WO2006035293A1 - Formes polymorphiques d'hemifumarate de quetiapine - Google Patents
Formes polymorphiques d'hemifumarate de quetiapine Download PDFInfo
- Publication number
- WO2006035293A1 WO2006035293A1 PCT/IB2005/002860 IB2005002860W WO2006035293A1 WO 2006035293 A1 WO2006035293 A1 WO 2006035293A1 IB 2005002860 W IB2005002860 W IB 2005002860W WO 2006035293 A1 WO2006035293 A1 WO 2006035293A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- quetiapine hemifumarate
- hemifumarate
- quetiapine
- values
- xrd pattern
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/16—[b, f]-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Definitions
- the present invention relates to polymorphic forms of quetiapine hemifumarate, processes for their preparation and pharmaceutical compositions thereof.
- quetiapine 2-[2-(4-dibenzo[Z?/J[l ,4]thiazepin-l l-ylpiperazin-l-yl)ethoxy]ethanol, commonly known as quetiapine (Formula I), is an antipsychotic drug belonging to the class of dibenzothiazepine derivatives. Quetiapine is commercially available in the form of its hemifumarate salt (2:1). Quetiapine hemifumarate is indicated for the management of the manifestations of psychotic disorders.
- U.S. Patent No. 4,879,288 discloses a process for the preparation of quetiapine hemifumarate.
- U.S. Patent No. 6,372,734 discloses a process for the purification of quetiapine which yields crystalline quetiapine.
- WO 03/80065 provides crystalline forms of quetiapine hemifumarate referred to as Form II and Form III that are solvated polymorphic forms with dichloromethane and chloroform. Summary of the Invention
- Form IV of quetiapine hemifumarate in one general aspect there is provided Form IV of quetiapine hemifumarate.
- the Form IV polymorph of quetiapine hemifumarate includes a XRD pattern that includes 2 ⁇ values of 16.96, 22.96, and 23.77.
- Embodiments of the present invention may include one or more of the following features.
- the Form IV of of quetiapine hemifumarate may include 2 ⁇ values of 20.80, 21.50, and 24.08 or it may include 2 ⁇ values of 8.98, 12.58, 15.62, 19.62, and 21.92.
- the Form IV of quetiapine hemifumarate may also include 2 ⁇ values of 8.98, 11.56, 11.90, 12.58, 13.92, 14.02, 14.32, 14.58, 15.04, 15.62, 15.84, 18.08, 18.40, 18.82, 19.62, 20.22, 20.80, 21.50, 21.92, 24.08, 25.48, 25.88, 26.80, 27.80, 28.00, 28.78, 29.26 and 30.30.
- Form V of quetiapine hemifumarate in another general aspect there is provided Form V of quetiapine hemifumarate.
- the Form V polymorph of quentiapine hemifumarate includes an XRD pattern that includes 2 ⁇ values at 16.80, 19.36, 22.72, and 23.16.
- Embodiments of the present invention include one or more of the following features.
- the Form V of quentiapine hemifumarate may include 2 ⁇ values at 11.64, 19.28, 19.58, and 23.46 or 2 ⁇ values at 7.52, 8.74, 1 1.64, 13.32, 14.26, 14.44, 14.92, 15.32, 15.72, 16.30, 17.54, 17.82, 18.38, 19.28, 19.58, 19.96, 20.20, 20.64, 20.94, 21.74, 22.32, 23.46, 23.84, 24.44, 25.18, 25.32, 26.32, 26.58, 26.64, 27.08, 27.96, 28.74, 29.06, 29.40, 29.94, 30.46, 30.82, 31.40, 31.76, 31.86, 32.10, 32.44, 33.00, 33.38, 34.04, 34.50, 35.10, 35.38, 36.12, 36.62, 37.50, 37.84, 38.30, 39.18 and 39.64.
- a process for the preparation of Form IV of quetiapine hemifumarate includes heating quetiapine hemifumarate with chloroform to form a reaction mass, cooling the reaction mass and isolating Form IV of quetiapine hemifumarate, wherein the Form IV of quetiapine hemifumarate has a XRD pattern includes 2 ⁇ values of 16.96, 22.96, and 23.77.
