WO2006065897A3 - Device for the detection of prions - Google Patents

Device for the detection of prions Download PDF

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Publication number
WO2006065897A3
WO2006065897A3 PCT/US2005/045229 US2005045229W WO2006065897A3 WO 2006065897 A3 WO2006065897 A3 WO 2006065897A3 US 2005045229 W US2005045229 W US 2005045229W WO 2006065897 A3 WO2006065897 A3 WO 2006065897A3
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WO
WIPO (PCT)
Prior art keywords
sample
prions
defective
animal
tube
Prior art date
Application number
PCT/US2005/045229
Other languages
French (fr)
Other versions
WO2006065897A2 (en
Inventor
Chester F King
Original Assignee
Chester F King
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chester F King filed Critical Chester F King
Publication of WO2006065897A2 publication Critical patent/WO2006065897A2/en
Publication of WO2006065897A3 publication Critical patent/WO2006065897A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A device capable of obtaining a sample from an animal or human and processing the sample to detect a molecule of interest. The device comprises a two-sided needle, a sample collection tube that interconnects with a second tube containing processing agents via a compatible threaded coupling present on each tube. A compatible detection tube is provided. The present invention also relates to methods detecting defective prions in a sample obtained from an animal or a human by obtaining a sample, contacting the sample with proteinase K/cell lysing solution to form a mixture that will digest extraneous proteins in the sample but leave defective prions that may be in the sample unaffected, adding a monoclonal antibody specific for defective prions to the mixture, and detecting defective prions. The present invention also relates to method of detecting BSE in an animal prior to destruction of the animal comprising detecting defective prions as described above where the presence of defective prion proteins indicates the presence of BSE.
PCT/US2005/045229 2004-12-14 2005-12-14 Device for the detection of prions WO2006065897A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1267604A 2004-12-14 2004-12-14
US11/012,676 2004-12-14

Publications (2)

Publication Number Publication Date
WO2006065897A2 WO2006065897A2 (en) 2006-06-22
WO2006065897A3 true WO2006065897A3 (en) 2007-04-19

Family

ID=36588507

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/045229 WO2006065897A2 (en) 2004-12-14 2005-12-14 Device for the detection of prions

Country Status (1)

Country Link
WO (1) WO2006065897A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117589546A (en) * 2024-01-19 2024-02-23 广东省大湾区华南理工大学聚集诱导发光高等研究院 Hair pyrolysis liquid and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6936036B2 (en) * 2001-08-17 2005-08-30 Becton, Dickinson And Company Blood collection agency

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6936036B2 (en) * 2001-08-17 2005-08-30 Becton, Dickinson And Company Blood collection agency

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BUTLER D.A. ET AL.: "Scrapie-Infected Murine Neuroblastoma Cells Produce Protease-Resistant Prion Proteins", JOURNAL OF VIROLOGY, vol. 62, no. 5, May 1988 (1988-05-01), pages 1558 - 1564, XP009034641 *

Also Published As

Publication number Publication date
WO2006065897A2 (en) 2006-06-22

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