WO2006016363A3 - Mixture of phytosterol ester(s) and 1, 3-diglyceride(s) for use in the treatment of medical conditions - Google Patents

Mixture of phytosterol ester(s) and 1, 3-diglyceride(s) for use in the treatment of medical conditions Download PDF

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Publication number
WO2006016363A3
WO2006016363A3 PCT/IL2005/000861 IL2005000861W WO2006016363A3 WO 2006016363 A3 WO2006016363 A3 WO 2006016363A3 IL 2005000861 W IL2005000861 W IL 2005000861W WO 2006016363 A3 WO2006016363 A3 WO 2006016363A3
Authority
WO
WIPO (PCT)
Prior art keywords
mixture
diglyceride
treatment
phytosterol ester
medical conditions
Prior art date
Application number
PCT/IL2005/000861
Other languages
French (fr)
Other versions
WO2006016363A2 (en
Inventor
Avidor Shulman
Dori Pelled
Tzafra Cohen
Orly Farkash
Original Assignee
Enzymotec Ltd
Avidor Shulman
Dori Pelled
Tzafra Cohen
Orly Farkash
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzymotec Ltd, Avidor Shulman, Dori Pelled, Tzafra Cohen, Orly Farkash filed Critical Enzymotec Ltd
Priority to EP05764602A priority Critical patent/EP1796726A2/en
Priority to AU2005270831A priority patent/AU2005270831B2/en
Priority to JP2007525450A priority patent/JP5118965B2/en
Priority to KR1020077005572A priority patent/KR101323513B1/en
Priority to BRPI0513461-7A priority patent/BRPI0513461A2/en
Priority to CN2005800330833A priority patent/CN101039585B/en
Publication of WO2006016363A2 publication Critical patent/WO2006016363A2/en
Publication of WO2006016363A3 publication Critical patent/WO2006016363A3/en
Priority to IL181234A priority patent/IL181234A0/en
Priority to US11/673,726 priority patent/US8772270B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
    • A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
    • A23D9/013—Other fatty acid esters, e.g. phosphatides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/14—Antivirals for RNA viruses
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Botany (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)

Abstract

Methods of treatment of conditions which require phytosterol therapy without adversely affecting the bioavailability of lipophilic vitamins or lipophilic drugs, consisting of administering a mixture of phytosterol ester(s) (PS-E) and 1,3-diglyceride(s) (DAG) dissolved in an edible oil or fat are described herein, together with a method of improving weight management and a method of treating metabolic conditions that result in overweight. Dietary nutrients and food supplements containing said mixture are also described herein.
PCT/IL2005/000861 2004-08-10 2005-08-10 Mixture of phytosterol ester(s) and 1, 3-diglyceride(s) for use in the treatment of medical conditions WO2006016363A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP05764602A EP1796726A2 (en) 2004-08-10 2005-08-10 Mixture of phytosterol ester(s) and 1,3-diglyceride(s) for use in the treatment of medical conditions
AU2005270831A AU2005270831B2 (en) 2004-08-10 2005-08-10 Mixture of phytosterol ester(s) and 1, 3-diglyceride(s) for use in the treatment of medical conditions
JP2007525450A JP5118965B2 (en) 2004-08-10 2005-08-10 Treatment methods that require plant components
KR1020077005572A KR101323513B1 (en) 2004-08-10 2005-08-10 Mixture of Phytosterol Ester(s) and 1,3-Diglyceride(s) for Use in the Treatment of Medical Conditions
BRPI0513461-7A BRPI0513461A2 (en) 2004-08-10 2005-08-10 Treatment methods requiring phyto ingredients
CN2005800330833A CN101039585B (en) 2004-08-10 2005-08-10 Mixture of phytosterol ester(s) and 1,3-diglyceride(s) for use in the treatment of medical conditions
IL181234A IL181234A0 (en) 2004-08-10 2007-02-08 Mixture of phytosterol ester(s) and 1,3-diglycerides(s) for use in the treatment of medical conditions
US11/673,726 US8772270B2 (en) 2004-08-10 2007-02-12 Treatment methods requiring phyto-ingredients

