WO2006003479A3 - New pseudopolymorph of desloratadine formed with carbon dioxide - Google Patents

New pseudopolymorph of desloratadine formed with carbon dioxide Download PDF

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Publication number
WO2006003479A3
WO2006003479A3 PCT/HU2005/000073 HU2005000073W WO2006003479A3 WO 2006003479 A3 WO2006003479 A3 WO 2006003479A3 HU 2005000073 W HU2005000073 W HU 2005000073W WO 2006003479 A3 WO2006003479 A3 WO 2006003479A3
Authority
WO
WIPO (PCT)
Prior art keywords
desloratadine
carbon dioxide
pseudopolymorph
formula
new pseudopolymorph
Prior art date
Application number
PCT/HU2005/000073
Other languages
French (fr)
Other versions
WO2006003479A2 (en
Inventor
Tibor Mezei
Gyula Simig
Gyula Lukacs
Marta Porcs-Makkay
Balazs Volk
Eniko Molnar
Fekete Valeria Hofmanne
Zsuzsanna Szent-Kirallyi
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Tibor Mezei
Gyula Simig
Gyula Lukacs
Marta Porcs-Makkay
Balazs Volk
Eniko Molnar
Fekete Valeria Hofmanne
Zsuzsanna Szent-Kirallyi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0401373A external-priority patent/HU0401373D0/en
Priority claimed from HU0500664A external-priority patent/HU226951B1/en
Application filed by Egyt Gyogyszervegyeszeti Gyar, Tibor Mezei, Gyula Simig, Gyula Lukacs, Marta Porcs-Makkay, Balazs Volk, Eniko Molnar, Fekete Valeria Hofmanne, Zsuzsanna Szent-Kirallyi filed Critical Egyt Gyogyszervegyeszeti Gyar
Priority to EA200700208A priority Critical patent/EA011894B1/en
Priority to SK5011-2007A priority patent/SK50112007A3/en
Priority to EP05763423A priority patent/EP1817307A2/en
Priority to RSP-2007/0008A priority patent/RS20070008A/en
Publication of WO2006003479A2 publication Critical patent/WO2006003479A2/en
Publication of WO2006003479A3 publication Critical patent/WO2006003479A3/en
Priority to HR20070025A priority patent/HRP20070025A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dairy Products (AREA)
  • Grain Derivatives (AREA)

Abstract

The pseudopolymorph of desloratadine formed with carbon dioxide of the formula (I) has valuable anti-allergic effect and can be used as pharmaceutical active ingredient. The present invention also relates to the preparation of desloratadine of high purity. The present invention also relates to the use of the pseudopolymorph of desloratadine of the formula (I) for the preparation of salts of desloratadine of the formula (VI) (wherein X stands for an anion and n is 1 or 2).
PCT/HU2005/000073 2004-07-07 2005-07-07 New pseudopolymorph of desloratadine formed with carbon dioxide WO2006003479A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EA200700208A EA011894B1 (en) 2004-07-07 2005-07-07 New pseudopolymorph of desloratadine formed with carbon dioxide
SK5011-2007A SK50112007A3 (en) 2004-07-07 2005-07-07 New pseudopolymorph of desloratadine formed with carbon dioxide
EP05763423A EP1817307A2 (en) 2004-07-07 2005-07-07 New pseudopolymorph of desloratadine formed with carbon dioxide
RSP-2007/0008A RS20070008A (en) 2004-07-07 2005-07-07 New pseudopolymorph of desloratidine formed with carbon dioxide
HR20070025A HRP20070025A2 (en) 2004-07-07 2007-01-26 New pseudopolymorph of desloratadine formed with carbon dioxide

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HUP0401373 2004-07-07
HU0401373A HU0401373D0 (en) 2004-07-07 2004-07-07 Pseudopolimorphic form of desloratadine with carbondioxide
HU0500664A HU226951B1 (en) 2005-07-06 2005-07-06 Pseudopolimorphic form of desloratadine with carbon dioxide, process for its preparation and its use
HUP0500664 2005-07-06

Publications (2)

Publication Number Publication Date
WO2006003479A2 WO2006003479A2 (en) 2006-01-12
WO2006003479A3 true WO2006003479A3 (en) 2006-06-08

