PT1828139E - A process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxyamide - Google Patents

A process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxyamide Download PDF

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Publication number
PT1828139E
PT1828139E PT05803124T PT05803124T PT1828139E PT 1828139 E PT1828139 E PT 1828139E PT 05803124 T PT05803124 T PT 05803124T PT 05803124 T PT05803124 T PT 05803124T PT 1828139 E PT1828139 E PT 1828139E
Authority
PT
Portugal
Prior art keywords
dibenz
azepine
dihydro
hydroxy
carboxyamide
Prior art date
Application number
PT05803124T
Other languages
Portuguese (pt)
Inventor
Gabriele Breviglieri
Mauro Panunzio
Eileen Campana
Original Assignee
Farchemia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farchemia Srl filed Critical Farchemia Srl
Publication of PT1828139E publication Critical patent/PT1828139E/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxyamide by hydrolysis of 5-cyano-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine with peroxy compounds in alkali medium and in the presence of solvents.
PT05803124T 2004-11-19 2005-11-10 A process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxyamide PT1828139E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT002230A ITMI20042230A1 (en) 2004-11-19 2004-11-19 PROCEDURE FOR THE PREPARATION OF 10,11-DIIDRO-10 HYDROXY-5H-DIBENZ-B, F-AZEPIN-5CARBOSSIAMMIDE

Publications (1)

Publication Number Publication Date
PT1828139E true PT1828139E (en) 2009-06-23

Family

ID=36407495

Family Applications (1)

Application Number Title Priority Date Filing Date
PT05803124T PT1828139E (en) 2004-11-19 2005-11-10 A process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxyamide

Country Status (10)

Country Link
US (1) US7858778B2 (en)
EP (1) EP1828139B1 (en)
AT (1) ATE430735T1 (en)
CA (1) CA2587486C (en)
CY (1) CY1110479T1 (en)
DE (1) DE602005014381D1 (en)
ES (1) ES2323975T3 (en)
IT (1) ITMI20042230A1 (en)
PT (1) PT1828139E (en)
WO (1) WO2006053674A2 (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH505101A (en) 1969-03-31 1971-03-31 Ciba Geigy Ag Process for the production of new azepine derivatives
WO1988007997A1 (en) 1987-04-10 1988-10-20 Monash University 1,2,3,4,10,14b-HEXAHYDRODIBENZO[c,f]PYRAZINO-[1,2-a]AZEPINO DERIVATIVES AND 10-AZA, 10-OXA AND 10-THIA ANALOGUES
US5049639A (en) * 1989-02-23 1991-09-17 First Chemical Corporation Ring-alkylated m-phenylene diamine blends for use in curing epoxy resins
PT101732B (en) * 1995-06-30 1997-12-31 Portela & Ca Sa SUBSTITUTED AZEPINES PROCESS FOR THE PREPARATION OF THE PHARMACEUTICAL COMPOSITIONS CONTAINED THEREOF AND USES OF THE NEW COMPOUNDS IN THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS EMPLOYED IN DISEASES OF THE NERVOUS SYSTEM
IT1317854B1 (en) * 2000-02-25 2003-07-15 Farchemia Srl 5-CIANO-10-IDROSSI-10,11-DIIDRO-5H-DIBENZ (B, F) AZEPIN AND PROCEDURES FOR ITS PREPARATION AND FOR ITS CONVERSION IN
GB0112812D0 (en) 2001-05-25 2001-07-18 Portela & Ca Sa Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom

Also Published As

Publication number Publication date
CA2587486C (en) 2013-08-06
CA2587486A1 (en) 2006-05-26
US20080221320A1 (en) 2008-09-11
ITMI20042230A1 (en) 2005-02-19
WO2006053674A3 (en) 2006-09-14
WO2006053674A2 (en) 2006-05-26
CY1110479T1 (en) 2015-04-29
DE602005014381D1 (en) 2009-06-18
US7858778B2 (en) 2010-12-28
ATE430735T1 (en) 2009-05-15
EP1828139B1 (en) 2009-05-06
EP1828139A2 (en) 2007-09-05
ES2323975T3 (en) 2009-07-28

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