WO2006053903A3 - Niedermolekulare inhibitoren von guaninnucleotid-austauschfaktoren der cytohesin-familie - Google Patents
Niedermolekulare inhibitoren von guaninnucleotid-austauschfaktoren der cytohesin-familie Download PDFInfo
- Publication number
- WO2006053903A3 WO2006053903A3 PCT/EP2005/056084 EP2005056084W WO2006053903A3 WO 2006053903 A3 WO2006053903 A3 WO 2006053903A3 EP 2005056084 W EP2005056084 W EP 2005056084W WO 2006053903 A3 WO2006053903 A3 WO 2006053903A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cytohesin
- low
- guanine nucleotide
- nucleotide exchange
- exchange factors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05810998A EP1811997A2 (de) | 2004-11-19 | 2005-11-18 | Niedermolekulare inhibitoren von guaninnucleotid-austauschfaktoren der cytohesin-familie |
US11/667,046 US8163788B2 (en) | 2004-11-19 | 2005-11-18 | Low-molecular inhibitors of cytohesin-family guanine nucleotide exchange factors |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004055998.8 | 2004-11-19 | ||
DE102004055998A DE102004055998A1 (de) | 2004-11-19 | 2004-11-19 | Niedermolekulare Inhibitoren von Guaninnucleotid-Austauschfaktoren der Cytohesin-Familie |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006053903A2 WO2006053903A2 (de) | 2006-05-26 |
WO2006053903A3 true WO2006053903A3 (de) | 2006-12-07 |
Family
ID=36168436
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2005/056084 WO2006053903A2 (de) | 2004-11-19 | 2005-11-18 | Niedermolekulare inhibitoren von guaninnucleotid-austauschfaktoren der cytohesin-familie |
Country Status (4)
Country | Link |
---|---|
US (1) | US8163788B2 (de) |
EP (1) | EP1811997A2 (de) |
DE (1) | DE102004055998A1 (de) |
WO (1) | WO2006053903A2 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102006054205A1 (de) * | 2006-11-15 | 2008-05-29 | Rheinische Friedrich-Wilhelms Universität | Verwendung von Cytohesin-Inhibitoren zur chemischen Induktion von Langlebigkeit |
WO2009117365A2 (en) | 2008-03-17 | 2009-09-24 | Northwestern University | Vaccine compositons for inducing immune responses against components of drusen |
CN101687014A (zh) * | 2008-04-16 | 2010-03-31 | 犹他大学研究基金会 | 用于治疗病理性血管生成和血管通透的组合物和方法 |
EP2286808A1 (de) | 2009-08-18 | 2011-02-23 | Rheinische Friedrich-Wilhelms Universität | Cytohesininhibitoren |
AU2014233168B2 (en) * | 2013-03-15 | 2018-11-22 | Cancer Research Technology, Llc | Methods and compositions for Gamma-glutamyl cycle modulation |
AU2015308350B2 (en) | 2014-08-29 | 2020-03-05 | Tes Pharma S.R.L. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
CN106146476A (zh) * | 2015-03-24 | 2016-11-23 | 重庆大学 | 一种抗前列腺癌转移的化合物及其应用 |
WO2019101647A1 (en) | 2017-11-21 | 2019-05-31 | Bayer Aktiengesellschaft | 2-phenylpyrimidine-4-carboxamides as ahr inhibitors |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6221841B1 (en) * | 1996-10-07 | 2001-04-24 | University Of Massachusetts Medical Center | General receptors for phosphoinositides and uses related thereto |
WO2002057240A1 (en) * | 2000-12-22 | 2002-07-25 | Ortho Mc Neil Pharmaceutical, Inc. | Substituted triazole diamine derivatives as kinase inhibitors |
WO2004030629A2 (en) * | 2002-10-01 | 2004-04-15 | Predix Pharmaceuticals | Novel neurokinin antagonists and methods of use thereof |
US20040116490A1 (en) * | 2002-03-28 | 2004-06-17 | Marino Jr. Joseph P. | Compounds and methods |
