WO2005110384A2 - Apiary veterinary composition - Google Patents
Apiary veterinary composition Download PDFInfo
- Publication number
- WO2005110384A2 WO2005110384A2 PCT/HU2005/000053 HU2005000053W WO2005110384A2 WO 2005110384 A2 WO2005110384 A2 WO 2005110384A2 HU 2005000053 W HU2005000053 W HU 2005000053W WO 2005110384 A2 WO2005110384 A2 WO 2005110384A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nosema
- bees
- composition
- treatment
- disease
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 31
- 201000010099 disease Diseases 0.000 claims abstract description 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 22
- 241001126829 Nosema Species 0.000 claims abstract description 17
- 230000002265 prevention Effects 0.000 claims abstract description 9
- 239000000126 substance Substances 0.000 claims abstract description 9
- 241000256837 Apidae Species 0.000 claims abstract description 7
- 235000021533 Beta vulgaris Nutrition 0.000 claims abstract description 6
- 241000335053 Beta vulgaris Species 0.000 claims abstract description 6
- 235000013379 molasses Nutrition 0.000 claims abstract description 6
- 241000208306 Apium Species 0.000 claims abstract description 4
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229960001138 acetylsalicylic acid Drugs 0.000 claims abstract description 4
- 150000003839 salts Chemical class 0.000 claims abstract description 3
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 abstract description 16
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 abstract description 8
- 229960004889 salicylic acid Drugs 0.000 abstract description 8
- 239000005711 Benzoic acid Substances 0.000 abstract description 6
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 241000257303 Hymenoptera Species 0.000 description 14
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- 241000256844 Apis mellifera Species 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 244000144987 brood Species 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 6
- 239000013543 active substance Substances 0.000 description 5
- 241000256836 Apis Species 0.000 description 4
- 241001492486 Nosema apis Species 0.000 description 4
- 210000004907 gland Anatomy 0.000 description 4
- 235000012907 honey Nutrition 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 4
- 229910052753 mercury Inorganic materials 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 239000002253 acid Substances 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000001186 cumulative effect Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000224489 Amoeba Species 0.000 description 2
- 241000218982 Populus nigra Species 0.000 description 2
- NGFMICBWJRZIBI-JZRPKSSGSA-N Salicin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O1)c1c(CO)cccc1 NGFMICBWJRZIBI-JZRPKSSGSA-N 0.000 description 2
- 241001278097 Salix alba Species 0.000 description 2
- NGFMICBWJRZIBI-UHFFFAOYSA-N alpha-salicin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UHFFFAOYSA-N 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- NGGMYCMLYOUNGM-CSDLUJIJSA-N fumagillin Chemical compound C([C@H]([C@H]([C@@H]1[C@]2(C)[C@H](O2)CC=C(C)C)OC)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O)C[C@@]21CO2 NGGMYCMLYOUNGM-CSDLUJIJSA-N 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- NGFMICBWJRZIBI-UJPOAAIJSA-N salicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UJPOAAIJSA-N 0.000 description 2
- 229940120668 salicin Drugs 0.000 description 2
- 235000020374 simple syrup Nutrition 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- DCNFJXWUPHHBKG-UHFFFAOYSA-N 2-acetyloxybenzoic acid;sodium Chemical compound [Na].CC(=O)OC1=CC=CC=C1C(O)=O DCNFJXWUPHHBKG-UHFFFAOYSA-N 0.000 description 1
- 241001225321 Aspergillus fumigatus Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241000124033 Salix Species 0.000 description 1
- 244000071131 Salix caprea Species 0.000 description 1
- 235000000516 Salix caprea Nutrition 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003356 anti-rheumatic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 229940091771 aspergillus fumigatus Drugs 0.000 description 1
- 210000001520 comb Anatomy 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000002498 deadly effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000007905 drug manufacturing Methods 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 230000017448 oviposition Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229910052573 porcelain Inorganic materials 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 229940109850 royal jelly Drugs 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 150000003872 salicylic acid derivatives Chemical class 0.000 description 1
- ABBQHOQBGMUPJH-UHFFFAOYSA-N sodium;2-hydroxybenzoic acid Chemical compound [Na+].OC(=O)C1=CC=CC=C1O ABBQHOQBGMUPJH-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/04—Amoebicides
Definitions
- the subject of the invention is a new apiary veterinary composition, which is suitable for the treatment and/or prevention of the nosema disease (Nosemosis apium) at honey-bees (Apis mellifera).
