WO2006086670A3 - Method for determining redox activity and screening compounds based on redox activity - Google Patents

Method for determining redox activity and screening compounds based on redox activity Download PDF

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Publication number
WO2006086670A3
WO2006086670A3 PCT/US2006/004803 US2006004803W WO2006086670A3 WO 2006086670 A3 WO2006086670 A3 WO 2006086670A3 US 2006004803 W US2006004803 W US 2006004803W WO 2006086670 A3 WO2006086670 A3 WO 2006086670A3
Authority
WO
WIPO (PCT)
Prior art keywords
redox activity
free
radical
activity
subject compound
Prior art date
Application number
PCT/US2006/004803
Other languages
French (fr)
Other versions
WO2006086670A2 (en
Inventor
Jonathan J Abramson
Benjamin S Marinov
Original Assignee
Oregon State
Jonathan J Abramson
Benjamin S Marinov
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/340,938 external-priority patent/US20060188997A1/en
Application filed by Oregon State, Jonathan J Abramson, Benjamin S Marinov filed Critical Oregon State
Priority to EP06734783A priority Critical patent/EP1848981A4/en
Priority to US11/884,051 priority patent/US8017401B2/en
Publication of WO2006086670A2 publication Critical patent/WO2006086670A2/en
Publication of WO2006086670A3 publication Critical patent/WO2006086670A3/en
Priority to US13/206,364 priority patent/US8323977B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • G01N31/223—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating presence of specific gases or aerosols
    • G01N31/224—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating presence of specific gases or aerosols for investigating presence of dangerous gases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/272—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration for following a reaction, e.g. for determining photometrically a reaction rate (photometric cinetic analysis)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks

Abstract

A method for identifying the redox activity of a subject compound is disclosed. The method can be performed aerobically and can include forming a mixture comprising a free-radical precursor and a compound to be tested, and converting the free-radical precursor into a free-radical anion and a free-radical cation. After the free radical cation and the free radical anion have been formed, the relative redox activity of the subject compound may cause a difference in the rate of photo-bleaching of the mixture and/or the rate of superoxide generation. These differences can be quantified and used to identify the redox activity of the subject compound. This sensitive technique for measuring redox activity can be used to screen compounds for various biological applications. Drugs also can be developed based on the relationship between redox activity and biological activity for particular biological applications.
PCT/US2006/004803 2005-01-28 2006-02-09 Method for determining redox activity and screening compounds based on redox activity WO2006086670A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP06734783A EP1848981A4 (en) 2005-02-09 2006-02-09 Method for determining redox activity and screening compounds based on redox activity
US11/884,051 US8017401B2 (en) 2005-01-28 2006-02-09 Method for determining redox activity and screening compounds based on redox activity
US13/206,364 US8323977B2 (en) 2005-01-28 2011-08-09 Method for determining redox activity and screening compounds based on redox activity

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US65173005P 2005-02-09 2005-02-09
US60/651,730 2005-02-09
US11/340,938 2006-01-27
US11/340,938 US20060188997A1 (en) 2005-01-28 2006-01-27 Detection of superoxide ions

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US11/340,938 Continuation-In-Part US20060188997A1 (en) 2005-01-28 2006-01-27 Detection of superoxide ions

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/884,051 A-371-Of-International US8017401B2 (en) 2005-01-28 2006-02-09 Method for determining redox activity and screening compounds based on redox activity
US13/206,364 Division US8323977B2 (en) 2005-01-28 2011-08-09 Method for determining redox activity and screening compounds based on redox activity

Publications (2)

Publication Number Publication Date
WO2006086670A2 WO2006086670A2 (en) 2006-08-17
WO2006086670A3 true WO2006086670A3 (en) 2007-01-11

Family

ID=36793779

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/004803 WO2006086670A2 (en) 2005-01-28 2006-02-09 Method for determining redox activity and screening compounds based on redox activity

Country Status (2)

Country Link
EP (1) EP1848981A4 (en)
WO (1) WO2006086670A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2418950A4 (en) 2009-04-15 2012-10-24 State Of Oregon By & Through The State Board Of Higher Education On Behalf Of Portland State Unv Compounds and methods for modulating activity of calcium release channels
CN113087703B (en) * 2021-03-03 2022-04-15 四川大学华西医院 Photosensitizer capable of specifically marking lipid droplets and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4233402A (en) * 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US5340716A (en) * 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
US20030219443A1 (en) * 1998-11-13 2003-11-27 Yung Shin Pharmaceutical Ind. Co., Ltd., A Taiwan Corporation Mycobacterium tuberculosis superoxide dismutase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4233402A (en) * 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US5340716A (en) * 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
US20030219443A1 (en) * 1998-11-13 2003-11-27 Yung Shin Pharmaceutical Ind. Co., Ltd., A Taiwan Corporation Mycobacterium tuberculosis superoxide dismutase

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KUTALA V.K.: "Reaction of superoxide with trityl radical: implications for the determination of superoxide by spectrophotometry", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 424, January 2004 (2004-01-01), pages 81 - 88, XP004494537 *
ROUBAUD V.: "Quantitative Meassurment of Superoxide Generation Using the Spin Trap 5-(Diethoxyphosphoryl-)5-methyl-1-pyrroline-N-oxide", vol. 247, May 1997 (1997-05-01), pages 404 - 411, XP008122169 *
See also references of EP1848981A4 *

Also Published As

Publication number Publication date
WO2006086670A2 (en) 2006-08-17
EP1848981A2 (en) 2007-10-31
EP1848981A4 (en) 2012-01-18

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