WO2005115245A1 - Dispositif intravesiculaire - Google Patents
Dispositif intravesiculaire Download PDFInfo
- Publication number
- WO2005115245A1 WO2005115245A1 PCT/IL2005/000550 IL2005000550W WO2005115245A1 WO 2005115245 A1 WO2005115245 A1 WO 2005115245A1 IL 2005000550 W IL2005000550 W IL 2005000550W WO 2005115245 A1 WO2005115245 A1 WO 2005115245A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- urine
- bladder
- probe
- urinary bladder
- intravesicular device
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
- A61B5/202—Assessing bladder functions, e.g. incontinence assessment
- A61B5/204—Determining bladder volume
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/107—Measuring physical dimensions, e.g. size of the entire body or parts thereof
- A61B5/1076—Measuring physical dimensions, e.g. size of the entire body or parts thereof for measuring dimensions inside body cavities, e.g. using catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
- A61B5/202—Assessing bladder functions, e.g. incontinence assessment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
- A61B5/202—Assessing bladder functions, e.g. incontinence assessment
- A61B5/205—Determining bladder or urethral pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
- A61B5/207—Sensing devices adapted to collect urine
- A61B5/208—Sensing devices adapted to collect urine adapted to determine urine quantity, e.g. flow, volume
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6874—Bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/03—Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs
- A61B5/036—Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs by means introduced into body tracts
Definitions
- the invention is in the field of implantable medical devices.
- Urinary Incontinence the involuntary leakage of urine from the bladder, is a common and debilitating problem for more than 40 million people worldwide. Its prevalence is higher among women and increases with increasing age. The inability to control the flow of urine may stem from detrusor overactivity, resulting in urge incontinence, or from sphincteric weakness and/or urethral hypermobility resulting in stress incontinence. More than 15 million people in the United States suffer from urinary incontinence. UI is a significant medical condition of the elderly, affecting women to a greater extent than men: 25-60% of postmenopausal women have UI 1 .
- the current gold standard method of diagnosing UI and bladder dysfunction is a urodynamics examination in which a catheter is passed through the urethra into the bladder that is used to retrogradely fill the bladder and measure bladder pressure (vesical pressure, or P ves ).
- a rectal probe is used to record abdominal pressure, P abd , and the detrusor pressure (Pd et ), is calculated as:
- the volume of urine in the bladder at the first sensation, maximum capacity, frequency of spontaneous unwanted bladder contractions, pressure at urine leakage, and pressure and flow rate during voiding are among the measured parameters.
- Diagnosis of stress incontinence is often made by measuring leak point pressure (LPP): the patient coughs or bears down until leakage occurs while vesicle pressure is measured.
- LPP leak point pressure
- Urodynamics is an extensive clinical evaluation involving significant cost and time by both the patient and the health care system and is therefore utilized mostly at tertiary care centers, usually university medical centers.
- urodynamics is a nonphysiological examination: it is performed in an artificial laboratory environment, the patient has little or no privacy, the bladder is catheterized through the urethra, and the bladder is filled retrograde with a room temperature isotonic saline solution or gas at rates often 10 times greater than physiological filling rates.
- the urinary bladder is a temperature-sensitive viscoelastic-plastic organ which responds to increased filling rate and low temperature with increased pressure and increased slope of the bladder pressure-volume relation.
- the bladder may exhibit responses that are not representative of normal bladder activity.
- a urodynamics test often results in difficulty reproducing patient complaints and symptoms of both urge and stress incontinence. All recordings are made through catheters, tethering the patient for the duration of the test, interfering with some flow rate measurements, and adding to patient discomfort. Despite attempts during urodynamics testing to simulate certain activities (coughing, sitting, walking, etc.), it is a one time spot examination that is not carried out under circumstances that are representative of the patient's routine activities. Efforts have been made to record bladder pressures in a more physiological manner via ambulatory monitoring.
- Urethral and rectal catheters are inserted into the patient and kept in place for several hours during which time, bladder pressures are recorded on a holter monitor.
- the bladder fills physiologically (anterograde from kidneys through ureters to the bladder), and at a physiological rate
- the indwelling catheter is often uncomfortable and causes bladder contractions by irritating the urethra and bladder wall.
- Bladder volume cannot be measured during ambulatory monitoring and has to be inferred posthoc from resultant voiding data.
- Conductance measurements of blood have been used to measure blood volume in the heart chambers.
- Conductivity is an intrinsic property and does not vary with increasing volume.
- conductance is a volumetric measure and varies with volume.
- the volume of the left ventricle (LV) for example, has been measured using a conductance catheter placed inside the LV.
- the method most often used to determine LV conductance is a dilution technique, which relies on the analysis of the conductance signal during an induced transient change in blood conductivity. A small bolus of hypertonic saline is injected into the pulmonary artery.
- the conductance catheter is an insulated catheter having two or more electrode pairs spaced along the portion of the catheter inserted into the LV. A weak alternating current is generated between the most distal and the most proximal electrodes. The electrodes in between measure the potential differences from which conductance is derived, since volume cannot be directly calibrated.
- the conductance technique has been applied to measure the cross- sectional area of the urethra in both women and men (Bagi, P. Urol. Res. 30:1-8, 2002). Two excitation and two signal electrodes were used to measure urethral cross-sectional area during a step-wise forced dilation procedure.
- PCT Publication WO 04/041242 discloses a balloon for insertion into the urinary bladder.
- the present invention provides a system and method for testing and monitoring urinary bladder function.
- the system of the invention monitors urine volume in the bladder continuously or periodically.
- the invention allows urodynamic measurements both in the laboratory and at home during activities of normal daily living, unencumbered by externally communicating catheters or wires.
- a conductance probe is mounted on an intravesicular device that is delivered deployed in the bladder.
- the device is a balloon that is filled with biocompatible fluid, which may be a liquid or a gas, having a specific gravity less than that of urine, so that it floats on the urine in the bladder.
- the device may be compressed prior to deployment in the bladder and then released in bladder and allowed to regain its original shape.
- the device when deployed, has a torroidal shape and electronic components associated with the device are contained in an insert immobilized in the central hole of the torus.
- Conductance measurements obtained by the probe may be stored on a data acquisition chip associated with the device. In this case, the data may be read after retrieval of the device from the bladder.
- the conductance measurements are wirelessly transmitted to a receiver located in a control unit.
- the control unit may be contained in a pouch adapted to be attached to the user's belt. Determination of urine volume determination based upon conductance measurements is dependent on urine temperature and possibly on other physiological variables (i.e. urine pH). Therefore, those parameters are preferably measured by the system in order to improve the accuracy of the volume measurement.
- the system of the invention may further comprise an intravaginal or intrarectal probe that measures abdominal pressure and temperature as well as patient position and acceleration.
- the system of the invention may also comprise a wireless microphone or event marker to allow the user to record relevant remarks.
- the system amy also include a heart rate sensor for recording the user's heart rate.
- the system includes a processor that is configured to calculate a urine volume in the bladder from the conductance measurements recorded by the conductance probes.
- the resistivity of the bladder wall is 500 Wcm and that of urine is 33 Wcm, making the bladder to urine resistivity ratio equal to 15.
- a calibration curve can be made in each patient at the time of balloon insertion by measuring volume during bladder filling and/or voiding.
- the control unit may also store correction factor tables or correction functions that are utilized in the calculation of the urine volume.
- the processor may perform several additional functions, such as : 1. Recording patient notations regarding urgency and/or incontinence episodes and physical activity, such as jumping, running, lifting, sneezing, or coughing, with the help of a voice recorder or event marker. 2. Continuously managing and storing the data from the probes and sensors of the system. 3. Interfacing with external computers and monitors; 4. Sending energy to transponders, for charging batteries associated with the implanted device;
- the system of the invention has the following features: 1. No catheters or wires extend out of the urethra, vagina, or anus; 2.
- the conducatance probe is preferably part of an ultraminiature device asocaiated with the device that includes a large diversity of electronics, including sensors, sensor interfaces, signal conditioning, a microprocessor core, memory, digital signal processing and wireless transmission technology.
- the sytem of the invention may be used by individual physicans, nursing homes and clinics which cannot afford expensive urodynamic equipment.
- the system may also be used as a long term indwelling device to notify patients, such as those with diabetes or spinal cord injury, who have lost bladder sensation, about the need to void based on volume and/or pressure thresholds.
- the system may be adapted to administer pharmacologic agents or electrical stimulation, sounding an alarm and ceasing treatment if threshold bladder volumes or pressures are exceeded.
- the invention provides a system for determining urine volume in a urinary bladder comprising an intravesicular device having a conductance probe adapted for determining a urine conductance in the bladder.
- the invention provides a method for determining urine volume in a urinary bladder comprising deploying in the urinary bladder an intravesicular device having a conductance probe adapted for determining a urine conductance in the bladder.
- Fig. 1 shows a system for measuring urine volume in a bladder in accordance with one embodiment of the system of the invention
- Fig. 2 shows a balloon for use in the system of Fig. 1 having a duck-bill type valve for filling from a syringe
- Fig. 3 shows a balloon for use in the system of Fig. 1 having a ball valve for filling from a syringe
- Fig. 4 shows deployment of the balloon system of the system of Fig. 1 in a female subject
- Fig. 5 shows retrieval of the balloon
- Fig. 6 shows a system for volume measurements in an excissed pig bladder
- Fig. 7 shows the output of the sensing electrodes of the system of Fig. 6 during three trials of filling and emptying the bladder.
- Fig. 1 shows a system 90 for measuring and monitoring the volume of urine in a urinary bladder in accordance with one embodiment of the invention.
- the system 90 includes a balloon system 100 comprising a balloon 1 having a wall 2 made of a flexible biocompatible material enclosing a lumen 4.
- the balloon after inflation, has a torroidal shape defining a central hole 80 that is generally cylindrical in shape.
- the balloon 1 may have an overall spherical shape, as shown in Fig. 1. This is by way of example only, and other shapes for intravesicular device, such as a cylindrical or ellipsoidal shape, are also contemplated within the scope of the invention.
- the balloon system 100 also includes a generally cylindrically shaped insert 82.
- the insert 82 is dimensioned to be received in the hole 80, as shown in Fig. lb. Grooves and ridges 84 on the external surface of the insert 82 may be received in complementary grooves and ridges 86 on the external surface of the wall 2 so as to retain the insert in the hole 80, and to prevent separation of the insert 82 from the balloon 1 during use of the system 100.
- the insert 100 may also be held in place in the hole 80 by means of an adhesive or by welding.
- the balloon system 100 comprises a conductance probe. In the embodiment of Fig.
- the conductance probe consists of at least one pair of conductance electrodes 101a and 101b, for measuring urine conductance after deployment of the balloon 1 in the urinary bladder and at least one pair of excitation electrodes 103a and 103b, after deployment of the balloon 1 in the urinary bladder, as described in detail below.
- the electrodes are connected to the insert via contacts 102 that may be wires or printed or deposited metal channels.
- the electrodes may be, for example, a thin foil of platinum, or elgiloy
- the electrodes may be adhered to the balloon surface with an adhesive that is flexible and biocompatible, such as silicones (e.g. Dow 748) or polyurethane (e.g. McMaster-Carr #7606A22) based adhesives.
- the electrodes may also be prepared by metal deposition (e.g. sputtering) directly onto the balloon surface.
- the electrodes may also be prepared from flexible conductive adhesives (silver-filled conductive adhesives) and hot melts.
- the surface of the electrodes may be provided with bumps (not shown) on their surface in order to increase the area of contact between the electrodes and the urine.
- the insert 82 may also include temperature and pH transducers.
- the insert 82 also includes a transmitter 83 for transmitting conductance measurements and other data collected by the balloon system 100 to a control unit 84.
- the control unit 91 has a receiver 86 that receives the transmitted data and stores the data in the memory 93.
- the control unit 91 also includes a processor 92 that processes the received data and stores the data in the memory 93.
