WO2007027742A3 - SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS - Google Patents

SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS Download PDF

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Publication number
WO2007027742A3
WO2007027742A3 PCT/US2006/033819 US2006033819W WO2007027742A3 WO 2007027742 A3 WO2007027742 A3 WO 2007027742A3 US 2006033819 W US2006033819 W US 2006033819W WO 2007027742 A3 WO2007027742 A3 WO 2007027742A3
Authority
WO
WIPO (PCT)
Prior art keywords
gpia
small molecule
iia
α2βl
integrin α2βl
Prior art date
Application number
PCT/US2006/033819
Other languages
French (fr)
Other versions
WO2007027742A2 (en
Inventor
Sungwook Choi
Seth E Snyder
William F Degrado
Joel S Bennett
Original Assignee
Univ Pennsylvania
Sungwook Choi
Seth E Snyder
William F Degrado
Joel S Bennett
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania, Sungwook Choi, Seth E Snyder, William F Degrado, Joel S Bennett filed Critical Univ Pennsylvania
Publication of WO2007027742A2 publication Critical patent/WO2007027742A2/en
Publication of WO2007027742A3 publication Critical patent/WO2007027742A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel compounds inhibiting the integrin α2βl /GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic uses. The compounds disclosed are useful, inter alia, as inhibitors of integrin α2βl/GPIa-IIa-mediated activity.
PCT/US2006/033819 2005-08-31 2006-08-29 SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS WO2007027742A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71277505P 2005-08-31 2005-08-31
US60/712,775 2005-08-31

Publications (2)

Publication Number Publication Date
WO2007027742A2 WO2007027742A2 (en) 2007-03-08
WO2007027742A3 true WO2007027742A3 (en) 2007-12-06

Family

ID=37809449

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/033819 WO2007027742A2 (en) 2005-08-31 2006-08-29 SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS

Country Status (1)

Country Link
WO (1) WO2007027742A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8987306B2 (en) 2005-06-07 2015-03-24 The Trustees Of The University Of Pennsylvania Inhibitors of integrin alpha2beta1 based on prolyl diaminopropionic acid scaffold
AU2006254936A1 (en) 2005-06-07 2006-12-14 The Trustees Of The University Of Pennesylvania Inhibitors of the alpha2beta1/GPIa-IIa integrin
HUE040417T2 (en) 2007-05-04 2019-03-28 Marina Biotech Inc Amino acid lipids and uses thereof
KR20110073580A (en) * 2008-10-17 2011-06-29 엑셀리시스, 인코포레이티드 Sphingosine-1-phosphate receptor antagonists
PL3160984T3 (en) * 2014-06-25 2021-10-25 Flamma S.P.A. Process for preparing d-arginyl-2,6-dimethyl-l-tyrosyl-l-lysyl-l-phenylalaninamide
ES2890676T3 (en) * 2014-06-30 2022-01-21 Flamma Spa Process for the production of D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096707A (en) * 1997-07-11 2000-08-01 Biotie Therapies Ltd. Integrin binding peptide and use thereof
US6369034B1 (en) * 1998-04-27 2002-04-09 Warner-Lambert Company Functionalized alkyl and alenyl side chain derivatives of glycinamides as farnesyl transferase inhibitors
US20040072850A1 (en) * 2002-06-28 2004-04-15 Ronald Knegtel Caspase inhibitors and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096707A (en) * 1997-07-11 2000-08-01 Biotie Therapies Ltd. Integrin binding peptide and use thereof
US6369034B1 (en) * 1998-04-27 2002-04-09 Warner-Lambert Company Functionalized alkyl and alenyl side chain derivatives of glycinamides as farnesyl transferase inhibitors
US20040072850A1 (en) * 2002-06-28 2004-04-15 Ronald Knegtel Caspase inhibitors and uses thereof

Also Published As

Publication number Publication date
WO2007027742A2 (en) 2007-03-08

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