WO2006053674A3 - A process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxyamide - Google Patents

A process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxyamide Download PDF

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Publication number
WO2006053674A3
WO2006053674A3 PCT/EP2005/012047 EP2005012047W WO2006053674A3 WO 2006053674 A3 WO2006053674 A3 WO 2006053674A3 EP 2005012047 W EP2005012047 W EP 2005012047W WO 2006053674 A3 WO2006053674 A3 WO 2006053674A3
Authority
WO
WIPO (PCT)
Prior art keywords
dibenz
azepine
dihydro
hydroxy
carboxyamide
Prior art date
Application number
PCT/EP2005/012047
Other languages
French (fr)
Other versions
WO2006053674A2 (en
Inventor
Mauro Panunzio
Eileen Campana
Gabriele Breviglieri
Original Assignee
Farchemia Srl
Mauro Panunzio
Eileen Campana
Gabriele Breviglieri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farchemia Srl, Mauro Panunzio, Eileen Campana, Gabriele Breviglieri filed Critical Farchemia Srl
Priority to CA2587486A priority Critical patent/CA2587486C/en
Priority to US11/791,008 priority patent/US7858778B2/en
Priority to DE602005014381T priority patent/DE602005014381D1/en
Priority to AT05803124T priority patent/ATE430735T1/en
Priority to EP05803124A priority patent/EP1828139B1/en
Publication of WO2006053674A2 publication Critical patent/WO2006053674A2/en
Publication of WO2006053674A3 publication Critical patent/WO2006053674A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A process for the preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxyamide by hydrolysis of 5-cyano-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine with peroxy compounds in alkali medium and in the presence of solvents. (I) (II) (III)
PCT/EP2005/012047 2004-11-19 2005-11-10 A process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxyamide WO2006053674A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA2587486A CA2587486C (en) 2004-11-19 2005-11-10 A process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxyamide
US11/791,008 US7858778B2 (en) 2004-11-19 2005-11-10 Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[B,F]azepine-5-carboxyamide
DE602005014381T DE602005014381D1 (en) 2004-11-19 2005-11-10 PROCESS FOR THE PREPARATION OF 10,11-DIHYDRO-10-HYDROXY-5-H-DIBENZEAE, FAZAZEPINE-5-CARBOXYLIC ACID AMID
AT05803124T ATE430735T1 (en) 2004-11-19 2005-11-10 METHOD FOR PRODUCING 10,11-DIHYDRO-10-HYDROXY-5-H-DIBENZÄB,FUAZEPINE-5-CARBONIC ACID AMIDE
EP05803124A EP1828139B1 (en) 2004-11-19 2005-11-10 A process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxyamide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT002230A ITMI20042230A1 (en) 2004-11-19 2004-11-19 PROCEDURE FOR THE PREPARATION OF 10,11-DIIDRO-10 HYDROXY-5H-DIBENZ-B, F-AZEPIN-5CARBOSSIAMMIDE
ITMI2004A002230 2004-11-19

Publications (2)

Publication Number Publication Date
WO2006053674A2 WO2006053674A2 (en) 2006-05-26
WO2006053674A3 true WO2006053674A3 (en) 2006-09-14

Family

ID=36407495

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/012047 WO2006053674A2 (en) 2004-11-19 2005-11-10 A process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxyamide

Country Status (10)

Country Link
US (1) US7858778B2 (en)
EP (1) EP1828139B1 (en)
AT (1) ATE430735T1 (en)
CA (1) CA2587486C (en)
CY (1) CY1110479T1 (en)
DE (1) DE602005014381D1 (en)
ES (1) ES2323975T3 (en)
IT (1) ITMI20042230A1 (en)
PT (1) PT1828139E (en)
WO (1) WO2006053674A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1310120A (en) * 1969-03-31 1973-03-14 Ciba Geigy Ag Azepine derivative its preparation and composition containing it
US5049637A (en) * 1987-04-10 1991-09-17 Monash University 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino-[1,2-a]azepino derivatives and 10-aza, 10-oxa and 10-thia analogues
EP1127877A2 (en) * 2000-02-25 2001-08-29 FARCHEMIA S.r.l. 5-Cyano-10-hydroxy-10,11-dihydro-5H-dibenz[b,f]azepine, processes for its preparation and for its conversion into 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine or into 5-carbamoyl-5H-dibenz[b,f]azepine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049639A (en) * 1989-02-23 1991-09-17 First Chemical Corporation Ring-alkylated m-phenylene diamine blends for use in curing epoxy resins
PT101732B (en) * 1995-06-30 1997-12-31 Portela & Ca Sa SUBSTITUTED AZEPINES PROCESS FOR THE PREPARATION OF THE PHARMACEUTICAL COMPOSITIONS CONTAINED THEREOF AND USES OF THE NEW COMPOUNDS IN THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS EMPLOYED IN DISEASES OF THE NERVOUS SYSTEM
GB0112812D0 (en) 2001-05-25 2001-07-18 Portela & Ca Sa Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1310120A (en) * 1969-03-31 1973-03-14 Ciba Geigy Ag Azepine derivative its preparation and composition containing it
US5049637A (en) * 1987-04-10 1991-09-17 Monash University 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino-[1,2-a]azepino derivatives and 10-aza, 10-oxa and 10-thia analogues
EP1127877A2 (en) * 2000-02-25 2001-08-29 FARCHEMIA S.r.l. 5-Cyano-10-hydroxy-10,11-dihydro-5H-dibenz[b,f]azepine, processes for its preparation and for its conversion into 5-carbamoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepine or into 5-carbamoyl-5H-dibenz[b,f]azepine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCHILL G ET AL: "Eine neue Synthese von Vinblastin-Derivaten II", TETRAHEDRON, vol. 43, no. 16, 1987, NL ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., pages 3729 - 3745, XP002373785 *

Also Published As

Publication number Publication date
PT1828139E (en) 2009-06-23
US20080221320A1 (en) 2008-09-11
US7858778B2 (en) 2010-12-28
ITMI20042230A1 (en) 2005-02-19
CA2587486A1 (en) 2006-05-26
ES2323975T3 (en) 2009-07-28
WO2006053674A2 (en) 2006-05-26
ATE430735T1 (en) 2009-05-15
CY1110479T1 (en) 2015-04-29
EP1828139A2 (en) 2007-09-05
CA2587486C (en) 2013-08-06
DE602005014381D1 (en) 2009-06-18
EP1828139B1 (en) 2009-05-06

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