WO2006039678A3 - Establishment of highly metastatic cell lines using nog mice - Google Patents
Establishment of highly metastatic cell lines using nog mice Download PDFInfo
- Publication number
- WO2006039678A3 WO2006039678A3 PCT/US2005/035565 US2005035565W WO2006039678A3 WO 2006039678 A3 WO2006039678 A3 WO 2006039678A3 US 2005035565 W US2005035565 W US 2005035565W WO 2006039678 A3 WO2006039678 A3 WO 2006039678A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- establishment
- cell lines
- highly metastatic
- metastatic cell
- nog mice
- Prior art date
Links
- 241000699670 Mus sp. Species 0.000 title 1
- 230000001394 metastastic effect Effects 0.000 title 1
- 206010061289 metastatic neoplasm Diseases 0.000 title 1
- 206010027476 Metastases Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 230000009401 metastasis Effects 0.000 abstract 2
- 238000011830 transgenic mouse model Methods 0.000 abstract 2
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
- C12N5/0694—Cells of blood, e.g. leukemia cells, myeloma cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Environmental Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007533795A JP2008514205A (en) | 2004-09-29 | 2005-09-29 | Establishment of highly metastatic cell lines using NOG mice |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/955,192 | 2004-09-29 | ||
US10/954,495 US20070092881A1 (en) | 2003-07-10 | 2004-09-29 | Gene markers of tumor metastasis |
US10/954,495 | 2004-09-29 | ||
US10/955,192 US20050249666A1 (en) | 2003-07-10 | 2004-09-29 | Establishment of human cancer cell lines with metastatic potential using NOD/SCID |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006039678A2 WO2006039678A2 (en) | 2006-04-13 |
WO2006039678A3 true WO2006039678A3 (en) | 2006-08-24 |
Family
ID=35546587
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/035539 WO2006039671A2 (en) | 2004-09-29 | 2005-09-29 | Gene markers of tumor metastasis |
PCT/US2005/035565 WO2006039678A2 (en) | 2004-09-29 | 2005-09-29 | Establishment of highly metastatic cell lines using nog mice |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/035539 WO2006039671A2 (en) | 2004-09-29 | 2005-09-29 | Gene markers of tumor metastasis |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP2008514205A (en) |
WO (2) | WO2006039671A2 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009051238A1 (en) * | 2007-10-18 | 2009-04-23 | Riken | Mouse having human leukemic stem cell and leukemic non-stem cell amplified therein, and method for production thereof |
JP5568807B2 (en) * | 2008-06-06 | 2014-08-13 | 静岡県 | Identification of melanoma markers using proteomic analysis |
JP5808054B2 (en) * | 2009-12-25 | 2015-11-10 | 中外製薬株式会社 | Anticancer drug target search and screening method using non-human animal model transplanted with NOG established cancer cell line |
SG189302A1 (en) | 2010-10-06 | 2013-05-31 | Pharmalogicals Res Pte Ltd | Cancer stem cell population and method for production thereof |
GB201103726D0 (en) * | 2011-03-04 | 2011-04-20 | Immunovia Ab | Method, array and use thereof |
CN102841200A (en) * | 2011-06-24 | 2012-12-26 | 中国科学院上海药物研究所 | Use of pIgR as molecular marker of early recurrence and/or metastasis of tumor and intervening target spot of anti-tumor metastasizing medicine |
WO2013035824A1 (en) | 2011-09-07 | 2013-03-14 | ファーマロジカルズ・リサーチ プライベート リミテッド | Cancer stem cell isolation |
US20140302511A1 (en) | 2011-10-28 | 2014-10-09 | Pharmalogicals Research Pte. Ltd. | Cancer stem cell-specific molecule |
CN103898205B (en) * | 2013-05-07 | 2016-04-27 | 上海良润生物医药科技有限公司 | The application of CST1 |
CN103941016B (en) * | 2013-05-07 | 2016-04-27 | 上海良润生物医药科技有限公司 | The use in conjunction of CST1 and carcinomebryonic antigen |
EP3310159A4 (en) | 2015-06-16 | 2019-02-20 | The Jackson Laboratory | Genetically modified non-human animals and methods relating to complement dependent cytotoxicity |
GB202010970D0 (en) | 2020-07-16 | 2020-09-02 | Immunovia Ab | Methods, arrays and uses thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1338198A1 (en) * | 2000-12-01 | 2003-08-27 | Central Institute For Experimental Animals | Method of constructing mouse suitable for the take, differentiation and proliferation of heterogenous cells, mouse constructed by this method and use of the mouse |
WO2005013682A2 (en) * | 2003-07-10 | 2005-02-17 | Central Institute For Experimental Animals | Animal model for the analysis of tumor metastasis |
-
2005
- 2005-09-29 JP JP2007533795A patent/JP2008514205A/en active Pending
- 2005-09-29 WO PCT/US2005/035539 patent/WO2006039671A2/en active Application Filing
- 2005-09-29 WO PCT/US2005/035565 patent/WO2006039678A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1338198A1 (en) * | 2000-12-01 | 2003-08-27 | Central Institute For Experimental Animals | Method of constructing mouse suitable for the take, differentiation and proliferation of heterogenous cells, mouse constructed by this method and use of the mouse |
WO2005013682A2 (en) * | 2003-07-10 | 2005-02-17 | Central Institute For Experimental Animals | Animal model for the analysis of tumor metastasis |
Non-Patent Citations (5)
Title |
---|
FUKUI ET AL: "Metastases-Related Genes in the Classification of Liver and Peritoneal Metastasis in Human Gastric Cancer", JOURNAL OF SURGICAL RESEARCH, ACADEMIC PRESS INC., SAN DIEGO, CA, US, vol. 129, no. 1, November 2005 (2005-11-01), pages 94 - 100, XP005118959, ISSN: 0022-4804 * |
LACOBUZIO-DONAHUE C A ET AL: "DISCOVERY OF NOVEL TUMOR MARKERS OF PANCREATIC CANCER USING GLOBAL GENE EXPRESSION TECHNOLOGY", AMERICAN JOURNAL OF PATHOLOGY, PHILADELPHIA, PA, US, vol. 160, no. 4, April 2002 (2002-04-01), pages 1239 - 1249, XP008003747, ISSN: 0002-9440 * |
MISSIAGLIA E ET AL: "ANALYSIS OF GENE EXPRESSION IN CANCER CELL LINES IDENTIFIES CANDIDATE MARKERS FOR PANCREATIC TUMORIGENESIS AND METASTASIS", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 112, no. 1, 2 June 2004 (2004-06-02), pages 100 - 112, XP002364281, ISSN: 0020-7136 * |
MON-NAI M ET AL: "NEW MODEL FOR HEPATIC METASTASIS OF HUMAN PANCREATIC CARCINOMA USING NOD/SCID/GAMMACNULL (NOG) MICE", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, NEW YORK, NY, US, vol. 44, July 2003 (2003-07-01), pages 582, XP001182951, ISSN: 0197-016X * |
NOMURA H, ET AL.: "A new liver metastatic and peritoneal dissemination model established from the same human pancreatic cancer cell line: analysis using cDNA macroarray.", CLIN EXP METASTASIS., vol. 19, no. 5, 2002, pages 391 - 399, XP002364243 * |
Also Published As
Publication number | Publication date |
---|---|
WO2006039671A2 (en) | 2006-04-13 |
WO2006039678A2 (en) | 2006-04-13 |
WO2006039671A3 (en) | 2006-10-12 |
JP2008514205A (en) | 2008-05-08 |
WO2006039671A9 (en) | 2006-06-29 |
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