- a process for preparation of Form V of quetiapine hemifumarate includes stirring quetiapine hemifumarate in tetrahydrofuran to form a mixture, and isolating Form V of quetiapine hemifumarate from the mixture, wherein the Form V of quetiapine hemifumarate has an XRD pattern includes 2 ⁇ values at 16.80, 19.36, 22.72, and 23.16.
- a pharmaceutical composition includes one or both of Form IV or Form V of quetiapine hemifumarate and one or more pharmaceutically acceptable excipients.
- a method for the management of the manifestations of psychotic disorders includes administering to a mammal in need thereof a pharmaceutical composition that includes one or both of Form IV or Form V of quetiapine hemifumarate and one or more pharmaceutically acceptable excipients.
- Figure 1 depicts an X-ray diffractogram of Form IV of quetiapine hemifumarate.
- Figure 2 depicts a FTIR spectrum of Form IV of quetiapine hemifumarate
- Figure 3 depicts an X-ray diffractogram of Form V of quetiapine hemifumarate.
- Figure 4 depict FTIR spectrum of Form V of quetiapine hemifumarate.
- Form IV and V polymorphic forms of quetiapine hemifumarate, hereinafter referred to as Form IV and V, which are characteristically different from the earlier knowns Form I, II and III.
- the present invention provides for a polymorph of quetiapine hemifumarate, Form IV, having a X-Ray Powder Diffraction (XRD) pattern as depicted in Figure 1.
- Form IV includes characteristic 2 ⁇ values at 8.98, 1 1.56, 1 1.90, 12.58, 13.92, 14.02, 14.32, 14.58, 15.04, 15.62, 15.84, 16.96, 18.08, 18.40, 18.82, 19.62, 20.22, 20.80, 21.50, 21.92, 22.96, 23.70, 24.08, 25.48, 25.88, 26.80, 27.80, 28.00, 28.78, 29.26 and 30.30.
- Form IV of quetiapine hemifumarate is a chloroform solvate of quetiapine hemifumarate.
- FTIR Fourier Transform Infrared
- Form V includes characteristic 2 ⁇ values at 7.52, 8.74, 1 1.64, 13.32, 14.26, 14.44, 14.92, 15.32, 15.72, 16.30, 16.80, 17.54, 17.82, 18.38, 19.28, 19.36, 19.58, 19.96, 20.20, 20.64, 20.94, 21.74, 22.32, 22.72, 23.16, 23.46, 23.84, 24.44, 25.18, 25.32, 26.32, 26.58, 26.64, 27.08, 27.96, 28.74, 29.06, 29.40, 29.94, 30.46, 30.82, 31.40, 31.76, 31.86, 32.10, 32.44, 33.00, 33.38, 34.04, 34.50, 35.10, 35.38, 36.12, 36.62, 37.50, 37.84, 38.30, 39
- Form V of quetiapine hemifumarate is a tetrahydrofuran solvate of quetiapine hemifumarate.
- the Fourier Transform Infrared (FTIR) spectrum of Form V of quetiapine hemifumarate in potassium bromide is depicted in Figure 4.
- Also provided in the present invention is a process for preparation of Form IV of quetiapine hemifumarate. The process includes heating quetiapine hemifumarate with chloroform to form a reaction mass, cooling the reaction mass and isolating Form IV of quetiapine hemifumarate.
- the quetiapine hemifumarate may be prepared by any processes reported in the art.
- the quetiapine hemifurate is heated in chloroform and the resultant reaction mass is slowly cooled.
- the reaction mass is separated, filtered and dried under vacuum at ambient temperature for 3 hours to get Form IV of quetiapine hemifumarate.
- the process includes stirring quetiapine hemifumarate in tetrahydrofuran and isolating Form V of quetiapine hemifumarate from the mixture.
- Quetiapine hemifumarate is stirred with tetrahydrofuran at ambient temperature for 3 hours to 80 hours and the resultant mass is filtered and dried under vacuum to get Form V of quetiapine hemifumarate.
- compositions which include Form IV and/or Form V of quetiapine hemifumarate.
- the pharmaceutical compositions may include one or more pharmaceutically acceptable excipients.
- the present invention also provides a method for the management of the manifestations of psychotic disorders.
- the method includes administering to a mammal in need thereof a therapeutically effective amount of Form IV and/or Form V of quetiapine hemifumarate.
