WO2006082213A1 - Compositions for controlling parasites comprising synergic combination of amitraz and chlorpyrifos - Google Patents
Compositions for controlling parasites comprising synergic combination of amitraz and chlorpyrifos Download PDFInfo
- Publication number
- WO2006082213A1 WO2006082213A1 PCT/EP2006/050614 EP2006050614W WO2006082213A1 WO 2006082213 A1 WO2006082213 A1 WO 2006082213A1 EP 2006050614 W EP2006050614 W EP 2006050614W WO 2006082213 A1 WO2006082213 A1 WO 2006082213A1
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- WO
- WIPO (PCT)
- Prior art keywords
- amitraz
- chlorpyrifos
- ppm
- composition
- animals
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/52—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing groups, e.g. carboxylic acid amidines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
- A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
- A01N57/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing heterocyclic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
Definitions
- the present invention relates to compositions for controlling parasites and the use of such compositions in the preparation of a medicament for controlling acarine parasites.
- Ticks are important blood feeding arthropod parasites that belong together with mites (Family: Psoroptidae) to the order Acarina (acarine parasites).
- mites Fluoroptidae
- Acarina acarine parasites
- Ixodidae hard ticks
- Argasidae soft ticks
- the Ixodidae species is of most economic importance and include the important species Boophilus spp., Rhipicephalus spp, Ixodes spp, Hyalomma spp., Amblyomma sp p. and Dermacentor spp.
- the cattle tick Boophilus microplus is the most economically important bovine parasite in Brazil, causing economic losses in the order of US$ 2 billion each year
- Each of the five Boophilus spp. has a one-host life cycle that may be completed in 3 to 4 weeks and results in a heavy tick burden.
- Treatment of hosts with acaricides to kill attached larvae, nymphs, and adults of ticks has been the most widely used control method.
- Chemical products are the major way of control of ticks.
- the main acaricide was arsenic trioxide.
- organochlorines, organophosphates, carbamates, amidines, pyrethroids, and avermectins have been used in different parts of the world.
- its frequent utilization led to resistant parasite population selection.
- Acaricide products resistance is widespread in the world and contemplates a lot of chemical products (Kunz & Kemp, 1994).
- acaricidal composition which demonstrates a high controlling effect even against ticks of Boophilus sp., which acquired resistance against amitraz and/or certain organophosphate compounds.
- the invention thus relates to a veterinary composition for the control of acarine parasites on animals comprising as active ingredient a synergistic combination of amitraz and chlorpyrifos.
- Amitraz is a known insecticide and acaricide and is the common name for N,N-bis (2,4-xylyliminomethyl)methylamine.
- Amitraz presents adrenergic activity by monoaminooxidasis inhibition, leading to noradrenalin and serotonin at central nervous system.
- Organophosphate compounds are for a long time used as insecticide and pesticide for plants and livestock as well as anthelmintic for animals.
- the acaricidal action of organophosphate compounds is due to the inhibition of the enzyme acetylcholinesterase, resulting in the accumulation of the neurotransmitter acetylcholine, at nerve endings. This results in excessive transmission of nerve impulses, which causes mortality in the target pest.
- organophosphate compounds are Profenofos, Dichlorvos, Fenamiphos, Fenitrothion, EPN , Diazinon Chlorpyrifos, Acephate, Prothiofos, Fosthiazate,
- Chlorpyrifos Especially preferred is Chlorpyrifos.
- the chemical name of chlorpyrifos is 0,0 - Diethyl-O-S.S. ⁇ -trichloro ⁇ -pyridylphosphorothioate.
- the composition of the invention it is suitable to formulate the composition e.g. as a wettable powder, aqueous concentrate, emulsifiable concentrate (EC) , liquid concentrate, sol (flowable agent), powder, aerosol, or the like, by conventional methods such as admixing the compounds separately with a suitable carrier and auxilliaries, such as emulsifiers, dispersants, stabilizers, suspending agents, penetrants, and the like and than combine the formulations for direct administration to the animal, optionally after diluting.
