIDINE-6,8-DIONE DERIVATIVES, USE, AND PROCESS FOR PREPARING THEM Download PDF

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Publication number
WO2006092032A3
WO2006092032A3 PCT/BR2006/000037 BR2006000037W WO2006092032A3 WO 2006092032 A3 WO2006092032 A3 WO 2006092032A3 BR 2006000037 W BR2006000037 W BR 2006000037W WO 2006092032 A3 WO2006092032 A3 WO 2006092032A3
Authority
WO
WIPO (PCT)
Prior art keywords
tetrahydropirazolo
pirrolo
methyl
pharmaceutical compositions
compositions containing
Prior art date
Application number
PCT/BR2006/000037
Other languages
French (fr)
Other versions
WO2006092032B1 (en
WO2006092032A2 (en
Inventor
Lacerda Barreiro Eliezer De De
Fraga Carlos Alberto Manssour
Sudo Gisele Zapata
Sudo Roberto Takashi
Ricardo Menegatti
Original Assignee
Univ Rio De Janeiro
Lacerda Barreiro Eliezer De De
Fraga Carlos Alberto Manssour
Sudo Gisele Zapata
Sudo Roberto Takashi
Ricardo Menegatti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rio De Janeiro, Lacerda Barreiro Eliezer De De, Fraga Carlos Alberto Manssour, Sudo Gisele Zapata, Sudo Roberto Takashi, Ricardo Menegatti filed Critical Univ Rio De Janeiro
Publication of WO2006092032A2 publication Critical patent/WO2006092032A2/en
Publication of WO2006092032A3 publication Critical patent/WO2006092032A3/en
Publication of WO2006092032B1 publication Critical patent/WO2006092032B1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention is related to new derivatives of 1-methyl-3,6,7,8- tetrahydropirazolo[3,4-b]pirrolo[4,3-d]piridin-6,8-dione nucleus, preferably heterocyclic derivatives, acting as hypnotics and analgesic in the central nervous system, being useful in the treatment of anxiety and central hyperalgesia, including: anxiety relief, central hyperalgesia relief in mammals, preferably humans. It is also described pharmaceutical compositions containing said compounds and preparation processes.
PCT/BR2006/000037 2005-03-03 2006-03-03 PHARMACEUTICAL COMPOSITIONS CONTAINING 1-METHYL-3,6,7,8-TETRAHYDROPIRAZOLO[3,4-b]PIRROLO[4,3-d]PYRIDINE-6,8-DIONE DERIVATIVES, USE, AND PROCESS FOR PREPARING THEM WO2006092032A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRPI050.0727-5 2005-03-03
BRPI0500727-5A BRPI0500727A (en) 2005-03-03 2005-03-03 1-methyl-3,6,7,8-tetrahydropyrazolo [3,4, -b] pyrrolo [4,3-d] pyridine-6,8-dione derivatives, preparation process, pharmaceutical compositions containing same and related uses

Publications (3)

Publication Number Publication Date
WO2006092032A2 WO2006092032A2 (en) 2006-09-08
WO2006092032A3 true WO2006092032A3 (en) 2006-11-02
WO2006092032B1 WO2006092032B1 (en) 2006-12-28

Family

ID=36941519

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2006/000037 WO2006092032A2 (en) 2005-03-03 2006-03-03 PHARMACEUTICAL COMPOSITIONS CONTAINING 1-METHYL-3,6,7,8-TETRAHYDROPIRAZOLO[3,4-b]PIRROLO[4,3-d]PYRIDINE-6,8-DIONE DERIVATIVES, USE, AND PROCESS FOR PREPARING THEM

Country Status (2)

Country Link
BR (1) BRPI0500727A (en)
WO (1) WO2006092032A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201100423A (en) 2009-03-31 2011-01-01 Arqule Inc Substituted pyrazolo-pyrrolo-pyridine-dione compounds
CN110156775A (en) * 2018-02-12 2019-08-23 新发药业有限公司 A kind of pyrrole former times replaces the simple and convenient process for preparing of Buddhist nun
RU2771024C1 (en) * 2021-05-28 2022-04-25 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Method and installation for the manufacture of diacetonitrile

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DIAZ-ORTIZ A. ET AL.: "Synthesis of Pyrazolo[3,4-b]pyridines by Cycloaddition Reactions under Microwave Irradiation", TETRAHEDRON, vol. 56, no. 11, March 2000 (2000-03-01), pages 1569 - 1577, XP004203036 *
MASON H.J. ET AL.: "Synthesis of fused pyridopyrrolidine dione derivatives using hetero Diels-Alder reaction", TETRAHEDRON LETTERS, vol. 42, no. 51, 17 December 2001 (2001-12-17), pages 8931 - 8934, XP003003602 *

Also Published As

Publication number Publication date
WO2006092032B1 (en) 2006-12-28
WO2006092032A2 (en) 2006-09-08
BRPI0500727A (en) 2006-10-17

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