GR1004637B - Synthesis, biological and preclinical evaluation of neurotensin (7-13) analogs modified with 1,4,8,11-tetraazaundecane derivatives and labeled with technetium-99m (or other technetium readionuclide) or/and rhenium-188 (or other rhenium radionuclide) for a application in oncology - Google Patents
Synthesis, biological and preclinical evaluation of neurotensin (7-13) analogs modified with 1,4,8,11-tetraazaundecane derivatives and labeled with technetium-99m (or other technetium readionuclide) or/and rhenium-188 (or other rhenium radionuclide) for a application in oncologyInfo
- Publication number
- GR1004637B GR1004637B GR20030100167A GR2003100167A GR1004637B GR 1004637 B GR1004637 B GR 1004637B GR 20030100167 A GR20030100167 A GR 20030100167A GR 2003100167 A GR2003100167 A GR 2003100167A GR 1004637 B GR1004637 B GR 1004637B
- Authority
- GR
- Greece
- Prior art keywords
- technetium
- rhenium
- tetraazaundecane
- neurotensin
- derivatives
- Prior art date
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
he invention includes description of the synthesis of neurotensin(7-13) analogs, coupled to 1,4,8,11-tetraazaundecane derivatives to enable labeling with technetium-99m (or other technetium radionuclides) and/or rhenium-188 (or other rhenium radionuclides) aiming toward their application in the targeted diagnostic imaging and staging of NTS-1-R-positive neoplasms in man employing SPECT (technetium-99m etc.) or PET (technetium-94m etc.) technology, or eventually in targeted radioendotherapy (rhenium-188 etc.). In addition, the method for labeling neurotensin (7-13) analogs modified with 1,4,8,11-tetraazaundecane derivatives with technetium-99m (or other technetium radionuclides) and/or rhenium-188 (or other rhenium radionuclides) is described. The invention includes also the radiochemical evaluation of the radiolabeled peptide analogs obtained from the above steps. Eventually, the invention includes detailed preclinical biological evaluation of the above analogs: - in NTS1-R positive cell lines - experimental animal models and study of their metabolism.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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GR20030100167A GR1004637B (en) | 2003-04-04 | 2003-04-04 | Synthesis, biological and preclinical evaluation of neurotensin (7-13) analogs modified with 1,4,8,11-tetraazaundecane derivatives and labeled with technetium-99m (or other technetium readionuclide) or/and rhenium-188 (or other rhenium radionuclide) for a application in oncology |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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GR20030100167A GR1004637B (en) | 2003-04-04 | 2003-04-04 | Synthesis, biological and preclinical evaluation of neurotensin (7-13) analogs modified with 1,4,8,11-tetraazaundecane derivatives and labeled with technetium-99m (or other technetium readionuclide) or/and rhenium-188 (or other rhenium radionuclide) for a application in oncology |
Publications (1)
Publication Number | Publication Date |
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GR1004637B true GR1004637B (en) | 2004-07-23 |
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Family Applications (1)
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GR20030100167A GR1004637B (en) | 2003-04-04 | 2003-04-04 | Synthesis, biological and preclinical evaluation of neurotensin (7-13) analogs modified with 1,4,8,11-tetraazaundecane derivatives and labeled with technetium-99m (or other technetium readionuclide) or/and rhenium-188 (or other rhenium radionuclide) for a application in oncology |
Country Status (1)
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GR (1) | GR1004637B (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1181936A1 (en) * | 2000-05-25 | 2002-02-27 | N.C.S.R. "DEMOKRITOS"-Institute of Radioisotopes & Radiodiagnostic Products | Synthesis, biological and preclinical evaluation of (D-Phe6,Leu-NHEt13,des-Met14)bombesin(6-14) analogs modified with 1,4,8,11-tetraazaundecane derivatives and labeled with technetium-99m for application in oncology |
US20020155064A1 (en) * | 1997-02-03 | 2002-10-24 | Jean-Claude Reubi | Method for detection and localization of malignant human tumours |
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2003
- 2003-04-04 GR GR20030100167A patent/GR1004637B/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020155064A1 (en) * | 1997-02-03 | 2002-10-24 | Jean-Claude Reubi | Method for detection and localization of malignant human tumours |
EP1181936A1 (en) * | 2000-05-25 | 2002-02-27 | N.C.S.R. "DEMOKRITOS"-Institute of Radioisotopes & Radiodiagnostic Products | Synthesis, biological and preclinical evaluation of (D-Phe6,Leu-NHEt13,des-Met14)bombesin(6-14) analogs modified with 1,4,8,11-tetraazaundecane derivatives and labeled with technetium-99m for application in oncology |
Non-Patent Citations (1)
Title |
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GARCÍA-GARAYOA ELISA ET AL: "Preclinical evaluation of a new, stabilized neurotensin(8--13) pseudopeptide radiolabeled with (99m)tc.", JOURNAL OF NUCLEAR MEDICINE : OFFICIAL PUBLICATION, SOCIETY OF NUCLEAR MEDICINE. MAR 2002, vol. 43, no. 3, March 2002 (2002-03-01), pages 374 - 383, XP002262249, ISSN: 0161-5505 * |
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