WO2006023672A3 - Dispositifs implantables comprenant des polymeres absorbables biologiquement presentant une vitesse de degradation constante et procedes permettant de produire ces dispositifs - Google Patents

Dispositifs implantables comprenant des polymeres absorbables biologiquement presentant une vitesse de degradation constante et procedes permettant de produire ces dispositifs Download PDF

Info

Publication number
WO2006023672A3
WO2006023672A3 PCT/US2005/029443 US2005029443W WO2006023672A3 WO 2006023672 A3 WO2006023672 A3 WO 2006023672A3 US 2005029443 W US2005029443 W US 2005029443W WO 2006023672 A3 WO2006023672 A3 WO 2006023672A3
Authority
WO
WIPO (PCT)
Prior art keywords
degradation
constant rate
implantable devices
absorbable polymers
biologically absorbable
Prior art date
Application number
PCT/US2005/029443
Other languages
English (en)
Other versions
WO2006023672A2 (fr
Inventor
Syed F A Hossainy
Stephen D Pacetti
David Gale
Original Assignee
Advanced Cardiovascular System
Syed F A Hossainy
Stephen D Pacetti
David Gale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Cardiovascular System, Syed F A Hossainy, Stephen D Pacetti, David Gale filed Critical Advanced Cardiovascular System
Publication of WO2006023672A2 publication Critical patent/WO2006023672A2/fr
Publication of WO2006023672A3 publication Critical patent/WO2006023672A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/02—Aliphatic polycarbonates
    • C08G64/0208—Aliphatic polycarbonates saturated
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/02—Aliphatic polycarbonates
    • C08G64/0208—Aliphatic polycarbonates saturated
    • C08G64/0225—Aliphatic polycarbonates saturated containing atoms other than carbon, hydrogen or oxygen
    • C08G64/0241—Aliphatic polycarbonates saturated containing atoms other than carbon, hydrogen or oxygen containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D167/00—Coating compositions based on polyesters obtained by reactions forming a carboxylic ester link in the main chain; Coating compositions based on derivatives of such polymers
    • C09D167/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D169/00—Coating compositions based on polycarbonates; Coating compositions based on derivatives of polycarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Polymers & Plastics (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention porte sur des polymères pouvant servir à former le support d'un dispositif médical implantable, et à former des revêtements de dispositifs médicaux implantables, et des procédés permettant de les fabriquer. Les revêtement décrits comprennent des polymères qui sont hydrolysés à une vitesse sensiblement constante, ou qui ont subi une préparation destinée à rendre leur vitesse de dégradation plus constante.
PCT/US2005/029443 2004-08-23 2005-08-17 Dispositifs implantables comprenant des polymeres absorbables biologiquement presentant une vitesse de degradation constante et procedes permettant de produire ces dispositifs WO2006023672A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/925,257 US20060041102A1 (en) 2004-08-23 2004-08-23 Implantable devices comprising biologically absorbable polymers having constant rate of degradation and methods for fabricating the same
US10/925,257 2004-08-23

Publications (2)

Publication Number Publication Date
WO2006023672A2 WO2006023672A2 (fr) 2006-03-02
WO2006023672A3 true WO2006023672A3 (fr) 2006-10-05

Family

ID=35910514

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/029443 WO2006023672A2 (fr) 2004-08-23 2005-08-17 Dispositifs implantables comprenant des polymeres absorbables biologiquement presentant une vitesse de degradation constante et procedes permettant de produire ces dispositifs

Country Status (2)

