WO2005107375A3 - Process for the preparation of olanzapine form-i - Google Patents

Process for the preparation of olanzapine form-i Download PDF

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Publication number
WO2005107375A3
WO2005107375A3 PCT/IN2005/000098 IN2005000098W WO2005107375A3 WO 2005107375 A3 WO2005107375 A3 WO 2005107375A3 IN 2005000098 W IN2005000098 W IN 2005000098W WO 2005107375 A3 WO2005107375 A3 WO 2005107375A3
Authority
WO
WIPO (PCT)
Prior art keywords
olanzapine
olanzapine form
preparation
minimal number
thieno
Prior art date
Application number
PCT/IN2005/000098
Other languages
French (fr)
Other versions
WO2005107375A2 (en
Inventor
Satyanarayana Chava
Seeta Ramanjaneyulu Gorantla
Jyothi Basu Abbineni
Original Assignee
Matrix Lab Ltd
Satyanarayana Chava
Seeta Ramanjaneyulu Gorantla
Jyothi Basu Abbineni
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Lab Ltd, Satyanarayana Chava, Seeta Ramanjaneyulu Gorantla, Jyothi Basu Abbineni filed Critical Matrix Lab Ltd
Publication of WO2005107375A2 publication Critical patent/WO2005107375A2/en
Publication of WO2005107375A3 publication Critical patent/WO2005107375A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

The present invention provides a reproducible, novel, commercially feasible process to obtain Olanzapine Form-I of substantial polymorphic purity with minimal number of steps using minimal number of solvents by condensation of 4-Aminomethyl-10H-thieno [2, 3-b] [1, 5] benzodiazepine hydrochloride with N-methyl piperazine followed by isolation of Olanzapine methylene chloride solvate and conversion of the same to Olanzapine Form-I.
PCT/IN2005/000098 2004-05-06 2005-04-04 Process for the preparation of olanzapine form-i WO2005107375A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN416CH2004 2004-05-06
IN416/CHE/2004 2004-05-06

Publications (2)

Publication Number Publication Date
WO2005107375A2 WO2005107375A2 (en) 2005-11-17
WO2005107375A3 true WO2005107375A3 (en) 2006-04-06

Family

ID=35320627

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2005/000098 WO2005107375A2 (en) 2004-05-06 2005-04-04 Process for the preparation of olanzapine form-i

Country Status (2)

Country Link
AR (1) AR050247A1 (en)
WO (1) WO2005107375A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1575962A1 (en) 2002-12-24 2005-09-21 Teva Pharmaceutical Industries Limited Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
US8106188B2 (en) 2006-06-01 2012-01-31 Aurobindo Pharma Ltd Process for preparing olanzapine form I
PL381564A1 (en) * 2007-01-22 2008-08-04 Koźluk Tomasz Nobilus Ent The manner of production of basically clean variety of polymorphic olanzapine
WO2008151430A1 (en) * 2007-06-14 2008-12-18 Apotex Pharmachem Inc. Novel processes to form-i of olanzapine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002018390A1 (en) * 2000-08-31 2002-03-07 Dr. Reddy's Laboratories Ltd. Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine
WO2003097650A1 (en) * 2002-05-17 2003-11-27 Institut Farmaceutyczny Methods for preparation of olanzapine polymorphic form i

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002018390A1 (en) * 2000-08-31 2002-03-07 Dr. Reddy's Laboratories Ltd. Process for preparation of hydrates of olanzapine and their conversion into crystalline forms of olanzapine
WO2003097650A1 (en) * 2002-05-17 2003-11-27 Institut Farmaceutyczny Methods for preparation of olanzapine polymorphic form i

Also Published As

Publication number Publication date
AR050247A1 (en) 2006-10-11
WO2005107375A2 (en) 2005-11-17

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