WO2005075630A3 - New acylglycerol acyltransferase-like proteins dc4 and uses thereof - Google Patents

New acylglycerol acyltransferase-like proteins dc4 and uses thereof Download PDF

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Publication number
WO2005075630A3
WO2005075630A3 PCT/EP2005/000631 EP2005000631W WO2005075630A3 WO 2005075630 A3 WO2005075630 A3 WO 2005075630A3 EP 2005000631 W EP2005000631 W EP 2005000631W WO 2005075630 A3 WO2005075630 A3 WO 2005075630A3
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WO
WIPO (PCT)
Prior art keywords
diseases
inflammation
muscle
cancer
urological
Prior art date
Application number
PCT/EP2005/000631
Other languages
French (fr)
Other versions
WO2005075630A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Publication of WO2005075630A2 publication Critical patent/WO2005075630A2/en
Publication of WO2005075630A3 publication Critical patent/WO2005075630A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91045—Acyltransferases (2.3)
    • G01N2333/91051—Acyltransferases other than aminoacyltransferases (general) (2.3.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention is directed to polynucleotide and polypeptide sequences of novel acylglycerol acyltransferase-like proteins DC4. The invention also provides the human, mouse and rat DC4 and rat and mouse DC4L associated with the cardiovascular diseases, dermatological diseases, metabolic diseases, muscle-skeleton disorders, cancer, inflammation, urological diseases, neurological diseases and hematological diseases. The invention also provides assays for the identification of compounds useful for the modulation of cardiovascular diseases, dermatological diseases, metabolic diseases, muscle-skeleton disorders, cancer, inflammation, urological diseases, neurological diseases and hematological diseases for treating of cardiovascular diseases, dermatological diseases, metabolic diseases, muscle-skeleton disorders, cancer, inflammation, urological diseases, neurological diseases and hematological diseases associated with expression of the DC4. The invention also features compounds which bind to and/or activate or inhibit the activity of DC4 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2005/000631 2004-02-05 2005-01-22 New acylglycerol acyltransferase-like proteins dc4 and uses thereof WO2005075630A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04002507 2004-02-05
EP04002507.4 2004-02-05

Publications (2)

Publication Number Publication Date
WO2005075630A2 WO2005075630A2 (en) 2005-08-18
WO2005075630A3 true WO2005075630A3 (en) 2005-10-27

Family

ID=34833573

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2005/000631 WO2005075630A2 (en) 2004-02-05 2005-01-22 New acylglycerol acyltransferase-like proteins dc4 and uses thereof

Country Status (1)

Country Link
WO (1) WO2005075630A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002068595A2 (en) * 2001-02-23 2002-09-06 The Regents Of The University Of California Mono-and diacylglycerol acyltransferases and methods of use thereof
WO2003053363A2 (en) * 2001-12-19 2003-07-03 Millennium Pharmaceuticals, Inc. Human diacylglycerol acyltransferase 2 (dgat2) family members and uses therefor
WO2004042014A2 (en) * 2002-10-31 2004-05-21 The J. David Gladstone Institutes Mono- and diacylglycerol acyltransferases and methods of use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002068595A2 (en) * 2001-02-23 2002-09-06 The Regents Of The University Of California Mono-and diacylglycerol acyltransferases and methods of use thereof
WO2003053363A2 (en) * 2001-12-19 2003-07-03 Millennium Pharmaceuticals, Inc. Human diacylglycerol acyltransferase 2 (dgat2) family members and uses therefor
WO2004042014A2 (en) * 2002-10-31 2004-05-21 The J. David Gladstone Institutes Mono- and diacylglycerol acyltransferases and methods of use thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CASES S ET AL: "Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 276, no. 42, 19 October 2001 (2001-10-19), pages 38870 - 38876, XP002199715, ISSN: 0021-9258 *
CHENG JEFFREY B ET AL: "Mammalian wax biosynthesis - II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 36, 3 September 2004 (2004-09-03), pages 37798 - 37807, XP002339073, ISSN: 0021-9258 *
DATABASE EMBL [online] 12 July 2004 (2004-07-12), "Homo sapiens wax synthase mRNA, complete cds.", XP002340501, retrieved from EBI accession no. EM_PRO:AY605053 Database accession no. AY605053 *
DATABASE EMBL [online] 16 May 2001 (2001-05-16), "602633307F1 NCI_CGAP_Skn3 Homo sapiens cDNA clone IMAGE:4778665 5', mRNA sequence.", XP002339952, retrieved from EBI accession no. EM_PRO:BG743236 Database accession no. BG743236 *
DATABASE EMBL [online] 2 May 2001 (2001-05-02), "602620181F1 NCI_CGAP_Skn3 Homo sapiens cDNA clone IMAGE:4745396 5', mRNA sequence.", XP002339953, retrieved from EBI accession no. EM_PRO:BG674003 Database accession no. BG674003 *

Also Published As

Publication number Publication date
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