WO2004052280A2 (en) * | 2002-12-10 | 2004-06-24 | Imclone Systems Incorporated | Anti-angiogenic compounds and their use in cancer treatment |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1223216A1 (de) * | 2000-12-30 | 2002-07-17 | NascaCell GmbH | Intrazelluläre Nukleinsäureinhibitoren kleiner Guaninnukleotid-Austauschfaktoren |
-
2004
- 2004-11-19 DE DE102004055998A patent/DE102004055998A1/de not_active Withdrawn
-
2005
- 2005-11-18 US US11/667,046 patent/US8163788B2/en not_active Expired - Fee Related
- 2005-11-18 WO PCT/EP2005/056084 patent/WO2006053903A2/de active Application Filing
- 2005-11-18 EP EP05810998A patent/EP1811997A2/de not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6221841B1 (en) * | 1996-10-07 | 2001-04-24 | University Of Massachusetts Medical Center | General receptors for phosphoinositides and uses related thereto |
WO2002057240A1 (en) * | 2000-12-22 | 2002-07-25 | Ortho Mc Neil Pharmaceutical, Inc. | Substituted triazole diamine derivatives as kinase inhibitors |
US20040116490A1 (en) * | 2002-03-28 | 2004-06-17 | Marino Jr. Joseph P. | Compounds and methods |
WO2004030629A2 (en) * | 2002-10-01 | 2004-04-15 | Predix Pharmaceuticals | Novel neurokinin antagonists and methods of use thereof |
WO2004052280A2 (en) * | 2002-12-10 | 2004-06-24 | Imclone Systems Incorporated | Anti-angiogenic compounds and their use in cancer treatment |
Non-Patent Citations (6)
Title |
---|
JACKSON C L ET AL: "TURNING ON ARF: THE SEC7 FAMILY OF GUANINE-NUCLEOTIDE-EXCHANGE FACTORS", TRENDS IN CELL BIOLOGY, ELSEVIER SCIENCE LTD, vol. 10, no. 2, February 2000 (2000-02-01), pages 60 - 67, XP000999945, ISSN: 0962-8924 * |
KOLANUS W ET AL: "ALPHALBETA2 INTEGRIN/LFA-1 BINDING TO ICAM-1 INDUCED BY CYTOHESIN-1, A CYTOPLASMIC REGULATORY MOLECULE", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 86, no. 2, 26 July 1996 (1996-07-26), pages 233 - 242, XP002040510, ISSN: 0092-8674 * |
MAYER G ET AL: "Controlling small guanine-nucleotide-exchange factor function through cytoplasmic RNA intramers", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 98, no. 9, 24 April 2001 (2001-04-24), pages 4961 - 4965, XP002168306, ISSN: 0027-8424 * |
MORINAGA N ET AL: "Cloning and expression of a cDNA encoding a bovine brain brefeldin A-sensitive guanine nucleotide-exchange protein for ADP-ribosylation factor", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 94, November 1997 (1997-11-01), pages 12926 - 12931, XP002966802, ISSN: 0027-8424 * |
RENAULT LOUIS ET AL: "Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor.", NATURE. 4 DEC 2003, vol. 426, no. 6966, 4 December 2003 (2003-12-04), pages 525 - 530, XP002378276, ISSN: 1476-4687 * |
SATA MAKOTO ET AL: "Structural basis for the inhibitory effect of brefeldin A on guanine nucleotide-exchange proteins for ADP-ribosylation factors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 96, no. 6, 16 March 1999 (1999-03-16), pages 2752 - 2757, XP002195637, ISSN: 0027-8424 * |
Also Published As
Publication number | Publication date |
---|---|
US8163788B2 (en) | 2012-04-24 |
US20090105286A1 (en) | 2009-04-23 |
EP1811997A2 (de) | 2007-08-01 |
WO2006053903A2 (de) | 2006-05-26 |
DE102004055998A1 (de) | 2006-05-24 |
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