Country Link
US (2) US20060041102A1 (fr)
WO (1) WO2006023672A2 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU716005B2 (en) * 1995-06-07 2000-02-17 Cook Medical Technologies Llc Implantable medical device
US8980300B2 (en) 2004-08-05 2015-03-17 Advanced Cardiovascular Systems, Inc. Plasticizers for coating compositions
US8007775B2 (en) * 2004-12-30 2011-08-30 Advanced Cardiovascular Systems, Inc. Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same
US20070020312A1 (en) * 2005-07-20 2007-01-25 Desnoyer Jessica R Method of fabricating a bioactive agent-releasing implantable medical device
US20070196423A1 (en) * 2005-11-21 2007-08-23 Med Institute, Inc. Implantable medical device coatings with biodegradable elastomer and releasable therapeutic agent
US8021678B2 (en) * 2006-02-10 2011-09-20 Advanced Cardiovascular Systems, Inc. Implantable medical device with polymer coating in a surface area to volume ratio providing surface erosion characteristics
US20070212393A1 (en) * 2006-03-08 2007-09-13 Sahajanand Medical Technologies Pvt. Ltd. Compositions and coatings for implantable medical devices
JP5102200B2 (ja) * 2006-03-30 2012-12-19 テルモ株式会社 生体内留置物
WO2007116646A1 (fr) * 2006-04-04 2007-10-18 Terumo Kabushiki Kaisha Sonde à demeure in vivo
US7794495B2 (en) * 2006-07-17 2010-09-14 Advanced Cardiovascular Systems, Inc. Controlled degradation of stents
EP3061791B1 (fr) * 2006-07-20 2019-01-16 OrbusNeich Medical, Inc. Composition polymère bioabsorbable pour un dispositif médical
US8016879B2 (en) 2006-08-01 2011-09-13 Abbott Cardiovascular Systems Inc. Drug delivery after biodegradation of the stent scaffolding
US9173733B1 (en) 2006-08-21 2015-11-03 Abbott Cardiovascular Systems Inc. Tracheobronchial implantable medical device and methods of use
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
US8691321B2 (en) * 2006-10-20 2014-04-08 Orbusneich Medical, Inc. Bioabsorbable polymeric composition and medical device background
US20090004243A1 (en) * 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
US8961589B2 (en) * 2007-08-01 2015-02-24 Abbott Cardiovascular Systems Inc. Bioabsorbable coating with tunable hydrophobicity
US9248219B2 (en) * 2007-09-14 2016-02-02 Boston Scientific Scimed, Inc. Medical devices having bioerodable layers for the release of therapeutic agents
US20090299464A1 (en) * 2008-06-02 2009-12-03 Medtronic Vascular, Inc. Reducing Bioabsorbtion Time of Polymer Coated Implantable Medical Devices Using Polymer Blends
US8129477B1 (en) 2008-08-06 2012-03-06 Medtronic, Inc. Medical devices and methods including blends of biodegradable polymers
US8642063B2 (en) * 2008-08-22 2014-02-04 Cook Medical Technologies Llc Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
US8461478B2 (en) 2009-02-03 2013-06-11 Abbott Cardiovascular Systems, Inc. Multiple beam laser system for forming stents
EP2393625A1 (fr) * 2009-02-03 2011-12-14 Abbott Cardiovascular Systems Inc. Procédé amélioré de coupe au laser pour former des stents
US8530783B2 (en) * 2009-02-03 2013-09-10 Abbott Cardiovascular Systems Inc. Laser cutting system
US9889238B2 (en) 2009-07-21 2018-02-13 Abbott Cardiovascular Systems Inc. Biodegradable stent with adjustable degradation rate
US8889823B2 (en) 2009-07-21 2014-11-18 Abbott Cardiovascular Systems Inc. Method to make poly(L-lactide) stent with tunable degradation rate
BR112012005864A2 (pt) * 2009-09-18 2016-11-22 Protherics Medicines Dev Ltd polímeros de gelação térmicos inversos reconstituíveis
US9155722B2 (en) * 2009-09-18 2015-10-13 Protherics Salt Lake City, Inc. Reconstitutable reverse thermal gelling polymers
US8556511B2 (en) 2010-09-08 2013-10-15 Abbott Cardiovascular Systems, Inc. Fluid bearing to support stent tubing during laser cutting
WO2012128720A1 (fr) * 2011-03-21 2012-09-27 Nanyang Technological University Endoprothèse trachéenne biorésorbable, et son procédé de fabrication
GB2512016A (en) 2012-09-24 2014-09-24 Arterius Ltd Methods
US20150328373A1 (en) * 2014-05-19 2015-11-19 Abbott Cardiovascular Systems Inc. Additives To Increase Degradation Rate Of A Biodegradable Scaffolding And Methods Of Forming Same

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886870A (en) * 1984-05-21 1989-12-12 Massachusetts Institute Of Technology Bioerodible articles useful as implants and prostheses having predictable degradation rates
US5061281A (en) * 1985-12-17 1991-10-29 Allied-Signal Inc. Bioresorbable polymers and implantation devices thereof
US5525646A (en) * 1991-03-04 1996-06-11 Lundgren; Dan Bioresorbable material and an article of manufacture made of such material for medical use
US5686540A (en) * 1995-09-29 1997-11-11 Dainippon Ink And Chemicals, Inc. Process for the preparation of lactic acid-based polyester
US5700901A (en) * 1989-06-09 1997-12-23 Boehringer Ingelheim Kg Resorbable mouldings and process for producing them
CN1241442A (zh) * 1999-07-27 2000-01-19 林代平 术后防粘连方法

