WO2006040625A1 - Novel dipeptidyl peptidase iv inhibitors, pharmaceutical compositions containing them, and process for their preparation - Google Patents
Novel dipeptidyl peptidase iv inhibitors, pharmaceutical compositions containing them, and process for their preparation Download PDFInfo
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- WO2006040625A1 WO2006040625A1 PCT/IB2005/002204 IB2005002204W WO2006040625A1 WO 2006040625 A1 WO2006040625 A1 WO 2006040625A1 IB 2005002204 W IB2005002204 W IB 2005002204W WO 2006040625 A1 WO2006040625 A1 WO 2006040625A1
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- Prior art keywords
- substituted
- unsubstituted
- acetyl
- ylmethyl
- mmol
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- 229940124213 Dipeptidyl peptidase 4 (DPP IV) inhibitor Drugs 0.000 title description 2
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- 125000001425 triazolyl group Chemical group 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
- 229960001641 troglitazone Drugs 0.000 description 1
- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical compound C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
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- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated
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Abstract
Description
Claims
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05784869.9A EP1799639B1 (en) | 2004-10-12 | 2005-07-26 | Novel dipeptidyl peptidase iv inhibitors, pharmaceutical compositions containing them, and process for their preparation |
BRPI0516340-4A BRPI0516340A (en) | 2004-10-12 | 2005-07-26 | compound, pharmaceutical composition, method for treating a condition that is regulated or normalized via dpp-iv inhibition, method for treating a metabolic disorder, method for treating type ii diabetes, method for lowering blood glucose, method for treating and prophylaxis of a disease, method for treating undamaged insulin-resistant glucose tolerance, method for the manufacture of a pharmaceutical composition and process for the preparation of compounds |
AU2005293266A AU2005293266B2 (en) | 2004-10-12 | 2005-07-26 | Novel dipeptidyl peptidase IV inhibitors, pharmaceutical compositions containing them, and process for their preparation |
CA2583457A CA2583457C (en) | 2004-10-12 | 2005-07-26 | Novel dipeptidyl peptidase iv inhibitors, pharmaceutical compositions containing them, and process for their preparation |
NZ554515A NZ554515A (en) | 2004-10-12 | 2005-07-26 | Novel dipeptidyl peptidase IV inhibitors, pharmaceutical compositions containing them, and process for their preparation |
MX2007004305A MX2007004305A (en) | 2004-10-12 | 2005-07-26 | Novel dipeptidyl peptidase iv inhibitors, pharmaceutical compositions containing them, and process for their preparation. |
JP2007536276A JP4959569B2 (en) | 2004-10-12 | 2005-07-26 | Novel dipeptidyl peptidase IV inhibitors, pharmaceutical compositions containing them, and processes for preparing them |
CN2005800374009A CN101087757B (en) | 2004-10-12 | 2005-07-26 | Novel dipeptidyl peptidase iv inhibitors, process for their preparation and compositions containing them |
AP2007003973A AP2007003973A0 (en) | 2004-10-12 | 2005-07-26 | Novel dideptidyl peptidase IV inhibitors, pharmaceutical compositions containing them, and proces for their preparation |
EA200700720A EA013463B1 (en) | 2004-10-12 | 2005-07-26 | Novel dipeptidyl peptidase iv inhibitors, pharmaceutical compositions containing them, process for their preparation and method for the treatment using thereof |
US11/250,195 US7205323B2 (en) | 2004-10-12 | 2005-10-12 | Dipeptidyl peptidase IV inhibitors pharmaceutical compositions containing them, and process for their preparation |
US11/675,180 US7538128B2 (en) | 2004-10-12 | 2007-02-15 | Dipeptidyl peptidase IV inhibitors, process for their preparation and compositions containing them |
US11/675,157 US7524844B2 (en) | 2004-10-12 | 2007-02-15 | Dipeptidyl peptidase IV inhibitors, process for their preparation and compositions containing them |
IL182444A IL182444A0 (en) | 2004-10-12 | 2007-04-10 | Novel dipeptidyl peptidase iv inhibitors, pharmaceutical compositions containing them, and process for their preparation |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
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US61810204P | 2004-10-12 | 2004-10-12 | |
US60/618,102 | 2004-10-12 | ||
IN1096MU2004 | 2004-10-14 | ||
IN1096/MUM/2004 | 2004-10-14 | ||
US63526604P | 2004-12-10 | 2004-12-10 | |
US60/635,266 | 2004-12-10 | ||
IN1332MU2004 | 2004-12-14 | ||
IN1332/MUM/2004 | 2004-12-14 |
Related Child Applications (1)
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US11/250,195 Continuation US7205323B2 (en) | 2004-10-12 | 2005-10-12 | Dipeptidyl peptidase IV inhibitors pharmaceutical compositions containing them, and process for their preparation |
Publications (1)
Publication Number | Publication Date |
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WO2006040625A1 true WO2006040625A1 (en) | 2006-04-20 |
Family
ID=35311627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/IB2005/002204 WO2006040625A1 (en) | 2004-10-12 | 2005-07-26 | Novel dipeptidyl peptidase iv inhibitors, pharmaceutical compositions containing them, and process for their preparation |
Country Status (16)
Country | Link |
---|---|
US (3) | US7205323B2 (en) |
EP (1) | EP1799639B1 (en) |
JP (1) | JP4959569B2 (en) |
KR (1) | KR20070073887A (en) |
AP (1) | AP2007003973A0 (en) |
AR (1) | AR053415A1 (en) |
AU (1) | AU2005293266B2 (en) |
BR (1) | BRPI0516340A (en) |
CA (1) | CA2583457C (en) |
EA (1) | EA013463B1 (en) |
IL (1) | IL182444A0 (en) |
MX (1) | MX2007004305A (en) |
MY (1) | MY142423A (en) |
NZ (1) | NZ554515A (en) |
TW (1) | TW200614988A (en) |
WO (1) | WO2006040625A1 (en) |
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CA2583457A1 (en) | 2006-04-20 |
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EA200700720A1 (en) | 2007-08-31 |
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US20070232608A1 (en) | 2007-10-04 |
US7205323B2 (en) | 2007-04-17 |
BRPI0516340A (en) | 2008-09-16 |
IL182444A0 (en) | 2007-07-24 |
AU2005293266A1 (en) | 2006-04-20 |
US20070238728A1 (en) | 2007-10-11 |
AR053415A1 (en) | 2007-05-09 |
TW200614988A (en) | 2006-05-16 |
MY142423A (en) | 2010-11-30 |
JP4959569B2 (en) | 2012-06-27 |
AU2005293266B2 (en) | 2011-09-29 |
US20060142585A1 (en) | 2006-06-29 |
JP2008515962A (en) | 2008-05-15 |
MX2007004305A (en) | 2007-06-18 |
US7524844B2 (en) | 2009-04-28 |
EA013463B1 (en) | 2010-04-30 |
EP1799639B1 (en) | 2013-09-04 |
CA2583457C (en) | 2013-01-29 |
KR20070073887A (en) | 2007-07-10 |
AP2007003973A0 (en) | 2007-07-30 |
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