- the excrements get on the bees, on the walls of the cells, on the cell-caps, pollen, and on the honey.
- the healthy members of the colony get infected due to their cleaning instinct.
- the cleaning bees suck the thin excrement and they lick the dried excrement, too, after previously moistening it.
- the bees get infected with huge amounts of Nosema apis spores.
- the vestigial pharyngeal gland is not able to produce enough royal jelly and consequently the malnutrition of the brood occurs, or the brood can even starve to death , underdeveloped bees hatch with incomplete wings.
- the proteins for the brood comes from the pharyngeal gland, it can be understood that the Nosema apis infection has its effect upon the brood raising.
- the untreated colonies are completely destroyed in most cases, thus the prevention or the treatment of the infected colonies is indispensable.
- the disease is not easy to be diagnosed based on the symptoms, but the experienced specialist is able to observe the typical symptoms.
- walking bees which are unable to fly and vibrate their outstretched wings.
- the ill worker walks weakly on the flight board and it falls easily on the ground in front of the hive. It climbs on the grass with vibrating wings and it tries to fly, but it falls back weakly.
- the hive on the comb and on the wood of the frames several excrement marks can be seen.
- the deserted hive is left by the queen, too, and in these severe cases the queen herself can be seen walking on the ground. If the queen is infected with nosema, it ceases egg laying and it dies within one or two weeks).
- the secure diagnosis of the disease involves laboratory examination, which is based on the determination of the spores.
- the successful determination of the pathogen in hugely influenced by the method of taking of the samples.
- a well-probed apiary complementary method is the disinfection of the hive and the comb with acetic acid.
- technical acetic acid is to be used. This has a concentration of 80%, so it is fluid under the temperature of 15 °C . In comparison the 100 % concentrated ice-acid gets solid under 15 °C.
- the calculated amount of technical acetic acid is poured into a porcelain bowl and put into the hive to be disinfected.
- the main disadvantage of the method is that the disinfected combs have to be aired for several days after usage, otherwise acid steams will lead to brood and bee destruction.
- a further disadvantage is that the vapour of the acetic acid have a negative effect on the metal objects. Thus it significantly diminishes the life-span of these of the hives and accessories.
- compositions with mercury content were extensively used in the treatment of the Nosemosis apis.
- the mercury content of these compositions endangered the honey, as a food-composition, and consequently these substances with mercury content were completely withdrawn from usage.
- the Fumagillin DCH pulvis produced by Sanofi-Chinoin Drug Manufacturing Company Budapest, Hungary is marketed in bottles containing 20 g.
- One bottle contains 0.5 g of pure active substance. According to the instructions of usage the content of one bottle is sufficient for the treatment of 10 mildly or 5 severely infected colonies.
- the content of the bottle Before the usage the content of the bottle has to be dissolved in 0.5 litres of tepid water, then is evenly mixed in 5 litres of sugar syrup in proportion of 1:1 cooled to 40 °C, and then the mixture is diluted to 25 litres with sugar syrup.
- the ill colonies are fed with 0.5 litres of the mixture daily.
- the usage of the compositions containing antibiotics is more and more restricted and even forbidden by the authorities of certain countries.
- the aim of the invention producing of such an effective -and if possible containing natural ingredients- medicine composition, with which the above mentioned disadvantages can be avoided and the nosema disease can be treated with good effectiveness or it can be prevented.
- the invention is based on the observation that according to the apiary experiences the nosema disease diminishes and even ceases in case of the visiting of bee pastures with high occurrence of willow. After the examination of several other kinds of plants and flowers my attention was attracted by these ones. I determined that according to the literature in the pussy willow of the white willow (Salix alba), but especially in the buds of the black poplar (Populus nigra) an important amount of 2-hidroxibenzil- ⁇ -D-glucopiranozid (salicin) can be found. This compound can be considered a precursor of the salicylic acid. This is because I presume that the salicin transforms into salicylic acid in the midgut of the bee (at the effect of acid, enzyme and given temperature), and this is how it can have its anti-nosema effect.
- the invention is such a veterinary composition, which is suitable for the treatment and/or prevention of the nosema disease (Nosemosis apium) at honeybees and which contains as active substance 2-hidroxi-benzoic acid (salicylic acid) or 2-acetoxi-benzoic acid (acetyl- salicylic acid) or the salt of these.
- the composition according to the invention contains in an advantageous form sugar-industry molasses as carrier matter (concentrated watery extract of Beta vulgaris cv altissima), and if necessary, other known auxiliary and carrier substance.
- the composition in its advantageous form contains basically two main components.
- the main active substance is the 2-hidroxi-benzoic acid (salicylic acid), which kills the parasite spore amoebae.
- the other component is the carrier substance Beta vulgaris cv altissima in concentrated fractionated watery extract (sugar-industry molasses), which contains such natural components (macro- and micro-elements, vitamins), winch partly diminish the shortages caused by sugar- feeding (alimentary saccharine), so the strengthened colonies can defend themselves more effectively against diseases, thus against the nosema disease as well.
- composition based on the invention beyond its main effect, enhances certain life activities of the colonies, for example the honey flow and the cleaning willingness, together with the brood willingness, thus indirectly helps the prevention and fight against the diseases. This positive side-effect was noticed by the bee-farmers who used the composition based on the invention.
- Example 1 50,0 ml concentrated fractionated watery extract of Beta vulgaris cv altissima (sugar-industry molasses); carrier substance
- Plastic bottle with safety cap (the bottle is white, the cap is green, the material used is high-pressure polyethylene). Quantity: minimum: 900 ml maximum: 1010 ml On the side of the bottle there is a printed label .
- Example 2 Table L Cumulative table Of the in vivo experiments related to the experimental composition suitable for the prevention and treatment of the installed nosema (Nosemosis apis) disease at honey-bees f Apis mellifera
- Example 2 Table 2. Cumulative table Of the in vivo experiments related to the experimental composition suitable for the prevention and treatment of the installed nosema fNosemosis apis) disease at honey-bees (Apis mellifera)
- Example 2 Table 3. Cumulative table Of the in vivo experiments related to the experimental composition suitable for the prevention and treatment of the installed nosema (Nosemosis apis) disease at honev-bees (Apis mellifera)
- Example 3 The colonies access to macro- and micro-elements Treatment according to Example 1. for 10 days, and during 10 days of feeding with honey
- Example 4 The colonies access to vitamins with the treatment according to Example 1 for 10 days, and according to the quantities found as proposed in the literature.
- Example 5 We did the same as in Example 1, with the only difference that instead of the 10.0 g of sodium salt of 2-hidroxi-benzoic acid we weighed 12.6 g of acetylsalicylic acid sodium.
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2005800158194A CN1993133B (en) | 2004-05-17 | 2005-05-13 | Apiary veterinary composition |
AT05745024T ATE445403T1 (en) | 2004-05-17 | 2005-05-13 | VETERINARY COMPOSITION FOR BEES |
EP05745024A EP1747002B1 (en) | 2004-05-17 | 2005-05-13 | New apiary veterinary composition |
US11/596,754 US20090209499A1 (en) | 2004-05-17 | 2005-05-13 | Apiary veterinary composition |
KR1020067026198A KR101185328B1 (en) | 2004-05-17 | 2005-05-13 | Apiary veterinary composition |
DE602005017137T DE602005017137D1 (en) | 2004-05-17 | 2005-05-13 | VETERINARY COMPOSITION FOR BEES |
HR20100021T HRP20100021T1 (en) | 2004-05-17 | 2010-01-11 | New apiary veterinary composition |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HUP0400982 | 2004-05-17 | ||
HU0400982A HUP0400982A2 (en) | 2004-05-17 | 2004-05-17 | New veterinary product for honeybees |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2005110384A2 true WO2005110384A2 (en) | 2005-11-24 |
WO2005110384A3 WO2005110384A3 (en) | 2006-03-09 |
WO2005110384B1 WO2005110384B1 (en) | 2006-11-02 |
Family
ID=89982225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/HU2005/000053 WO2005110384A2 (en) | 2004-05-17 | 2005-05-13 | Apiary veterinary composition |
Country Status (12)
Country | Link |
---|---|
US (1) | US20090209499A1 (en) |
EP (1) | EP1747002B1 (en) |
KR (1) | KR101185328B1 (en) |
CN (1) | CN1993133B (en) |
AT (1) | ATE445403T1 (en) |
DE (1) | DE602005017137D1 (en) |
ES (1) | ES2335024T3 (en) |
HR (1) | HRP20100021T1 (en) |
HU (1) | HUP0400982A2 (en) |
PT (1) | PT1747002E (en) |
SI (1) | SI1747002T1 (en) |
WO (1) | WO2005110384A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011029754A2 (en) | 2009-09-14 | 2011-03-17 | Basf Se | Dispenser comprising a polyester membrane for control of mites in bee hives |
NL2009308C2 (en) * | 2012-08-09 | 2014-02-11 | Science In Water B V | A composition and method for improving survival of bee colonies. |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITRM20110450A1 (en) * | 2011-08-26 | 2013-02-27 | Vecchio Francesca Del | EQUIPMENT METHOD INGREDIENTS AND FORMULATIONS FOR PRODUCING SOLUTIONS WITH A HIGH NOURISHING AND CURIOUS RECONSTITUTING NOURISHING EFFECT FOR A COMPLETE AND AUTOMATED SYSTEM TO PREVENT AND FIGHT THE BEALS SPLASH SYNDROME |
WO2017093986A1 (en) * | 2015-12-05 | 2017-06-08 | Canabuzz-Med | Veterinary composition and methods for production and use |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4859658A (en) * | 1987-03-02 | 1989-08-22 | Ricerfarma S.R.L. | Compound compositions with improved analgesic antipyretic and anti-inflammatory activity |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3703105A1 (en) * | 1987-02-03 | 1988-08-11 | Bayer Ag | MEDICINE AGAINST PROTOCOES IN INSECTS |
DE3805660A1 (en) * | 1988-02-24 | 1989-09-07 | Bayer Ag | SUBSTITUTED 1,2,4-TRIAZINDIONES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE |
DE4030042A1 (en) * | 1990-05-17 | 1991-11-21 | Bayer Ag | USE OF SUBSTITUTED 1,2,4-TRIAZINDIONES |
FR2744918B1 (en) * | 1996-02-19 | 1998-05-07 | Sanofi Sa | NEW COMBINATIONS OF ACTIVE INGREDIENTS CONTAINING THIENO (3,2-C) PYRIDINE DERIVATIVE AND AN ANTITHROMBOTIC |
RU2153327C2 (en) * | 1997-10-23 | 2000-07-27 | Дальневосточный государственный аграрный университет | Ointment "chernaia" for treatment of arachnosis and dermato-mycosis |
