WO2005084736A2 - Pulverisateur destine a la delivrance d'une dose de matieres pulverisables, notamment a l'application de principes actifs pharmaceutiques pulverulents - Google Patents

Pulverisateur destine a la delivrance d'une dose de matieres pulverisables, notamment a l'application de principes actifs pharmaceutiques pulverulents Download PDF

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Publication number
WO2005084736A2
WO2005084736A2 PCT/EP2005/002343 EP2005002343W WO2005084736A2 WO 2005084736 A2 WO2005084736 A2 WO 2005084736A2 EP 2005002343 W EP2005002343 W EP 2005002343W WO 2005084736 A2 WO2005084736 A2 WO 2005084736A2
Authority
WO
WIPO (PCT)
Prior art keywords
ring
actuating
shaft
tank
toothing
Prior art date
Application number
PCT/EP2005/002343
Other languages
German (de)
English (en)
Other versions
WO2005084736A3 (fr
Inventor
Ludwig Giebel
Freddy Metzmann
Original Assignee
Friedrich Sanner Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Friedrich Sanner Gmbh & Co. Kg filed Critical Friedrich Sanner Gmbh & Co. Kg
Publication of WO2005084736A2 publication Critical patent/WO2005084736A2/fr
Publication of WO2005084736A3 publication Critical patent/WO2005084736A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0073—Mechanical counters having a display or indicator on a ring
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/04—Design features of general application for driving the stage of lowest order
    • G06M1/045—Design features of general application for driving the stage of lowest order for dial, pointer, or similar type indicating means
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06M—COUNTING MECHANISMS; COUNTING OF OBJECTS NOT OTHERWISE PROVIDED FOR
    • G06M1/00—Design features of general application
    • G06M1/08—Design features of general application for actuating the drive
    • G06M1/083—Design features of general application for actuating the drive by mechanical means

