WO2006039678A3 - Establishment of highly metastatic cell lines using nog mice - Google Patents

Establishment of highly metastatic cell lines using nog mice Download PDF

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Publication number
WO2006039678A3
WO2006039678A3 PCT/US2005/035565 US2005035565W WO2006039678A3 WO 2006039678 A3 WO2006039678 A3 WO 2006039678A3 US 2005035565 W US2005035565 W US 2005035565W WO 2006039678 A3 WO2006039678 A3 WO 2006039678A3
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WO
WIPO (PCT)
Prior art keywords
establishment
cell lines
highly metastatic
metastatic cell
nog mice
Prior art date
Application number
PCT/US2005/035565
Other languages
French (fr)
Other versions
WO2006039678A2 (en
Inventor
Masato Nakamura
Yasuyuki Ohnishi
Hiroshi Suemizu
Makoto Monnai
Original Assignee
Central Institue For Ex Animal
Ct For Advancement Of Health A
Masato Nakamura
Yasuyuki Ohnishi
Hiroshi Suemizu
Makoto Monnai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/954,495 external-priority patent/US20070092881A1/en
Priority claimed from US10/955,192 external-priority patent/US20050249666A1/en
Application filed by Central Institue For Ex Animal, Ct For Advancement Of Health A, Masato Nakamura, Yasuyuki Ohnishi, Hiroshi Suemizu, Makoto Monnai filed Critical Central Institue For Ex Animal
Priority to JP2007533795A priority Critical patent/JP2008514205A/en
Publication of WO2006039678A2 publication Critical patent/WO2006039678A2/en
Publication of WO2006039678A3 publication Critical patent/WO2006039678A3/en

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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0271Chimeric vertebrates, e.g. comprising exogenous cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0693Tumour cells; Cancer cells
    • C12N5/0694Cells of blood, e.g. leukemia cells, myeloma cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/0331Animal model for proliferative diseases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00Uses of viruses
    • C12N2799/02Uses of viruses as vector
    • C12N2799/021Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Environmental Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides a new reproducible transgenic mouse model for the study of tumor metastasis. In particular, the invention concerns the study of tumor metastasis in a NOD/SCID/Ϝcnull transgenic mouse model.
PCT/US2005/035565 2004-09-29 2005-09-29 Establishment of highly metastatic cell lines using nog mice WO2006039678A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2007533795A JP2008514205A (en) 2004-09-29 2005-09-29 Establishment of highly metastatic cell lines using NOG mice

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/955,192 2004-09-29
US10/954,495 US20070092881A1 (en) 2003-07-10 2004-09-29 Gene markers of tumor metastasis
US10/954,495 2004-09-29
US10/955,192 US20050249666A1 (en) 2003-07-10 2004-09-29 Establishment of human cancer cell lines with metastatic potential using NOD/SCID

Publications (2)

Publication Number Publication Date
WO2006039678A2 WO2006039678A2 (en) 2006-04-13
WO2006039678A3 true WO2006039678A3 (en) 2006-08-24

Family

ID=35546587

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2005/035539 WO2006039671A2 (en) 2004-09-29 2005-09-29 Gene markers of tumor metastasis
PCT/US2005/035565 WO2006039678A2 (en) 2004-09-29 2005-09-29 Establishment of highly metastatic cell lines using nog mice

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2005/035539 WO2006039671A2 (en) 2004-09-29 2005-09-29 Gene markers of tumor metastasis

Country Status (2)

