WO2005113572A3 - Isolated nucleic acid molecules encoding a novel phosphoprotein-darpp-32, encoded protein and uses thereof - Google Patents

Isolated nucleic acid molecules encoding a novel phosphoprotein-darpp-32, encoded protein and uses thereof Download PDF

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Publication number
WO2005113572A3
WO2005113572A3 PCT/US2005/017356 US2005017356W WO2005113572A3 WO 2005113572 A3 WO2005113572 A3 WO 2005113572A3 US 2005017356 W US2005017356 W US 2005017356W WO 2005113572 A3 WO2005113572 A3 WO 2005113572A3
Authority
WO
WIPO (PCT)
Prior art keywords
darpp
nucleic acid
acid molecules
isolated nucleic
molecules encoding
Prior art date
Application number
PCT/US2005/017356
Other languages
French (fr)
Other versions
WO2005113572A2 (en
Inventor
Philip E Brandish
Paul J Acton
Nan Wei
Original Assignee
Merck & Co Inc
Philip E Brandish
Paul J Acton
Nan Wei
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Philip E Brandish, Paul J Acton, Nan Wei filed Critical Merck & Co Inc
Priority to EP05750662A priority Critical patent/EP1756144A4/en
Priority to CA002565014A priority patent/CA2565014A1/en
Publication of WO2005113572A2 publication Critical patent/WO2005113572A2/en
Publication of WO2005113572A3 publication Critical patent/WO2005113572A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Provided herein are novel nucleic acid and amino acids sequences of a phosphoprotein derived from a Guinea pig. Methods and compositions for modulating the phosphorylation of the novel protein in a dopaminergic signaling pathway are also provided. Compounds identified by the disclosed methods may be used to treat disorders characterized by a aberrant or dysfunctional intracellular signaling pathway regulated by DARPP-32.
PCT/US2005/017356 2004-05-19 2005-05-17 Isolated nucleic acid molecules encoding a novel phosphoprotein-darpp-32, encoded protein and uses thereof WO2005113572A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP05750662A EP1756144A4 (en) 2004-05-19 2005-05-17 Isolated nucleic acid molecules encoding a novel phosphoprotein-darpp-32, encoded protein and uses thereof
CA002565014A CA2565014A1 (en) 2004-05-19 2005-05-17 Isolated nucleic acid molecules encoding a novel phosphoprotein-darpp-32, encoded protein and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57263404P 2004-05-19 2004-05-19
US60/572,634 2004-05-19

Publications (2)

Publication Number Publication Date
WO2005113572A2 WO2005113572A2 (en) 2005-12-01
WO2005113572A3 true WO2005113572A3 (en) 2006-02-16

Family

ID=35428910

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/017356 WO2005113572A2 (en) 2004-05-19 2005-05-17 Isolated nucleic acid molecules encoding a novel phosphoprotein-darpp-32, encoded protein and uses thereof

Country Status (3)

Country Link
EP (1) EP1756144A4 (en)
CA (1) CA2565014A1 (en)
WO (1) WO2005113572A2 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1103699A (en) * 1997-10-17 1999-05-10 Rockefeller University, The Use of an inhibitor of the dephosphorylation of darpp-32 for treating schizophrenia
CA2456942A1 (en) * 2001-08-10 2003-02-20 The Rockefeller University Compositions and methods for modulation of darpp-32 phosphorylation
AU2002323530B2 (en) * 2001-08-31 2007-09-06 The Rockefeller University Method for classification of anti-psychotic drugs
US20030211040A1 (en) * 2001-08-31 2003-11-13 Paul Greengard Phosphodiesterase activity and regulation of phosphodiesterase 1B-mediated signaling in brain

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIBB J.A. ET AL: "Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons.", NATURE., vol. 402, no. 6762, 9 December 1999 (1999-12-09), pages 669 - 671, XP000999338 *
KURIHARA T ET AL: "Cloning of cDNA for DARPP-32, a dopamine- and cyclic AMP-regulated neuronal phosphoprotein.", J NEUROSCIENCE., vol. 8, no. 2, February 1988 (1988-02-01), pages 508 - 517, XP002993645 *
See also references of EP1756144A4 *

Also Published As

Publication number Publication date
EP1756144A4 (en) 2008-08-20
CA2565014A1 (en) 2005-12-01
EP1756144A2 (en) 2007-02-28
WO2005113572A2 (en) 2005-12-01

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