Definitions

  • Spray device for the metered delivery of sprayable substances, in particular for the application of non-powdered pharmaceutical active substances
  • the invention relates to a spray device for the metered delivery of sprayable substances, in particular a spray inhalation device for the application of active pharmaceutical ingredients, with a hollow mouthpiece provided with a delivery opening, at the end of which is opposite the delivery opening, preferably a hollow shaft is attached via a hollow angle piece, in which a with the sprayable substance and a propellant filled tank can be used axially displaceably, which is provided with a metering valve which can be actuated by axially displacing a dispensing tube protruding from an end face of the tank into the interior of the tank.
  • Sprayers for metered delivery Fabrics in which a predetermined amount of a substance to be sprayed is released during the actuation stroke have been developed for a wide variety of applications.
  • Spray devices used as spray inhalation devices may be mentioned here as an example.
  • Such inhalers have been used for many years to treat or alleviate acute symptoms of respiratory diseases such as asthma, emphysema and chronic bronchitis.
  • the inhalation devices are designed in such a way that with each actuation stroke, a predetermined dose of the active ingredient can be introduced directly into the airways as a spray. Due to the comparatively small dimensions of the devices, these can be carried by the patient at all times so that they can be used immediately in the event of an impending acute attack of shortness of breath. It is unsatisfactory that in the known devices the residual amount of the active ingredient still contained in the active ingredient tank is difficult to estimate.
  • the invention is based on the object of creating a possibility of precisely monitoring the emptying of the active substance tank of the spraying devices in question, which ensures that the user is reliably informed when the active substance supply in the device is running low, that a further metered spray function is no longer guaranteed with certainty.
  • the function display should be so reliable that an early replacement of the active ingredient supply or the entire sprayer is not necessary for reasons of caution.
  • this object is achieved according to the invention in that a counter is provided for the number of actuation strokes of the tank, which inevitably causes an axial relative displacement of the tank in the shaft into a rotation of a for the purpose of dispensing sprayable material Indicator ring arranged to rotate in the circumferential direction by a predetermined angle of rotation, that in the area of the indicator ring in the device a display window is provided, through which a portion of the outside of the indicator ring can be observed, and that the area of the outside of the indicator ring that is used when spraying of the tank, starting from the filled tank until the tank is completely emptied, is successively visible in the display window, and the information that characterizes the respective remaining fill quantity of the sprayable substance in the tank is provided.
  • the configuration can advantageously be such that the shaft which axially displaceably accommodates the tank at its open end facing away from the mouthpiece with a cover which engages on the bottom of the tank and is guided axially displaceably together with the tank by an amount corresponding to the actuation stroke of the tank! - or plug-like actuator is closed.
  • the actuating element is expediently secured on or in the shaft against non-destructive dismantling.
  • An embodiment is advantageous in which the mouthpiece, the possibly provided angle piece and the shaft are connected to one another to form an indissolubly fixed unit.
  • the mouthpiece can be connected to the optionally provided angle piece or the metering valve-side end region of the shaft in a non-destructive manner and detachably connected to the bar.
  • the end of the tank on the metering valve side is expediently held in the shaft, even when the mouthpiece is removed, so that it cannot be removed from the shaft.
  • the configuration is such that the actuating element receiving the counter has an upper housing part and a lower housing part, which in the assembled state form a closed actuating housing that is provided with the display window in a partial area of its peripheral wall that the actuating housing in the shaft is non-rotatably but longitudinally displaceably mounted in the shaft, that the indicator ring, which is rotatably mounted in the actuating housing, is provided on its inner side facing away from the window with a toothing forming part of the counter mechanism, with which a toothing of a rotatably mounted gearwheel meshes, and that the gearwheel with a locking mechanism is coupled, which the indicator ring during an actuation stroke of the actuation housing directed into the shaft by one of the sprays specified by a single actuation of the metering valve
  • the dose of the sprayable substance is rotated by the corresponding angle, but is locked against turning back during the subsequent return stroke of the actuating housing.
  • the configuration is such that the indicator ring is connected in a rotationally fixed manner to the outer edge region of a disk-shaped adjusting ring, which is rotatably mounted in the end walls of the upper housing part or lower housing part by means of bearing journals protruding from its opposite flat sides, and that on the underside of the edge area of the adjusting ring there is a ring of locking teeth, each with a first tooth flank that projects essentially at right angles and radially from the underside of the adjusting ring and a second, in contrast, ramp-like, oblique tooth flank, in the interstices of which one after the other one stroke from the top of a coaxial to each actuation stroke Adjusting ring rotatably mounted in the actuating housing, resiliently springing parallel to the longitudinal direction of the shaft, but in the setting ring circumferential direction of the lever arm designed to be rigid matures.
  • the drive of the indicator ring can be realized in such a way that on the underside of the lever arm opposite the pawl there is a projection provided at its downward-facing free end with a ramp surface which slopes obliquely in the circumferential direction and which in the unactuated state of the bed tigurig element above the upper End of a rib protruding in the longitudinal direction of the shaft from the inner wall of the shaft through a recess in the lower housing part into the actuating element, so that the ramp surface runs against the upper end of the rib during the actuating stroke and transmits a radial component of motion to the lever arm due to the slope of the ramp surface, and that on the lever arm, on the other hand, a spring supported on the lower housing part is provided, which is tensioned by the radial movement component of the lever arm in the sense of a backward rotation of the lever arm.
  • rotation of the actuating element in the shaft is prevented in that the peripheral wall of the actuating element in the area accommodated within the shaft has at least one projection which projects into an associated recess in the inner wall of the shaft and which defines the actuating element relative to the
  • the shaft is non-rotatable in the circumferential direction, but is or can be displaced in the actuating direction by the amount of the actuating stroke.
  • At least two, preferably three or more, projections on the actuating element and associated depressions in the inner wall of the shaft are preferably offset in the circumferential direction.
  • the rear boundary edges of the projections and the depressions are designed so that they are secured against disassembly in a non-actuated state by positive locking against each other are.
  • a return safety device is expediently provided, which is designed in such a way that an essentially tangential resilient tongue is provided in the lower part of the actuating element below the ring of ratchet teeth, of which a radially extending free end
  • the ratchet tooth engages in the spaces formed between the ratchet teeth on the underside of the adjusting ring, the ratchet tooth protruding from the resilient tongue having a ram extending complementarily obliquely to the inclined ramp surfaces of the adjusting ring ratchet teeth.