Country Link
JP (1) JP2008514205A (en)
WO (2) WO2006039671A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009051238A1 (en) * 2007-10-18 2009-04-23 Riken Mouse having human leukemic stem cell and leukemic non-stem cell amplified therein, and method for production thereof
JP5568807B2 (en) * 2008-06-06 2014-08-13 静岡県 Identification of melanoma markers using proteomic analysis
JP5808054B2 (en) * 2009-12-25 2015-11-10 中外製薬株式会社 Anticancer drug target search and screening method using non-human animal model transplanted with NOG established cancer cell line
SG189302A1 (en) 2010-10-06 2013-05-31 Pharmalogicals Res Pte Ltd Cancer stem cell population and method for production thereof
GB201103726D0 (en) * 2011-03-04 2011-04-20 Immunovia Ab Method, array and use thereof
CN102841200A (en) * 2011-06-24 2012-12-26 中国科学院上海药物研究所 Use of pIgR as molecular marker of early recurrence and/or metastasis of tumor and intervening target spot of anti-tumor metastasizing medicine
WO2013035824A1 (en) 2011-09-07 2013-03-14 ファーマロジカルズ・リサーチ プライベート リミテッド Cancer stem cell isolation
US20140302511A1 (en) 2011-10-28 2014-10-09 Pharmalogicals Research Pte. Ltd. Cancer stem cell-specific molecule
CN103898205B (en) * 2013-05-07 2016-04-27 上海良润生物医药科技有限公司 The application of CST1
CN103941016B (en) * 2013-05-07 2016-04-27 上海良润生物医药科技有限公司 The use in conjunction of CST1 and carcinomebryonic antigen
EP3310159A4 (en) 2015-06-16 2019-02-20 The Jackson Laboratory Genetically modified non-human animals and methods relating to complement dependent cytotoxicity
GB202010970D0 (en) 2020-07-16 2020-09-02 Immunovia Ab Methods, arrays and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1338198A1 (en) * 2000-12-01 2003-08-27 Central Institute For Experimental Animals Method of constructing mouse suitable for the take, differentiation and proliferation of heterogenous cells, mouse constructed by this method and use of the mouse
WO2005013682A2 (en) * 2003-07-10 2005-02-17 Central Institute For Experimental Animals Animal model for the analysis of tumor metastasis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1338198A1 (en) * 2000-12-01 2003-08-27 Central Institute For Experimental Animals Method of constructing mouse suitable for the take, differentiation and proliferation of heterogenous cells, mouse constructed by this method and use of the mouse
WO2005013682A2 (en) * 2003-07-10 2005-02-17 Central Institute For Experimental Animals Animal model for the analysis of tumor metastasis

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FUKUI ET AL: "Metastases-Related Genes in the Classification of Liver and Peritoneal Metastasis in Human Gastric Cancer", JOURNAL OF SURGICAL RESEARCH, ACADEMIC PRESS INC., SAN DIEGO, CA, US, vol. 129, no. 1, November 2005 (2005-11-01), pages 94 - 100, XP005118959, ISSN: 0022-4804 *
LACOBUZIO-DONAHUE C A ET AL: "DISCOVERY OF NOVEL TUMOR MARKERS OF PANCREATIC CANCER USING GLOBAL GENE EXPRESSION TECHNOLOGY", AMERICAN JOURNAL OF PATHOLOGY, PHILADELPHIA, PA, US, vol. 160, no. 4, April 2002 (2002-04-01), pages 1239 - 1249, XP008003747, ISSN: 0002-9440 *
MISSIAGLIA E ET AL: "ANALYSIS OF GENE EXPRESSION IN CANCER CELL LINES IDENTIFIES CANDIDATE MARKERS FOR PANCREATIC TUMORIGENESIS AND METASTASIS", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 112, no. 1, 2 June 2004 (2004-06-02), pages 100 - 112, XP002364281, ISSN: 0020-7136 *
MON-NAI M ET AL: "NEW MODEL FOR HEPATIC METASTASIS OF HUMAN PANCREATIC CARCINOMA USING NOD/SCID/GAMMACNULL (NOG) MICE", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, NEW YORK, NY, US, vol. 44, July 2003 (2003-07-01), pages 582, XP001182951, ISSN: 0197-016X *
NOMURA H, ET AL.: "A new liver metastatic and peritoneal dissemination model established from the same human pancreatic cancer cell line: analysis using cDNA macroarray.", CLIN EXP METASTASIS., vol. 19, no. 5, 2002, pages 391 - 399, XP002364243 *

Also Published As

Publication number Publication date
WO2006039671A2 (en) 2006-04-13
WO2006039678A2 (en) 2006-04-13
WO2006039671A3 (en) 2006-10-12
JP2008514205A (en) 2008-05-08
WO2006039671A9 (en) 2006-06-29

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