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6037735B2 (ja) * 1978-10-18 1985-08-28 住友電気工業株式会社 人工血管
US4902289A (en) * 1982-04-19 1990-02-20 Massachusetts Institute Of Technology Multilayer bioreplaceable blood vessel prosthesis
US4656083A (en) * 1983-08-01 1987-04-07 Washington Research Foundation Plasma gas discharge treatment for improving the biocompatibility of biomaterials
US5197977A (en) * 1984-01-30 1993-03-30 Meadox Medicals, Inc. Drug delivery collagen-impregnated synthetic vascular graft
US4633873A (en) * 1984-04-26 1987-01-06 American Cyanamid Company Surgical repair mesh
IT1186142B (it) * 1984-12-05 1987-11-18 Medinvent Sa Dispositivo di impiantazione transluminale
US4718907A (en) * 1985-06-20 1988-01-12 Atrium Medical Corporation Vascular prosthesis having fluorinated coating with varying F/C ratio
US4818559A (en) * 1985-08-08 1989-04-04 Sumitomo Chemical Company, Limited Method for producing endosseous implants
US4733665C2 (en) * 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4740207A (en) * 1986-09-10 1988-04-26 Kreamer Jeffry W Intralumenal graft
US4723549A (en) * 1986-09-18 1988-02-09 Wholey Mark H Method and apparatus for dilating blood vessels
US4722335A (en) * 1986-10-20 1988-02-02 Vilasi Joseph A Expandable endotracheal tube
US4800882A (en) * 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US4816339A (en) * 1987-04-28 1989-03-28 Baxter International Inc. Multi-layered poly(tetrafluoroethylene)/elastomer materials useful for in vivo implantation
US5059211A (en) * 1987-06-25 1991-10-22 Duke University Absorbable vascular stent
US5192311A (en) * 1988-04-25 1993-03-09 Angeion Corporation Medical implant and method of making
US4994298A (en) * 1988-06-07 1991-02-19 Biogold Inc. Method of making a biocompatible prosthesis
US5502158A (en) * 1988-08-08 1996-03-26 Ecopol, Llc Degradable polymer composition
US5085629A (en) * 1988-10-06 1992-02-04 Medical Engineering Corporation Biodegradable stent
US5289831A (en) * 1989-03-09 1994-03-01 Vance Products Incorporated Surface-treated stent, catheter, cannula, and the like
US5108755A (en) * 1989-04-27 1992-04-28 Sri International Biodegradable composites for internal medical use
US5100429A (en) * 1989-04-28 1992-03-31 C. R. Bard, Inc. Endovascular stent and delivery system
US5084065A (en) * 1989-07-10 1992-01-28 Corvita Corporation Reinforced graft assembly
US5290271A (en) * 1990-05-14 1994-03-01 Jernberg Gary R Surgical implant and method for controlled release of chemotherapeutic agents
US5279594A (en) * 1990-05-23 1994-01-18 Jackson Richard R Intubation devices with local anesthetic effect for medical use
EP0546021B1 (fr) * 1990-08-28 1995-11-08 Meadox Medicals, Inc. Greffe vasculaire tissee autoporteuse
US5258020A (en) * 1990-09-14 1993-11-02 Michael Froix Method of using expandable polymeric stent with memory
US5108417A (en) * 1990-09-14 1992-04-28 Interface Biomedical Laboratories Corp. Anti-turbulent, anti-thrombogenic intravascular stent
US5104410A (en) * 1990-10-22 1992-04-14 Intermedics Orthopedics, Inc Surgical implant having multiple layers of sintered porous coating and method
EP0525210A4 (en) * 1991-02-20 1993-07-28 Tdk Corporation Composite bio-implant and production method therefor
US5383925A (en) * 1992-09-14 1995-01-24 Meadox Medicals, Inc. Three-dimensional braided soft tissue prosthesis
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) * 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5282860A (en) * 1991-10-16 1994-02-01 Olympus Optical Co., Ltd. Stent tube for medical use
CA2087132A1 (fr) * 1992-01-31 1993-08-01 Michael S. Williams Moulage de maintien pouvant se fixer a l'interieur d'une lumiere organique
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US5306294A (en) * 1992-08-05 1994-04-26 Ultrasonic Sensing And Monitoring Systems, Inc. Stent construction of rolled configuration
FI92465C (fi) * 1993-04-14 1994-11-25 Risto Tapani Lehtinen Menetelmä endo-osteaalisten materiaalien käsittelemiseksi
US5441515A (en) * 1993-04-23 1995-08-15 Advanced Cardiovascular Systems, Inc. Ratcheting stent
US5886026A (en) * 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
US5389106A (en) * 1993-10-29 1995-02-14 Numed, Inc. Impermeable expandable intravascular stent
US5599301A (en) * 1993-11-22 1997-02-04 Advanced Cardiovascular Systems, Inc. Motor control system for an automatic catheter inflation system
US5556413A (en) * 1994-03-11 1996-09-17 Advanced Cardiovascular Systems, Inc. Coiled stent with locking ends
US5726297A (en) * 1994-03-18 1998-03-10 Lynx Therapeutics, Inc. Oligodeoxyribonucleotide N3' P5' phosphoramidates
US5599922A (en) * 1994-03-18 1997-02-04 Lynx Therapeutics, Inc. Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties
US5399666A (en) * 1994-04-21 1995-03-21 E. I. Du Pont De Nemours And Company Easily degradable star-block copolymers
US5817327A (en) * 1994-07-27 1998-10-06 The Trustees Of The University Of Pennsylvania Incorporation of biologically active molecules into bioactive glasses
US5593403A (en) * 1994-09-14 1997-01-14 Scimed Life Systems Inc. Method for modifying a stent in an implanted site
DE69520044T2 (de) * 1994-10-12 2001-06-13 Focal, Inc. Zielgerichte verabreichung mittels biologisch abbaubarer polymere
US5707385A (en) * 1994-11-16 1998-01-13 Advanced Cardiovascular Systems, Inc. Drug loaded elastic membrane and method for delivery
