WO2006050148A3 - Propargyl trifluoromethoxy aminobenzimidazole derivatives - Google Patents

Propargyl trifluoromethoxy aminobenzimidazole derivatives Download PDF

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Publication number
WO2006050148A3
WO2006050148A3 PCT/US2005/039050 US2005039050W WO2006050148A3 WO 2006050148 A3 WO2006050148 A3 WO 2006050148A3 US 2005039050 W US2005039050 W US 2005039050W WO 2006050148 A3 WO2006050148 A3 WO 2006050148A3
Authority
WO
WIPO (PCT)
Prior art keywords
propargyl
trifluoromethoxy
aminobenzimidazole derivatives
aminobenzimidazole
derivatives
Prior art date
Application number
PCT/US2005/039050
Other languages
French (fr)
Other versions
WO2006050148A2 (en
Inventor
Yaacov Herzig
Istvan Miskolczi
Konstantin Ulanenko
Jeffrey Sterling
Original Assignee
Teva Pharma
Yaacov Herzig
Istvan Miskolczi
Konstantin Ulanenko
Jeffrey Sterling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma, Yaacov Herzig, Istvan Miskolczi, Konstantin Ulanenko, Jeffrey Sterling filed Critical Teva Pharma
Publication of WO2006050148A2 publication Critical patent/WO2006050148A2/en
Publication of WO2006050148A3 publication Critical patent/WO2006050148A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed are compounds having the structure: wherein X is a) where R1 is H, C1-C6 alkyl, C3-C6 alkenyl, or C3-C6 alkynyl; R2 is H or C1-C4 alkyl; and R3 is H or C1-C4 alkyl, or b) -OH, halide, SR5, SO3H or SO2R5
PCT/US2005/039050 2004-10-29 2005-10-27 Propargyl trifluoromethoxy aminobenzimidazole derivatives WO2006050148A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62373404P 2004-10-29 2004-10-29
US97830404A 2004-10-29 2004-10-29
US60/623,734 2004-10-29
US10/978,304 2004-10-29

Publications (2)

Publication Number Publication Date
WO2006050148A2 WO2006050148A2 (en) 2006-05-11
WO2006050148A3 true WO2006050148A3 (en) 2007-01-04

Family

ID=36319681

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/039050 WO2006050148A2 (en) 2004-10-29 2005-10-27 Propargyl trifluoromethoxy aminobenzimidazole derivatives

Country Status (1)

Country Link
WO (1) WO2006050148A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201704665QA (en) 2012-04-20 2017-07-28 Merial Inc Parasiticidal compositions comprising benzimidazole derivatives, methods and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049574A (en) * 1989-02-20 1991-09-17 Rhone-Poulenc Sante 5-trifluormethoxy-2-benzimidazolamine compounds
US5475005A (en) * 1991-11-12 1995-12-12 Pfizer Inc. Benzimidazole anthelmintic agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049574A (en) * 1989-02-20 1991-09-17 Rhone-Poulenc Sante 5-trifluormethoxy-2-benzimidazolamine compounds
US5475005A (en) * 1991-11-12 1995-12-12 Pfizer Inc. Benzimidazole anthelmintic agents

Also Published As

Publication number Publication date
WO2006050148A2 (en) 2006-05-11

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