WO2005090568A3 - Promoter chain reaction - Google Patents

Promoter chain reaction Download PDF

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Publication number
WO2005090568A3
WO2005090568A3 PCT/GB2005/001113 GB2005001113W WO2005090568A3 WO 2005090568 A3 WO2005090568 A3 WO 2005090568A3 GB 2005001113 W GB2005001113 W GB 2005001113W WO 2005090568 A3 WO2005090568 A3 WO 2005090568A3
Authority
WO
WIPO (PCT)
Prior art keywords
chain reaction
promoter
promoter chain
genes
critically
Prior art date
Application number
PCT/GB2005/001113
Other languages
French (fr)
Other versions
WO2005090568A2 (en
Inventor
Stephen Dower
Eva Qwarnstrom
Endre Kiss-Toth
Original Assignee
Univ Sheffield
Stephen Dower
Eva Qwarnstrom
Endre Kiss-Toth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Sheffield, Stephen Dower, Eva Qwarnstrom, Endre Kiss-Toth filed Critical Univ Sheffield
Publication of WO2005090568A2 publication Critical patent/WO2005090568A2/en
Publication of WO2005090568A3 publication Critical patent/WO2005090568A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1086—Preparation or screening of expression libraries, e.g. reporter assays

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

We describe a method for the identification of genes that critically enhance or repress transcription from promoters that regulate typically but not exclusively, pro-inflammatory genes and including vectors used in said method.
PCT/GB2005/001113 2004-03-20 2005-03-17 Promoter chain reaction WO2005090568A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0406330.1 2004-03-20
GB0406330A GB0406330D0 (en) 2004-03-20 2004-03-20 Gene screen

Publications (2)

Publication Number Publication Date
WO2005090568A2 WO2005090568A2 (en) 2005-09-29
WO2005090568A3 true WO2005090568A3 (en) 2005-11-03

Family

ID=32118101

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2005/001113 WO2005090568A2 (en) 2004-03-20 2005-03-17 Promoter chain reaction

Country Status (2)

Country Link
GB (1) GB0406330D0 (en)
WO (1) WO2005090568A2 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026911A1 (en) * 1993-05-14 1994-11-24 Ohio University Edison Animal Biotechnology Institute A gene expression system utilizing an rna polymerase prebound to dna
WO1997041243A2 (en) * 1996-04-26 1997-11-06 University Of Pittsburgh A cytoplasmic gene expression system which utilizes a prokaryotic rna polymerase autogene
WO1998007876A2 (en) * 1996-08-16 1998-02-26 Medical Research Council Self-replicating episomal expression vectors conferring tissue-specific gene expression
WO1999031277A1 (en) * 1997-12-15 1999-06-24 Medical Science Systems, Inc. Expression cloning and single cell detection of phenotype
US5939285A (en) * 1995-03-23 1999-08-17 Institut National De La Recherche Scientifique Agronomique (Inra) Method for regulating the expression of a gene in a baculovirus using a retinoic acid receptor binding site and vector therefor
WO2002053743A2 (en) * 2001-01-08 2002-07-11 Interleukin Genetics, Inc. Mammalian tribbles signaling pathways and methods and reagents related thereto

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026911A1 (en) * 1993-05-14 1994-11-24 Ohio University Edison Animal Biotechnology Institute A gene expression system utilizing an rna polymerase prebound to dna
US5939285A (en) * 1995-03-23 1999-08-17 Institut National De La Recherche Scientifique Agronomique (Inra) Method for regulating the expression of a gene in a baculovirus using a retinoic acid receptor binding site and vector therefor
WO1997041243A2 (en) * 1996-04-26 1997-11-06 University Of Pittsburgh A cytoplasmic gene expression system which utilizes a prokaryotic rna polymerase autogene
WO1998007876A2 (en) * 1996-08-16 1998-02-26 Medical Research Council Self-replicating episomal expression vectors conferring tissue-specific gene expression
WO1999031277A1 (en) * 1997-12-15 1999-06-24 Medical Science Systems, Inc. Expression cloning and single cell detection of phenotype
WO2002053743A2 (en) * 2001-01-08 2002-07-11 Interleukin Genetics, Inc. Mammalian tribbles signaling pathways and methods and reagents related thereto

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KISS-TOTH E ET AL: "A novel mammalian expression screen exploiting green fluorescent protein-based transcription detection in single cells", JOURNAL OF IMMUNOLOGICAL METHODS, vol. 239, no. 1-2, 26 May 2000 (2000-05-26), pages 125 - 135, XP002342511, ISSN: 0022-1759 *
ZHANG LIQUN ET AL: "Molecular engineering of a two-step transcription amplification (TSTA) system for transgene delivery in prostate cancer.", MOLECULAR THERAPY : THE JOURNAL OF THE AMERICAN SOCIETY OF GENE THERAPY. MAR 2002, vol. 5, no. 3, March 2002 (2002-03-01), pages 223 - 232, XP002342512, ISSN: 1525-0016 *

Also Published As

Publication number Publication date
WO2005090568A2 (en) 2005-09-29
GB0406330D0 (en) 2004-04-21

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