  • Pen surface and a tooth flank projecting substantially perpendicularly from the tongue is provided.
  • Fig. 1 shows a first embodiment l of a spray device according to the invention, wherein
  • 1a is a perspective view of the first embodiment
  • FIG. 1 b is a vertical longitudinal central section through the embodiment shown in FIG. 1 a,
  • 1c shows a partially sectioned perspective view of the upper end of the shaft for receiving the active substance tank with the counter arranged there,
  • FIG. 1d shows a perspective view of the functional parts of the counter in a position rotated counterclockwise by approximately 90 ° with respect to the illustration according to FIG. 1c;
  • Fig. 2 shows a second embodiment II of a spray device according to the invention, wherein
  • FIG. 2c is a partially sectioned perspective view of the lower transition area of the shaft receiving the counter into the mouthpiece of the exemplary embodiment on an enlarged scale
  • Fig. 2d is a perspective view of the part of the counter housing and the associated actuating ring of the embodiment
  • Figure 2e shows a perspective view of the housing shown in Figure 2d without the actuation ring
  • Fig. 3 shows a third embodiment III of a spray device according to the invention, wherein
  • 3a is a perspective view of the third embodiment
  • 3b is a sectional perspective view of the lower transition region of the shaft receiving the counter into the mouthpiece on an enlarged scale in a position rotated relative to the illustration according to FIG. 3a,
  • FIG. 3c is a perspective view corresponding to FIG. 3b, in which the parts of the counter are not cut, and
  • Fig. 3d shows the functional parts of the counter of the third embodiment
  • Fig. 4 shows a fourth embodiment IV of a spray device according to the invention, wherein
  • Fig. 4c is a partially sectioned perspective view of the transition area receiving the counter of Shaft to mouthpiece of the exemplary embodiment on an enlarged scale
  • 4d shows four perspective representations of functional parts of the counter in different viewing directions and different positions
  • Fig. 5 shows a fifth embodiment V of a spray device according to the invention, wherein
  • 5a is a perspective view of the fifth embodiment
  • 5c shows a sectional perspective view of the transition region of the shaft and mouthpiece of the exemplary embodiment which accommodates the counter, on an enlarged scale
  • FIG. 5d shows a view corresponding to FIG. 5c in a different position of the functional parts of the counter.
  • Fig. 6 shows a sixth preferred embodiment VI of a spray device according to the invention, wherein
  • ⁇ a is a perspective view of embodiment VI
  • 6b is a perspective view of the actuating element
  • 6c is a perspective view of the upper end of the shaft, in which the actuating element according to FIG. 6b is used
  • 6d is a perspective view of the lower part of the actuating element with an inserted part of a drive mechanism for an adjusting spring component forming an indicator ring, which is shown separately in addition to the lower part.
  • FIG. 6e is a perspective view of the actuating spring component according to FIG. 6d with further parts of the drive mechanism forming gear elements,
  • 6f is a perspective view of the upper end of the shaft of the sprayer with the actuating element mounted, cut in a vertical central plane,
  • FIG. 6g shows a subassembly of the actuating element comprising the parts of the drive mechanism shown in FIGS. 6d and 6e in a perspective partial sectional view with the cut shown in FIG. 6d by the arrows 6g-6g,
  • FIG. 6h shows an uncut perspective view corresponding to the view according to FIG. 6g, in which the indicator ring of the drive mechanism is additionally shown;
  • FIG. 6i shows a perspective view corresponding to FIG. 6a, in which the actuating element is shown in the unassembled state above the shaft even before the active substance tank is inserted into the shaft.
  • the spraying devices - known per se - to be provided with a counter in the manner according to the invention consist of a hollow mouthpiece a which can be inserted into the mouth of a user and at the opposite end of which can be inserted into the mouth
  • a hollow cylindrical shaft c is attached, at least over the greater part of its length, in the mouth piece facing away from it open end an active substance tank d filled with an active substance and a propellant can be used.
  • a spray tube of the active substance tank engages in a suitable outlet bore, which is pushed back into the active substance tank when it is pressed and thereby opens a metering valve (not shown) , which allows a predetermined amount of the active ingredient to pass into the mouthpiece in the form of a spray.
  • the counter is placed on top of the active ingredient tank d in the shaft c.
  • the length of the shaft c makes it almost impossible to operate the inhalation device without a counter with one hand, since the active substance tank d is recessed in the shaft c.
  • the counter is a preassembled unit, which is snapped into the shaft and can be moved down and back up during operation with the active ingredient tank in the shaft.
  • the counter consists of the following parts: housing 101, indicator ring 102, cover 103, spring element 104, Rocker 105, and holding element for rocker 106, the housing 101 and the cover 103 enclose all other parts of the counter, so that the rocker 105 can rotate about a horizontal axis 111. Rotation of the indicator ring 102 is possible when the inhalation device is actuated.
  • the spring element is pre-tensioned at the factory to enable the indicator ring to be rotated through 360 °.
  • the outer tooth 109 of the rocker 105 which is always hooked into the toothing of the indicator ring 102 in the idle state, is unhooked, and the inner tooth 110 is almost directly
  • the counter is placed at the bottom of the elbow b under the agent tank d.
  • the display is just above the transition between elbow b and shaft c.
  • the length of the shaft c makes it almost impossible to operate the counter with a finger, since the counter lies within the angle piece b
  • the counter is a preassembled unit, which is snapped into the contra-angle handpiece and is initiated during operation by pressing down the active substance tank.
  • the counter consists of the following parts: bezel 201, indicator ring 202, cover 203, spring element 204, actuating ring 205, and frame part or housing 206.
  • Axial fastening of the bezel is provided in shaft 207, so that bezel 201 holds indicator ring 202 visually - with the exception of the display window 209 - fades out. Rotation of the indicator ring 202 is possible when the inhalation device is actuated.
  • the actuating ring 205 is also pressed down and a resilient nose 210 on the actuating ring is pressed in laterally and radially from a 3-dimensional link 211 in the frame part or housing 206.
  • the link 211 allows the resilient nose 210 to relax in the radial direction, so that only the lateral tension is maintained.
  • Embodiment III The counter is placed at the bottom of the elbow b under the agent tank d.
  • the display takes place through a window in the elbow b. Due to the length of the shaft c, operation of the counter with the finger is almost impossible, since the counter is located in the angle piece b below.
  • the counter is a preassembled unit, which is snapped into the contra-angle and is initiated by pressing down the active substance tank during operation.
  • the counter consists of the following parts: indicator ring 301, unrest 302, actuation ring 303, and frame part or housing 304.
  • the housing contains all other parts of the counter, the indicator ring 301 being about the vertical axis when the inhaler is actuated and the unrest 302 being one horizontal axis 310 can rotate, and the actuating ring 303 is guided vertically.
  • the actuation ring 303 is also pressed down and a spring arm 305 on the unrest 302 is bent by a nose 306 on the actuation ring 303.
  • the restlessness 302 is tipped over, so that a tooth 307 engaging in the idle state unhooks from the toothing 308 of the indicator ring 301, and a spring tooth 309 is pressed into the toothing 308 of the indicator ring 301.
  • This spring tooth 309 is bent when the restlessness tips over, whereby it rotates the indicator ring 301 by one tooth.
  • the counter is placed at the bottom of the elbow b under the agent tank d.