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL163447 2004-08-10
IL16344704 2004-08-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/673,726 Continuation-In-Part US8772270B2 (en) 2004-08-10 2007-02-12 Treatment methods requiring phyto-ingredients

Publications (2)

Publication Number Publication Date
WO2006016363A2 WO2006016363A2 (en) 2006-02-16
WO2006016363A3 true WO2006016363A3 (en) 2006-03-16

Family

ID=35064686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2005/000861 WO2006016363A2 (en) 2004-08-10 2005-08-10 Mixture of phytosterol ester(s) and 1, 3-diglyceride(s) for use in the treatment of medical conditions

Country Status (10)

Country Link
US (1) US8772270B2 (en)
EP (1) EP1796726A2 (en)
JP (1) JP5118965B2 (en)
KR (1) KR101323513B1 (en)
CN (1) CN101039585B (en)
AU (1) AU2005270831B2 (en)
BR (1) BRPI0513461A2 (en)
IL (1) IL181234A0 (en)
RU (1) RU2394576C2 (en)
WO (1) WO2006016363A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8772270B2 (en) 2004-08-10 2014-07-08 Enzymotec Ltd. Treatment methods requiring phyto-ingredients

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL147942A0 (en) * 2002-01-31 2002-08-14 Enzymotec Ltd Method of fractionation of phytosterol esters in oil and products obtained thereby
ITBA20060049A1 (en) * 2006-08-02 2008-02-03 Pierre S R L FOOD SUPPLEMENT BASED ON BIOLOGICAL LYCOPENE AND PROCEDURE FOR OBTAINING BIOLOGICAL LICOPENE.
MY184667A (en) 2007-07-23 2021-04-15 Malaysian Palm Oil Board An antiviral composition
US20090202704A1 (en) * 2008-02-13 2009-08-13 Kao Corporation Postprandial hyperglycemia-improving agent
US8518459B2 (en) 2009-04-15 2013-08-27 Actigenomics S.A. Composition for regulating lipid metabolism
CA2822435C (en) * 2009-12-31 2018-09-11 Differential Drug Development Associates, Llc Modulation of solubility, stability, absorption, metabolism, and pharmacokinetic profile of lipophilic drugs by sterols
WO2011120766A1 (en) 2010-03-29 2011-10-06 Unilever Nv Edible tomato-based product comprising orally bioavailable endogenous micronutrients
US8039025B1 (en) * 2010-10-15 2011-10-18 Life Plus, LLC Methods and dosage forms for the treatment of human cancers
CN103054025A (en) * 2013-01-04 2013-04-24 浙江大学 Health-care food composition for preventing and treating prostate disease
CN105188670B (en) 2013-03-15 2018-11-02 马留斯医药有限责任公司 Emulsion formulations
AU2014251259A1 (en) * 2013-03-15 2015-10-01 Nutramax Laboratories, Inc. Sulforaphane/sulforaphane precursor and phytosterol/phytostanol compositions
JP2015003877A (en) * 2013-06-20 2015-01-08 国立大学法人 筑波大学 Composition comprising hydroxytyrosol or salt thereof
JP6963507B2 (en) * 2015-12-09 2021-11-10 ポビバ コーポレーションPoviva Corp. A method for formulating an orally ingestible composition containing a fat-soluble active substance.
EP3231421A1 (en) * 2016-04-11 2017-10-18 Greenaltech, S.L. Uses of a carotenoid in the treatment or prevention of stress induced conditions
KR102139994B1 (en) * 2017-10-25 2020-07-31 대구대학교 산학협력단 Pharmaceutical composition for use in preventing or treating osteoporosis containing stigmasterol as an active ingredient
CN109513006A (en) * 2018-12-18 2019-03-26 江苏大学附属医院 It is a kind of to treat metabolic syndrome morbidity drug and its measuring method

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999059423A1 (en) * 1998-04-30 1999-11-25 Kao Corporation Oil and fat composition containing phytosterol
EP0990391A1 (en) * 1998-03-24 2000-04-05 Kao Corporation Phytosterol-containing fat composition
WO2002011550A2 (en) * 2000-08-08 2002-02-14 Kao Corporation Oil/fat composition
US20020045000A1 (en) * 2000-07-19 2002-04-18 Kao Corporation Edible oil and production process thereof
WO2003064444A1 (en) * 2002-01-31 2003-08-07 Enzymotec Ltd. Fractionation of phytosterol esters in oil
US6605452B1 (en) * 1997-09-24 2003-08-12 Enzymotec, Ltd. Fatty acid polyol ester-coated lipase complex immobilized on insoluble matrix
WO2004069150A2 (en) * 2003-02-10 2004-08-19 Enzymotec Ltd. Oils enriched with diacylglycerols and phytosterol esters for use in the reduction of cholesterol and triglycerides

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2248921C3 (en) 1972-10-05 1981-11-12 Harburger Oelwerke Brinckman & Mergell, 2100 Hamburg Process for the production of a mixture of vegetable and animal oils or fats and fatty acid ester esters
US4064236A (en) 1975-12-23 1977-12-20 Merck & Co., Inc. Peptide carbazates and pharmaceutical composition
DE3117934A1 (en) 1981-05-06 1982-12-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen NEW PEPTIDE, METHOD FOR ITS PRODUCTION AND MEDICINAL PRODUCT CONTAINING IT
ATE22328T1 (en) 1981-05-07 1986-10-15 Unilever Nv TREATMENT OF FATS.
DE3225705A1 (en) 1982-07-09 1984-01-12 A. Nattermann & Cie GmbH, 5000 Köln METHOD FOR APPLYING PLANT PROTECTION AGENT SPLASHES BY SPRAYING AND PACKING UNIT FOR CONCENTRATES
JPS608225A (en) 1983-06-29 1985-01-17 Kowa Co Drug composition for alimentary canal absorption
JPS60136596A (en) 1983-12-26 1985-07-20 Suntory Ltd Peptide and diuretic comprising it as active ingredient
EP0195311B2 (en) 1985-03-06 1996-01-17 Yoshikawa Oil & Fat Co., Ltd. Process for preparing fatty acid esters
FI851609A0 (en) 1985-04-23 1985-04-23 Valio Meijerien FOERFARANDE FOER FRAMSTAELLNING AV MJOELKBASERADE KLINISKA NAERINGSPREPARAT.
EP0231039B1 (en) 1986-01-14 1992-01-08 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur Process for preparing immunological complexes and pharmaceutical composition containing these complexes
HU210122B (en) 1988-03-23 1995-02-28 Biorex Kutato Fejlesztoe Kft Process for production of composition against thromboembolytic conditions of circulating system and heart
US5164372A (en) 1989-04-28 1992-11-17 Fujisawa Pharmaceutical Company, Ltd. Peptide compounds having substance p antagonism, processes for preparation thereof and pharmaceutical composition comprising the same
US5439688A (en) 1989-07-28 1995-08-08 Debio Recherche Pharmaceutique S.A. Process for preparing a pharmaceutical composition
CA2050425A1 (en) 1990-09-03 1992-03-04 Yoshiaki Uda Pharmaceutical composition and its mucous use
US5298246A (en) 1991-01-09 1994-03-29 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Stable pharmaceutical composition and method for its production
JP2925391B2 (en) 1992-01-09 1999-07-28 サントリー株式会社 Pharmaceutical composition for treating ARDS
RU2107692C1 (en) 1995-06-07 1998-03-27 Дейгин Владислав Исакович Peptide and method for its preparation
JPH0827018A (en) 1994-07-22 1996-01-30 Sanwa Kagaku Kenkyusho Co Ltd Medicinal composition containing physiologically active peptide or protein
US5512691A (en) 1994-11-07 1996-04-30 Eastman Chemical Company Process for the production of tocopherol concentrates
US5843499A (en) 1995-12-08 1998-12-01 The United States Of America As Represented By The Secretary Of Agriculture Corn fiber oil its preparation and use
US6440464B1 (en) 1996-06-10 2002-08-27 Viva Life Science Nutritive composition for cardiovascular health containing fish oil, garlic, rutin, capsaicin, selenium, vitamins and juice concentrates
FR2750606B1 (en) 1996-07-03 1999-01-29 Maurel Sante ORGANOMETALLIC COMPLEXES BASED ON SITOSTEROLS AND DIGLYCERIDES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
US6046022A (en) * 1996-09-30 2000-04-04 Peking University Methods and compositions employing red rice fermentation products
US5998396A (en) * 1996-11-05 1999-12-07 Riken Vitamin Co., Ltd. Oil solubilized solutions and foods containing phytosterols and process for their production
FI107538B (en) 1997-02-26 2001-08-31 Raisio Benecol Oy Process for the preparation of stanol esters
FR2761887B1 (en) 1997-04-11 1999-06-18 Roland Asmar MEDICATION FOR MULTIFACTORIAL PREVENTION OF CARDIOVASCULAR DISEASES
GB9715444D0 (en) 1997-07-22 1997-09-24 Scotia Holdings Plc Therapeutic and dietary compositions
DE69826592T2 (en) 1997-08-22 2006-02-23 Unilever N.V. Process for the preparation of stanol esters
KR100583211B1 (en) * 1997-08-29 2006-05-24 더 라이섹스 캄파니, 인코포레이티드 A method for treating diabetes, hyperglycemia and hypoglycemia
US5993866A (en) 1997-09-12 1999-11-30 Shapira; Niva Process of making food products having reduced methionine ratios
IL129086A0 (en) 1999-03-22 2000-02-17 Enzymotec Ltd Surfactant-lipase complex immobilized on insoluble matrix
US6139897A (en) * 1998-03-24 2000-10-31 Kao Corporation Oil or fat composition containing phytosterol
FI111513B (en) 1998-05-06 2003-08-15 Raisio Benecol Oy Novel compositions of phytosterol and phytostanol fatty acid esters, products containing them and processes for their preparation
US6087353A (en) * 1998-05-15 2000-07-11 Forbes Medi-Tech Inc. Phytosterol compositions and use thereof in foods, beverages, pharmaceuticals, nutraceuticals and the like
SE514725C2 (en) 1998-06-02 2001-04-09 Karlshamns Ab Fractionation Procedure
NZ333817A (en) * 1998-08-25 2000-09-29 Mcneil Ppc Inc Process for preparing stanol/sterol fatty acid esters such as beta sitosterol fatty acid esters, useful in reducing cholesterol levels
FI982125A0 (en) 1998-10-01 1998-10-01 Hk Ruokatalo Oyj Food that has a positive effect on health
US6277431B1 (en) 1998-10-14 2001-08-21 Redeem, Inc. Anticholesterolemic edible oil
WO2002060272A1 (en) 2001-01-29 2002-08-08 Redeem, Inc. Anticholesterolemic edible oil
US6113972A (en) * 1998-12-03 2000-09-05 Monsanto Co. Phytosterol protein complex
US6129945A (en) * 1998-12-10 2000-10-10 Michael E. George Methods to reduce free fatty acids and cholesterol in anhydrous animal fat
CH692263A5 (en) 1999-04-29 2002-04-30 Europ Foodtec Gmbh Meat products with omega-3 fatty acid and vitamin.
WO2000073407A1 (en) 1999-05-26 2000-12-07 Asahi Denka Kogyo Kabushiki Kaisha Vegetable sterol-containing fat compositions and process for producing the same
US6080173A (en) 1999-05-26 2000-06-27 Idx Medical Ltd. Tissue punching instrument
JP4526147B2 (en) 1999-05-26 2010-08-18 株式会社Ａｄｅｋａ Method for producing plant sterol fatty acid ester-containing composition
US6365211B1 (en) * 1999-06-18 2002-04-02 The Procter & Gamble Co. Cooking aid with reduced foaming
WO2001015552A1 (en) 1999-08-30 2001-03-08 Ocean Nutrition Canada Ltd. A nutritional supplement for lowering serum triglyceride and cholesterol levels
CN1244281C (en) 1999-11-03 2006-03-08 福布斯梅迪泰克公司 Compositions comprising edible oils or fats and phytosterols and/or phytostanols substantially dissolved therein
JP4907816B2 (en) 1999-11-05 2012-04-04 ライシオ ベネコール オサケユイチア Edible fat compound
DK1121928T3 (en) 2000-01-31 2008-03-17 Haerting S A Compositions containing phytosterol and policosanol esters of fatty acids to reduce the level of blood cholesterol and triglycerides
JP2001247473A (en) 2000-03-06 2001-09-11 Kao Corp Agent for improving insulin resistance
US20020132035A1 (en) * 2001-01-10 2002-09-19 Dov Tamarkin Synthetic fat composition
US20020016317A1 (en) 2000-03-27 2002-02-07 Schul David Allen Sterol ester compositions
IL135466A (en) 2000-04-04 2006-07-05 Sobhi Basheer Process for selective alcoholysis of free sterols in fat-based product with an insoluble matrix-immobilized lipase complex
JP4911815B2 (en) 2000-04-28 2012-04-04 株式会社Ａｄｅｋａ Plant sterol-containing oil and fat composition
US20020025349A1 (en) * 2000-05-02 2002-02-28 Brindavanam Narasimha Baba Novel herbal composition for diabetes patients and a process for producing the same
US7147859B2 (en) * 2000-05-15 2006-12-12 Laboratorios Biosintetica Ltda. Application of phytosterols (and their isomers), folic acid, cyanocobalamin and pyridoxin in dietetic (alimentary) fibers
JP4031219B2 (en) 2000-08-08 2008-01-09 花王株式会社 Oil composition
BG540Y1 (en) 2000-08-18 2002-06-28 "Ел Би Булгарикум" ЕАД Dietetic dessert milk drink
CN1204238C (en) 2000-10-18 2005-06-01 李大鹏 Kenrel oil composite extracted from plant kernel and its extraction process and application
SE523094C2 (en) * 2001-01-11 2004-03-30 Karlshamns Ab Process for the preparation of a fat composition containing sterol esters, free sterols and glycerides, fat composition prepared by the process and use of the fat composition
KR100344400B1 (en) 2001-01-18 2002-07-24 주식회사 온바이오 Method for preparation of high diglyceride containing oil composition
US6667068B2 (en) * 2001-01-29 2003-12-23 Kraft Foods Holdings, Inc. Method for preparing solid milk product
GB0104074D0 (en) 2001-02-19 2001-04-04 Novartis Ag New composition
US6956058B2 (en) * 2001-04-26 2005-10-18 Kao Corporation Method for improving insulin resistance
JP4995377B2 (en) * 2001-04-26 2012-08-08 花王株式会社 Oil composition
CA2447579A1 (en) * 2001-05-23 2002-11-28 Nutricopia, Inc. Nutritional frozen dessert and methods of manufacture
GB0114014D0 (en) 2001-06-08 2001-08-01 Novartis Nutrition Ag Compostion and use
US6787151B2 (en) 2001-08-10 2004-09-07 Lipton, Division Of Conopco, Inc. Composition for lowering blood cholesterol
ES2193874B1 (en) 2002-04-03 2005-03-01 Puleva Biotech, S.A. NATURAL AND DERIVATIVE COMPOUNDS OF THESE FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR, HEPATIC, RENAL AND COSMETIC DISEASES.
JP3836819B2 (en) 2002-07-01 2006-10-25 花王株式会社 Acid oil-in-water emulsified composition
JP2004210652A (en) 2002-12-27 2004-07-29 Kao Corp Lipid metabolism-improving agent in diabetic mellitus patient
US20060233863A1 (en) 2003-02-10 2006-10-19 Enzymotec Ltd. Oils enriched with diacylglycerols and phytosterol esters and unit dosage forms thereof for use in therapy
US20040219188A1 (en) * 2003-05-02 2004-11-04 Comer Gail M. Composition and methods for nutritional management of patients with hepatic disease
US20050032757A1 (en) * 2003-08-06 2005-02-10 Cho Suk H. Nutritional supplements
CN101035594B (en) * 2004-08-09 2013-10-23 酶学技术有限公司 Food products for diabetics
JP5118965B2 (en) 2004-08-10 2013-01-16 エンジモテック リミテッド Treatment methods that require plant components

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6605452B1 (en) * 1997-09-24 2003-08-12 Enzymotec, Ltd. Fatty acid polyol ester-coated lipase complex immobilized on insoluble matrix
EP0990391A1 (en) * 1998-03-24 2000-04-05 Kao Corporation Phytosterol-containing fat composition
WO1999059423A1 (en) * 1998-04-30 1999-11-25 Kao Corporation Oil and fat composition containing phytosterol
US20020045000A1 (en) * 2000-07-19 2002-04-18 Kao Corporation Edible oil and production process thereof
WO2002011550A2 (en) * 2000-08-08 2002-02-14 Kao Corporation Oil/fat composition
WO2003064444A1 (en) * 2002-01-31 2003-08-07 Enzymotec Ltd. Fractionation of phytosterol esters in oil
WO2004069150A2 (en) * 2003-02-10 2004-08-19 Enzymotec Ltd. Oils enriched with diacylglycerols and phytosterol esters for use in the reduction of cholesterol and triglycerides

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
"Enzymotec launches healthy oil ingredient", NUTRACEUTICALS INTERNATIONAL, April 2003 (2003-04-01), pages 24, XP009058643, ISSN: 1362-4511 *
ANONYMOUS: "Functional oil shows triple action against heart disease", INTERNET ARTICLE, 11 February 2004 (2004-02-11), XP002359318, Retrieved from the Internet <URL:http://www.nutraingredients.com/news/ng.asp?n=49812-functional-oil-shows> [retrieved on 20051209] *
ANONYMOUS: "Supplementing with enhanced phytosterols", INTERNET ARTICLE, April 2004 (2004-04-01), XP002359317, Retrieved from the Internet <URL:http://www.findarticles.com/p/articles/mi_m3289/is_4_173/ai_n5998862> [retrieved on 20051209] *
INTERNATIONAL SOCIETY FOR THE STUDY OF FATTY ACIDS AND LIPIDS: "ISSFAL Newsletter", ISSFAL NEWSLETTER, vol. 10, no. 3, 2003, U.K., pages 1 - 28, XP002359319, ISSN: 1081-6208 *
JAVED M AKHTAR ET AL: "Fatty acid and lipid composition of Sesamum indicum DC", PAKISTAN JOURNAL OF SCIENTIFIC AND INDUSTRIAL RESEARCH, vol. 43, no. 1, February 2000 (2000-02-01), pages 23 - 25, XP009058587, ISSN: 0030-9885 *
LING W H ET AL: "MINIREVIEW DIETARY PHYTOSTEROLS: A REVIEW OF METABOLISM, BENEFITS AND SIDE EFFECTS", LIFE SCIENCES, PERGAMON PRESS, OXFORD, GB, vol. 57, no. 3, 1995, pages 195 - 206, XP000995149, ISSN: 0024-3205 *
MEGURO S ET AL: "SOLUBILIZATION OF PHYTOSTEROLS IN DIACYLGLYCEROL VERSUS TRIACYLGLYCEROL IMPROVES THE SERUM CHOLESTEROL-LOWERING EFFECT", EUROPEAN JOURNAL OF CLINICAL NUTRITION, vol. 55, no. 7, 2001, pages 513 - 517, XP009021731 *
MUSSNER M J ET AL: "Effects of Phytosterol Ester-Enriched Margarine on Plasma Lipoproteins in Mild to Moderate Hypercholesterolemia Are Related to Basal Cholesterol and Fat Intake", METABOLISM, CLINICAL AND EXPERIMENTAL, W.B. SAUNDERS CO., PHILADELPHIA, PA, US, vol. 51, no. 2, February 2002 (2002-02-01), pages 189 - 194, XP002267083, ISSN: 0026-0495 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8772270B2 (en) 2004-08-10 2014-07-08 Enzymotec Ltd. Treatment methods requiring phyto-ingredients

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