- the processing may include determining a urine volume in the bladder. Determining a urine volume from the conductance measurements may be done using a calibration curve or look-up-table obtained on the user at the time the balloon system 100 is deployed. A calibration curve or look-up table may be obtained by filling the bladder with a known volume of saline and determining the output of the signal probes.
- volume determination based on conductance measurements is sensitive to urine temperature and conductivity and possibly on other physiological variables (i.e. urine pH). Therefore, those parameters are preferably measured by the balloon system 100 and transmitted to the processor 87 in order to improve the accuracy of the volume determination.
- the processor 92 may also be configured to communicate with an external computer (not shown) for examination or further analysis of the data.
- the control unit 91 may be enclosed in a pouch 81 adapted to be carried by the user.
- the pouch 81 may be provided with one or more loops 94 to allow the pouch 81 to be mounted onto the user's belt and to be carried on the user's waist.
- the system of the invention may further comprise a probe 17 that measures abdominal pressure, temperature, acceleration, and position data (inclinometer).
- the probe may be adapted for insertion into the rectum, or, in the case of a female user, into the vagina.
- the accelerometer is used for detecting dynamic events that can influence bladder dynamics (cough, sneezing, falling, running, etc.)
- the inclinometer provides additional information about body orientation (lying, sitting, standing, etc.).
- Bladder and abdominal pressure, from the intravesicular device and the probe 17, respectively, may be used by the processor 87 to calculate detrusor pressure according to equation (a) above.
- Bladder volume is necessary to determine the volume at leakage, voiding, and/or high bladder pressures. Flow rate during voiding and volume of leakage can be derived from intravesical volume.
- the pressure sensor may be, for example, an ultraminiature pressure sensor made by Entran Co. (model EPE-54X).
- For temperature monitoring Omega's thin Film RTD elements may be used.
- For readout an Omega monitor model DP460- RTD may be used.
- For conductivity measurements the fast conductivity sensor made by Precision Engineering Co. may be used and for readout a micro scale conductivity and temperature instrument may be used.
- the Analog Device accelerometer ADXL320 and inclinometer (SignalQuest SQ-S12X-360DA), respectively, may be used.
- the system of the invention may also comprise a wireless microphone and associated transmitter 97, or an event marker (not shown) that transmits the user's remarks to the control unit 84.
- the system 100 further includes an applicator 20 for deploying the balloon 1 in a urinary bladder, and a retriever 30 for retrieving the balloon 1 from the bladder, described in detail below,.
- the balloon 1 or the insert 82 may further comprise a magnetizable portion 3 in order to assist in deploying the balloon 1 in the urinary bladder or in retrieving the balloon 1 from the bladder.
- the magnetizable portion 3 may consist for example, of one or more metal particles which may be free in the lumen 3a of the balloon 1 (as in Fig. lb), attached to the inner surface 3b of the balloon 100 (as in Fig. lc), embedded in the wall 3c of the balloon 1 (as in Fig. Id), or attached to the insert 82 (3e) as shown in Fig.
- a self-sealing valve 5 in the wall of the balloon is used to fill the balloon.
- the valve 5 may be for example a duck-bill type valve as shown in Fig. 2 or a ball valve as shown in Fig. 3 in which a ball 8 may be in a sealing position (Fig. 3 a) or an unsealing position (Fig. 3c).
- the cannula 6 of a syringe 7 is inserted through the valve 5 into the lumen 4 of the balloon. Fluid 24 is injected into the lumen 4 from the syringe 7 causing the balloon to expand. After filling, the syringe needle 6 is withdrawn, and the valve 5 seals itself.
- the fluid is a biocompatible fluid having a specific gravity less than that of urine, that may be pre-sterilized, such as air or an oil such as liquid paraffin.
- the inflated balloon thus floats in the urine.
- Fig. 4 shows use of the applicator 20 for deploying the balloon system 100 into the lumen 41 of the urinary bladder 42 of a female individual.
- the balloon system 100 is initially grasped by the closed flanges 23a at the distal end of the applicator 20 (Fig. 4a).
- the distal end of the applicator-device combination is inserted into the urethra until it reaches the lumen 41 of the bladder 42.
