WO2005123123A3 - Reprogrammation therapeutique, cellules souches hybrides et maturation - Google Patents

Reprogrammation therapeutique, cellules souches hybrides et maturation Download PDF

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Publication number
WO2005123123A3
WO2005123123A3 PCT/US2005/005052 US2005005052W WO2005123123A3 WO 2005123123 A3 WO2005123123 A3 WO 2005123123A3 US 2005005052 W US2005005052 W US 2005005052W WO 2005123123 A3 WO2005123123 A3 WO 2005123123A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
stem cells
maturation
therapeutically
therapeutic reprogramming
Prior art date
Application number
PCT/US2005/005052
Other languages
English (en)
Other versions
WO2005123123A2 (fr
Inventor
Chauncey B Sayre
Francisco J Silva
Original Assignee
Primegen Biotech Llc
Chauncey B Sayre
Francisco J Silva
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/864,788 external-priority patent/US20050090004A1/en
Application filed by Primegen Biotech Llc, Chauncey B Sayre, Francisco J Silva filed Critical Primegen Biotech Llc
Priority to BRPI0511889-1A priority Critical patent/BRPI0511889A/pt
Priority to AU2005253923A priority patent/AU2005253923A1/en
Priority to RU2006147263/14A priority patent/RU2006147263A/ru
Priority to EP05723204A priority patent/EP1758989A2/fr
Priority to CA002567692A priority patent/CA2567692A1/fr
Priority to JP2007527196A priority patent/JP2008501795A/ja
Publication of WO2005123123A2 publication Critical patent/WO2005123123A2/fr
Publication of WO2005123123A3 publication Critical patent/WO2005123123A3/fr
Priority to IL179927A priority patent/IL179927A0/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0608—Germ cells
    • C12N5/061—Sperm cells, spermatogonia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/06—Anti-neoplasic drugs, anti-retroviral drugs, e.g. azacytidine, cyclophosphamide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/04—Cells produced using nuclear transfer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/10—Conditioning of cells for in vitro fecondation or nuclear transfer

Abstract

L'invention concerne des cellules programmées par voie thérapeutique et des procédés de production desdites cellules. Les cellules programmées par voie thérapeutique sont des cellules souches qui ont été portées à maturation de façon à représenter un état plus différencié ou un état moins différencié après mise en contact avec des facteurs de stimulation. Lesdites cellules programmées par voie thérapeutique sont destinées à être utilisées en thérapie régénérative cellulaire et présentent un potentiel de différenciation en lignées cellulaires plus engagées. L'invention concerne en outre des cellules souches hybrides pour la reprogrammation thérapeutique et la thérapie régénérative cellulaire.
PCT/US2005/005052 2004-06-08 2005-02-16 Reprogrammation therapeutique, cellules souches hybrides et maturation WO2005123123A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
BRPI0511889-1A BRPI0511889A (pt) 2004-06-08 2005-02-16 reprogramação terapêutica, células-tronco hìbridas e maturação
AU2005253923A AU2005253923A1 (en) 2004-06-08 2005-02-16 Therapeutic reprogramming, hybrid stem cells and maturation
RU2006147263/14A RU2006147263A (ru) 2004-06-08 2005-02-16 Терапевтическое перепрограммирование, гибридные стволовые клетки и созревание
EP05723204A EP1758989A2 (fr) 2004-06-08 2005-02-16 Reprogrammation therapeutique, cellules souches hybrides et maturation
CA002567692A CA2567692A1 (fr) 2004-06-08 2005-02-16 Reprogrammation therapeutique, cellules souches hybrides et maturation
JP2007527196A JP2008501795A (ja) 2004-06-08 2005-02-16 ハイブリッド幹細胞の治療的再プログラミングおよび成熟
IL179927A IL179927A0 (en) 2004-06-08 2006-12-07 Therapeutic reprogramming, hybrid stem cells and maturation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/864,788 2004-06-08
US10/864,788 US20050090004A1 (en) 2003-01-16 2004-06-08 Stem cell maturation for all tissue lines
US58814604P 2004-07-15 2004-07-15
US60/588,146 2004-07-15

Publications (2)

Publication Number Publication Date
WO2005123123A2 WO2005123123A2 (fr) 2005-12-29
WO2005123123A3 true WO2005123123A3 (fr) 2006-03-02

Family

ID=35355246

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/005052 WO2005123123A2 (fr) 2004-06-08 2005-02-16 Reprogrammation therapeutique, cellules souches hybrides et maturation

Country Status (7)

