WO2006040534A3 - Method of detecting the presence or activity of g - protein coupled receptor 92 (gpr92) - Google Patents

Method of detecting the presence or activity of g - protein coupled receptor 92 (gpr92) Download PDF

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Publication number
WO2006040534A3
WO2006040534A3 PCT/GB2005/003900 GB2005003900W WO2006040534A3 WO 2006040534 A3 WO2006040534 A3 WO 2006040534A3 GB 2005003900 W GB2005003900 W GB 2005003900W WO 2006040534 A3 WO2006040534 A3 WO 2006040534A3
Authority
WO
WIPO (PCT)
Prior art keywords
detecting
gpr92
activity
coupled receptor
protein coupled
Prior art date
Application number
PCT/GB2005/003900
Other languages
French (fr)
Other versions
WO2006040534A2 (en
Inventor
Jonathan Ellery
Original Assignee
Paradigm Therapeutics Ltd
Jonathan Ellery
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0422526A external-priority patent/GB0422526D0/en
Application filed by Paradigm Therapeutics Ltd, Jonathan Ellery filed Critical Paradigm Therapeutics Ltd
Publication of WO2006040534A2 publication Critical patent/WO2006040534A2/en
Publication of WO2006040534A3 publication Critical patent/WO2006040534A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

We describe a method comprising detecting GPR92 modulated expression of an NF-κB, API, CRE or p53 sensitive reporter, preferably for detecting the presence, quantity, activity or a change in any of these of a GPCR. These methods are useful for identifying agonists and antagonists or inverse agonist of GPCRs. We also provide cells for use in these methods.
PCT/GB2005/003900 2004-10-11 2005-10-11 Method of detecting the presence or activity of g - protein coupled receptor 92 (gpr92) WO2006040534A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0422526.4 2004-10-11
GB0422526A GB0422526D0 (en) 2004-10-11 2004-10-11 Method
US65138305P 2005-02-09 2005-02-09
US60/651,383 2005-02-09

Publications (2)

Publication Number Publication Date
WO2006040534A2 WO2006040534A2 (en) 2006-04-20
WO2006040534A3 true WO2006040534A3 (en) 2007-04-12

Family

ID=36128252

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/003900 WO2006040534A2 (en) 2004-10-11 2005-10-11 Method of detecting the presence or activity of g - protein coupled receptor 92 (gpr92)

Country Status (1)

Country Link
WO (1) WO2006040534A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7039483B2 (en) 2016-04-14 2022-03-22 マース インコーポレーテッド Identification method of regulator of GPR92

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001031014A2 (en) * 1999-10-27 2001-05-03 Pharmacia & Upjohn Company G protein-coupled receptors expressed in human brain
US20040091928A1 (en) * 1999-10-27 2004-05-13 Pharmacia & Upjohn Company G protein-coupled receptors expressed in brain

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001031014A2 (en) * 1999-10-27 2001-05-03 Pharmacia & Upjohn Company G protein-coupled receptors expressed in human brain
US20040091928A1 (en) * 1999-10-27 2004-05-13 Pharmacia & Upjohn Company G protein-coupled receptors expressed in brain

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GEORGE S E ET AL: "Functional coupling of endogenous serotonin (5-HT1B) and calcitonin (C1a) receptors in CHO cells to a cyclic AMP-responsive luciferase reporter gene.", JOURNAL OF NEUROCHEMISTRY. SEP 1997, vol. 69, no. 3, September 1997 (1997-09-01), pages 1278 - 1285, XP002102384, ISSN: 0022-3042 *
STRATAGENE: "Determine the in vivo effects of your gene", STRATEGIES, vol. 15, no. 4, 2002, pages 90 - 91, XP002377090 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7039483B2 (en) 2016-04-14 2022-03-22 マース インコーポレーテッド Identification method of regulator of GPR92

Also Published As

Publication number Publication date
WO2006040534A2 (en) 2006-04-20

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