WO2006089298A3 - Pyrimidine-fused diazepine derivatives and indole-fused pteridines - Google Patents

Pyrimidine-fused diazepine derivatives and indole-fused pteridines Download PDF

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Publication number
WO2006089298A3
WO2006089298A3 PCT/US2006/006303 US2006006303W WO2006089298A3 WO 2006089298 A3 WO2006089298 A3 WO 2006089298A3 US 2006006303 W US2006006303 W US 2006006303W WO 2006089298 A3 WO2006089298 A3 WO 2006089298A3
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WO
WIPO (PCT)
Prior art keywords
fused
indole
pyrimidine
pteridines
diazepine derivatives
Prior art date
Application number
PCT/US2006/006303
Other languages
French (fr)
Other versions
WO2006089298A2 (en
Inventor
Xu Bai Bai
Qun Dang
Robert J Ternansky Ternansky
Original Assignee
Attenuon Llc
Changchun Discovery Sciences L
Xu Bai Bai
Qun Dang
Robert J Ternansky Ternansky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Attenuon Llc, Changchun Discovery Sciences L, Xu Bai Bai, Qun Dang, Robert J Ternansky Ternansky filed Critical Attenuon Llc
Priority to EP06748243A priority Critical patent/EP1848506A2/en
Publication of WO2006089298A2 publication Critical patent/WO2006089298A2/en
Publication of WO2006089298A3 publication Critical patent/WO2006089298A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

The present invention relates to pyrimidine-fused benzodiazepine derivative and indole-fused pteridine compounds. The invention further relates to libraries containing two or more of such compounds and methods of making such compounds. The invention also relates to methods of screening for bioactive pyrimidine-fused benzodiazepine derivative and indole-fused pteridine compounds.
PCT/US2006/006303 2005-02-18 2006-02-21 Pyrimidine-fused diazepine derivatives and indole-fused pteridines WO2006089298A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06748243A EP1848506A2 (en) 2005-02-18 2006-02-21 Pyrimidine-fused diazepine derivatives and indole-fused pteridines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65460605P 2005-02-18 2005-02-18
US60/654,606 2005-02-18

Publications (2)

Publication Number Publication Date
WO2006089298A2 WO2006089298A2 (en) 2006-08-24
WO2006089298A3 true WO2006089298A3 (en) 2007-01-25

Family

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Family Applications (1)

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PCT/US2006/006303 WO2006089298A2 (en) 2005-02-18 2006-02-21 Pyrimidine-fused diazepine derivatives and indole-fused pteridines

Country Status (3)