-
2004
- 2004-05-17 HU HU0400982A patent/HUP0400982A2/en unknown
-
2005
- 2005-05-13 US US11/596,754 patent/US20090209499A1/en not_active Abandoned
- 2005-05-13 EP EP05745024A patent/EP1747002B1/en active Active
- 2005-05-13 PT PT05745024T patent/PT1747002E/en unknown
- 2005-05-13 SI SI200530884T patent/SI1747002T1/en unknown
- 2005-05-13 CN CN2005800158194A patent/CN1993133B/en not_active Expired - Fee Related
- 2005-05-13 ES ES05745024T patent/ES2335024T3/en active Active
- 2005-05-13 KR KR1020067026198A patent/KR101185328B1/en active IP Right Review Request
- 2005-05-13 WO PCT/HU2005/000053 patent/WO2005110384A2/en active Application Filing
- 2005-05-13 AT AT05745024T patent/ATE445403T1/en active
- 2005-05-13 DE DE602005017137T patent/DE602005017137D1/en active Active
-
2010
- 2010-01-11 HR HR20100021T patent/HRP20100021T1/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4859658A (en) * | 1987-03-02 | 1989-08-22 | Ricerfarma S.R.L. | Compound compositions with improved analgesic antipyretic and anti-inflammatory activity |
Non-Patent Citations (4)
Title |
---|
DATABASE BIOSIS [Online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2000, MLADJAN V ET AL: "Preventive action of fumagillin on the degree of infection with Nosema apis in the digestive tract of bees" XP002351527 Database accession no. PREV200100017927 & ACTA VETERINARIA (BELGRADE), vol. 50, no. 4, 2000, pages 241-252, ISSN: 0567-8315 * |
DATABASE CA [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; GONTARSKI, H. ET AL: "Quantitative studies on the chemotherapeutic treatment of the honey bee against Nosema apis" XP002351526 retrieved from STN Database accession no. 1954:50494 & ARZNEIMITTEL-FORSCHUNG , 4, 161-8 CODEN: ARZNAD; ISSN: 0004-4172, 1954, * |
DATABASE WPI Section Ch, Week 200116 Derwent Publications Ltd., London, GB; Class B05, AN 2001-157202 XP002351533 & RU 2 153 327 C2 (UNIV FAR E AGRIC) 27 July 2000 (2000-07-27) * |
SAMSINAKOVA A ET AL: "EFFECTS OF SOME ANTI MYCOTICS AND DISINFECTANTS ON THE ASCOSPHAERA-APIS FUNGUS IN-VITRO" ZEITSCHRIFT FUER ANGEWANDTE ENTOMOLOGIE, vol. 84, no. 3, 1977, pages 225-232, XP008054809 ISSN: 0044-2240 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011029754A2 (en) | 2009-09-14 | 2011-03-17 | Basf Se | Dispenser comprising a polyester membrane for control of mites in bee hives |
NL2009308C2 (en) * | 2012-08-09 | 2014-02-11 | Science In Water B V | A composition and method for improving survival of bee colonies. |
US9333188B2 (en) | 2012-08-09 | 2016-05-10 | Science In Water B.V. | Composition and method for improving survival of bee colonies |
Also Published As
Publication number | Publication date |
---|---|
DE602005017137D1 (en) | 2009-11-26 |
US20090209499A1 (en) | 2009-08-20 |
WO2005110384B1 (en) | 2006-11-02 |
ATE445403T1 (en) | 2009-10-15 |
EP1747002A2 (en) | 2007-01-31 |
KR101185328B1 (en) | 2012-09-21 |
CN1993133A (en) | 2007-07-04 |
EP1747002B1 (en) | 2009-10-14 |
HRP20100021T1 (en) | 2010-02-28 |
ES2335024T3 (en) | 2010-03-18 |
CN1993133B (en) | 2010-11-10 |
WO2005110384A3 (en) | 2006-03-09 |
PT1747002E (en) | 2010-01-18 |
HU0400982D0 (en) | 2004-07-28 |
HUP0400982A2 (en) | 2006-08-28 |
SI1747002T1 (en) | 2010-04-30 |
KR20070015960A (en) | 2007-02-06 |
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