US5876743A (en) * 1995-03-21 1999-03-02 Den-Mat Corporation Biocompatible adhesion in tissue repair
US5605696A (en) * 1995-03-30 1997-02-25 Advanced Cardiovascular Systems, Inc. Drug loaded polymeric material and method of manufacture
US6099562A (en) * 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
JP2795824B2 (ja) * 1995-05-12 1998-09-10 オオタ株式会社 チタン系インプラントの表面処理方法及び生体親和性チタン系インプラント
AU716005B2 (en) * 1995-06-07 2000-02-17 Cook Medical Technologies Llc Implantable medical device
US5820917A (en) * 1995-06-07 1998-10-13 Medtronic, Inc. Blood-contacting medical device and method
US5591199A (en) * 1995-06-07 1997-01-07 Porter; Christopher H. Curable fiber composite stent and delivery system
US5736152A (en) * 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
US5607442A (en) * 1995-11-13 1997-03-04 Isostent, Inc. Stent with improved radiopacity and appearance characteristics
US6048964A (en) * 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
WO1997022371A1 (fr) * 1995-12-18 1997-06-26 Collagen Corporation Composition a base de polymeres reticules et leur procede d'utilisation
US5733326A (en) * 1996-05-28 1998-03-31 Cordis Corporation Composite material endoprosthesis
US5874165A (en) * 1996-06-03 1999-02-23 Gore Enterprise Holdings, Inc. Materials and method for the immobilization of bioactive species onto polymeric subtrates
US5914182A (en) * 1996-06-03 1999-06-22 Gore Hybrid Technologies, Inc. Materials and methods for the immobilization of bioactive species onto polymeric substrates
US5855618A (en) * 1996-09-13 1999-01-05 Meadox Medicals, Inc. Polyurethanes grafted with polyethylene oxide chains containing covalently bonded heparin
US5807404A (en) * 1996-09-19 1998-09-15 Medinol Ltd. Stent with variable features to optimize support and method of making such stent
US5868781A (en) * 1996-10-22 1999-02-09 Scimed Life Systems, Inc. Locking stent
US5741881A (en) * 1996-11-25 1998-04-21 Meadox Medicals, Inc. Process for preparing covalently bound-heparin containing polyurethane-peo-heparin coating compositions
US5728751A (en) * 1996-11-25 1998-03-17 Meadox Medicals, Inc. Bonding bio-active materials to substrate surfaces
US5877263A (en) * 1996-11-25 1999-03-02 Meadox Medicals, Inc. Process for preparing polymer coatings grafted with polyethylene oxide chains containing covalently bonded bio-active agents
US5733330A (en) * 1997-01-13 1998-03-31 Advanced Cardiovascular Systems, Inc. Balloon-expandable, crush-resistant locking stent
US6210715B1 (en) * 1997-04-01 2001-04-03 Cap Biotechnology, Inc. Calcium phosphate microcarriers and microspheres
US5874101A (en) * 1997-04-14 1999-02-23 Usbiomaterials Corp. Bioactive-gel compositions and methods
US5879697A (en) * 1997-04-30 1999-03-09 Schneider Usa Inc Drug-releasing coatings for medical devices
US5891192A (en) * 1997-05-22 1999-04-06 The Regents Of The University Of California Ion-implanted protein-coated intralumenal implants
DE19731021A1 (de) * 1997-07-18 1999-01-21 Meyer Joerg In vivo abbaubares metallisches Implantat
US6174330B1 (en) * 1997-08-01 2001-01-16 Schneider (Usa) Inc Bioabsorbable marker having radiopaque constituents
US6010445A (en) * 1997-09-11 2000-01-04 Implant Sciences Corporation Radioactive medical device and process
US6015541A (en) * 1997-11-03 2000-01-18 Micro Therapeutics, Inc. Radioactive embolizing compositions
WO1999034750A1 (fr) * 1998-01-06 1999-07-15 Bioamide, Inc. Fibres bioabsorbables et composites renforces produits a partir de celles-ci
DE19855421C2 (de) * 1998-11-02 2001-09-20 Alcove Surfaces Gmbh Implantat
US6187045B1 (en) * 1999-02-10 2001-02-13 Thomas K. Fehring Enhanced biocompatible implants and alloys
US6183505B1 (en) * 1999-03-11 2001-02-06 Medtronic Ave, Inc. Method of stent retention to a delivery catheter balloon-braided retainers
US6177523B1 (en) * 1999-07-14 2001-01-23 Cardiotech International, Inc. Functionalized polyurethanes
DE19938704C1 (de) * 1999-08-14 2001-10-31 Ivoclar Vivadent Ag Verfahren zur Herstellung von Reaktionssystemen zur Implantation in den menschlichen und tierischen Körper als Knochenersatz, die u.a. Calcium und Phosphor enthalten
US6379381B1 (en) * 1999-09-03 2002-04-30 Advanced Cardiovascular Systems, Inc. Porous prosthesis and a method of depositing substances into the pores
DE19953771C1 (de) * 1999-11-09 2001-06-13 Coripharm Medizinprodukte Gmbh Resorbierbares Knochen-Implantatmaterial sowie Verfahren zur Herstellung desselben
US6981987B2 (en) * 1999-12-22 2006-01-03 Ethicon, Inc. Removable stent for body lumens
US6375826B1 (en) * 2000-02-14 2002-04-23 Advanced Cardiovascular Systems, Inc. Electro-polishing fixture and electrolyte solution for polishing stents and method
KR100371559B1 (ko) * 2000-04-03 2003-02-06 주식회사 경원메디칼 생체적합적 골재생을 촉진하는 골대체 및 재생소재용칼슘포스페이트 인조골
US6527801B1 (en) * 2000-04-13 2003-03-04 Advanced Cardiovascular Systems, Inc. Biodegradable drug delivery material for stent
US6517888B1 (en) * 2000-11-28 2003-02-11 Scimed Life Systems, Inc. Method for manufacturing a medical device having a coated portion by laser ablation
CA2398774C (fr) * 2001-02-27 2009-11-10 Kabushikikaisha Igaki Iryo Sekkei Element porte-extenseur et systeme d'application d'extenseur
US6679980B1 (en) * 2001-06-13 2004-01-20 Advanced Cardiovascular Systems, Inc. Apparatus for electropolishing a stent
US6846323B2 (en) * 2003-05-15 2005-01-25 Advanced Cardiovascular Systems, Inc. Intravascular stent

