WO2005123761A8 - GnRH ANALOGS BACKBONE CYCLIZED THROUGH METAL COMPLEXATION - Google Patents

GnRH ANALOGS BACKBONE CYCLIZED THROUGH METAL COMPLEXATION

Info

Publication number
WO2005123761A8
WO2005123761A8 PCT/IL2005/000661 IL2005000661W WO2005123761A8 WO 2005123761 A8 WO2005123761 A8 WO 2005123761A8 IL 2005000661 W IL2005000661 W IL 2005000661W WO 2005123761 A8 WO2005123761 A8 WO 2005123761A8
Authority
WO
WIPO (PCT)
Prior art keywords
analogs
backbone cyclized
gnrh analogs
metal complexation
gnrh
Prior art date
Application number
PCT/IL2005/000661
Other languages
French (fr)
Other versions
WO2005123761A1 (en
Inventor
Chaim Gilon
Yaniv Barda
Eyal Mishani
Nassi Cohen
Original Assignee
Univ Jerusalem Yissum Res Dev
Ltd Hadasit Medical Res Servic
Chaim Gilon
Yaniv Barda
Eyal Mishani
Nassi Cohen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Jerusalem Yissum Res Dev, Ltd Hadasit Medical Res Servic, Chaim Gilon, Yaniv Barda, Eyal Mishani, Nassi Cohen filed Critical Univ Jerusalem Yissum Res Dev
Publication of WO2005123761A1 publication Critical patent/WO2005123761A1/en
Publication of WO2005123761A8 publication Critical patent/WO2005123761A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides novel diagnostic and therapeutic peptides, specifically GnRH analogs backbone cyclized though metal complexation. The backbone cyclized peptide analogs disclosed possess unique and superior properties over other analogs, such as chemical and metabolic stability, increased bioavailability and improved pharmacokinetics. Pharmaceutical compositions comprising the backbone cyclized GnRH analogs and radiolabelled analogs, kits and reagents for synthesizing same, and methods using such compositions for diagnostic and therapeutic purposes are also disclosed.
PCT/IL2005/000661 2004-06-21 2005-06-21 GnRH ANALOGS BACKBONE CYCLIZED THROUGH METAL COMPLEXATION WO2005123761A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58072504P 2004-06-21 2004-06-21
US60/580,725 2004-06-21

Publications (2)

Publication Number Publication Date
WO2005123761A1 WO2005123761A1 (en) 2005-12-29
WO2005123761A8 true WO2005123761A8 (en) 2006-02-23

Family

ID=34979792

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2005/000661 WO2005123761A1 (en) 2004-06-21 2005-06-21 GnRH ANALOGS BACKBONE CYCLIZED THROUGH METAL COMPLEXATION

Country Status (1)

Country Link
WO (1) WO2005123761A1 (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
US5753206A (en) * 1995-06-07 1998-05-19 Immunomedics, Inc. Radiometal-binding analogues of luteinizing hormone releasing hormone
WO1998002192A1 (en) * 1996-07-12 1998-01-22 Immunomedics, Inc. Radiometal-binding peptide analogues
WO2001002022A1 (en) * 1999-05-19 2001-01-11 The Curators Of The University Of Missouri New melanotropin analogs for potential radiopharmaceuticals for diagnosis and treatment of melanoma
EP1468013A4 (en) * 2002-01-03 2005-03-16 Yissum Res Dev Co Conformationally constrained c-backbone cyclic peptides
IL150384A0 (en) * 2002-06-24 2002-12-01 Peptor Ltd Radiolabelled somatostatin analogs backbone cyclized through metal complexation

Also Published As

Publication number Publication date
WO2005123761A1 (en) 2005-12-29

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