WO2006091813A3 - Novel thermophilic proteins and the nucleic acids encoding them - Google Patents

Novel thermophilic proteins and the nucleic acids encoding them Download PDF

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Publication number
WO2006091813A3
WO2006091813A3 PCT/US2006/006593 US2006006593W WO2006091813A3 WO 2006091813 A3 WO2006091813 A3 WO 2006091813A3 US 2006006593 W US2006006593 W US 2006006593W WO 2006091813 A3 WO2006091813 A3 WO 2006091813A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
acids encoding
proteins
thermophilic proteins
novel thermophilic
Prior art date
Application number
PCT/US2006/006593
Other languages
French (fr)
Other versions
WO2006091813A2 (en
Inventor
Arcady Mushegian
Jing Liu
Konstantin Severinov
Tatyana Naryshkina
Original Assignee
Stowers Institute For Medical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stowers Institute For Medical Research filed Critical Stowers Institute For Medical Research
Publication of WO2006091813A2 publication Critical patent/WO2006091813A2/en
Publication of WO2006091813A3 publication Critical patent/WO2006091813A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10111—Myoviridae
    • C12N2795/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Abstract

The disclosed invention relates to the fields of molecular biology and biochemistry. Thermophilic proteins and the nucleic acids encoding them are disclosed. The thermophilic proteins are from, or derived from, a bacteriophage, YS40, that infects the thermophilic bacterium Thermus thermophilus. These proteins have enhances stability, particularly at high temperatures.
PCT/US2006/006593 2005-02-25 2006-02-24 Novel thermophilic proteins and the nucleic acids encoding them WO2006091813A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65622905P 2005-02-25 2005-02-25
US60/656,229 2005-02-25

Publications (2)

Publication Number Publication Date
WO2006091813A2 WO2006091813A2 (en) 2006-08-31
WO2006091813A3 true WO2006091813A3 (en) 2009-08-27

Family

ID=36928041

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/006593 WO2006091813A2 (en) 2005-02-25 2006-02-24 Novel thermophilic proteins and the nucleic acids encoding them

Country Status (1)

Country Link
WO (1) WO2006091813A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102851246B (en) * 2012-09-14 2013-08-21 大地绿源环保科技(北京)有限公司 Thermus thermophilus UTM802 and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6368801B1 (en) * 2000-04-12 2002-04-09 Molecular Staging, Inc. Detection and amplification of RNA using target-mediated ligation of DNA by RNA ligase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6368801B1 (en) * 2000-04-12 2002-04-09 Molecular Staging, Inc. Detection and amplification of RNA using target-mediated ligation of DNA by RNA ligase

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
NARYSHKINA ET AL., ACCESSION AOMN, 12 December 2006 (2006-12-12), pages 19 *
NARYSHKINA ET AL., J MOL BIOL., vol. 364, no. 4, 8 December 2006 (2006-12-08), pages 667 - 77 *
SAKAKI ET AL., J VIROL., vol. 15, no. 6, June 1975 (1975-06-01), pages 1449 - 53 *
SAMBROOK ET AL., MOLECULAR CLONING A LABORATORY MANNUAL, 1989, N.Y., pages 8.46 - 8.52 AND *
STANDING ET AL., CURR OPIN STRUCT BIOL., vol. 13, no. 5, October 2003 (2003-10-01), pages 595 - 601 *

Also Published As

Publication number Publication date
WO2006091813A2 (en) 2006-08-31

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