WO2006016020A3 - Nanoparticules comprenant un coeur constitue essentiellement d’un polymere cyanoacrylique et une ecorce d’un polymere amphiphile, et eventuellement un principe actif qui est preferablement du busulfan - Google Patents

Nanoparticules comprenant un coeur constitue essentiellement d’un polymere cyanoacrylique et une ecorce d’un polymere amphiphile, et eventuellement un principe actif qui est preferablement du busulfan Download PDF

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Publication number
WO2006016020A3
WO2006016020A3 PCT/FR2005/001398 FR2005001398W WO2006016020A3 WO 2006016020 A3 WO2006016020 A3 WO 2006016020A3 FR 2005001398 W FR2005001398 W FR 2005001398W WO 2006016020 A3 WO2006016020 A3 WO 2006016020A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymer
nanoparticles
active principle
bisulfan
optionally
Prior art date
Application number
PCT/FR2005/001398
Other languages
English (en)
Other versions
WO2006016020A2 (fr
Inventor
Anne Magali Layre
Ruxandra Gref
Patrick Couvreur
Joel Richard
Original Assignee
Ethypharm Sa
Anne Magali Layre
Ruxandra Gref
Patrick Couvreur
Joel Richard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm Sa, Anne Magali Layre, Ruxandra Gref, Patrick Couvreur, Joel Richard filed Critical Ethypharm Sa
Publication of WO2006016020A2 publication Critical patent/WO2006016020A2/fr
Publication of WO2006016020A3 publication Critical patent/WO2006016020A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention se rapporte à des nanoparticules polymériques composites biodégradables, pouvant contenir éventuellement un principe actif, ainsi qu'à des suspensions en milieu aqueux de telles particules, leur préparation et leur utilisation.
PCT/FR2005/001398 2004-07-07 2005-06-07 Nanoparticules comprenant un coeur constitue essentiellement d’un polymere cyanoacrylique et une ecorce d’un polymere amphiphile, et eventuellement un principe actif qui est preferablement du busulfan WO2006016020A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0407569 2004-07-07
FR0407569A FR2872703B1 (fr) 2004-07-07 2004-07-07 Nanoparticules polymeriques composites

Publications (2)

Publication Number Publication Date
WO2006016020A2 WO2006016020A2 (fr) 2006-02-16
WO2006016020A3 true WO2006016020A3 (fr) 2006-07-13

Family

ID=34946547

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2005/001398 WO2006016020A2 (fr) 2004-07-07 2005-06-07 Nanoparticules comprenant un coeur constitue essentiellement d’un polymere cyanoacrylique et une ecorce d’un polymere amphiphile, et eventuellement un principe actif qui est preferablement du busulfan

Country Status (2)

Country Link
FR (1) FR2872703B1 (fr)
WO (1) WO2006016020A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010523557A (ja) * 2007-03-30 2010-07-15 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 疎水性量子ドットのカプセル化
HUE034480T2 (en) 2011-04-28 2018-02-28 Platform Brightworks Two Ltd Improved parenteral formulations of lipophilic pharmaceutical agents and methods for their preparation and use
CA2913328C (fr) 2013-05-28 2021-08-24 Sintef Tto As Procede de preparation de nanoparticules furtives
CN108453927A (zh) * 2018-02-08 2018-08-28 西安交通大学 一种可生物降解PCL/Mg复合材料FDM耗材的制备工艺
JP7317038B2 (ja) * 2018-03-27 2023-07-28 シンテフ ティーティーオー エイエス がん治療に使用するためのポリ（アルキルシアノアクリレート）ナノ粒子

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007895A1 (fr) * 1978-07-19 1980-02-06 Patrick Couvreur Nanoparticules biodégradables, compositions pharmaceutiques les contenant et procédé pour leur préparation
FR2608942A1 (fr) * 1986-12-31 1988-07-01 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
EP0447318A1 (fr) * 1990-03-16 1991-09-18 L'oreal Composition pour le traitement cosmétique et/ou pharmaceutique des couches supérieures de l'épiderme par application topique sur la peau et procédé de préparation correspondant
WO1996031231A1 (fr) * 1995-04-04 1996-10-10 Elan Corporation, Plc Nanoparticules biodegradables a liberation lente renfermant de l'insuline
WO1999043359A1 (fr) * 1998-02-27 1999-09-02 Bioalliance Pharma (S.A.) Nanoparticules comprenant polyisobutylcyanoacrylate et cyclodextrines
WO2003017987A1 (fr) * 2001-08-31 2003-03-06 Mcgill University Nanocapsules polymeres biodegradables et utilisation de celles-ci
CN1417242A (zh) * 2002-11-14 2003-05-14 天津大学 聚乙二醇接枝修饰的聚氰基丙烯酸酯共聚物及其制备方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0007895A1 (fr) * 1978-07-19 1980-02-06 Patrick Couvreur Nanoparticules biodégradables, compositions pharmaceutiques les contenant et procédé pour leur préparation
FR2608942A1 (fr) * 1986-12-31 1988-07-01 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
EP0447318A1 (fr) * 1990-03-16 1991-09-18 L'oreal Composition pour le traitement cosmétique et/ou pharmaceutique des couches supérieures de l'épiderme par application topique sur la peau et procédé de préparation correspondant
WO1996031231A1 (fr) * 1995-04-04 1996-10-10 Elan Corporation, Plc Nanoparticules biodegradables a liberation lente renfermant de l'insuline
WO1999043359A1 (fr) * 1998-02-27 1999-09-02 Bioalliance Pharma (S.A.) Nanoparticules comprenant polyisobutylcyanoacrylate et cyclodextrines
WO2003017987A1 (fr) * 2001-08-31 2003-03-06 Mcgill University Nanocapsules polymeres biodegradables et utilisation de celles-ci
CN1417242A (zh) * 2002-11-14 2003-05-14 天津大学 聚乙二醇接枝修饰的聚氰基丙烯酸酯共聚物及其制备方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 200370, Derwent World Patents Index; Class A14, AN 2003-732339, XP002317291 *
HASSAN M ET AL: "A phase II trial of liposomal busulphan as an intravenous myeloablative agent prior to stem transplantation: 500 mg/m<2> as a optimal total dose for conditioning", BONE MARROW TRANSPLANTATION 2002 UNITED KINGDOM, vol. 30, no. 12, 2002, pages 833 - 841, XP002367646, ISSN: 0268-3369 *

Also Published As

Publication number Publication date
FR2872703B1 (fr) 2006-10-06
WO2006016020A2 (fr) 2006-02-16
FR2872703A1 (fr) 2006-01-13

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