Family

ID=89986128

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2005/000073 WO2006003479A2 (en) 2004-07-07 2005-07-07 New pseudopolymorph of desloratadine formed with carbon dioxide

Country Status (9)

Country Link
EP (1) EP1817307A2 (en)
BG (1) BG109814A (en)
CZ (1) CZ200798A3 (en)
EA (1) EA011894B1 (en)
HR (1) HRP20070025A2 (en)
PL (1) PL381813A1 (en)
RS (1) RS20070008A (en)
SK (1) SK50112007A3 (en)
WO (1) WO2006003479A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU230417B1 (en) * 2006-10-26 2016-05-30 Egis Gyógyszergyár Zrt Process for producing adduct comprising desloratadine and carbon dioxide
CN103755682A (en) * 2013-12-30 2014-04-30 山东达因海洋生物制药股份有限公司 Novel crystal form for desloratadine and preparation method thereof
WO2016024249A1 (en) * 2014-08-14 2016-02-18 Sun Pharmaceutical Industries Limited Crystalline forms of palbociclib
CN104610225B (en) * 2014-12-29 2017-02-01 广东九明制药有限公司 Preparation method of desloratadine

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0152897A1 (en) * 1984-02-15 1985-08-28 Schering Corporation 8-Chloro-6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta-[1,2-b]pyridine and its salts, processes for the production thereof and pharmaceutical compositions containing these compounds
US5595997A (en) * 1994-12-30 1997-01-21 Sepracor Inc. Methods and compositions for treating allergic rhinitis and other disorders using descarboethoxyloratadine
WO1999001450A1 (en) * 1997-07-02 1999-01-14 Schering Corporation POLYMORPHS OF 8-CHLORO-6, 11-DIHYDRO-11- (4-PIPERIDYLIDENE) -5H-BENZO[5,6] CYCLOHEPTA[1,2-b]PYRIDINE
WO2002042290A1 (en) * 2000-11-23 2002-05-30 Richter Gedeon Vegyészeti Gyár Rt. New desloratadine salts, process for their synthesis and pharmaceutical compositions thereof
WO2004012738A1 (en) * 2002-08-05 2004-02-12 Sandoz Ag Novel salt and polymorphs of desloratadine hemifumarate
WO2004029039A1 (en) * 2002-09-24 2004-04-08 Morepen Laboratories Limited An improved process for the production of desloratadine

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0152897A1 (en) * 1984-02-15 1985-08-28 Schering Corporation 8-Chloro-6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta-[1,2-b]pyridine and its salts, processes for the production thereof and pharmaceutical compositions containing these compounds
US5595997A (en) * 1994-12-30 1997-01-21 Sepracor Inc. Methods and compositions for treating allergic rhinitis and other disorders using descarboethoxyloratadine
WO1999001450A1 (en) * 1997-07-02 1999-01-14 Schering Corporation POLYMORPHS OF 8-CHLORO-6, 11-DIHYDRO-11- (4-PIPERIDYLIDENE) -5H-BENZO[5,6] CYCLOHEPTA[1,2-b]PYRIDINE
WO2002042290A1 (en) * 2000-11-23 2002-05-30 Richter Gedeon Vegyészeti Gyár Rt. New desloratadine salts, process for their synthesis and pharmaceutical compositions thereof
WO2004012738A1 (en) * 2002-08-05 2004-02-12 Sandoz Ag Novel salt and polymorphs of desloratadine hemifumarate
WO2004029039A1 (en) * 2002-09-24 2004-04-08 Morepen Laboratories Limited An improved process for the production of desloratadine

Also Published As

Publication number Publication date
SK50112007A3 (en) 2007-07-06
EA200700208A1 (en) 2007-08-31
CZ200798A3 (en) 2007-06-20
EA011894B1 (en) 2009-06-30
HRP20070025A2 (en) 2008-11-30
BG109814A (en) 2008-04-30
RS20070008A (en) 2008-11-28
EP1817307A2 (en) 2007-08-15
PL381813A1 (en) 2007-07-23
WO2006003479A2 (en) 2006-01-12

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