MX2010005950A - 2-fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors. - Google Patents
2-fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors.Info
- Publication number
- MX2010005950A MX2010005950A MX2010005950A MX2010005950A MX2010005950A MX 2010005950 A MX2010005950 A MX 2010005950A MX 2010005950 A MX2010005950 A MX 2010005950A MX 2010005950 A MX2010005950 A MX 2010005950A MX 2010005950 A MX2010005950 A MX 2010005950A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitors
- methods
- fluoropyrazolo
- pyrimidines
- protein kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Pyrazolo[1,5-a]pyrimidine-based inhibitors of various kinase, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions that contain such inhibitors are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 or CHK-1 inhibitor compounds, methods of inhibiting CDK-2 or CHK-1, and methods for treating disease or disease symptoms.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99073607P | 2007-11-28 | 2007-11-28 | |
PCT/US2008/084643 WO2009070567A1 (en) | 2007-11-28 | 2008-11-25 | 2-fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2010005950A true MX2010005950A (en) | 2010-06-17 |
Family
ID=40343608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2010005950A MX2010005950A (en) | 2007-11-28 | 2008-11-25 | 2-fluoropyrazolo[1,5-a]pyrimidines as protein kinase inhibitors. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP2225247A1 (en) |
JP (1) | JP2011504931A (en) |
CN (1) | CN101970440A (en) |
CA (1) | CA2706946A1 (en) |
MX (1) | MX2010005950A (en) |
WO (1) | WO2009070567A1 (en) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS57221B2 (en) | 2008-10-22 | 2020-08-31 | Array Biopharma Inc | Substituted pyrazolo[1,5-]pyrimidine compounds as trk kinase inhibitors |
AR077468A1 (en) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS |
RU2735545C2 (en) | 2010-05-20 | 2020-11-03 | Эррэй Биофарма Инк. | Macrocyclic compounds as trk kinase inhibitors |
US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
HUE055618T2 (en) | 2012-12-07 | 2021-12-28 | Vertex Pharma | 2-amino-n-(piperidin-1-yl-pyridin-3-yl) pyrazolo[1,5alpha]pyrimidine-3-carboxamid as inhibitor of atr kinase |
EP2970286A1 (en) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Inc. | Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase |
EP2970289A1 (en) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Inc. | Compounds useful as inhibitors of atr kinase |
EP2970288A1 (en) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
CA2932757C (en) | 2013-12-06 | 2023-10-31 | Vertex Pharmaceuticals Incorporated | 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof |
US9969687B2 (en) | 2013-12-23 | 2018-05-15 | Norgine B.V. | Compounds useful as CCR9 modulators |
RU2020110358A (en) | 2014-06-05 | 2020-04-30 | Вертекс Фармасьютикалз Инкорпорейтед | RADIOACTIVELY LABORATED DERIVATIVES 2-AMINO-6-fluoro-N- [5-fluoro-pyridin-3-yl] -pyrazole [1,5-a] pyrimidine-3-carboxamide used as inositol, inositol COMPOUNDS AND ITS VARIOUS SOLID FORMS |
DK3157566T3 (en) | 2014-06-17 | 2019-07-22 | Vertex Pharma | METHOD OF TREATING CANCER USING A COMBINATION CHK1 AND ATR INHIBITORS |
EP3215505B1 (en) | 2014-11-03 | 2019-07-24 | Bayer Pharma Aktiengesellschaft | Piperidinylpyrazolopyrimidinones and their use |
CA2966583A1 (en) | 2014-11-06 | 2016-05-12 | Lysosomal Therapeutics Inc. | Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders |
AU2015342883B2 (en) | 2014-11-06 | 2020-07-02 | Bial - R&D Investments, S.A. | Substituted pyrrolo(1,2-a)pyrimidines and their use in the treatment of medical disorders |
ES2958391T3 (en) | 2014-11-06 | 2024-02-08 | Bial R&D Invest S A | Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders |
SG11201703962XA (en) | 2014-11-16 | 2017-06-29 | Array Biopharma Inc | Crystalline form of (s)-n-(5-((r)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide hydrogen sulfate |