Country Link
EP (1) EP1758989A2 (fr)
JP (1) JP2008501795A (fr)
AU (1) AU2005253923A1 (fr)
BR (1) BRPI0511889A (fr)
CA (1) CA2567692A1 (fr)
RU (1) RU2006147263A (fr)
WO (1) WO2005123123A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5491871B2 (ja) 2007-02-28 2014-05-14 アドビナス セラピュティックス プライベート リミテッド グルコキナーゼ活性化因子としての２，２，２−三置換アセトアミド誘導体、その方法及び薬学的応用
EP2155720B1 (fr) 2007-06-08 2013-07-17 Advinus Therapeutics Private Limited Nouveaux dérivés de pyrrole-2-carboxamide en tant qu'activateurs de la glucokinase, leur procédé d'obtention et leur application pharmaceutique
EP2090649A1 (fr) 2008-02-13 2009-08-19 Fondazione Telethon Procédé de reprogrammation de cellules différentiées
EP2402327B1 (fr) 2010-06-29 2018-03-07 Impetis Biosciences Ltd. Composés d'acétamide en tant qu'activateurs de la glucokinase, leur procédé et applications médicales
EP2796873A1 (fr) * 2013-04-25 2014-10-29 QGel SA Procédé pour un test de criblage de médicaments à base de cellules et son utilisation

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000006701A1 (fr) * 1998-07-31 2000-02-10 Genzyme Corporation Amelioration du fonctionnement cardiaque par transplantation de cellules souches mesenchymateuses
WO2002051980A2 (fr) * 2000-12-12 2002-07-04 Nucleus Remodeling, Inc. Cellules souches adultes multipotentes derivees in vitro et leurs utilisations
WO2003027278A1 (fr) * 2001-09-21 2003-04-03 Reprocell Inc. Cellules souches multifonctionnelles adaptees et utilisation de ces dernieres
WO2003062384A2 (fr) * 2002-01-16 2003-07-31 Chauncey Sayre Maturation de cellules souches pour tous les types de tissus
WO2003102126A1 (fr) * 2002-05-31 2003-12-11 Apollo Life Sciences Pty Ltd Methode de therapie cellulaire faisant appel a des hybrides cellulaires fusionnes
WO2004046312A2 (fr) * 2002-11-15 2004-06-03 The Board Of Trustees Of The University Of Illinois Methodes de developpement in vitro de cellules souches hematopoietiques

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000006701A1 (fr) * 1998-07-31 2000-02-10 Genzyme Corporation Amelioration du fonctionnement cardiaque par transplantation de cellules souches mesenchymateuses
WO2002051980A2 (fr) * 2000-12-12 2002-07-04 Nucleus Remodeling, Inc. Cellules souches adultes multipotentes derivees in vitro et leurs utilisations
WO2003027278A1 (fr) * 2001-09-21 2003-04-03 Reprocell Inc. Cellules souches multifonctionnelles adaptees et utilisation de ces dernieres
EP1437404A1 (fr) * 2001-09-21 2004-07-14 ReproCELL Inc. Cellules souches multifonctionnelles adaptees et utilisation de ces dernieres
WO2003062384A2 (fr) * 2002-01-16 2003-07-31 Chauncey Sayre Maturation de cellules souches pour tous les types de tissus
WO2003102126A1 (fr) * 2002-05-31 2003-12-11 Apollo Life Sciences Pty Ltd Methode de therapie cellulaire faisant appel a des hybrides cellulaires fusionnes
WO2004046312A2 (fr) * 2002-11-15 2004-06-03 The Board Of Trustees Of The University Of Illinois Methodes de developpement in vitro de cellules souches hematopoietiques

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DONOVAN P J & DE MIGUEL M P: "Turning germ cells into stem cells.", CURRENT OPINION IN GENETICS & DEVELOPMENT, vol. 13, no. 5, October 2003 (2003-10-01), pages 463 - 471, XP002355791, ISSN: 0959-437X *
MOENS A ET AL: "Differential ability of male and female rabbit fetal germ cell nuclei to be reprogrammed by nuclear transfer.", DIFFERENTIATION, vol. 60, no. 5, September 1996 (1996-09-01), pages 339 - 345, XP002355344, ISSN: 0301-4681 *
TADA M ET AL: "Embryonic germ cells induce epigenetic reprogramming of somatic nuclear in hybrid cells", EMBO JOURNAL, vol. 16, no. 21, 1997, pages 6510 - 6520, XP002960229, ISSN: 0261-4189 *
TADA M ET AL: "Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells", CURRENT BIOLOGY, vol. 11, no. 19, 2 October 2001 (2001-10-02), pages 1553 - 1558, XP002960228, ISSN: 0960-9822 *
YAMAZAKI Y ET AL: "Adult mice cloned from migrating primordial germ cells.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 102, no. 32, 9 August 2005 (2005-08-09), pages 11361 - 11366, XP002355792, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
EP1758989A2 (fr) 2007-03-07
AU2005253923A1 (en) 2005-12-29
CA2567692A1 (fr) 2005-12-29
JP2008501795A (ja) 2008-01-24
WO2005123123A2 (fr) 2005-12-29
BRPI0511889A (pt) 2008-01-15
RU2006147263A (ru) 2008-07-20

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