- Fig. 5 shows use of the retrieval device 30 for removing the device 100 from the bladder.
- a catheter 27 has at its distal end 28 a magnetizable portion 29 so as to hold the balloon at the distal end 28 by means of the magnetizable particles 3 associated with the balloon system 100.
- the retrieval device is inserted into the bladder.
- the engaging probe 32 After opening the flanges 31 of the retrieval device, the engaging probe 32, with magnetizable portion 29 in its tip, is inserted into the bladder so as to engage the magnetizable particle 3. The probe 32 is then pulled so as to bring the device into the grasp of the flanges 31 of the retrieval device. A piercer 33 is inserted into the balloon 1 to drain the fluid contained in its lumen 4 into an attached syringe (not shown) or into the body cavity. The retrieving device 30 is then withdrawn from the patient together with the deflated balloon 1 and the insert 82.
- the insert the insert 82 may optionally be configured to release one or more substances in the urinary bladder such as pharmaceuticals, immunoglobulins, or radioactive substances.
- the insert 82 may optionally comprise a micro-video camera for. imaging the interior of the bladder.
- the insert 82 may optionally comprise one or more measuring devices for measuring one or more parameters associated with the bladder, for example, urine pressure, urine temperature, urine density, or fluid composition. Measurements recorded by the measuring devices may be transmitted to the control unit 84.
- the system may further comprise a displacing member comprising a magnetizable portion to position the balloon system 100 at a desired location within the urinary bladder.
- the displacing member is placed at a location on the surface of the user's body so as to draw the balloon to a desired location in the bladder by the magnetizable particle 3 associated with the balloon system.
- the system may then be used for treating urinary incontinence.
- a spherical probe was designed having electrodes on its surface. As shown in Fig. 6, a spherical probe 105 was fitted with four electrodes each of which consisted of a 1/8 by 2 inch metal strip. Each electrode covered an arc of about 30° along a circumference of the sphere.
- a pair of excitation electrodes 110a and 110b were placed on a first circumference and a pair of signal electrodes Ilia and 111b were placed on a second circumference that was perpendicular to the first circumference.
- the probe 105 was immersed in an excised pig bladder 115.
- the bladder 115 was immersed in a temperature controlled water bath 130 that was provided with an accelerometer 135.
- the bladder 115 and the probe 105 were held in place holder 113.
- a conductivity sensor 140 and a pressure sensor 145 were also positioned in the saline 120.
- the excitation electrodes 110a and 110b were connected to a signal generator 150 via wires 151a and 151b, respectively.
- a 1000 Ohm resistor 160 was included in the circuit.
- the signal electrodes Ilia and 111b were connected to an amplifier recording system 162 via wires 163a and 163b, respectively.
- a selectable amount of saline 120 was introduced from a source (not shown) into the bladder via a pump 168 and delivery tube 169.
- An experiment was conducted to determine the voltage output of the signal electrodes as a function of the volume of saline in the bladder.
- Fig. 7 shows the results obtained from three trials consisting of filling and emptying of the bladder.
- a square wave signal (800 Hz, IV amplitude) was input to the excitation electrodes and the output voltage from the signal electrodes was recorded as the bladder was first filled and then emptied of saline..
- the output voltage range from 10 mV to 19.5 mV gave the lowest volume measurement error and the greatest reproducibility at the sensing electrodes.
- a curve of the type shown in Fig. 7, when obtained by the system 100 in the urinary bladder of a user at the time of deployment of the system 100 in the bladder, can be used as a calibration curve for subsequent volume determinations based upon conductance measurements.
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US57517304P | 2004-05-28 | 2004-05-28 | |
US60/575,173 | 2004-05-28 |
Publications (1)
Publication Number | Publication Date |
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WO2005115245A1 true WO2005115245A1 (fr) | 2005-12-08 |
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ID=34970972
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PCT/IL2005/000550 WO2005115245A1 (fr) | 2004-05-28 | 2005-05-29 | Dispositif intravesiculaire |
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Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2008070817A1 (fr) * | 2006-12-07 | 2008-06-12 | Ethicon, Inc. | Système et procédé destinés à une évaluation urodynamique utilisant une technologie de système micro-électro-mécanique |
WO2008130467A1 (fr) * | 2007-04-17 | 2008-10-30 | Boston Scientific Scimed, Inc. | Urodynamique ambulatoire |
US8182464B2 (en) | 2005-08-11 | 2012-05-22 | Massachusetts Institute Of Technology | Method for intravesical drug delivery |
WO2013109163A1 (fr) * | 2012-01-17 | 2013-07-25 | Lobkarev Alexey Olegovich | Procédé de mesure de pression de la vessie et dispositif de mise en œuvre dudit procédé |
US9017312B2 (en) | 2009-09-10 | 2015-04-28 | Taris Biomedical Llc | Implantable device for controlled drug delivery |
US9107816B2 (en) | 2011-02-04 | 2015-08-18 | Taris Biomedical Llc | Implantable device for controlled dissolution and diffusion of low solubility drug |
US9114111B2 (en) | 2011-01-10 | 2015-08-25 | Allergan, Inc. | Methods for sustained treatment of bladder pain and irritative voiding |
US9283361B2 (en) | 2010-08-05 | 2016-03-15 | Taris Biomedical Llc | Implantable drug delivery devices for genitourinary sites |
US9586035B2 (en) | 2007-12-11 | 2017-03-07 | Massachusetts Institute Of Technology | Implantable drug delivery device and methods for treatment of the bladder and other body vesicles or lumens |
US10137078B2 (en) | 2009-06-26 | 2018-11-27 | Taris Biomedical Llc | Methods for intravesical drug delivery and methods and systems for loading devices with drug tablets |
US10286199B2 (en) | 2013-03-15 | 2019-05-14 | Taris Biomedical Llc | Drug delivery devices with drug-permeable component and methods |
US10532132B2 (en) | 2005-08-11 | 2020-01-14 | Children's Medical Center Corporation | Implantable drug delivery device and methods |
US10729823B2 (en) | 2013-08-19 | 2020-08-04 | Taris Biomedical Llc | Multi-unit drug delivery devices and methods |
US10894150B2 (en) | 2015-04-23 | 2021-01-19 | Taris Biomedical Llc | Drug delivery devices with drug-permeable component and methods |
US20210196203A1 (en) * | 2018-05-25 | 2021-07-01 | The Cleveland Clinic Foundation | Sensing device for ambulatory urodynamics having a pressure sensitive housing |
US11241538B2 (en) | 2019-10-02 | 2022-02-08 | Watershed Medical, Inc. | Device and method for improving retention of a therapy in the bladder |
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Cited By (30)
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US9561353B2 (en) | 2005-08-11 | 2017-02-07 | Massachusetts Institute Of Technology | Intravesical drug delivery device |
US8801694B2 (en) | 2005-08-11 | 2014-08-12 | Massachusetts Institute Of Technology | Intravesical drug delivery device |
US10532132B2 (en) | 2005-08-11 | 2020-01-14 | Children's Medical Center Corporation | Implantable drug delivery device and methods |
US8182464B2 (en) | 2005-08-11 | 2012-05-22 | Massachusetts Institute Of Technology | Method for intravesical drug delivery |
US8128576B2 (en) | 2006-12-07 | 2012-03-06 | Ethicon, Inc. | System and method for urodynamic evaluation utilizing micro electro-mechanical system technology |
WO2008070817A1 (fr) * | 2006-12-07 | 2008-06-12 | Ethicon, Inc. | Système et procédé destinés à une évaluation urodynamique utilisant une technologie de système micro-électro-mécanique |
WO2008130467A1 (fr) * | 2007-04-17 | 2008-10-30 | Boston Scientific Scimed, Inc. | Urodynamique ambulatoire |
US10646691B2 (en) | 2007-12-11 | 2020-05-12 | Massachusetts Institute Of Technology | Intravesical drug delivery methods and devices |
US9586035B2 (en) | 2007-12-11 | 2017-03-07 | Massachusetts Institute Of Technology | Implantable drug delivery device and methods for treatment of the bladder and other body vesicles or lumens |
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