WO2005086568A3 - Anticorps anti-icam 1 humains et utilisations de ceux-ci - Google Patents
Anticorps anti-icam 1 humains et utilisations de ceux-ci Download PDFInfo
- Publication number
- WO2005086568A3 WO2005086568A3 PCT/IB2005/002041 IB2005002041W WO2005086568A3 WO 2005086568 A3 WO2005086568 A3 WO 2005086568A3 IB 2005002041 W IB2005002041 W IB 2005002041W WO 2005086568 A3 WO2005086568 A3 WO 2005086568A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antibodies
- icam
- binding regions
- disorders associated
- role
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53849904P | 2004-01-26 | 2004-01-26 | |
US60/538,499 | 2004-01-26 | ||
US57294804P | 2004-05-21 | 2004-05-21 | |
US60/572,948 | 2004-05-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005086568A2 WO2005086568A2 (fr) | 2005-09-22 |
WO2005086568A3 true WO2005086568A3 (fr) | 2006-05-04 |
Family
ID=34976014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2005/002041 WO2005086568A2 (fr) | 2004-01-26 | 2005-01-26 | Anticorps anti-icam 1 humains et utilisations de ceux-ci |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2005086568A2 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0525214D0 (en) | 2005-12-12 | 2006-01-18 | Bioinvent Int Ab | Biological materials and uses thereof |
US20100168392A1 (en) * | 2007-08-10 | 2010-07-01 | Wacker Chemie Ag | Expression of full length igg and secretion into the culture medium of prokaryotic cells |
US8026343B2 (en) | 2008-08-08 | 2011-09-27 | Dinona Inc. | Antibody modulating the differentiation and function of dendritic cells via binding intercellular adhesion molecule-1 and use thereof |
US8623369B2 (en) * | 2010-04-27 | 2014-01-07 | National Research Council Of Canada | Anti-ICAM-1 single domain antibody and uses thereof |
WO2011160078A2 (fr) * | 2010-06-17 | 2011-12-22 | The Johns Hopkins University | Utilisation de régions variables de chaîne lourde variable dérivées de camélidés ciblant cd18 et icam-1 en tant que microbicide pour prévenir la transmission de vih-1 |
KR101434029B1 (ko) * | 2012-09-14 | 2014-08-26 | 서울대학교산학협력단 | Icam-1에 대한 항체 및 그 용도 |
TWI781108B (zh) * | 2016-07-20 | 2022-10-21 | 比利時商健生藥品公司 | 抗gprc5d抗體、結合gprc5d與cd3之雙特異性抗原結合分子及其用途 |
WO2018204976A1 (fr) * | 2017-05-09 | 2018-11-15 | The Council Of The Queensland Institute Of Medical Research | Agents anti-inflammatoires et méthodes de traitement |
KR102063341B1 (ko) * | 2018-12-31 | 2020-01-07 | 다이노나(주) | Icam-1에 특이적으로 결합하는 항체 및 그의 용도 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003035696A2 (fr) * | 2001-07-19 | 2003-05-01 | Perlan Therapeutics, Inc. | Anticorps humanises |
-
2005
- 2005-01-26 WO PCT/IB2005/002041 patent/WO2005086568A2/fr active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003035696A2 (fr) * | 2001-07-19 | 2003-05-01 | Perlan Therapeutics, Inc. | Anticorps humanises |
Non-Patent Citations (9)
Title |
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BELLA JORDI ET AL: "The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 95, no. 8, 14 April 1998 (1998-04-14), pages 4140 - 4145, XP002368956, ISSN: 0027-8424 * |
BOEHNCKE W -H ET AL: "Efficacy of the fully human monoclonal antibody MOR102 (#5) against intercellular adhesion molecule 1 in the psoriasis-severe combined immunodeficient mouse model", BRITISH JOURNAL OF DERMATOLOGY, vol. 153, no. 4, October 2005 (2005-10-01), pages 758 - 766, XP002368881, ISSN: 0007-0963 * |
BOEHNCKE W -H ET AL: "Efficacy of the fully human monoclonal antibody MOR102 against ICAM-1 in the psoriasis SCID mouse model", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 123, no. 2, August 2004 (2004-08-01), & 34TH ANNUAL MEETING OF THE EUROPEAN SOCIETY FOR DERMATOLOGICAL RESEARCH (ESDR); VIENNA, AUSTRIA; SEPTEMBER 09-11, 2004, XP009061702, ISSN: 0022-202X * |
CASALI P ET AL: "Probing the human B-cell repertoire with EBV: polyreactive antibodies and CD5+ B lymphocytes.", ANNUAL REVIEW OF IMMUNOLOGY. 1989, vol. 7, 1989, pages 513 - 535, XP009061721, ISSN: 0732-0582 * |
FRISCH C ET AL: "From EST to IHC: human antibody pipeline for target research", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 275, no. 1-2, 1 April 2003 (2003-04-01), pages 203 - 212, XP004416756, ISSN: 0022-1759 * |
KELLERMANN SIRID AIME ET AL: "Antibody discovery: the use of transgenic mice to generate human monoclonal antibodies for therapeutics", CURRENT OPINION IN BIOTECHNOLOGY, LONDON, GB, vol. 13, no. 6, December 2002 (2002-12-01), pages 593 - 597, XP002293544, ISSN: 0958-1669 * |
KNAPPIK A ET AL: "Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 296, no. 1, 11 February 2000 (2000-02-11), pages 57 - 86, XP004461525, ISSN: 0022-2836 * |
KREBS B ET AL: "High-throughput generation and engineering of recombinant human antibodies", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 254, no. 1-2, 1 August 2001 (2001-08-01), pages 67 - 84, XP004245443, ISSN: 0022-1759 * |
LUO G X ET AL: "Humanization of an anti-ICAM-1 antibody with over 50-fold affinity and functional improvement", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 275, no. 1-2, 1 April 2003 (2003-04-01), pages 31 - 40, XP004416747, ISSN: 0022-1759 * |
Also Published As
Publication number | Publication date |
---|---|
WO2005086568A2 (fr) | 2005-09-22 |
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