WO2005087275A3 - Metal radiolabeled pet imaging agents - Google Patents

Metal radiolabeled pet imaging agents Download PDF

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Publication number
WO2005087275A3
WO2005087275A3 PCT/US2005/007686 US2005007686W WO2005087275A3 WO 2005087275 A3 WO2005087275 A3 WO 2005087275A3 US 2005007686 W US2005007686 W US 2005007686W WO 2005087275 A3 WO2005087275 A3 WO 2005087275A3
Authority
WO
WIPO (PCT)
Prior art keywords
pet imaging
nitroimidazole
radioisotope
radiolabeled
agents
Prior art date
Application number
PCT/US2005/007686
Other languages
French (fr)
Other versions
WO2005087275A2 (en
Inventor
K S Clifford Chao
David J Yang
Original Assignee
Univ Texas
K S Clifford Chao
David J Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, K S Clifford Chao, David J Yang filed Critical Univ Texas
Publication of WO2005087275A2 publication Critical patent/WO2005087275A2/en
Publication of WO2005087275A3 publication Critical patent/WO2005087275A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers

Abstract

The invention relates to radiolabeled PET agents including a radioisotope, a chelator and a specific ligand. The radioisotope may include 60Cu, 62Cu, 61Cu, 64Cu and 68Ga. Generator-produced 68Ga radioisotopes may be used. Specific chelators include N2S2 moieties and N3S moieties. Specific ligands may include purine and pyrimidine bases, particularly adenine and guanine, a sugar-containing base, particularly glucosamine, galactosamine, or mannosamine, or a nitroimidazole analogue, such as a 2-nitroimidazole or a 5-nitroimidazole, particularly metronidazole. Radiolabeled agents may be formed by first forming a chelator-ligand complex, which may be stored until it is needed, at which time the radioisotope may be added. Radiolabeled agents may be used in traditional PET imaging or in dynamic PET imaging.
PCT/US2005/007686 2004-03-11 2005-03-09 Metal radiolabeled pet imaging agents WO2005087275A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55224404P 2004-03-11 2004-03-11
US55266104P 2004-03-11 2004-03-11
US60/552,244 2004-03-11
US60/552,661 2004-03-11

Publications (2)

Publication Number Publication Date
WO2005087275A2 WO2005087275A2 (en) 2005-09-22
WO2005087275A3 true WO2005087275A3 (en) 2006-06-08

Family

ID=34964778

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/007686 WO2005087275A2 (en) 2004-03-11 2005-03-09 Metal radiolabeled pet imaging agents

Country Status (1)

Country Link
WO (1) WO2005087275A2 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8388977B2 (en) 2001-05-02 2013-03-05 Purdue Research Foundation Diagnosis of macrophage mediated disease
US8795633B2 (en) 2005-09-23 2014-08-05 Purdue Research Foundation Multiphoton in vivo flow cytometry method and device
US8858914B2 (en) 2002-02-07 2014-10-14 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
US8865128B2 (en) 2002-02-07 2014-10-21 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
US8961926B2 (en) 2007-05-25 2015-02-24 Purdue Research Foundation Method of imaging localized infections
US9180215B2 (en) 2007-02-07 2015-11-10 Purdue Research Foundation Positron emission tomography imaging method
US9279813B2 (en) 2006-11-03 2016-03-08 Purdue Research Foundation Ex vivo flow cytometry method and device

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602004017452D1 (en) 2003-05-30 2008-12-11 Purdue Research Foundation DIAGNOSTIC PROCEDURE FOR ATHEROSCLEROSIS
WO2006071754A2 (en) * 2004-12-23 2006-07-06 Purdue Research Foundation Positron emission tomography imaging method
WO2007006041A2 (en) 2005-07-05 2007-01-11 Purdue Research Foundation Imaging and therapeutic method using monocytes
CN101721720B (en) * 2008-10-29 2011-08-24 阮建评 Nitroimidazole-amino acid compound nuclide hypoxic contrast agent and precursor thereof

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2000043004A1 (en) * 1999-01-26 2000-07-27 Fox Chase Cancer Center 1,4,8,11-tetraazacyclotetradecane derivatives as radiodiganostic agents and their use in determining hypoxia and radioresistance of tumors
WO2001091807A2 (en) * 2000-06-02 2001-12-06 Board Of Regents Ethylenedicysteine (ec)-drug conjugates
WO2004044227A2 (en) * 2002-11-07 2004-05-27 Board Of Regents, The University Of Texas System Ethylenedicysteine (ec)-drug conjugates, compositions and methods for tissue specific disease imaging

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000043004A1 (en) * 1999-01-26 2000-07-27 Fox Chase Cancer Center 1,4,8,11-tetraazacyclotetradecane derivatives as radiodiganostic agents and their use in determining hypoxia and radioresistance of tumors
WO2001091807A2 (en) * 2000-06-02 2001-12-06 Board Of Regents Ethylenedicysteine (ec)-drug conjugates
WO2004044227A2 (en) * 2002-11-07 2004-05-27 Board Of Regents, The University Of Texas System Ethylenedicysteine (ec)-drug conjugates, compositions and methods for tissue specific disease imaging

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GOODWIN D A ET AL: "Rapid synthesis and quality control of <68>Ga-labeled chelates for clinical use", NUCLEAR MEDICINE AND BIOLOGY 1994 UNITED KINGDOM, vol. 21, no. 6, 1994, pages 897 - 899, XP002351672, ISSN: 0969-8051 *
HENZE M ET AL: "PET imaging of somatostatin receptors using [68GA]DOTA-D-Phe1-Tyr3-Octreotide: first results in patients with meningiomas", JOURNAL OF NUCLEAR MEDICINE, NEW YORK, NY, US, vol. 42, no. 7, July 2001 (2001-07-01), pages 1053 - 1056, XP002245466, ISSN: 0161-5505 *
HEPPELER A ET AL: "RECEPTOR TARGETING FOR TUMOR LOCALISATION AND THERAPY WITH RADIOPETIDES", CURRENT MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS BV, BE, vol. 7, no. 9, 2000, pages 971 - 994, XP000982225, ISSN: 0929-8673 *
HOFMANN M ET AL: "Biokinetics and imaging with the somatostatin receptor PET radioligand <68>Ga-DOTATOC: Preliminary data", EUROPEAN JOURNAL OF NUCLEAR MEDICINE 2001 GERMANY, vol. 28, no. 12, 2001, pages 1751 - 1757, XP002351670, ISSN: 0340-6997 *
PAGANI M ET AL: "Alternative positron emission tomography with non-conventional positron emitters: Effects of their physical properties on image quality and potential clinical applications", EUROPEAN JOURNAL OF NUCLEAR MEDICINE 1997 GERMANY, vol. 24, no. 10, 1997, pages 1301 - 1327, XP002351671, ISSN: 0340-6997 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8388977B2 (en) 2001-05-02 2013-03-05 Purdue Research Foundation Diagnosis of macrophage mediated disease
US8916167B2 (en) 2001-05-02 2014-12-23 Purdue Research Foundation Treatment and diagnosis of macrophage mediated disease
US8858914B2 (en) 2002-02-07 2014-10-14 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
US8865128B2 (en) 2002-02-07 2014-10-21 Endocyte, Inc. Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology
US8795633B2 (en) 2005-09-23 2014-08-05 Purdue Research Foundation Multiphoton in vivo flow cytometry method and device
US9279813B2 (en) 2006-11-03 2016-03-08 Purdue Research Foundation Ex vivo flow cytometry method and device
US9180215B2 (en) 2007-02-07 2015-11-10 Purdue Research Foundation Positron emission tomography imaging method
US8961926B2 (en) 2007-05-25 2015-02-24 Purdue Research Foundation Method of imaging localized infections

Also Published As

Publication number Publication date
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