Country Link
EP (1) EP1848506A2 (en)
CN (1) CN101257948A (en)
WO (1) WO2006089298A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11851434B2 (en) 2017-01-18 2023-12-26 Array Biopharma Inc. Substituted pyrazolo[1,5-A]pyrazine compounds as ret kinase inhibitors
US11998545B2 (en) 2023-06-27 2024-06-04 Array Biopharma Inc. Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5635395B2 (en) * 2007-04-11 2014-12-03 メルク・シャープ・エンド・ドーム・ベー・フェー Process for the preparation of enantiomerically pure benzazepine
US8557738B2 (en) 2008-08-12 2013-10-15 Nippon Soda Co., Ltd. Nitrogen-containing heterocyclic derivative and fungicide for agricultural and horticultural use
US9062024B2 (en) 2009-09-28 2015-06-23 Nippon Soda Co., Ltd. Nitrogen-containing heterocyclic compound and salt thereof, and a fungicide for agricultural and horticultural use
EP2918588B1 (en) 2010-05-20 2017-05-03 Array Biopharma, Inc. Macrocyclic compounds as TRK kinase inhibitors
CN102690278B (en) * 2011-03-21 2015-07-15 长春吉大天元化学技术股份有限公司 Novel pyrimidine-fused cyclic compounds as cytokine inhibitors
CN102807574B (en) * 2011-05-30 2015-09-02 长春吉大天元化学技术股份有限公司 New pyridine sulphur nitrogen seven-membered ring derivative as antitumor drug, and its preparation method and application
CN103509024B (en) * 2012-06-28 2015-10-28 上海医药工业研究院 Kui Linpyrimido quinoline benzazepine compounds and the application as antitumor drug thereof
PT3322706T (en) 2015-07-16 2021-03-08 Array Biopharma Inc Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
MX2018009189A (en) * 2016-03-04 2018-11-09 Ani New Star Pharmaceutical Dev Co Ltd Pyrimidine seven-membered-ring compounds, preparation method therefor, pharmaceutical composition thereof, and uses thereof.
WO2017165300A1 (en) * 2016-03-21 2017-09-28 Regents Of The University Of Minnesota Indole and indazole compounds and therapeutic uses thereof
TWI704148B (en) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
JOP20190077A1 (en) 2016-10-10 2019-04-09 Array Biopharma Inc Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors
WO2018136663A1 (en) 2017-01-18 2018-07-26 Array Biopharma, Inc. Ret inhibitors
JOP20190213A1 (en) 2017-03-16 2019-09-16 Array Biopharma Inc Macrocyclic compounds as ros1 kinase inhibitors
TWI791053B (en) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 Crystalline forms of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile and pharmaceutical composition thereof
TWI812649B (en) 2017-10-10 2023-08-21 美商絡速藥業公司 Formulations of 6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
AU2018392805A1 (en) 2017-12-22 2020-05-07 Dana-Farber Cancer Institute, Inc. NEK inhibitors and methods of use
JP7061195B2 (en) 2018-01-18 2022-04-27 アレイ バイオファーマ インコーポレイテッド Substituted pyrazolo [3,4-d] pyrimidine compound as a RET kinase inhibitor
JP7060694B2 (en) 2018-01-18 2022-04-26 アレイ バイオファーマ インコーポレイテッド Substituted pyrolo [2,3-D] pyrimidine compounds as RET kinase inhibitors
CN111615514B (en) 2018-01-18 2022-10-11 奥瑞生物药品公司 Substituted pyrazolo [4,3-C ] pyridine compounds as RET kinase inhibitors
JP2022500383A (en) 2018-09-10 2022-01-04 アレイ バイオファーマ インコーポレイテッド Condensed heterocyclic compound as a RET kinase inhibitor
KR102498531B1 (en) * 2020-06-29 2023-02-13 한국과학기술연구원 Novel pyrimidodiazepin derivatives as selective protein kinase TRKC inhibitor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009384A2 (en) * 2003-07-21 2005-02-03 Imclone Systems Incorporated Egfr tyrosine kinase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005009384A2 (en) * 2003-07-21 2005-02-03 Imclone Systems Incorporated Egfr tyrosine kinase inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FU ET AL.: "Synthesis of Novel Tricyclic Pyrimido[4,5-b][1,4]benzothiazepines via Bischler-Napieralski-Type Reactions", JOURNAL OF ORGANIC CHEMISTRY, vol. 70, no. 26, 23 December 2005 (2005-12-23), pages 10810 - 10816, XP003006644 *
YANG ET AL.: "Synthesis of Tricyclic-4-Chloro-pyrimido[4,5-b][1,4]benzodiazepines", ORGANIC LETTERS, vol. 7, no. 8, 14 April 2005 (2005-04-14), pages 1541 - 1543, XP003006645 *
ZHENG ET AL.: "Novel Heterocyclic Scaffold Consisting of Indole-Fused Pteridines", JOURNAL OF COMBINATORIAL CHEMISTRY, vol. 7, no. 6, November 2005 (2005-11-01), pages 813 - 815, XP008075077 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11851434B2 (en) 2017-01-18 2023-12-26 Array Biopharma Inc. Substituted pyrazolo[1,5-A]pyrazine compounds as ret kinase inhibitors
US11998545B2 (en) 2023-06-27 2024-06-04 Array Biopharma Inc. Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors

Also Published As

Publication number Publication date
WO2006089298A2 (en) 2006-08-24
EP1848506A2 (en) 2007-10-31
CN101257948A (en) 2008-09-03

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