  • the display takes place through a window in the elbow b. Due to the length of the shaft c, operation of the counter with the finger is almost impossible, since the counter is located in the angle piece b below.
  • the counter is a preassembled unit, which snaps into the elbow b and is initiated during operation by pressing down the active substance tank d.
  • the counter consists of the following parts: indicator ring 401, actuation ring 402, translation ring 403, and frame part or housing 404.
  • the indicator ring 401 and the translation ring 403 are fixedly mounted in the housing 404, the indicator ring being able to rotate about the vertical axis and the translation ring 403 about a horizontal axis 405, so that it behaves like a seesaw.
  • a spring tooth 412 on the frame part 404 functions as a ratchet to prevent the indicator ring 401 from turning back
  • the counter is placed at the bottom of the elbow b under the agent tank d.
  • the display is shown through a vertical window in the contra-angle handpiece.
  • the length of the shaft makes it almost impossible to operate the counter with your finger, since the counter is located in the contra-angle handpiece below.
  • the counter is a preassembled unit, which snaps into the elbow b and is initiated during operation by pressing down the active substance tank d.
  • the counter consists of the following parts: mounting ring 501, initiation ring 502, indicator ring 503, and frame part or housing 504.
  • the frame part 504 is snapped into the angle piece so that it cannot twist.
  • the other parts hang on the active substance tank d, the fastening ring 501 being snapped directly around the crimp 505 of the active substance tank.
  • the initiation ring 502 can rotate about the fastening ring 501.
  • the indicator ring 503 can also be rotated by the initiation ring 502 when the inhalation device is actuated.
  • the fastening ring 501, the initiation ring 502 and the indicator ring 503 are also pressed down, friction points 508 running onto the indicator ring 503 on the inside of the housing 504.
  • the indicator ring remains slightly behind, the lower toothing 509 of the indicator ring 503 is unhooked from the toothing 510 of the fastening ring 501, and the upper toothing 507 of the indicator ring 503 is hooked into the toothing 506 of the initiation ring 502.
  • the initiation ring is rotated by guiding the guide lugs 511 on the initiation ring 502 through guide tracks 512 in the housing 504, as a result of which the indicator ring 503 is rotated by one step.
  • the indicator ring 503 will remain briefly due to the friction of the friction points 508 and thus be unhooked from the toothing 506 of the initiation ring 502 and hooked into the toothing 510 of the fastening ring 501. This prevents the indicator ring 503 from turning back with the initiation ring 502.
  • the counter is arranged as a preassembled unit in a closed actuating element 620 composed of a lower housing part 616 and an upper housing part 618, which can therefore also be referred to as an actuating housing.
  • the actuating element 620 is fitted and snapped into the upper open end of the shaft c and is therefore secured against disassembly.
  • low projections 622 protrude from the peripheral surface of the actuating element 620, which in the state snapped into the shaft c in engage associated recesses 624 in the inner surface of the shaft c, the width of the projections 622 and the associated recess being dimensioned the same in the circumferential direction, and a positive locking against rotation for the actuating element 620 in the shaft c is thus obtained.
  • the depressions 624 are dimensioned longer than the projections 622 by the amount of the required actuation stroke, so that a displacement of the actuation element 620 by the actuation stroke into the interior of the shaft c is possible.
  • a display window 626 is provided in the peripheral wall of the actuating element 620, in which a partial section of an indicator ring 628 rotatably mounted in the actuating element or housing is visible, which is provided with a scale, the information about the remaining amount of the sprayable active substance still present in the tank d gives.
  • the scaling can either numerically represent the number of remaining actuation strokes or, alternatively, color markings can also be provided on the outside of the indicator ring 628, which change their height visible in the window 626 as a function of the remaining amount of active substance.
  • the part of the indicator mechanism forming indicator ring 628 is provided on its inside with a toothing (FIG. 6h) with which a toothing of a rotatably mounted gearwheel 630 meshes, which in turn meshes with a toothing of a further gearwheel 632 arranged centrally in the actuating element, which engages the upper side of a disk-shaped adjusting ring 634 is provided, which is rotatably supported in the end walls of the upper housing part 618 or the lower housing part 616 by means of bearing pins protruding centrally from its opposite flat sides.
  • a ring 636 of locking teeth which project essentially at right angles and radially from the underside of the adjusting ring, one of the tooth flanks of the locking teeth essentially projecting at right angles and radially from the underside of the adjusting ring, while the second, in contrast, runs obliquely in a ramp-like manner.
  • the indicator ring 628 is held on the top of the adjusting ring 634 in a rotationally fixed manner.
  • a pawl 638 engages successively in the spaces between the locking teeth of the adjusting ring at the outer end of a lever arm 640, which is rotatably mounted in the actuating element by a certain angular amount and is elastically resilient parallel to the longitudinal direction of the shaft, but is rigid in the adjusting ring circumferential direction.
  • a projection 642 which is provided at its free ends pointing downward with a ramp surface which slopes obliquely in the circumferential direction and which in the unactuated state of the loading active element 620 above the upper end of a rib 644 protruding in the longitudinal direction of the shaft from the inner wall of the shaft c through a recess in the lower housing part 616 into the actuating element 620, so that the ramp surface runs against the upper end of the rib 644 during the actuating stroke and due to the inclination of the ramp surface transmits a radial component of motion to the lever arm 640.
  • the actuation stroke that is to say when the actuating element 620 is pressed into the interior of the shaft, the adjusting ring 634 and with it the indicator ring 628 are rotated by a predetermined angular dimension due to the interaction of the inclined ramp surface of the projection 642 with the rib 644, the spring 646 being tensioned.
  • the pawl provided on the upper side of the lever arm 640 can slide back over the oblique tooth flanks of the ratchet teeth of the ring 636 due to the elasticity of the lever arm and thus pass into the next following ratchet space.
  • an anti-rotation device is also provided in the lower housing part 616 in the form of a locking tooth 648 which also interacts with the adjusting ring locking teeth and which is below the ring 636 of locking teeth of the adjusting ring is provided on the top of a substantially tangential resilient tongue 650, and the tooth flanks of which are formed, on the one hand, by a ramp surface that extends obliquely to the inclined ramp surfaces of the collar locking teeth and, on the other hand, a tooth flank that projects substantially perpendicularly from the tongue 650.
  • the snap assembly of the actuating element 620 in the upper open end of the shaft c is designed by the cooperating projections 622 and depressions 624 in such a way that the pressing of the actuating element into the open mouth of the shaft until the projections 622 snap into the depressions 624 under elastic Widening of the shaft c is possible.
  • a retraction of the actuating element 620 from the shaft is not possible due to the corresponding course of the abutting edges of the projections or depressions directed towards one another in the pulling-out direction. This reliably precludes a user from equipping the sprayer with a new tank d after the sprayable substance contained in the original tank d has been used, e.g. in the case of use as a spray inhaler, is filled with an active ingredient which does not correspond to the original active ingredient and which may therefore be harmful to the user,

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
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Abstract

L'invention concerne un pulvérisateur permettant de délivrer des matières pulvérisables dosées, notamment un appareil d'inhalation/pulvérisation permettant l'application de principes actifs pharmaceutiques non pulvérulents dosés. Ce pulvérisateur comprend un embout buccal creux (a) à l'extrémité duquel, extrémité opposée à l'extrémité que l'utilisateur introduit dans sa bouche, on assemble un tube (c) ayant au moins partiellement une section en forme de cylindre creux, de préférence à l'aide d'une pièce coudée creuse (b). Un réservoir (d) rempli du principe actif et d'un agent de propulsion est inséré dans ce tube de manière axialement mobile et pourvu d'une soupape de dosage. Cette soupape de dosage peut être actionnée par le déplacement axial à l'intérieur du réservoir de principe actif (d) d'un tube de délivrance faisant saillie de la face frontale du réservoir de principe actif. L'inhalateur est pourvu d'un compteur destiné au nombre de poussées d'actionnement du réservoir de matière active (d), tout déplacement relatif axial du réservoir de matière active (d) dans le tube (c), déplacement effectué aux fins de la délivrance de la matière active, étant transmis à un anneau d'affichage partiellement visible dans une fenêtre d'affichage. Cet anneau d'affichage est pourvu des informations concernant la quantité restante respective de matière active dans le réservoir (d) dans les zones qui apparaissent successivement dans la fenêtre d'affichage.
PCT/EP2005/002343 2004-03-08 2005-03-05 Pulverisateur destine a la delivrance d'une dose de matieres pulverisables, notamment a l'application de principes actifs pharmaceutiques pulverulents WO2005084736A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102004011510.9 2004-03-08
DE102004011510 2004-03-08
DE102004050468.7 2004-10-16
DE102004050468A DE102004050468A1 (de) 2004-03-08 2004-10-16 Sprühgerät zur dosierten Abgabe von versprühbaren Stoffen, insbesondere zur Applikation von nicht pulverförmigen pharmazeutischen Wirkstoffen

