WO2005106471A3 - Diagnostics et therapies pour des maladies associees a un recepteur 4 de chimiokine c-c (ccr4) - Google Patents

Diagnostics et therapies pour des maladies associees a un recepteur 4 de chimiokine c-c (ccr4) Download PDF

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Publication number
WO2005106471A3
WO2005106471A3 PCT/EP2005/004108 EP2005004108W WO2005106471A3 WO 2005106471 A3 WO2005106471 A3 WO 2005106471A3 EP 2005004108 W EP2005004108 W EP 2005004108W WO 2005106471 A3 WO2005106471 A3 WO 2005106471A3
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WO
WIPO (PCT)
Prior art keywords
disorders
diseases
ccr4
therapeutics
diagnostics
Prior art date
Application number
PCT/EP2005/004108
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English (en)
Other versions
WO2005106471A2 (fr
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Holger Summer
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Holger Summer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts, Holger Summer filed Critical Bayer Healthcare Ag
Publication of WO2005106471A2 publication Critical patent/WO2005106471A2/fr
Publication of WO2005106471A3 publication Critical patent/WO2005106471A3/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Un CCR4 humain associé à des troubles cardio-vasculaires, à des maladies gastro-intestinales et hépatiques, à des maladies inflammatoires, à des maladies métaboliques, à des troubles hématologiques, à des troubles cancéreux, à des troubles neurologiques, à des maladies respiratoires et à des troubles de la reproduction. Des essais pour l'identification de composés utiles dans le traitement ou la prévention de troubles cardio-vasculaires, de maladies gastro-intestinales et hépatiques, de maladies inflammatoires, de maladies métaboliques, de troubles hématologiques, de troubles cancéreux, de troubles neurologiques, de maladies respiratoires et de troubles de la reproduction. Des composés se liant et/ou activant et inhibant l'activité de CCR4 ainsi que des compositions pharmaceutiques comprenant de tels composés.
PCT/EP2005/004108 2004-04-30 2005-04-18 Diagnostics et therapies pour des maladies associees a un recepteur 4 de chimiokine c-c (ccr4) WO2005106471A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04010389.7 2004-04-30
EP04010389 2004-04-30

Publications (2)

Publication Number Publication Date
WO2005106471A2 WO2005106471A2 (fr) 2005-11-10
WO2005106471A3 true WO2005106471A3 (fr) 2006-05-11

Family

ID=35242294

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/004108 WO2005106471A2 (fr) 2004-04-30 2005-04-18 Diagnostics et therapies pour des maladies associees a un recepteur 4 de chimiokine c-c (ccr4)

Country Status (1)

Country Link
WO (1) WO2005106471A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7018618B2 (ja) 2020-04-16 2022-02-14 国立研究開発法人国立国際医療研究センター 呼吸器感染症の重症化の予測を補助する方法、バイオマーカーの測定値をモニタリングする方法、およびこれらの方法に用いられる試薬キット

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0718167D0 (en) 2007-09-18 2007-10-31 Cancer Rec Tech Ltd Cancer marker and therapeutic target
AU2013203349B2 (en) * 2007-09-18 2016-06-02 Cancer Research Technology Ltd Cancer marker and therapeutic target
EA201370030A1 (ru) * 2010-08-10 2013-06-28 Амген Инк. Бифункциональный количественный анализ in vitro связывания мишени для обнаружения нейтрализующих антител к антителам-мишеням
CN108250290B (zh) * 2018-02-23 2024-03-12 上海捌加壹医药科技有限公司 Ccr4的n端重组蛋白及其用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000041724A1 (fr) * 1999-01-15 2000-07-20 The Board Of Trustees Of The Leland Stanford Junior University Modulation du trafic des lymphocytes t a memoire de la circulation systemique
WO2001057188A2 (fr) * 2000-02-03 2001-08-09 Hyseq, Inc. Nouveaux acides nucleiques et polypeptides
US6500938B1 (en) * 1998-01-30 2002-12-31 Incyte Genomics, Inc. Composition for the detection of signaling pathway gene expression
US6607879B1 (en) * 1998-02-09 2003-08-19 Incyte Corporation Compositions for the detection of blood cell and immunological response gene expression
WO2003090694A2 (fr) * 2002-04-24 2003-11-06 Expression Diagnostics, Inc. Methodes et compositions pour diagnostiquer et controler des maladies inflammatoires auto-immunes et chroniques

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500938B1 (en) * 1998-01-30 2002-12-31 Incyte Genomics, Inc. Composition for the detection of signaling pathway gene expression
US20040010136A1 (en) * 1998-01-30 2004-01-15 Incyte Genomics, Inc. Composition for the detection of signaling pathway gene expression
US6607879B1 (en) * 1998-02-09 2003-08-19 Incyte Corporation Compositions for the detection of blood cell and immunological response gene expression
WO2000041724A1 (fr) * 1999-01-15 2000-07-20 The Board Of Trustees Of The Leland Stanford Junior University Modulation du trafic des lymphocytes t a memoire de la circulation systemique
US20020019341A1 (en) * 1999-01-15 2002-02-14 Butcher Eugene C. Modulation of systemic memory T cell trafficking
WO2001057188A2 (fr) * 2000-02-03 2001-08-09 Hyseq, Inc. Nouveaux acides nucleiques et polypeptides
WO2003090694A2 (fr) * 2002-04-24 2003-11-06 Expression Diagnostics, Inc. Methodes et compositions pour diagnostiquer et controler des maladies inflammatoires auto-immunes et chroniques

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7018618B2 (ja) 2020-04-16 2022-02-14 国立研究開発法人国立国際医療研究センター 呼吸器感染症の重症化の予測を補助する方法、バイオマーカーの測定値をモニタリングする方法、およびこれらの方法に用いられる試薬キット

Also Published As

Publication number Publication date
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