WO2006051241A3 - Procede de couplage de molecules non immunogenes, compose intermediaire, produit final obtenu et utilisations - Google Patents

Procede de couplage de molecules non immunogenes, compose intermediaire, produit final obtenu et utilisations Download PDF

Info

Publication number
WO2006051241A3
WO2006051241A3 PCT/FR2005/050942 FR2005050942W WO2006051241A3 WO 2006051241 A3 WO2006051241 A3 WO 2006051241A3 FR 2005050942 W FR2005050942 W FR 2005050942W WO 2006051241 A3 WO2006051241 A3 WO 2006051241A3
Authority
WO
WIPO (PCT)
Prior art keywords
intermediate compound
final product
product obtained
immunogenic molecules
coupling non
Prior art date
Application number
PCT/FR2005/050942
Other languages
English (en)
Other versions
WO2006051241A2 (fr
Inventor
Michel Geffard
Original Assignee
Gemac
Michel Geffard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gemac, Michel Geffard filed Critical Gemac
Publication of WO2006051241A2 publication Critical patent/WO2006051241A2/fr
Publication of WO2006051241A3 publication Critical patent/WO2006051241A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'objet de l'invention est un procédé de couplage d'une première molécule de poids moléculaire inférieur à 1000 Da avec une seconde molécule de poids moléculaire supérieur à 10 000 Da, caractérisé en ce qu'on réalise une amidification d'un composé intermédiaire obtenu à partir de la première molécule, possédant au moins un hétérocycle et au moins un groupement carboxyle, ladite amidification portant sur la seconde molécule. L'invention couvre également le composé intermédiaire intervenant dans ce procédé, le procédé d'obtention de ce composé intermédiaire, le produit final obtenu et ses utilisations.
PCT/FR2005/050942 2004-11-10 2005-11-10 Procede de couplage de molecules non immunogenes, compose intermediaire, produit final obtenu et utilisations WO2006051241A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0452591 2004-11-10
FR0452591A FR2877668B1 (fr) 2004-11-10 2004-11-10 Procede de couplage de molecules non immunogenes, compose intermediaire, produit final obtenu et utilisations

Publications (2)

Publication Number Publication Date
WO2006051241A2 WO2006051241A2 (fr) 2006-05-18
WO2006051241A3 true WO2006051241A3 (fr) 2006-11-09

Family

ID=34954138

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2005/050942 WO2006051241A2 (fr) 2004-11-10 2005-11-10 Procede de couplage de molecules non immunogenes, compose intermediaire, produit final obtenu et utilisations

Country Status (2)

Country Link
FR (1) FR2877668B1 (fr)
WO (1) WO2006051241A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102008732B (zh) * 2010-11-08 2012-10-24 武汉华耀生物医药有限公司 一种叶酸偶联抗体药物及其制备方法与应用
US20190343951A1 (en) * 2017-01-13 2019-11-14 National Research Council Of Canada Method of optimizing peptide immuno-epitope by glycosylation, optimized peptide thereof and its use for conjugate vaccines

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876727A (en) * 1995-03-31 1999-03-02 Immulogic Pharmaceutical Corporation Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
US20030077287A1 (en) * 1997-09-19 2003-04-24 Serex, Inc. Methods to improve immunogenicity of antigens and specificity of antibodies

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5876727A (en) * 1995-03-31 1999-03-02 Immulogic Pharmaceutical Corporation Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same
US20030077287A1 (en) * 1997-09-19 2003-04-24 Serex, Inc. Methods to improve immunogenicity of antigens and specificity of antibodies