- a suitable carrier and auxilliaries such as emulsifiers, dispersants, stabilizers, suspending agents, penetrants, and the like and than combine the formulations for direct administration to the animal, optionally after diluting.
- Amitraz is preferably formulated as wettable powder and the organophosphate compound (e.g. chlorpyrifos) as emulsifiable concentrate and the final composition is mixed with water immediately before application to the animal.
- the organophosphate compound e.g. chlorpyrifos
- amitraz and the organophosphate compound are formulated as wettable powder and mixed with water immediately before application to the animal to form the final formulation.
- An emulsifiable concentrate comprises the active ingredient dissolved in water- immiscible solvent which is formed into an emulsion with water in the presence of an emulsifying agent.
- a dispersible or wettable powder usually comprises the active ingredients in admixture with a suitable surfactant and an inert powder diluent such as china clay.
- Suitable formulations are usually composed of 0.001 to 99 parts by weight, preferably 0.01 to 95 parts by weight, more preferably 0.01 to 80 parts by weight of an active ingredient and 1 to 99.999 parts by weight, preferably 5 to 99.99 parts by weight, more preferably 20 to 99.99 parts by weight of suitable carrier and auxilliaries.
- composition may be formulated for application by a particular method, for example spraying, in which case the formulation may be presented as an aerosol using a liquid or gas propellent.
- suitable carrier and auxilliaries there may be mentioned carriers, emulsifiers, suspending agents, dispersants, extenders, penetrating agents, wetting agents, thickeners, defoaming agents, stabilizers or antifreezing agents. They may be added as the case requires.
- the ratio of the organophosphate compound to amitraz in the acaricidal composition of the invention is about 1 weight part of the amitraz to about 0.5-10 weight parts, preferably about 1-5 weight parts, of the organophosphate compound
- the composition of the invention may also be present in a mixture with other active agents, for example various insecticidal, or acaricidal agents in order to expand its applicability.
- pesticide compounds may include active ingredients which have an immediate effect, rather than the relatively slowly acting IGR.
- Other ingredients that may be included in the composition of the current invention are pesticidial active ingredients e.g. synthetic pyrethroids ( e.g permethrin, deltamethrin, cypermethrin, lambdacyhalothrin, fenvalerate, resmethrin, tralomethrin), acetylcholinesterase Inhibitors as carbamates (e.g. carbaryl, benziocarb, fenoxycarb, proxopur), acetylcholine mimics (e.g. nicotine, imidacloprid), GABA Antagonists (e.g. fipronil).
- carbamates e.g. carbaryl, benz
- the invention relates to the use of the composition according to the invention for the manufacture of a veterinary medicament for the control of parasites, especially parasitic acarid- infestations on host animals.
- example 3 the therapeutic efficacy and residual period of the composition according to the invention was evaluated, after spray administration of the water- diluted composition manufactured according to example 1 to Boophilus microplus infested cattle in different Brazilian regions. These experiments conducted in cattle demonstrated that the association showed a higher efficacy against ticks of Boophilus sp., when compared to the efficacy of the separate compounds.
- compositions of the invention are intended for use for controlling a parasitic acarid infestation.
- controlling a parasitic acarid infestation refers to preventing, reducing or eliminating an infestation by such parasites on animals preferably by killing the insects and/ or acarids within hours or days.
- parasitic acarid refers to ectoparasites e.g. acarine pests that commonly infest or infect animals. Examples of such ectoparasites include the egg, larval, pupal, nymphal and adult stages of mites and ticks.
- animals may be dipped in a bath with water diluted acaricide. Dipping vats are constructed so that animals are thoroughly immersed in the vat fluid, and the liquid that drains from the animals, returns to the vat.
- Aqueous emulsions or suspensions may also be applied by spraying.
- Sprayers are generally portable and may be hand- or motor-driven, and only enough acaricide to treat a specific number of animals needs be prepared. Hand application of insecticides as washes, ointments, dusts, mist sprays, spray foams, aerosols, etc, can also be done.
- Ear ticks may be controlled by insecticides applied directly into the ears.
- Other treatments applied by hand include the pour-on method, which consists of applying a water-diluted, emulsifiable concentrate or a ready-to-use formulation. The liquid should be poured along the backline from the shoulders to the hip bones.
- the spot-on treatment method consists of applying a small volume of concentrated insecticide to a single spot on the animal's back
- compositions of the invention may be employed in many forms and are often most conveniently prepared in aqueous form immediately prior to use.
- Tank mixing One method of preparing such a composition is referred to as "tank mixing" in which the ingredients in their commercially available form are mixed together by the user in a quantity of water.
- compositions containing amitraz and the organophosphate may be formulated into a more concentrated primary composition which is diluted with water or other diluent before use.
- Such compositions may comprise a surface active agent in addition to the active ingredients.
- It can be a dispersable solution which comprises the active ingredient dissolved in a water-miscible solvent with the addition of a disperging agent.
- it can comprise the ingredients in the form of a finely ground powder in association with a disperging agent and intimately mixed with water
- the active ingredients are diluted in water.
- the final concentration of amitraz and the organophosphate in the diluted ready to use formulation is between 50 ppm and 800 ppm.
- the diluted composition contains 250 ppm amitraz and 500 ppm chlorpyrifos.
- the diluted composition is preferably administered to the animal by spray or dip. Preferably 5 liters of the diluted composition are applied to each animal.
- the active ingredients are formulated separately and they are mixed together immediately before administration to the animal.
- the host animal is a bovine.
- the method may be also be used to treat or control parasites on a variety of other animals including livestock animals as sheep, deer, goats, pigs, and companion animals as horses, dogs and cats.
- livestock animals as sheep, deer, goats, pigs, and companion animals as horses, dogs and cats.
- the composition according to the invention is used to control acarine parasites on animals, especially for the control of ticks, especially Boophilus sp..
- the composition of the invention is further illustrated in the following examples.
- GLORIA M.A.
- FLAUSINO J.R.N.
- GRISI L. Resistencia do Boophilus microplus ao amitraz no estado do Rio de Janeiro, com base em testes de imersao de femeas ingurgitadas.
- Seminario Bras de Parasitologia Veterinaria, 7., 1993, Londrina. Anais... Londrina. 1993. p. A7.
- GRISI L. et al. lmpacto econ ⁇ mico das principals ectoparasitoses em bovinos no Brasil. A Hora Veterinaria , ano 21, n. 125, p. 8-10, 2002.
- KUNZ E. S.
- KEMP H. D. Insecticides and acaricides: resistance and environmental impact. Rev. Sci. Tech. Off. Int. Epiz. v.13, .4, p.1249-1286, 1994.
- Amitraz wettable powder Composition for 10O g:
- Aerosol OT-B 1.00 g Amorphous alumina silicate 19.0O g
- the active ingredients are diluted in water.
- the two active ingredients are formulated separately and they are mixed just before use.
- Amitraz wettable powder (wp) Composition for 100 g:
- the amount of each formulation is: 10 g of amitraz wp and 20 g of chlorpyrifos wp.
- Example 3 Efficacy of amitraz + chlorpyrifos composition against tick infestation of cattle
- Table 1 Description of the experiments, describing tested products and sites of execution.
- experiment 1 the efficacy of the association was compared to the efficacy of the isolated actives. Ticks counts in chlorpyrifos + amitraz treated animals differed from the control group from day + 1 to day +21 post treatment. Expressive efficacy of isolated chlorpyrifos was seen only until day +7. Amitraz presented almost no efficacy, and the counts in this group didn't differ from control group from day + 14. Amitraz results were very poor, making evident the occurrence of resistance against this active. Thus, the association performance was highly better than when the actives were administered at isolated form.