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Publication Number Publication Date
WO2005084736A2 true WO2005084736A2 (fr) 2005-09-15
WO2005084736A3 WO2005084736A3 (fr) 2005-12-08

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WO (1) WO2005084736A2 (fr)

Cited By (4)

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WO2007045904A1 (fr) * 2005-10-22 2007-04-26 42 Technology Limited Compteur de doses pour dispositifs d'inhalation
WO2007077450A2 (fr) * 2006-01-04 2007-07-12 42 Technology Limited Compteur de doses avec un affichage du type odometre
WO2011154295A3 (fr) * 2010-06-08 2012-07-05 Boehringer Ingelheim International Gmbh Appareil médical équipé d'un dispositif de comptage à plage de comptage préréglée et appareil permettant une variation du dispositif de comptage
US8459253B2 (en) 2007-04-02 2013-06-11 3M Innovative Properties Company Dose counter

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GB9211436D0 (en) * 1992-05-29 1992-07-15 Norton Healthcare Ltd Dose indicating device
TW533865U (en) * 1997-06-10 2003-05-21 Glaxo Group Ltd Dispenser for dispensing medicament and actuation indicating device
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WO2007045904A1 (fr) * 2005-10-22 2007-04-26 42 Technology Limited Compteur de doses pour dispositifs d'inhalation
WO2007077450A2 (fr) * 2006-01-04 2007-07-12 42 Technology Limited Compteur de doses avec un affichage du type odometre
WO2007077450A3 (fr) * 2006-01-04 2007-08-30 42 Technology Ltd Compteur de doses avec un affichage du type odometre
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