CN107108633B (en) * | 2014-12-19 | 2020-05-12 | 詹森药业有限公司 | Heterocyclyl-linked imidazopyridazine derivatives as PI3K β inhibitors |
RU2768621C1 (en) | 2015-09-30 | 2022-03-24 | Вертекс Фармасьютикалз Инкорпорейтед | Method of treating cancer using a combination of dna damaging agents and atr inhibitors |
RU2744852C2 (en) | 2015-10-26 | 2021-03-16 | Локсо Онколоджи, Инк. | Point mutations in trk inhibitor-resistant malignant tumors and related methods |
KR102400423B1 (en) | 2016-04-04 | 2022-05-19 | 록쏘 온콜로지, 인코포레이티드 | (S)-N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-A]pyrimidine-3- Liquid formulation of yl)-3-hydroxypyrrolidine-1-carboxamide |
US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
EP3440081A4 (en) | 2016-04-06 | 2019-09-18 | Lysosomal Therapeutics Inc. | Pyrrolo[1,2-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
KR20230104752A (en) | 2016-04-06 | 2023-07-10 | 비알 - 알&디 인베스트먼츠, 에스.에이. | Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
CA3020305A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
WO2017192931A1 (en) | 2016-05-05 | 2017-11-09 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
CA3022670A1 (en) | 2016-05-05 | 2017-11-09 | Lysosomal Therapeutics Inc. | Substituted imidazo[1,2-b]pyridazines, substituted imidazo[1,5-b]pyridazines, related compounds, and their use in the treatment of medical disorders |
LT3800189T (en) | 2016-05-18 | 2023-10-10 | Loxo Oncology, Inc. | Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide |
JP7165126B2 (en) | 2016-09-19 | 2022-11-02 | バイエル・クロップサイエンス・アクチェンゲゼルシャフト | Pyrazolo[1,5-a]pyridine derivatives and their use as pesticides |
JOP20190092A1 (en) | 2016-10-26 | 2019-04-25 | Array Biopharma Inc | PROCESS FOR THE PREPARATION OF PYRAZOLO[1,5-a]PYRIMIDINES AND SALTS THEREOF |
JOP20190213A1 (en) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | Macrocyclic compounds as ros1 kinase inhibitors |
CN115485030A (en) * | 2020-03-06 | 2022-12-16 | 拜耳公司 | Imidazotriazines acting on cancer through inhibition of CDK12 |
JP7224548B2 (en) * | 2020-06-01 | 2023-02-17 | ユニマテック株式会社 | Fluorine-containing condensed pyrimidine compound and method for producing the same |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004052315A2 (en) * | 2002-12-11 | 2004-06-24 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
BRPI0407834A (en) * | 2003-02-28 | 2006-02-14 | Teijin Pharma Ltd | compound, process for the manufacture thereof, composition, process for the manufacture thereof, method of treating or preventing a protein kinase-mediated disorder in an individual, use of a compound, assay to determine the activity of the compounds, and method inhibiting the activity or function of a protein kinase |
TW200643022A (en) * | 2005-03-02 | 2006-12-16 | Basf Ag | 2-substituted 7-aminoazolopyrimidines, processes for their preparation and their use for controlling harmful fungi, and compositions comprising these compounds |
-
2008
- 2008-11-25 EP EP08854702A patent/EP2225247A1/en not_active Withdrawn
- 2008-11-25 CA CA2706946A patent/CA2706946A1/en not_active Abandoned
- 2008-11-25 CN CN2008801257650A patent/CN101970440A/en active Pending
- 2008-11-25 MX MX2010005950A patent/MX2010005950A/en not_active Application Discontinuation
- 2008-11-25 JP JP2010536116A patent/JP2011504931A/en not_active Withdrawn
- 2008-11-25 WO PCT/US2008/084643 patent/WO2009070567A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
JP2011504931A (en) | 2011-02-17 |
CA2706946A1 (en) | 2009-06-04 |
CN101970440A (en) | 2011-02-09 |
EP2225247A1 (en) | 2010-09-08 |
WO2009070567A1 (en) | 2009-06-04 |
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Legal Events
Date | Code | Title | Description |
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FA | Abandonment or withdrawal |