- Example 1 Preparation of Form IV of Quetiapine Hemifumarate
- Quetiapine hemifumarate (2 gm) was heated with chloroform (10 ml) for 30 minutes at reflux temperature. The resultant mass was cooled to an ambient temperature and stirred for between 28 to 30 hours. The separated product was filtered and washed with chilled chloroform. The resulting cake was dried in a vacuum oven at about 25 0 C to 3O 0 C for between 4 to 16 hours to get Form IV of quetiapine hemifumarate. Yield: 1.6 gm.
- Example 2 Preparation of Form V of Quetiapine Hemifumarate Quetiapine hemifumarate Form IV (1 gm) was mixed in to tetrahydrofuran (10 ml).
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- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN1852DE2004 | 2004-09-27 | ||
IN1852/DEL/2004 | 2004-09-27 |
Publications (1)
Publication Number | Publication Date |
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WO2006035293A1 true WO2006035293A1 (fr) | 2006-04-06 |
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PCT/IB2005/002860 WO2006035293A1 (fr) | 2004-09-27 | 2005-09-27 | Formes polymorphiques d'hemifumarate de quetiapine |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7687622B2 (en) | 2005-04-14 | 2010-03-30 | Teva Pharmaceutical Industries, Ltd | Process for preparing quetiapine fumarate |
WO2010100623A1 (fr) | 2009-03-04 | 2010-09-10 | Ranbaxy Laboratories Limited | Procede de preparation de fumarate de quetiapine |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4879288A (en) * | 1986-03-27 | 1989-11-07 | Ici Americas Inc. | Novel dibenzothiazepine antipsychotic |
WO2001055125A1 (fr) * | 2000-01-25 | 2001-08-02 | EGIS Gyógyszergyár Rt. | Procédé de préparation de quétiapine et des ses intermédiaires |
US6372734B1 (en) * | 1997-08-01 | 2002-04-16 | Zeneca Limited | Crystalline dibenzothiazepine derivative and its use as an antipsychotic agent |
WO2003080065A1 (fr) * | 2002-03-20 | 2003-10-02 | Teva Pharmaceutical Industries Ltd. | Formes cristallines d'hemifumarate de quetiapine |
WO2004078735A1 (fr) * | 2003-03-03 | 2004-09-16 | Hetero Drugs Limited | Nouveaux polymorphes du fumarate de quetiapine |
-
2005
- 2005-09-27 WO PCT/IB2005/002860 patent/WO2006035293A1/fr active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4879288A (en) * | 1986-03-27 | 1989-11-07 | Ici Americas Inc. | Novel dibenzothiazepine antipsychotic |
US6372734B1 (en) * | 1997-08-01 | 2002-04-16 | Zeneca Limited | Crystalline dibenzothiazepine derivative and its use as an antipsychotic agent |
WO2001055125A1 (fr) * | 2000-01-25 | 2001-08-02 | EGIS Gyógyszergyár Rt. | Procédé de préparation de quétiapine et des ses intermédiaires |
WO2003080065A1 (fr) * | 2002-03-20 | 2003-10-02 | Teva Pharmaceutical Industries Ltd. | Formes cristallines d'hemifumarate de quetiapine |
WO2004078735A1 (fr) * | 2003-03-03 | 2004-09-16 | Hetero Drugs Limited | Nouveaux polymorphes du fumarate de quetiapine |
Non-Patent Citations (3)
Title |
---|
CAIRA, M. R.: "CRYSTALLINE POLYMORPHISM OF ORGANIC COMPOUNDS", TOPICS IN CURRENT CHEMISTRY, SPRINGER, BERLIN, DE, vol. 198, 1998, pages 163 - 208, XP001156954, ISSN: 0340-1022 * |
U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES: "Guidance for Industry: Q3C - Tables and List, Revision 1", November 2003, FOOD AND DRUG ADMINISTRATION, ROCKVILLE, MD, USA, XP002360437 * |
WARAWA E J ET AL: "Behavioral approach to nondyskinetic dopamine antagonists: Identification of Seroquel", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 44, 1 February 2001 (2001-02-01), pages 372 - 389, XP002213291, ISSN: 0022-2623 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7687622B2 (en) | 2005-04-14 | 2010-03-30 | Teva Pharmaceutical Industries, Ltd | Process for preparing quetiapine fumarate |
WO2010100623A1 (fr) | 2009-03-04 | 2010-09-10 | Ranbaxy Laboratories Limited | Procede de preparation de fumarate de quetiapine |
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