WO2006032970A3 - PROCESS FOR PREPARING 7α-ALKOXYCARBONYL SUBSTITUTED STEROIDS - Google Patents
PROCESS FOR PREPARING 7α-ALKOXYCARBONYL SUBSTITUTED STEROIDS Download PDFInfo
- Publication number
- WO2006032970A3 WO2006032970A3 PCT/IB2005/002757 IB2005002757W WO2006032970A3 WO 2006032970 A3 WO2006032970 A3 WO 2006032970A3 IB 2005002757 W IB2005002757 W IB 2005002757W WO 2006032970 A3 WO2006032970 A3 WO 2006032970A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkoxycarbonyl
- substrate
- reaction
- enester
- product
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/001—Lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MX2007002846A MX2007002846A (en) | 2004-09-09 | 2005-08-25 | Process for preparing 7 -alkoxycarbonyl substituted steroids. |
BRPI0515106-6A BRPI0515106A (en) | 2004-09-09 | 2005-08-25 | process for preparing substituted 7 (alpha) -alkoxycarbonyl steroids |
CA002579954A CA2579954A1 (en) | 2004-09-09 | 2005-08-25 | Process for preparing 7.alpha.-alkoxycarbonyl substituted steroids |
JP2007530794A JP2008512439A (en) | 2004-09-09 | 2005-08-25 | Process for preparing 7α-alkoxycarbonyl substituted steroids |
EP05805074A EP1794177A2 (en) | 2004-09-09 | 2005-08-25 | Process for preparing 7 -alkoxycarbonyl substituted steroids |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60842504P | 2004-09-09 | 2004-09-09 | |
US60/608,425 | 2004-09-09 | ||
US61213304P | 2004-09-22 | 2004-09-22 | |
US60/612,133 | 2004-09-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006032970A2 WO2006032970A2 (en) | 2006-03-30 |
WO2006032970A3 true WO2006032970A3 (en) | 2006-08-17 |
Family
ID=35519906
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2005/002757 WO2006032970A2 (en) | 2004-09-09 | 2005-08-25 | PROCESS FOR PREPARING 7α-ALKOXYCARBONYL SUBSTITUTED STEROIDS |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1794177A2 (en) |
JP (1) | JP2008512439A (en) |
AR (1) | AR050632A1 (en) |
BR (1) | BRPI0515106A (en) |
CA (1) | CA2579954A1 (en) |
MX (1) | MX2007002846A (en) |
TW (1) | TW200617020A (en) |
WO (1) | WO2006032970A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104262450A (en) * | 2014-09-19 | 2015-01-07 | 江苏嘉逸医药有限公司 | Method for preparing and refining eplerenone |
CN104725461B (en) * | 2015-04-02 | 2016-08-17 | 山东新华制药股份有限公司 | The preparation method of eplerenone |
CN108129536A (en) * | 2017-12-25 | 2018-06-08 | 江西赣亮医药原料有限公司 | A kind of preparation method of Dexamethasone Intermediate |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2241680A1 (en) * | 1971-08-25 | 1973-03-01 | Searle & Co | 17-HYDROXY-7- (LOWER ALCOXY) CARBONYL3-OXO-17ALPHA-PREGN-4-EN-21-CARBONIC ACID GAMMA-LACTONES, THE ACIDS AND THEIR SALTS UNDER THEM |
US3787396A (en) * | 1972-08-24 | 1974-01-22 | Searle & Co | 17-hydroxy-7-(lower alkoxy)carbonyl-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid ypsilon-lactones and congeners |
DE2443746A1 (en) * | 1973-09-14 | 1975-03-20 | Searle & Co | 4 ', 5-DIHYDRO-7ALPHA-ALKOXYCARBONYLSPIRO SQUARE CLAMP ON ANDROST-4-EN17.2' (3'H) -FURAN SQUARE BRACKET TO -3-ONE AND CORRESPONDING DELTA HIGH 1.4 CONNECTIONS |
DE2609695A1 (en) * | 1976-03-05 | 1977-09-15 | Schering Ag | (17-Alpha)-(3)-hydroxypropyl-(17-beta)-hydroxy androstenones - aldosterone antagonist type diuretics and intermediates for spironolactone |
DE2627186A1 (en) * | 1976-03-05 | 1977-12-29 | Schering Ag | (17-Alpha)-(3)-hydroxypropyl-(17-beta)-hydroxy androstenones - aldosterone antagonist type diuretics and intermediates for spironolactone |
EP1148061A2 (en) * | 1996-12-11 | 2001-10-24 | G.D. Searle & Co. | Process for preparation of 9, 11- epoxy steroids and intermediates useful therein |
-
2005
- 2005-08-25 WO PCT/IB2005/002757 patent/WO2006032970A2/en active Application Filing
- 2005-08-25 MX MX2007002846A patent/MX2007002846A/en unknown
- 2005-08-25 CA CA002579954A patent/CA2579954A1/en not_active Abandoned
- 2005-08-25 BR BRPI0515106-6A patent/BRPI0515106A/en not_active Application Discontinuation
- 2005-08-25 EP EP05805074A patent/EP1794177A2/en not_active Withdrawn
- 2005-08-25 JP JP2007530794A patent/JP2008512439A/en not_active Withdrawn
- 2005-09-07 AR ARP050103739A patent/AR050632A1/en unknown
- 2005-09-08 TW TW094130861A patent/TW200617020A/en unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2241680A1 (en) * | 1971-08-25 | 1973-03-01 | Searle & Co | 17-HYDROXY-7- (LOWER ALCOXY) CARBONYL3-OXO-17ALPHA-PREGN-4-EN-21-CARBONIC ACID GAMMA-LACTONES, THE ACIDS AND THEIR SALTS UNDER THEM |
US3787396A (en) * | 1972-08-24 | 1974-01-22 | Searle & Co | 17-hydroxy-7-(lower alkoxy)carbonyl-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid ypsilon-lactones and congeners |
DE2443746A1 (en) * | 1973-09-14 | 1975-03-20 | Searle & Co | 4 ', 5-DIHYDRO-7ALPHA-ALKOXYCARBONYLSPIRO SQUARE CLAMP ON ANDROST-4-EN17.2' (3'H) -FURAN SQUARE BRACKET TO -3-ONE AND CORRESPONDING DELTA HIGH 1.4 CONNECTIONS |
DE2609695A1 (en) * | 1976-03-05 | 1977-09-15 | Schering Ag | (17-Alpha)-(3)-hydroxypropyl-(17-beta)-hydroxy androstenones - aldosterone antagonist type diuretics and intermediates for spironolactone |
DE2627186A1 (en) * | 1976-03-05 | 1977-12-29 | Schering Ag | (17-Alpha)-(3)-hydroxypropyl-(17-beta)-hydroxy androstenones - aldosterone antagonist type diuretics and intermediates for spironolactone |
EP1148061A2 (en) * | 1996-12-11 | 2001-10-24 | G.D. Searle & Co. | Process for preparation of 9, 11- epoxy steroids and intermediates useful therein |
Also Published As
Publication number | Publication date |
---|---|
EP1794177A2 (en) | 2007-06-13 |
BRPI0515106A (en) | 2008-07-08 |
JP2008512439A (en) | 2008-04-24 |
CA2579954A1 (en) | 2006-03-30 |
TW200617020A (en) | 2006-06-01 |
WO2006032970A2 (en) | 2006-03-30 |
AR050632A1 (en) | 2006-11-08 |
MX2007002846A (en) | 2007-04-30 |
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