GB1310120A - Azepine derivative its preparation and composition containing it - Google Patents

Azepine derivative its preparation and composition containing it

Info

Publication number
GB1310120A
GB1310120A GB1111170A GB1111170A GB1310120A GB 1310120 A GB1310120 A GB 1310120A GB 1111170 A GB1111170 A GB 1111170A GB 1111170 A GB1111170 A GB 1111170A GB 1310120 A GB1310120 A GB 1310120A
Authority
GB
United Kingdom
Prior art keywords
azepine
preparation
composition containing
dibenz
carboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1111170A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of GB1310120A publication Critical patent/GB1310120A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

1310120 Dibenzazepine derivative CIBAGEIGY AG 9 March 1970 [31 March 1969] 11111/70 Heading C2C The novel compound, 10-hydroxy-10,11- dihydro - 5H - dibenz[b,f]azepine - 5 - carboxamide, is prepared by reduction, e.g. with hydrogen in the presence of copper chromite, of 10 - oxo - 10,11 - dihydro - 5H - dibenz[b,f]azepine-5-carboxamide. Pharmaceutical compositions having central depressant and anticonvulsive action, for oral or rectal administration, comprise the above novel compound together with a pharmaceutical carrier.
GB1111170A 1969-03-31 1970-03-09 Azepine derivative its preparation and composition containing it Expired GB1310120A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH484469A CH505101A (en) 1969-03-31 1969-03-31 Process for the production of new azepine derivatives

Publications (1)

Publication Number Publication Date
GB1310120A true GB1310120A (en) 1973-03-14

Family

ID=4283538

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1111170A Expired GB1310120A (en) 1969-03-31 1970-03-09 Azepine derivative its preparation and composition containing it

Country Status (20)

Country Link
AT (1) AT294106B (en)
BE (1) BE747086A (en)
BG (1) BG17600A3 (en)
BR (1) BR7017333D0 (en)
CA (1) CA920587A (en)
CH (1) CH505101A (en)
CS (1) CS154295B2 (en)
DE (1) DE2011045C3 (en)
DK (1) DK133898B (en)
ES (1) ES377280A1 (en)
FI (1) FI50524C (en)
FR (1) FR2035999B1 (en)
GB (1) GB1310120A (en)
IE (1) IE34050B1 (en)
IL (1) IL34027A (en)
NL (1) NL159972C (en)
NO (1) NO131546C (en)
PL (1) PL80544B1 (en)
SE (1) SE354069B (en)
YU (1) YU33863B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997002250A1 (en) * 1995-06-30 1997-01-23 Portela & Ca., S.A. 10-ACYLOXY-10,11-DIHYDRODIBENZ/b,f/AZEPINE-5-CARBOXAMIDES USEFUL FOR TREATING NERVOUS SYSTEM DISORDERS
WO2003042182A1 (en) 2001-11-12 2003-05-22 Novartis Ag Monohydroxycarbamazepine for use in the preparation of a medicament for the treatment of affective and attention disorder and neuropathic pain
WO2004071513A1 (en) * 2003-02-17 2004-08-26 Novartis Ag Use of r-10-hydroxy-10, 11-dihydro-carbamazepine in neuropathic pain
US7037525B2 (en) 1997-02-14 2006-05-02 Novartis Ag Oxacarbazepine film-coated tablets
WO2006053674A2 (en) * 2004-11-19 2006-05-26 Farchemia S.R.L. A process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxyamide
US9763954B2 (en) 2007-01-15 2017-09-19 Bial—Portela & Ca, S.A. Therapeutical uses of eslicarbazepine
US10675287B2 (en) 2005-05-06 2020-06-09 Bial-Portela & Ca S.A. Methods of treatment of partial onset seizures using eslicarbazepine acetate

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789320A (en) * 1971-09-30 1973-03-27 Takeda Chemical Industries Ltd DIBENZOXIRENAZEPINE DERIVATIVES
EP0108715A1 (en) * 1982-10-15 1984-05-16 Ciba-Geigy Ag Dibenzazepine carboxamides
AT408224B (en) * 1999-03-15 2001-09-25 Dsm Fine Chem Austria Gmbh METHOD FOR PRODUCING OXCARBAZEPINE

