WO2005108612A3 - Nanoscale biosensor device, system and technique - Google Patents

Nanoscale biosensor device, system and technique Download PDF

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Publication number
WO2005108612A3
WO2005108612A3 PCT/US2004/039928 US2004039928W WO2005108612A3 WO 2005108612 A3 WO2005108612 A3 WO 2005108612A3 US 2004039928 W US2004039928 W US 2004039928W WO 2005108612 A3 WO2005108612 A3 WO 2005108612A3
Authority
WO
WIPO (PCT)
Prior art keywords
technique
nucleic acids
biosensor device
electrodes
nanoscale
Prior art date
Application number
PCT/US2004/039928
Other languages
French (fr)
Other versions
WO2005108612A2 (en
Inventor
Sobha Pisharody
Beverly Freeman
George Mathai
Kristian M Scaboo
Thomas Adams
Jiaxiong Wang
Original Assignee
Genorx Inc
Sobha Pisharody
Beverly Freeman
George Mathai
Kristian M Scaboo
Thomas Adams
Jiaxiong Wang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genorx Inc, Sobha Pisharody, Beverly Freeman, George Mathai, Kristian M Scaboo, Thomas Adams, Jiaxiong Wang filed Critical Genorx Inc
Publication of WO2005108612A2 publication Critical patent/WO2005108612A2/en
Publication of WO2005108612A3 publication Critical patent/WO2005108612A3/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • General Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)

Abstract

The present invention provides biosensors for the detection of nucleic acids, such as double stranded DNA. The biosensors are electrodes on a solid support that have means for binding nucleic acids near the electrodes. The nucleic acids are captured such that they span the electrode pair, and the capture can be detected by electrical means.
PCT/US2004/039928 2003-11-28 2004-11-29 Nanoscale biosensor device, system and technique WO2005108612A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52569703P 2003-11-28 2003-11-28
US60/525,697 2003-11-28

Publications (2)

Publication Number Publication Date
WO2005108612A2 WO2005108612A2 (en) 2005-11-17
WO2005108612A3 true WO2005108612A3 (en) 2006-08-17

Family

ID=35320806

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/039928 WO2005108612A2 (en) 2003-11-28 2004-11-29 Nanoscale biosensor device, system and technique

Country Status (1)

Country Link
WO (1) WO2005108612A2 (en)

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ITTO20070341A1 (en) * 2007-05-15 2008-11-16 Consiglio Nazionale Ricerche PROCEDURE AND DEVICE FOR ELECTRIC TRANSDUCTION FOR THE DETECTION OF BIO-RECOGNITION EVENTS IN BIOMOLECULAR INTERACTION PROCESSES FOR GENOMIC / PROTEOMIC ANALYSIS
US9184099B2 (en) 2010-10-04 2015-11-10 The Board Of Trustees Of The Leland Stanford Junior University Biosensor devices, systems and methods therefor
US9399217B2 (en) 2010-10-04 2016-07-26 Genapsys, Inc. Chamber free nanoreactor system
EP2625526B1 (en) 2010-10-04 2017-03-15 Genapsys Inc. Systems and methods for automated reusable parallel biological reactions
TWI495727B (en) * 2010-10-08 2015-08-11 Nat Applied Res Laboratories A micro electrochemical multiplex real time pcr system
US9926596B2 (en) 2011-05-27 2018-03-27 Genapsys, Inc. Systems and methods for genetic and biological analysis
US8585973B2 (en) 2011-05-27 2013-11-19 The Board Of Trustees Of The Leland Stanford Junior University Nano-sensor array
CN106591103B (en) 2011-12-01 2021-06-04 吉纳普赛斯股份有限公司 System and method for efficient electronic sequencing and detection
WO2014152625A1 (en) 2013-03-15 2014-09-25 Genapsys, Inc. Systems and methods for biological analysis
WO2015089238A1 (en) 2013-12-11 2015-06-18 Genapsys, Inc. Systems and methods for biological analysis and computation
US9822401B2 (en) 2014-04-18 2017-11-21 Genapsys, Inc. Methods and systems for nucleic acid amplification
KR102489353B1 (en) 2015-06-01 2023-01-17 캘리포니아 인스티튜트 오브 테크놀로지 Compositions and methods for screening T cells with antigens to specific populations
JP7166586B2 (en) * 2015-06-25 2022-11-08 ロズウェル バイオテクノロジーズ，インコーポレイテッド Biomolecular sensor and method
CN109328301B (en) 2016-01-28 2021-03-12 罗斯韦尔生物技术股份有限公司 Large-scale parallel DNA sequencing device
CN109071212A (en) 2016-01-28 2018-12-21 罗斯韦尔生物技术股份有限公司 Use the method and apparatus of large-scale molecular electronic sensor array measurement analyte
KR20180104159A (en) 2016-02-09 2018-09-19 로스웰 바이오테크놀로지스 인코포레이티드 Electron non-labeled DNA and genomic sequencing
US10597767B2 (en) 2016-02-22 2020-03-24 Roswell Biotechnologies, Inc. Nanoparticle fabrication
CN105648033B (en) * 2016-02-23 2019-06-04 青岛科技大学 A method of trypsase in measurement exercised rats pancreatic tissue sample
EP3488017A4 (en) 2016-07-20 2020-02-26 Genapsys Inc. Systems and methods for nucleic acid sequencing
US9829456B1 (en) 2016-07-26 2017-11-28 Roswell Biotechnologies, Inc. Method of making a multi-electrode structure usable in molecular sensing devices
EP3568407A4 (en) 2017-01-10 2020-12-23 Roswell Biotechnologies, Inc Methods and systems for dna data storage
EP3571286A4 (en) 2017-01-19 2020-10-28 Roswell Biotechnologies, Inc Solid state sequencing devices comprising two dimensional layer materials
CN110546276A (en) 2017-04-25 2019-12-06 罗斯威尔生命技术公司 Enzyme circuit for molecular sensors
US10508296B2 (en) 2017-04-25 2019-12-17 Roswell Biotechnologies, Inc. Enzymatic circuits for molecular sensors
EP4023764A3 (en) 2017-05-09 2022-09-21 Roswell Biotechnologies, Inc. Binding probe circuits for molecular sensors
WO2018213790A2 (en) * 2017-05-18 2018-11-22 Arizona Board Of Regents On Behaft Of Arizona State University Apparatus for analyzing and detecting interactions and reactions of molecules
CN110770575A (en) * 2017-06-22 2020-02-07 伊士曼化工公司 Physical vapor deposition electrode for electrochemical sensors
KR20200039795A (en) 2017-08-30 2020-04-16 로스웰 바이오테크놀로지스 인코포레이티드 Progressive enzyme molecular electronic sensors for DNA data storage
JP2021500858A (en) 2017-09-21 2021-01-14 ジナプシス インコーポレイテッド Systems and methods for nucleic acid sequencing
EP3694990A4 (en) 2017-10-10 2022-06-15 Roswell Biotechnologies, Inc. Methods, apparatus and systems for amplification-free dna data storage
EP3806996A4 (en) * 2018-06-14 2022-06-08 Corning Incorporated Patterned flow cells for biomolecular analysis
US20210213448A1 (en) * 2018-06-14 2021-07-15 Corning Incorporated Nano-patterned surfaces for microfluidic devices and methods for manufacturing the same
CN110760566B (en) * 2019-11-08 2022-07-26 江南大学 Homogeneous anode photoelectrochemical aflatoxin detection method based on bismuth tungstate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060023A (en) * 1998-03-31 2000-05-09 Motorola, Inc. Molecular sensing apparatus
US20030129622A1 (en) * 2001-08-28 2003-07-10 Hellinga Homme W. Biosensor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060023A (en) * 1998-03-31 2000-05-09 Motorola, Inc. Molecular sensing apparatus
US20030129622A1 (en) * 2001-08-28 2003-07-10 Hellinga Homme W. Biosensor

Also Published As

Publication number Publication date
WO2005108612A2 (en) 2005-11-17

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