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886870A (en) * 1984-05-21 1989-12-12 Massachusetts Institute Of Technology Bioerodible articles useful as implants and prostheses having predictable degradation rates
US5061281A (en) * 1985-12-17 1991-10-29 Allied-Signal Inc. Bioresorbable polymers and implantation devices thereof
US5700901A (en) * 1989-06-09 1997-12-23 Boehringer Ingelheim Kg Resorbable mouldings and process for producing them
US5525646A (en) * 1991-03-04 1996-06-11 Lundgren; Dan Bioresorbable material and an article of manufacture made of such material for medical use
US5686540A (en) * 1995-09-29 1997-11-11 Dainippon Ink And Chemicals, Inc. Process for the preparation of lactic acid-based polyester
CN1241442A (zh) * 1999-07-27 2000-01-19 林代平 术后防粘连方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 200037, Derwent World Patents Index; Class A23, AN 2000-424024, XP002393762 *
EIDELMAN NAOMI ET AL: "Characterization of combinatorial polymer blend composition gradients by FTIR microspectroscopy", J RES NATL INST STAND TECHNOL; JOURNAL OF RESEARCH OF THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY MARCH/APRIL 2004, vol. 109, no. 2, March 2004 (2004-03-01), pages 219 - 231, XP009070601 *