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753646A (en) * 1995-06-30 1998-05-19 Portela & Ca., S.A. Substituted dihydrodibenzo/b,f/azepines, method of their preparation, their use in the treatment of some central nervous system disorders, and pharmaceutical compositions containing them
CN1070853C (en) * 1995-06-30 2001-09-12 波特拉和卡公司 10-acyloxy-10,11-dihydrodibenz/b, f/azepine-5-carboxamides useful for treating nervous system disorders
WO1997002250A1 (en) * 1995-06-30 1997-01-23 Portela & Ca., S.A. 10-ACYLOXY-10,11-DIHYDRODIBENZ/b,f/AZEPINE-5-CARBOXAMIDES USEFUL FOR TREATING NERVOUS SYSTEM DISORDERS
US7037525B2 (en) 1997-02-14 2006-05-02 Novartis Ag Oxacarbazepine film-coated tablets
EP2048135A1 (en) 2001-11-12 2009-04-15 Novartis AG Use of monohydroxycarbamazepine in the treatment of neuropathic pain and related disorders
WO2003042182A1 (en) 2001-11-12 2003-05-22 Novartis Ag Monohydroxycarbamazepine for use in the preparation of a medicament for the treatment of affective and attention disorder and neuropathic pain
JP2005511623A (en) * 2001-11-12 2005-04-28 ノバルティス アクチエンゲゼルシャフト Monohydroxycarbamazepine for use in the manufacture of a medicament for the treatment of emotional and attention disorders, neuropathic pain
AU2007201925B2 (en) * 2001-11-12 2009-06-04 Novartis Ag Monohydroxycarbamazepine for use in the preparation of a medicament for the treatment of affective and attention disorder and neuropathic pain
WO2004071513A1 (en) * 2003-02-17 2004-08-26 Novartis Ag Use of r-10-hydroxy-10, 11-dihydro-carbamazepine in neuropathic pain
WO2006053674A3 (en) * 2004-11-19 2006-09-14 Farchemia Srl A process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxyamide
WO2006053674A2 (en) * 2004-11-19 2006-05-26 Farchemia S.R.L. A process for the preparation of 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxyamide
US7858778B2 (en) 2004-11-19 2010-12-28 Farchemia S.R.L. Process for the preparation of 10,11-dihydro-10-hydroxy-5H-dibenz[B,F]azepine-5-carboxyamide
US10675287B2 (en) 2005-05-06 2020-06-09 Bial-Portela & Ca S.A. Methods of treatment of partial onset seizures using eslicarbazepine acetate
US10695354B2 (en) 2005-05-06 2020-06-30 Bial-Portela & Ca S.A. Methods of treatment of partial onset seizures using eslicarbazepine acetate
US10702536B2 (en) 2005-05-06 2020-07-07 Bial-Portela & Ca S.A. Methods of treatment of partial onset seizures using eslicarbazepine acetate
US11364247B2 (en) 2005-05-06 2022-06-21 Bial-Portela & Ca S.A. Methods of treatment of partial onset seizures using eslicarbazepine acetate
US9763954B2 (en) 2007-01-15 2017-09-19 Bial—Portela & Ca, S.A. Therapeutical uses of eslicarbazepine

Also Published As

Publication number Publication date
DE2011045A1 (en) 1970-10-08
CA920587A (en) 1973-02-06
CS154295B2 (en) 1974-03-29
FR2035999B1 (en) 1973-04-06
NO131546B (en) 1975-03-10
FI50524C (en) 1976-04-12
YU53770A (en) 1977-12-31
DE2011045C3 (en) 1979-05-31
NL159972C (en) 1979-09-17
NL7003026A (en) 1970-10-02
ES377280A1 (en) 1972-06-16
NO131546C (en) 1975-06-25
PL80544B1 (en) 1975-08-30
DK133898B (en) 1976-08-09
DK133898C (en) 1977-03-07
FI50524B (en) 1975-12-31
IL34027A0 (en) 1970-05-21
DE2011045B2 (en) 1978-10-05
FR2035999A1 (en) 1970-12-24
BG17600A3 (en) 1973-11-10
BR7017333D0 (en) 1973-05-31
AT294106B (en) 1971-11-10
SE354069B (en) 1973-02-26
IE34050L (en) 1970-09-30
IE34050B1 (en) 1975-01-22
BE747086A (en) 1970-09-09
IL34027A (en) 1972-12-29
CH505101A (en) 1971-03-31
YU33863B (en) 1978-06-30

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee