WO2005093641A1 - Localisation, identification et poursuite d'echantillons biologiques, systeme et procede utilisant une etiquette electronique - Google Patents

Localisation, identification et poursuite d'echantillons biologiques, systeme et procede utilisant une etiquette electronique Download PDF

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Publication number
WO2005093641A1
WO2005093641A1 PCT/BE2005/000040 BE2005000040W WO2005093641A1 WO 2005093641 A1 WO2005093641 A1 WO 2005093641A1 BE 2005000040 W BE2005000040 W BE 2005000040W WO 2005093641 A1 WO2005093641 A1 WO 2005093641A1
Authority
WO
WIPO (PCT)
Prior art keywords
detection system
biological sample
solid support
electronic tag
support
Prior art date
Application number
PCT/BE2005/000040
Other languages
English (en)
Inventor
Michel Milinkovitch
Cedric Szpirer
Philippe Gabant
David Vecchia Dalla
Pascal Dal Farra
Daniel Penninck
Original Assignee
Universite Libre De Bruxelles
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite Libre De Bruxelles filed Critical Universite Libre De Bruxelles
Publication of WO2005093641A1 publication Critical patent/WO2005093641A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/54—Labware with identification means
    • B01L3/545—Labware with identification means for laboratory containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B01L2300/022—Transponder chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/023—Sending and receiving of information, e.g. using bluetooth
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/024—Storing results with means integrated into the container
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N2035/00891—Displaying information to the operator

Definitions

  • BIOLOGICAL SAMPLES LOCALISATION, IDENTIFICATION AND TRACKZNG, SYSTEM AND METHOD USING ELECTRONIC TAG
  • the present invention is related to a tracJcing and detection system and method adapted for the localisation, identification and/or tracking of one or more biological sample (s) included in/or present in different supports by using electronic tag with or without integrated sensors.
  • the temperature of 120° C or more is used for obtaining a sterilization of various supports for said biological samples; while the biological samples can be maintained at different temperatures for different purposes (room temperature, 4°C, - 16°C - 178 °C for conservation of the biological samples, etc.)
  • Various solid supports such as cylindrical laboratory tubes (of a few centimetres of diameter) , mic-rro- tubes (well-plates) or microarrays conserved in specific packaging or boxer (made of expanded polystyrene or ottier polymeric materials) are usually disposed in specific compartments of a freezer. Therefore, a freezer could contain up to several thousand different biological samples.
  • the physical stress cycle on the samples (as a temperature cycle for example) can have an important impact on the quality of the reagent/biological sample itself. In the extreme case, bad cycles can cause the complete deterioration of the content.
  • Some samples have an expiration date associated. This expiration date can be associated to a specific time (absolute time) or to a specific manipulation (relative time) (example: this sample must be used in the minutes following defrost) .
  • the history process of a sample, corresponding to the manipulation cycle, (preferably under an established protocol) this sample in a laboratory, is a succession of physical stress cycles (temperature, humidity, centrifugation,...) , add of new reagent (s) or biological component (s) , and interaction with different kind of apparatus (centrifuge, magnetic stirrer, pipette,).
  • said biological samples were identified by a bar code or by a manual registration (ink) printed on the support.
  • a bar code or a manual registration system used in an identification of various biological samples required that each support was extracted from the freezer and manipulated at room temperature. Said manipulation generates solid condensation phenomena (inverse sublimisation) upon the label. Therefore, the support of the biological sample is covered with ice which renders the identification of the biological sample complex or even renders impossible the reading of the bar code .
  • said direct manipulation of the solid support is dangerous due to the temperature of the solid support, while the size of said solid support does not always allow the use of protective gloves.
  • a direct contact with the solid support could lead to the destruction of the bar code or the manual registration printed upon the solid support and (due to the modification of temperature) it could affect the characteristics of the biological sample (rapid heating at room temperature of the biological sample which could lead to a partial or a complete destruction of the biological sample) .
  • a fridge may contain up to several thousand different biological samples, it is not obvious for the operator to identify directly the correct biological sample, in the correct box of a correct compartment .
  • the present invention aims to provide a new tracking and detection system and method, as well as any devices (apparatus, freezers, reading apparatus, computer,...) comprising it adapted for the localization, the identification and/or the tracking of a biological sample included in or present in a support which does not present drawbacks of the state of the art and which is simple, efficient and not expensive.
  • the present invention is related to a detection system and method adapted for the localization, the identification and/or tracking of a biological sample or chemical reagents that can react with a biological sample included in or present in a solid support.
  • Said system comprising: a software designed for tracking information related to a life cycle of a biological sample and related to this biological sample (including specific data, like taxonomic identity of the sample, taxonomic sequences of nucleic acids, vector information (such as restriction map of viruses, plasmids, etc) , protocol to use, added biological component (s) or reagent (s) to the initial sample, temperature and other physical stress (osmotic pressure, pH, modification, ...) submitted to the sample, apparatus (pipette, vortex, centrifuge) , sequencer, cycler, ...) used during the sample lifecycle and configuration parameters (t°, time, number of cycles ...) of these apparatus, sample expiration date, stock location reference, etc; all these information (s) can be associated to a
  • the information contained in the sample is of the same type as the information in the software database.
  • the system according to the invention could also comprise mobile or fixed reading apparatus with reading means that are able to read (and record) information contained in the tag and possibly in the associated sensors, and possibly transfer (by wireless mode) these information (s) to a database.
  • the reading apparatus could also be used to write information (s) in order to include additional information (s) into the tag and possibly in the associated sensors.
  • Such apparatus could be any apparatus which allows a treatment of the biological sample during its life cycle. Example of these apparatus are centrifuges, magnetic stirrer, pipettes, ... involved in the treatment of the biological sample or allowing addition of reagents to the biological sample.
  • the tag of the system could be also used for obtaining an identification of the person which has performed one or more steps of an established laboratory protocol to be applied upon the biological sample.
  • the added reagents are also identified with an electronic tag integrated into the recipient of these reagents.
  • the operator working with the sample are also identified by various means, such as a card embedded with an electronic tag, present on the clothes of the operator.
  • the fridge can identify him or her and records which sample has been removed or added. The information can be recorded either on the memory of the tag associated to the sample or by a separated data base or both.
  • the reagents and samples are identified.
  • the operator can automatically record which reagent has been or should be (according to a specific laboratory protocol) added to a specific sample, either with a desktop or a mobile application.
  • the operator can input the quantity of reagents used.
  • the apparatus can combine its own data (parameters, calibration, ...) and communicate them to a database and/or to the manipulated samples.
  • the detection system of the invention comprises an anti-collision mode so that a specific information may be read or written thereon and therein, even when trie labelled support is present among other labelled supports (different supports present in the same box or in the same compartment of a fridge) .
  • the biological sample, or its reagents is any biological sample which could be used in a laboratory for specific biological experiments (laboratory protocol) or is part of a collection of micro-organisms.
  • the said biological sample and reagents comprise but are not limited to cells (eukaryote cells or prokaryote cells, such as animal (including human) cells, plant cells, yeast cells, bacteria cells, micoplasms, viruses, peptides and proteins, amino-acids, nucleotides and nucleotide sequences, vectors, saccharides, antibiotics, lipids and lipid vesicles, vitamins, physiological media (such as buffers) , comprising each of said elements and a mixture thereof .
  • cells eukaryote cells or prokaryote cells, such as animal (including human) cells, plant cells, yeast cells, bacteria cells, micoplasms, viruses, peptides and proteins, amino-acids, nucleotides and nucleotide sequences, vectors
  • the solid support could be also further labelled by means of another detection system such as a bar code.
  • the solid support used in the detection system according to the invention could be a laboratory tube, a micro-tube, a test- tube, flasks, pipettes, infusion bottles (baxters) , microarirays (biochips) , plates, multi well-plates, etc.
  • the tag system could be an active or a passive system associated physically, directly or indirectly to the support comprising the biological sample or reagents or a container comprising multiple supports for said biological sample.
  • the electronic tag is used for three different purposes, it contains an electronic identification card which can be read without contact, it comprises a system for the localization of the biological samples or its solid support and it comprises a "stress" registration system of the biological and/or physico-chemical modifications of the biological sample based on sensors that can be integrated to the tag.
  • a tag can comprise specific sensors with temperature pressure and movement measurements that can record relevant physical information (s) directly in own memory. Such temperature sensor allows the monitoring of storage and manipulation temperature.
  • the electronic tag can comprise additional data related to the characteristic of the sample and reagents or the protocol submitted by the sample or to be applied to the sample .
  • the operator can be identified by another electronic tag enabling the system (reading apparatus) to automatically trace which operator has performed a given step of a treatment protocol to be applied to the said sample.
  • the detection system of the invention may also comprise a controller (in the reading apparatus) allowing a specific identification of which solid support has to be used in a specific laboratory protocol (manipulation process of the biological sample) and possibly an alarm device for the operator manipulating the apparatus with an unidentified solid support or with a solid support that should not be used in this specific laboratory protocol.
  • This electronic tag could be directly linked to the biological sample in the form of a sterilised and watertight capsule or physically associated with the container (system introduced into the top of the container, system glued to the container, etc.)
  • the electronic tag according to the present invention was tested and presents unexpectedly a higher resistance (resistance to high temperature (up to 120°C or higher) , resistance to high pressure (up to 1 bar, above atmospheric pressure, or higher) , resistance to low temperature (up to -80°C or lower) for long period (several months) , to high stress induced by centrifuge, magnetic stirrer, ...) compared to a bar code and therefore can be present in the packaging of the support and does not require a visibility to obtain the information reading (advantageously, the box, the fridge or the solid support should not be present in an open position and several electronic tag can be identified and differentiated among other electronic tag present in the same fridge at the same time) .
  • the reading and/or writing step could be advant geously performed simultaneously.
  • the information capacity of this system is more important than the one of a bar code system and this reading and writing system allows the possible reuse of the electronic tag upon another support for the identification, localization and/or tracking of other biological samples .
  • This system will also allow a rapid detection of samples and reagents to be used in a test and also integrated these data in a LIMS system (Laboratory Integrated
  • the present invention is also related to any device (apparatus, fridge, box, automate performing purification sequencing, amplification, identification or quantification steps upon biological sample ...) , operator 2 clothes or plant (rooms of production, of sample collection, etc.) comprising chemical or biological samples and said system and the software able to conduct said identification, localisation and tracking of biological samples with the system of the invention, possibly combined with one or more database (s), comprising collected information (s) and protocols to be used.
  • s database
  • the complete system composed of the software, the tags on the different component (s) and apparatus allow tracking all the processes on the sample during his lifecycle in an automatic way.
  • An electronic tag (chip) contained into a capsule comprises an unique numeric alpha code which identify a sample or its container and could also be used to comprise (totally or partially) the genetic or proteic sequence of the samples or any other information (by using a genetic code - ACGT letter for DNA sequences and letters or triplets for amino acids sequences) . [0048] Therefore, the operator could directly identify correctly the sample by a direct lecture of the sequence or through a coupling of the system to a database. Other information regarding the characteristics of the biological sample could be also incorporated upon the chips.
  • the electric tag used in the present invention hereafter also called "radio frequency label” comprises chips which contain all the required information (unique alphanumeric code and possibly a memory unit which may comprise additional information which are specific of the biological samples of interest) and a reading encoder connected to an antenna.
  • This system can be active or passive (which means that it can comprise its own battery for having autonomy of several months up to several years) .
  • the electronic tag allows the following functions: reading (the electronic tag comprises only an unique code integrated during the production of the chips) ; reading and writing system (the electronic tagging comprises in addition to its unique code, one or more memory units which allows the reading and the writing of additional data) ; an anti-collision mode (this function present in the electronic tag allows that a specific information may be read or written thereon and therein, even when the labelled support is present among other labelled supports) ; - EAS system (this function allows the detection of the presence of different electronic tags in the field of a single antenna) .
  • Example 2 a complete tracking solution integrating sample- apparatus - operator
  • the biological samples and reagents used in a process are identified with an electronic tag that could integrate different kind of physical stress sensors (temperature sensor, pH sensor, moisture sensor, etc .
  • Electronic tag or reader/writer can be associated with specific apparatus (centrifuge, magnetic stirrer, pipette,). With integrated reader/writer, the apparatus can combine its own data (parameters, calibration%) and communicate them to the central system and/or to the manipulated sample.
  • a apparatus used for taking small volumes ( ⁇ 1 ⁇ l up to 5 ml) comprises a RFID reader/writer system that identifies correctly the laboratory tube comprising a specific tag and that records volume taken.
  • This information can be written on the specific sample or it can be communicated to a data base of the system.
  • the complete system allows the tracking of all the information. This communication is between 1 [sample, reagent, apparatus (centrifuge, magnetic stirrer, pipette,%), operator] and 2 [reader, integrated reader (in apparatus, in specific sample, in specific reagent, etc] That way, it is possible to track all the information corresponding to a process [origin of the sample, quantity used, physical stress constraints (temperature,%), apparatus process/ parameters/ calibration, person doing a specific manipulation, ...] for each sample.
  • This information is managed by a software and its corresponding database that allows to see how a specific sample is managed and to dynamically link all the information between all the different interactions corresponding to the steps leading to the final result.
  • the system can generate the corresponding manipulation protocol (based on one or several experiences) .
  • the system can also be used to insure that a specific manipulation has been realized in accordance with a specific protocol .
  • the pipette containing the reader/writer system is able to control if all the steps of a protocol are realized sequentially or in parallel by identification of the tubes (containing each a RFID tag) .
  • the pipette is also able, with or without communication with another device (computer, alarm device) , to warn the operator or to stop or to modify the protocol when a specific step is forgotten or cancelled.
  • Example 3 A solid support (laboratory tubes) comprising a tag integrated in the solid support material or the top of the laboratory tube or included inside the tube with the biological sample or reagents, has been submitted to various tests summarised in the following table 1.
  • a pipette used for taking small volumes can comprise a RFID lecture system that identifies correctly the laboratory tube comprising a specific tag and that identifies if the correct volume has been taken.

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La présente invention concerne un système de détection destiné à la localisation, l'identification et/ou la poursuite d'un échantillon biologique inclus dans ou présent sur un support solide. Ce système de détection comprend une étiquette électronique située dans ou sur le support de manière à obtenir un support étiqueté, ce support étiqueté contenant des données d'information relatives à la localisation, l'identité et/ou l'état biologique et/ou physique de l'échantillon biologique, et un appareil de lecture permettant de lire et d'enregistrer ces données d'information (voir revandication 1).
PCT/BE2005/000040 2004-03-26 2005-03-25 Localisation, identification et poursuite d'echantillons biologiques, systeme et procede utilisant une etiquette electronique WO2005093641A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55660404P 2004-03-26 2004-03-26
US60/556,604 2004-03-26

Publications (1)

Publication Number Publication Date
WO2005093641A1 true WO2005093641A1 (fr) 2005-10-06

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Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006130760A2 (fr) * 2005-05-31 2006-12-07 Smart Medical Technologies, Llc Systemes de traçage et d'analyse d'echantillons medicaux et de donnees medicales
US7860727B2 (en) 2003-07-17 2010-12-28 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
EP2339353A1 (fr) * 2009-12-23 2011-06-29 F. Hoffmann-La Roche AG Système d'analyse et procédé informatique pour analyser les échantillons biologiques
WO2012015968A3 (fr) * 2010-07-27 2012-03-29 Bioarts International Appareil et procédé pour distribuer du matériel biologique
CN103366145A (zh) * 2013-07-01 2013-10-23 北京印刷学院 基于磁性编码与识别技术的样册生产防错检测方法与系统
DE102012107651A1 (de) * 2012-08-21 2014-02-27 Astrium Gmbh Verfahren zur Durchführung einer biochemischen Analyse, insbesondere im Weltraum
US8719053B2 (en) 2003-07-17 2014-05-06 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
CN107328635A (zh) * 2017-08-31 2017-11-07 东软安德医疗科技有限公司 体外诊断设备及其搅拌桨防撞装置
EP3246412A1 (fr) * 2016-05-17 2017-11-22 DName-iT NV Procédés d'identification d'échantillons
WO2017198742A1 (fr) * 2016-05-17 2017-11-23 Dname-It Nv Procédés d'identification d'échantillons
WO2017198830A1 (fr) * 2016-05-19 2017-11-23 Roche Diagnostics Gmbh Systèmes et procédés de repérage de dispositifis rfid
US10973226B2 (en) 2018-10-05 2021-04-13 TMRW Life Sciences, Inc. Apparatus to preserve and identify biological samples at cryogenic conditions
USD951481S1 (en) 2020-09-01 2022-05-10 TMRW Life Sciences, Inc. Cryogenic vial
USD963194S1 (en) 2020-12-09 2022-09-06 TMRW Life Sciences, Inc. Cryogenic vial carrier
US11607691B2 (en) 2019-10-29 2023-03-21 TMRW Life Sciences, Inc. Apparatus to facilitate transfer of biological specimens stored at cryogenic conditions
US11817187B2 (en) 2020-05-18 2023-11-14 TMRW Life Sciences, Inc. Handling and tracking of biological specimens for cryogenic storage
US12017227B2 (en) 2021-12-09 2024-06-25 TMRW Life Sciences, Inc. Specimen holder with wireless transponder for attachment to specimen collection body

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EP0974798A2 (fr) * 1998-07-20 2000-01-26 Liebherr-Hausgeräte Gmbh Congélateur
WO2001094016A1 (fr) * 2000-06-06 2001-12-13 Glaxo Group Limited Recipient d'echantillon a marqueur d'identification radiofrequence
DE20121738U1 (de) * 2001-10-08 2003-09-11 Mecadi Gmbh Chemicals Proc Identifizierbare Träger für parallelisierte Prozesse und Apparate dazu
WO2003061381A1 (fr) * 2002-01-22 2003-07-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Dispositif de stockage cryogenique pourvu d'un transpondeur

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8719053B2 (en) 2003-07-17 2014-05-06 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
US7860727B2 (en) 2003-07-17 2010-12-28 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
US8812329B2 (en) 2003-07-17 2014-08-19 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
WO2006130760A3 (fr) * 2005-05-31 2007-06-28 Smart Medical Technologies Llc Systemes de traçage et d'analyse d'echantillons medicaux et de donnees medicales
WO2006130760A2 (fr) * 2005-05-31 2006-12-07 Smart Medical Technologies, Llc Systemes de traçage et d'analyse d'echantillons medicaux et de donnees medicales
EP2339353A1 (fr) * 2009-12-23 2011-06-29 F. Hoffmann-La Roche AG Système d'analyse et procédé informatique pour analyser les échantillons biologiques
JP2011133476A (ja) * 2009-12-23 2011-07-07 F Hoffmann La Roche Ag 生体試料を分析するための分析システム及びコンピュータによって実行される方法
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WO2012015968A3 (fr) * 2010-07-27 2012-03-29 Bioarts International Appareil et procédé pour distribuer du matériel biologique
DE102012107651A1 (de) * 2012-08-21 2014-02-27 Astrium Gmbh Verfahren zur Durchführung einer biochemischen Analyse, insbesondere im Weltraum
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CN103366145A (zh) * 2013-07-01 2013-10-23 北京印刷学院 基于磁性编码与识别技术的样册生产防错检测方法与系统
EP3246412A1 (fr) * 2016-05-17 2017-11-22 DName-iT NV Procédés d'identification d'échantillons
WO2017198742A1 (fr) * 2016-05-17 2017-11-23 Dname-It Nv Procédés d'identification d'échantillons
WO2017198830A1 (fr) * 2016-05-19 2017-11-23 Roche Diagnostics Gmbh Systèmes et procédés de repérage de dispositifis rfid
CN107328635A (zh) * 2017-08-31 2017-11-07 东软安德医疗科技有限公司 体外诊断设备及其搅拌桨防撞装置
US10973226B2 (en) 2018-10-05 2021-04-13 TMRW Life Sciences, Inc. Apparatus to preserve and identify biological samples at cryogenic conditions
US11252956B2 (en) 2018-10-05 2022-02-22 TMRW Life Sciences, Inc. Apparatus to preserve and identify biological samples at cryogenic conditions
US11607691B2 (en) 2019-10-29 2023-03-21 TMRW Life Sciences, Inc. Apparatus to facilitate transfer of biological specimens stored at cryogenic conditions
US11817187B2 (en) 2020-05-18 2023-11-14 TMRW Life Sciences, Inc. Handling and tracking of biological specimens for cryogenic storage
USD951481S1 (en) 2020-09-01 2022-05-10 TMRW Life Sciences, Inc. Cryogenic vial
USD963194S1 (en) 2020-12-09 2022-09-06 TMRW Life Sciences, Inc. Cryogenic vial carrier
USD1002868S1 (en) 2020-12-09 2023-10-24 TMRW Life Sciences, Inc. Cryogenic vial carrier
US12017227B2 (en) 2021-12-09 2024-06-25 TMRW Life Sciences, Inc. Specimen holder with wireless transponder for attachment to specimen collection body

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