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CONCHILLO A ET AL: "3 4 EPOXYPRECOCENES AS MODELS OF CYTOTOXIC EPOXIDES SYNTHESIS OF THE CIS ADDUCTS OCCURRING IN THE GLUTATHIONE METABOLIC PATHWAY", JOURNAL OF ORGANIC CHEMISTRY, vol. 55, no. 6, 1990, pages 1728 - 1735, XP002375121, ISSN: 0022-3263 *
GLUSHKOV A N ET AL: "Antisera to polycyclic aromatic hydrocarbons and their application on the detection of chemical carcinogens in blood sera of oncological patients", EXPERIMENTAL ONCOLOGY 2004 UKRAINE, vol. 26, no. 2, June 2004 (2004-06-01), pages 145 - 148, XP002375119, ISSN: 0204-3564 *
LEE JAE KOO ET AL: "Development of an immunoassay for the residues of the herbicide bensulfuron-methyl", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 50, no. 7, 27 March 2002 (2002-03-27), pages 1791 - 1803, XP002374931, ISSN: 0021-8561 *
LI KAI ET AL: "Development of an enzyme-linked immunosorbent assay for the insecticide imidacloprid", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 48, no. 8, August 2000 (2000-08-01), pages 3378 - 3382, XP002374930, ISSN: 0021-8561 *
MARCO MARIA-PILAR ET AL: "Hapten design and development of an ELISA (enzyme-linked immunosorbent assay) for the detection of the mercapturic acid conjugates of naphthalene", JOURNAL OF ORGANIC CHEMISTRY, vol. 58, no. 26, 1993, pages 7548 - 7556, XP002374932, ISSN: 0022-3263 *
MARCO M-P ET AL: "Enzyme-linked immunosorbent assay for the specific detection of the mercapturic acid metabolites of naphthalene", CHEMICAL RESEARCH IN TOXICOLOGY 1993 UNITED STATES, vol. 6, no. 3, 1993, pages 284 - 293, XP002374933, ISSN: 0893-228X *
MURTY V S ET AL: "Characterization of mercapturic acid and glutathionyl conjugates of benzo[a]pyrene-7,8-dione by two-dimensional NMR.", BIOCONJUGATE CHEMISTRY. 1992 MAY-JUN, vol. 3, no. 3, May 1992 (1992-05-01), pages 218 - 224, XP002375120, ISSN: 1043-1802 *
YANG Y ET AL: "Liquid chromatography-mass spectrometry with collision-induced dissociation of conjugated metabolites of benzo[a]pyrene", JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY 1997 UNITED STATES, vol. 8, no. 1, 1997, pages 50 - 61, XP005271113, ISSN: 1044-0305 *

Also Published As

Publication number Publication date
FR2877668A1 (fr) 2006-05-12
FR2877668B1 (fr) 2007-07-06
WO2006051241A2 (fr) 2006-05-18

Similar Documents

Publication Publication Date Title
WO2006128685A3 (fr) Procede de fabrication d'hydrolysat de gelatine a faible poids moleculaire et compositions d'hydrolysat de gelatine
WO2008012542A3 (fr) Dérivatisation d'érythropoïétine
WO2007038571A3 (fr) Antagonistes de la prolyl-hydroxylase
WO2008003321A3 (fr) Compositions avec plusieurs fractions d'acide hyaluronique destinées à un usage cosmétique
WO2007079458A3 (fr) Hydrolysats de proteines et procede de production
WO2004084453A3 (fr) Procedes de fabrication de 2'-desoxy-$g(b)-l-nucleosides
WO2003077792A3 (fr) Compositions de poly-hema de faible polydispersite
CA2522232A1 (fr) Composition de polysaccharide reticule
WO2005086617A3 (fr) Polymeres conjugues cationiques de conformation flexible
MX2007004045A (es) Producto de confiteria.
WO2009155557A3 (fr) Compositions d'hydrolysats de protéines stables dans des conditions acides
WO2008045372A3 (fr) Polymères ramifiés et leurs procédés de synthèse et d'utilisation
WO2006103277A3 (fr) Piperidines substituees
WO2006119020A3 (fr) Biopolymeres modifies a polymere hyperbranche, leurs matieres a base biologique et procede de preparation associe
WO2008049106A3 (fr) Procédé de préparation de domaines Fc d'anticorps non agrégés
WO2007133184A3 (fr) Polypeptides et voies de synthèse biologique destinés à produire des stéréoisomères de monatine et leurs précurseurs
WO2008077956A3 (fr) Conjugués oligonucléotide-, protéine- et/ou peptide-polymère
WO2007066353A3 (fr) Nouveaux polymeres de derives 3,4-propylenedioxythiophene ayant des groupes fonctionnels lateraux
WO2009077153A8 (fr) Procédé de production d'un dérivé d'amidon hydroxyalkylé comportant deux séquences de liaison
AU2001279660A1 (en) Modified polyamides, polyamide compositions, and method for making same
WO2007047482A3 (fr) Composés et méthodes pour l'obtention de particules de condensat d'acide ribonucléique de peptides pour thérapie par arn
WO2006051241A3 (fr) Procede de couplage de molecules non immunogenes, compose intermediaire, produit final obtenu et utilisations
UA93284C2 (uk) Поліетиленгліколь-g-csf кон'югат
WO2007017510A3 (fr) Diamides d'acide isophtalique pour le traitement de la maladie d'alzheimer
WO2008011165A3 (fr) Réactifs polymères comprenant un groupe vinylique terminal et conjugués formés à partir de ceux-ci

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LC LK LR LS LT LU LV LY MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase

Ref document number: 05819283

Country of ref document: EP

Kind code of ref document: A2