- association was compared to amitraz in three experiments (II, III and IV). In all of them, ticks counts for association treated animals differed from control from day +1 to day +28 post treatment, reflecting its expressive effectiveness. Statistical difference between the association and amitraz treatments is shown on days +21 (Exp II), +7 and +14 (Exp Il and IV) and +3 (Exp. IV). Taking these experiments together, it can be presumed that amitraz resistant tick strains are present. However, when the active is associated to chlopyrifos, good control could be obtained.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0606794-8A BRPI0606794A2 (en) | 2005-02-03 | 2006-02-02 | veterinary composition for the control of mite parasites in animals, and use of a |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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EP05100739.1 | 2005-02-03 | ||
EP05100739 | 2005-02-03 |
Publications (1)
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WO2006082213A1 true WO2006082213A1 (en) | 2006-08-10 |
Family
ID=34938628
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2006/050614 WO2006082213A1 (en) | 2005-02-03 | 2006-02-02 | Compositions for controlling parasites comprising synergic combination of amitraz and chlorpyrifos |
Country Status (4)
Country | Link |
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AR (1) | AR053804A1 (en) |
BR (1) | BRPI0606794A2 (en) |
WO (1) | WO2006082213A1 (en) |
ZA (1) | ZA200705786B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102630701A (en) * | 2012-04-11 | 2012-08-15 | 苏州佳辉化工有限公司 | Environment-friendly pesticide containing chlorpyrifos and preparation method thereof |
WO2018127928A1 (en) * | 2017-01-09 | 2018-07-12 | The Australian National University | Synergists for improved pesticides |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998023158A1 (en) * | 1996-11-26 | 1998-06-04 | Zeneca Limited | Insecticidal compositions and methods |
EP0979605A1 (en) * | 1998-08-07 | 2000-02-16 | Pfizer Products Inc. | Collar containing a novel gel formulation to control arthropod infestation of animals |
-
2006
- 2006-02-02 BR BRPI0606794-8A patent/BRPI0606794A2/en not_active Application Discontinuation
- 2006-02-02 AR ARP060100372A patent/AR053804A1/en not_active Application Discontinuation
- 2006-02-02 WO PCT/EP2006/050614 patent/WO2006082213A1/en not_active Application Discontinuation
-
2007
- 2007-07-13 ZA ZA200705786A patent/ZA200705786B/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998023158A1 (en) * | 1996-11-26 | 1998-06-04 | Zeneca Limited | Insecticidal compositions and methods |
EP0979605A1 (en) * | 1998-08-07 | 2000-02-16 | Pfizer Products Inc. | Collar containing a novel gel formulation to control arthropod infestation of animals |
Non-Patent Citations (3)
Title |
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BARNARD D R ET AL: "ACARICIDE SUSCEPTIBILITY IN THE LONE-STAR TICK AMBLYOMMA-AMERICANUM ASSAY TECHNIQUES AND BASELINE DATA", JOURNAL OF ECONOMIC ENTOMOLOGY, vol. 74, no. 4, 1981, pages 466 - 469, XP001207212, ISSN: 0022-0493 * |
HOROWITZ A R ET AL: "SYNERGISTIC ACTIVITY OF BINARY MIXTURES OF INSECTICIDES ON TOBACCO BUDWORM LEPIDOPTERA NOCTUIDAE EGGS", JOURNAL OF ECONOMIC ENTOMOLOGY, vol. 80, no. 2, 1987, pages 333 - 337, XP009051489, ISSN: 0022-0493 * |
LI ANDREW Y ET AL: "Detection and characterization of amitraz resistance in the southern cattle tick, Boophilus microplus (Acari: Ixodidae).", JOURNAL OF MEDICAL ENTOMOLOGY, vol. 41, no. 2, March 2004 (2004-03-01), pages 193 - 200, XP002338433, ISSN: 0022-2585 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102630701A (en) * | 2012-04-11 | 2012-08-15 | 苏州佳辉化工有限公司 | Environment-friendly pesticide containing chlorpyrifos and preparation method thereof |
WO2018127928A1 (en) * | 2017-01-09 | 2018-07-12 | The Australian National University | Synergists for improved pesticides |
Also Published As
Publication number | Publication date |
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ZA200705786B (en) | 2008-05-28 |
AR053804A1 (en) | 2007-05-23 |
BRPI0606794A2 (en) | 2010-02-09 |
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