Also Published As

Publication number Publication date
US20060041102A1 (en) 2006-02-23
US20080004400A1 (en) 2008-01-03
WO2006023672A2 (fr) 2006-03-02

Similar Documents

Publication Publication Date Title
WO2006023672A3 (fr) Dispositifs implantables comprenant des polymeres absorbables biologiquement presentant une vitesse de degradation constante et procedes permettant de produire ces dispositifs
WO2006049907A3 (fr) Dispositifs implantables comprenant des polymeres en etoile biologiquement absorbables, procedes de fabrication de ces derniers
WO2005089824A3 (fr) Revetements biologiquement absorbables pour dispositifs implantables bases sur des copolymeres presentant des liaisons ester, et procedes de fabrication desdits revetements
WO2005011770A3 (fr) Revetements biologiquement absorbables pour dispositifs implantables, et leurs procedes de fabrication
WO2009005909A3 (fr) Copolymères triséquencés biodégradables pour dispositifs implantables
WO2006002399A3 (fr) Dispositifs medicaux biodegradables implantables, procedes et systemes associes
WO2004101018A8 (fr) Revetements pour stent comprenant des additifs hydrophiles
ATE496081T1 (de) Beschichtungen für implantierbare vorrichtungen mit poly(hydroxy-alkanoaten) und disäure- bindungen
WO2007111811A3 (fr) Revetements resistant a la corrosion pour des implants metalliques biodegradables
WO2004000379A8 (fr) Enrobages d'endoprothese vasculaire a liberation medicamenteuse prolongee
WO2007056134A3 (fr) Polymeres phenoliques resorbables
TW200519181A (en) Crosslinkable arylamine compounds and conjugated oligomers or polymers based thereon
WO2007024481A3 (fr) Compositions polymeres a base de 4-aza-caprolactone utiles pour la fabrication de dispositifs medicaux biodegradables et en tant que revetements pour dispositifs medicaux
WO2004101017A3 (fr) Implants medicaux revetus de maniere biocompatible
WO2007143116A3 (fr) dispositifs médicaux implantables en polymères ramifiés
WO2009126590A3 (fr) Revêtement comprenant un réseau interpénétrant de poly(éthylène glycol)-poly(lactide-glycolide-caprolactone)
AU2003249736A1 (en) Purified polymers for coatings of implantable medical devices
WO2007147010A3 (fr) Appareils médicaux implantables et méthodes pour les fabriquer
AU2003268062A1 (en) Electroactive polymer actuated medical devices
WO2006074406A3 (fr) Compositions de revetement biodegradables comprenant plusieurs couches
ATE389423T1 (de) Beschichtungen für implantierbare vorrichtungen enthaltend blockcopolymeren aus milchsäure und ethylenglykol
WO2006104894A3 (fr) Enrobage pour dispositifs implantables et leur methode de formation
WO2007092583A3 (fr) Fonctionnalisation de dispositifs implantables avec un polymère de poly(diol-co-citrate)
WO2008011615A3 (fr) Composition polymérique bioabsorbable pour un dispositif médical
WO2008121508A3 (fr) Dispositifs médicaux implantables fabriqués à partir de copolymères séquencés

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase