WO2006074389A3 - Four-helical bundle protein zsig99 - Google Patents

Four-helical bundle protein zsig99 Download PDF

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Publication number
WO2006074389A3
WO2006074389A3 PCT/US2006/000494 US2006000494W WO2006074389A3 WO 2006074389 A3 WO2006074389 A3 WO 2006074389A3 US 2006000494 W US2006000494 W US 2006000494W WO 2006074389 A3 WO2006074389 A3 WO 2006074389A3
Authority
WO
WIPO (PCT)
Prior art keywords
zsig99
polypeptide
helical bundle
lif
disclosed
Prior art date
Application number
PCT/US2006/000494
Other languages
French (fr)
Other versions
WO2006074389A2 (en
Inventor
Brian A Fox
James W West
Stacey Tannheimer
Original Assignee
Zymogenetics Inc
Brian A Fox
James W West
Stacey Tannheimer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc, Brian A Fox, James W West, Stacey Tannheimer filed Critical Zymogenetics Inc
Publication of WO2006074389A2 publication Critical patent/WO2006074389A2/en
Publication of WO2006074389A3 publication Critical patent/WO2006074389A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5415—Leukaemia inhibitory factor [LIF]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A four helical bundle cytokine has been identified and designated zsig99. The polypeptide is 201 amino acids in length with the mature polypeptide starting at residue 43 as is shown in SEQ ID NO:2. When the zsig99 polynucleotide is co-expressed with a polynucleotide encoding for leukemia inhibitory factor (LIF), a heterodimer comprising zsig99 and LIF is secreted. Also disclosed are antibodies to zsig99, methods for producing the polypeptide using expression vectors and host cells. Diagnostic methods for identifying the presence of zsig99 polypeptide are also disclosed.
PCT/US2006/000494 2005-01-07 2006-01-06 Four-helical bundle protein zsig99 WO2006074389A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64196505P 2005-01-07 2005-01-07
US60/641,965 2005-01-07

Publications (2)

Publication Number Publication Date
WO2006074389A2 WO2006074389A2 (en) 2006-07-13
WO2006074389A3 true WO2006074389A3 (en) 2006-11-02

Family

ID=36263821

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/000494 WO2006074389A2 (en) 2005-01-07 2006-01-06 Four-helical bundle protein zsig99

Country Status (1)

Country Link
WO (1) WO2006074389A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002099066A2 (en) * 2001-06-06 2002-12-12 Human Genome Sciences, Inc. 20 human secreted proteins

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002099066A2 (en) * 2001-06-06 2002-12-12 Human Genome Sciences, Inc. 20 human secreted proteins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE UniProt [online] 5 July 2004 (2004-07-05), "LOC399888 protein (Fragment).", XP002380964, retrieved from EBI accession no. UNIPROT:Q6P0A1 Database accession no. Q6P0A1 *

Also Published As

Publication number Publication date
WO2006074389A2 (en) 2006-07-13

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