WO2005078417A1

WO2005078417A1 - Method of screening deodorizing effect or method of evaluation thereof

Info

Publication number: WO2005078417A1
Application number: PCT/JP2005/000387
Authority: WO
Inventors: Toshihiko Tsuda
Original assignee: Kobayashi Pharmaceutical Co., Ltd.
Priority date: 2004-01-16
Filing date: 2005-01-14
Publication date: 2005-08-25
Also published as: JP2005201827A; JP3924757B2

Abstract

[PROBLEMS] To provide a method capable of grasping the odor eliminating effect of deodorant by means of images within a short period of time and in a simple and easy manner. [MEANS FOR SOLVING PROBLEMS] There is provided a method of screening a test article, comprising the step of disposing test subjects in a colored gas atmosphere and sorting a test article out of the test subjects by the use of the removal of color from the colored gas atmosphere as an indicator.

Description

Screening method or evaluation method of deodorant effect

Technical field

The present invention relates to a method for screening a test substance and a method for visually evaluating the deodorizing effect of the test substance.

Background art

[0002] With the improvement of living standards, there is an increasing demand for removing odors in living room spaces, and deodorants are used in various places such as toilets, kitchens, entrances, and living rooms. For the deodorizing effect of the deodorant, sensory tests and quantitative tests using devices or detector tubes are currently used (see, for example, Patent Document 1).

[0003] However, in such a sensory test or a quantitative test, it takes time to measure the deodorizing effect of the test substance and wait for the result, which is laborious.

[0004] Therefore, there is a strong demand for a method for quickly and easily confirming the deodorizing effect of a test substance.

Disclosure of the invention

Problems to be solved by the invention

[0005] A first object of the present invention is to provide a method for easily screening a test substance for a test substance having a deodorizing effect in a short time. A second object of the present invention is to provide a method for easily and simply evaluating the deodorant effect of a test substance.

Means for solving the problem

[0006] The present invention relates to the following method.

[0007] 1. Screening of a test substance, comprising a step of placing a test substance in a colored gas atmosphere and selecting the test substance from the test substance using the disappearance of the color in the colored gas atmosphere as an indicator. Method.

[0008] 2. The method for selecting a test substance is a method for simultaneously selecting a deodorant substance. Screening method.

[0009] 3. The method according to the above item 1 or 2, wherein the colored gas is a nitrogen gas.

[0010] 4. A method for visually evaluating the deodorizing effect of the test substance, which comprises placing the test substance in a colored gas atmosphere and measuring a change in color in the colored gas atmosphere.

[0011] 5. The method according to item 4, wherein the colored gas is a nitrogen oxide.

[0012] 6. A kit for use in the method according to the above item 1 or 5, comprising a colored gas, a colored gas-adsorbing substance, and, if necessary, a sealed container.

[0013] (1) Screening method

The present invention provides a method for screening a test substance. The screening method is a method for selecting a substance having an adsorption effect (adsorbable substance) from a large number of test substances.Specifically, the target test substance is placed in a colored gas atmosphere. It can be carried out by selecting an adsorbable substance from the test substance using the disappearance of the color of the colored gas as an index.

[0014] The presence or absence of the disappearance of the color of the colored gas can also be visually observed. For example, a method in which a photograph of a container is taken with a digital camera and then measured with a color difference meter is also possible. In addition, first, an adsorbable substance is sieved from a large number of test substance groups by visual screening, and then the sieved test substance is subjected to screening using the above-described method, thereby obtaining the test substance. By changing the method of detecting the disappearance of the color of a colored gas, for example, by selecting a desired adsorbent substance from among them, it is possible to select and acquire the desired adsorbent substance efficiently, simply, and accurately.

[0015] The colored gas used in the screening method differs depending on the type of the adsorptive substance to be obtained, but is not particularly limited as long as it is a gas having a color in principle. Examples of the colored gas include nitrogen dioxide, fluorine, chlorine, bromine, iodine, and chlorine dioxide. Colored gas can also include tobacco smoke, smoke from factories and incinerators, and exhaust gas from cars, buses and trucks. Among these, nitrogen dioxide, chlorine, chlorine dioxide, and the like are colored gases that are suitably used because of their excellent visual effects. More preferably, it is nitrogen dioxide.

[0016] As the colored gas used in the present invention, a commercially available gas can be used, or a known gas can be used. It can also be manufactured by a method. For example, nitrogen dioxide can be obtained by reacting copper and nitric acid.

[0017] In addition, when the colored gas has an odor at the same time as the color, by performing the above-described screening method, the test substance can be selected and, at the same time, a deodorant substance (a substance exhibiting a deodorant effect) is obtained. Can also be sorted out. Therefore, in this case, the screening method of the present invention can be referred to as a screening method for a deodorant substance.

[0018] Examples of the colored gas having an odor at the same time as the color include nitrogen dioxide, fluorine, chlorine, bromine, iodine, diacid chloride, and the like. , Chlorine, chlorine dioxide and the like, more preferably nitrogen dioxide and the like can be suitably used.

[0019] Such a screening method of the present invention may be performed under an open condition or under a closed (closed) condition as long as the disappearance of the color of the colored gas can be visually recognized. Preferably, it is carried out under closed (closed) conditions. In the closed (closed) condition, since the gas does not flow under the colored gas atmosphere, the color disappearance process can be observed more accurately and clearly, and the odor due to the colored gas, coloring, etc. This is because it can prevent ivy from being contaminated.

[0020] As a method for screening under closed (closed) conditions, a method using a closed container can be used simply. The closed container is not particularly limited as long as the colored gas contained therein has such a tightness that the colored gas does not flow out of the container or hardly flows out of the container. More preferably, the material is a material in which the colored gas does not adhere or adsorb to the surface inside the closed container, and even if the inside of the container has been subjected to a surface treatment to prevent adsorption of the colored gas Z adsorption. Good. Further, in the present invention, since it is necessary to visually confirm (through visual sense) the deodorizing effect of the test substance, the closed container has a transparent or translucent window partially. Or they must all be transparent or translucent.

[0021] Further, at least one surface of the container may be colored, or a colored material may be attached to at least one surface so that the colored gas can be clearly observed.

[0022] The container needs to be able to take in and out the colored gas and the colored gas adsorbing substance, but its size and shape are not limited. The size that is powerful The shape can be appropriately selected according to the size of the colored gas-adsorbing substance having the product form to be disposed therein, the concentration of the colored gas to be used, and the like. For example, shapes such as a box shape (cube shape, rectangular parallelepiped shape, etc.), a columnar shape, a triangular pyramid shape, a spherical shape, and the like can be exemplified, but the shape is not limited thereto. The material of the container is not limited as long as it is as described above, and examples thereof include glass, acrylic resin, plastic, and polyethylene resin. Further, the inner surface of the container may be subjected to fluorine processing, or the inner surface of the container may be covered with a fluorine-processed transparent or translucent sheet. Further, in the present invention, the container includes a bag such as a plastic bag, for example, a tetra bag, and the bag can be used as long as the bag can seal a colored gas.

When performing the screening of the present invention using a closed container, first, a colored gas is sealed and filled in a closed container. Filling with colored gas Z filling may be performed using a tool such as a syringe, or may be performed directly from a container containing the gas. Next, the test substance is placed in the container. However, the order in which the colored gas and the test substance are arranged in the closed vessel is not limited to the above, and the colored gas may be sealed in a closed vessel in which the test substance is placed in advance.

[0024] By arranging the substance in the container, the colored gas in the container is adsorbed by the substance, and the color in the container disappears with time. By confirming the color change over time (discoloration change), the deodorizing effect of the test substance can be quickly and easily captured as an image.

[0025] The screening method is also preferably performed under closed (closed) conditions as described above. Specifically, there is a case where the test substance is placed in a sealed container filled with colored gas and filled with Z, and a case where the test substance is not placed in a closed container filled with colored gas and filled with Z (control). The state of the color change in the container over time is shown in contrast. Thereby, even if the test substance has a weak deodorizing effect, the effect can be confirmed.

[0026] When gas is filled in two or more containers, it is preferable that the amount or concentration of gas in each container be the same!

[0027] In performing the above screening method, the amount or concentration of the colored gas filled in the closed container, the size and shape of the test substance, and the like are not limited. Can be appropriately selected according to the size of the image. [0028] (2) Evaluation method of the Fufu effect

The present invention also provides a method for visually evaluating the deodorizing effect of a test substance. Specifically, the evaluation method can be performed by arranging a test substance under a colored gas atmosphere and measuring a color change in the colored gas atmosphere. At this time, if the color in the colored gas atmosphere disappears, it is determined that the test substance has a deodorizing effect, and if the color in the colored gas atmosphere does not disappear, it is determined that the test substance has no deodorizing effect. Can be done.

[0029] The colored gas used in the method of the present invention is a colored gas having an odor at the same time as its color, and examples thereof include nitrogen dioxide, chlorine, bromine, iodine, and diacid chloride. . Among them, nitrogen dioxide, chlorine, and nitrogen dioxide, which is preferred by chlorine dioxide, are particularly preferred.

In the present invention, the change in the color of the colored gas (the presence or absence of disappearance) can be visually measured. For example, a method in which a photograph of a container is taken with a digital camera and then measured with a color difference meter. It is possible. In addition, the presence or absence of the deodorizing effect of the test substance can be roughly determined by visual measurement, and if necessary, the deodorizing effect of the test substance can be more accurately evaluated by the measurement according to the above method. It is possible.

[0031] The evaluation method of the present invention is preferably performed under closed (closed) conditions using the closed container or the like described in the section of the above screening method. Note that the description of the above-described screening method can be referred to for the type and specific method of a powerful closed container.

[0032] (3) Kit

The sealed container, the colored gas, and the test substance used in the present invention can be used as a kit. By using these as a kit, the kit can be easily carried, and the method of the present invention can be quickly and easily carried out in various places.

The invention's effect

According to the screening method of the present invention, substances having an adsorption effect or Z and deodorizing effects can be visually and quickly and easily selected from many test substances. Furthermore, according to the evaluation method of the present invention, the deodorizing effect of the test Can be easily evaluated.

BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, examples will be shown to further clarify the features of the present invention. The present invention is not limited to these examples.

Example

Example 1

A copper plate (50 mm X 25 mm X 1 mm; JISH3100 manufactured by Nippon Test Panel Osaka Co., Ltd.) was placed in a 300 ml Erlenmeyer flask, and 50 ml of nitric acid was added thereto (Chemical No. 141-0136 manufactured by Wako Pure Chemical Industries, Ltd.). Immediately, the above triangular flask was placed in a 10 L Tedlar bag (GL Science) and sealed with a clip (GL Science).

Wait until the Tedlar bag is filled with nitrogen dioxide (reddish brown) (about 10 minutes), use a glass syringe (200 ml), inject 500 ml of nitrogen dioxide in the Tedlar bag into the acrylic box, and occupy the lid. And sealed. Another acrylic container was prepared.

[0037] One of the acrylic containers, as a test substance, was prepared by adhering paper sludge to clay fired in an unfired state (Japanese Patent Application No. 2003-342699: "Charcoal power (Kobayashi Pharmaceutical Co., Ltd.)") Was placed. The change in color in the container observed over time is shown in FIGS. Figure 1 shows 0 minutes after the addition of the test substance, Figure 2 shows 15 minutes after the addition of the test substance, Figure 3 shows 30 minutes after the addition of the test substance, and Figure 4 shows the addition of the test substance And show the state after 60 minutes.

[0038] As a result of performing a deodorization test using a nitrogen oxide (No. 10) gas detector tube (manufactured by Gastec), both containers had lOOOOppm before the test substance was placed. Was. One hour after placing the test substance, the concentration was 9000 ppm in the container without the test substance and 200 ppm in the container with the test substance. From this, it was confirmed that the test substance had a deodorizing effect.

[0039] From these figures, it was clearly confirmed that the color in the container in which the test substance was placed disappeared with time. Therefore, according to the above method, it can be used for evaluating the deodorizing effect of the test substance, whereby a desired adsorbent substance can be selected from a large number of test substances. it is conceivable that. That is, the above method can be suitably used as a method for screening an adsorptive substance. Brief Description of Drawings

FIG. 1 shows a state in Example 1 at 0 minutes after addition of a test substance. The right figure shows the case where the test substance is arranged, and the left figure shows the case where the colored gas adsorbing substance is not arranged (the original is a color diagram).

FIG. 2 shows a state in Example 1 15 minutes after the addition of the test substance. The right figure shows the case where the test substance is arranged, and the left figure shows the case where the test substance is not arranged (the original is a color diagram).

FIG. 3 shows a state in Example 1 30 minutes after the addition of the test substance. The right figure shows the case where the test substance is arranged, and the left figure shows the case where the test substance is not arranged (the original is a color diagram).

FIG. 4 shows a state 60 minutes after the addition of the test substance in Example 1. The right figure shows the case where the test substance is arranged, and the left figure shows the case where the test substance is not arranged (the original is a color diagram).

Claims

The scope of the claims

[1] A method for screening a test substance, comprising the steps of: placing a test substance in a colored gas atmosphere, and selecting the test substance from the test substance using the disappearance of the color in the colored gas atmosphere as an index.

[2] The screening method according to claim 1, wherein the screening of the test substance is a method of simultaneously screening the deodorant substance.

[3] The method according to claim 1 or 2, wherein the colored gas is a nitrogen oxide.

[4] A method for visually evaluating the deodorizing effect of a test substance, comprising placing the test substance in a colored gas atmosphere and measuring a change in color in the colored gas atmosphere.

[5] The method according to claim 4, wherein the colored gas is a nitrogen oxide.

[6] A kit for use in the method according to claim 1 or 5, comprising a colored gas, a colored gas-adsorbing substance, and, if necessary, a sealed container.