BRPI0500727A - 1-methyl-3,6,7,8-tetrahydropyrazolo [3,4, -b] pyrrolo [4,3-d] pyridine-6,8-dione derivatives, preparation process, pharmaceutical compositions containing same and related uses - Google Patents

1-methyl-3,6,7,8-tetrahydropyrazolo [3,4, -b] pyrrolo [4,3-d] pyridine-6,8-dione derivatives, preparation process, pharmaceutical compositions containing same and related uses

Info

Publication number
BRPI0500727A
BRPI0500727A BRPI0500727-5A BRPI0500727A BRPI0500727A BR PI0500727 A BRPI0500727 A BR PI0500727A BR PI0500727 A BRPI0500727 A BR PI0500727A BR PI0500727 A BRPI0500727 A BR PI0500727A
Authority
BR
Brazil
Prior art keywords
methyl
pharmaceutical compositions
compositions containing
pyrrolo
pyridine
Prior art date
Application number
BRPI0500727-5A
Other languages
Portuguese (pt)
Inventor
Ricardo Menegatti
Gisele Zapata-Sudo
Roberto Takashi Sudo
Eliezer De Jesus De L Barreiro
Carlos Alberto Manssour Fraga
Original Assignee
Univ Rio De Janeiro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rio De Janeiro filed Critical Univ Rio De Janeiro
Priority to BRPI0500727-5A priority Critical patent/BRPI0500727A/en
Priority to PCT/BR2006/000037 priority patent/WO2006092032A2/en
Publication of BRPI0500727A publication Critical patent/BRPI0500727A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

"DERIVADOS 1-METIL-3,6,7,8-TETRAHIDROPIRAZOLO¢3,4-b!PIRROLO¢4,3-d! PIRIDINA-6,8-DIONA, PROCESSO DE PREPARAçãO, COMPOSIçõES FARMACêUTICAS CONTENDO OS MESMOS E USOS RELACIONADOS". A presente invenção se relaciona a novos derivados do núcleo 1-metil-3,6,7,8-tetrahidropirazolo¢3,4-b!pirrolo¢4,3-d!piridin-6,8-diona, preferencialmente heterocíclicos, que atuam como hipnóticos e analgésicos com ação no sistema nervoso central, sendo, portanto, úteis no tratamento da ansiedade e hiperalgesia central, incluindo: o alívio da ansiedade; alívio da hiperalgesia central em mamíferos, preferencialmente humanos. São também descritas composições farmacêuticas contendo os referidos compostos e processo para sua preparação."1-METHYL-3,6,7,8-TETRAHYDROPYRAZOLA ¢ 3,4-b! PYROROLO ¢ 4,3-d! PYRIDINE-6,8-DIONA DERIVATIVES, PREPARATION PROCESS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND RELATED USES " The present invention relates to novel derivatives of the preferably heterocyclic 1-methyl-3,6,7,8-tetrahydropyrazole ¢ 3,4-b-pyrrolo ¢ 4,3-dpyridin-6,8-dione nucleus derivatives which are preferably heterocyclic. They act as hypnotics and analgesics with action on the central nervous system and are therefore useful in treating anxiety and central hyperalgesia, including: anxiety relief; relief of central hyperalgesia in mammals, preferably humans. Also disclosed are pharmaceutical compositions containing said compounds and process for their preparation.

BRPI0500727-5A 2005-03-03 2005-03-03 1-methyl-3,6,7,8-tetrahydropyrazolo [3,4, -b] pyrrolo [4,3-d] pyridine-6,8-dione derivatives, preparation process, pharmaceutical compositions containing same and related uses BRPI0500727A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BRPI0500727-5A BRPI0500727A (en) 2005-03-03 2005-03-03 1-methyl-3,6,7,8-tetrahydropyrazolo [3,4, -b] pyrrolo [4,3-d] pyridine-6,8-dione derivatives, preparation process, pharmaceutical compositions containing same and related uses
PCT/BR2006/000037 WO2006092032A2 (en) 2005-03-03 2006-03-03 PHARMACEUTICAL COMPOSITIONS CONTAINING 1-METHYL-3,6,7,8-TETRAHYDROPIRAZOLO[3,4-b]PIRROLO[4,3-d]PYRIDINE-6,8-DIONE DERIVATIVES, USE, AND PROCESS FOR PREPARING THEM

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0500727-5A BRPI0500727A (en) 2005-03-03 2005-03-03 1-methyl-3,6,7,8-tetrahydropyrazolo [3,4, -b] pyrrolo [4,3-d] pyridine-6,8-dione derivatives, preparation process, pharmaceutical compositions containing same and related uses

Publications (1)

Publication Number Publication Date
BRPI0500727A true BRPI0500727A (en) 2006-10-17

Family

ID=36941519

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0500727-5A BRPI0500727A (en) 2005-03-03 2005-03-03 1-methyl-3,6,7,8-tetrahydropyrazolo [3,4, -b] pyrrolo [4,3-d] pyridine-6,8-dione derivatives, preparation process, pharmaceutical compositions containing same and related uses

Country Status (2)

Country Link
BR (1) BRPI0500727A (en)
WO (1) WO2006092032A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2756810A1 (en) 2009-03-31 2010-10-07 Arqule, Inc. Pyrazolo-pyrrolopyridine-dione derivatives useful in the treatment of cancer
CN110156775A (en) * 2018-02-12 2019-08-23 新发药业有限公司 A kind of pyrrole former times replaces the simple and convenient process for preparing of Buddhist nun
RU2771024C1 (en) * 2021-05-28 2022-04-25 Федеральное государственное автономное образовательное учреждение высшего образования "Белгородский государственный национальный исследовательский университет" (НИУ "БелГУ") Method and installation for the manufacture of diacetonitrile

Also Published As

Publication number Publication date
WO2006092032A2 (en) 2006-09-08
WO2006092032B1 (en) 2006-12-28
WO2006092032A3 (en) 2006-11-02

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B07D Technical examination (opinion) related to article 229 of industrial property law
B08F Application fees: dismissal - article 86 of industrial property law

Free format text: REFERENTE A 12A ANUIDADE.

B08G Application fees: restoration
B07E Notice of approval relating to section 229 industrial property law
B15K Others concerning applications: alteration of classification

Ipc: C07D 471/14 (2006.01), A61K 31/437 (2006.01), A61P

B06A Notification to applicant to reply to the report for non-patentability or inadequacy of the application according art. 36 industrial patent law
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements