WO2005069964A3 - Appareil et procede de deplacement de micro-gouttelettes au moyen de gradients thermiques induits par laser - Google Patents

Appareil et procede de deplacement de micro-gouttelettes au moyen de gradients thermiques induits par laser Download PDF

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Publication number
WO2005069964A3
WO2005069964A3 PCT/US2005/002033 US2005002033W WO2005069964A3 WO 2005069964 A3 WO2005069964 A3 WO 2005069964A3 US 2005002033 W US2005002033 W US 2005002033W WO 2005069964 A3 WO2005069964 A3 WO 2005069964A3
Authority
WO
WIPO (PCT)
Prior art keywords
droplet
liquid phase
droplets
laser
light
Prior art date
Application number
PCT/US2005/002033
Other languages
English (en)
Other versions
WO2005069964A2 (fr
Inventor
Gregory Faris
Kenneth T Kotz
Kyle Noble
Original Assignee
Stanford Res Inst Int
Gregory Faris
Kenneth T Kotz
Kyle Noble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int, Gregory Faris, Kenneth T Kotz, Kyle Noble filed Critical Stanford Res Inst Int
Priority to US10/597,372 priority Critical patent/US7582858B2/en
Publication of WO2005069964A2 publication Critical patent/WO2005069964A2/fr
Publication of WO2005069964A3 publication Critical patent/WO2005069964A3/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/05—Mixers using radiation, e.g. magnetic fields or microwaves to mix the material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/05—Mixers using radiation, e.g. magnetic fields or microwaves to mix the material
    • B01F33/054—Mixers using radiation, e.g. magnetic fields or microwaves to mix the material the energy being in the form of a laser to modify the characteristics or conditions of the products, e.g. for heating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/302—Micromixers the materials to be mixed flowing in the form of droplets
    • B01F33/3021—Micromixers the materials to be mixed flowing in the form of droplets the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/3033—Micromixers using heat to mix or move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/142—Preventing evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1046—Levitated, suspended drops

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

La présente invention a trait à un appareil et un procédé de déplacement de micro-gouttelettes. Une phase liquide se trouve sur une surface. Dans la phase liquide se trouve une gouttelette. Un faisceau lumineux se trouve focalisé au niveau d'un bord de la gouttelette. Le faisceau lumineux produit un gradient thermique suffisant pour induire le déplacement de la gouttelette selon l'effet de Marangoni. Le gradient thermique d'induction de déplacement peut apparaître au sein de la gouttelette ou au sein de la phase liquide. La composition de la gouttelette, la phase liquide, et la longueur d'onde du faisceau lumineux peuvent coopérer pour entraîner un réchauffement au sein de la gouttelette, de la phase liquide, ou des deux. Par exemple, un laser infrarouge peut entraîner une vibration d'une liaison O-H dans une gouttelette aqueuse (ou dans la phase liquide). Dans un autre mode de réalisation, l'ajout de colorant à une gouttelette ou à la phase liquide permet l'absorption de la lumière en provenance d'un laser à argon ionisé. L'appareil et le procédé sont particulièrement applicables dans des dosages biologiques et chimiques à haut rendement.
PCT/US2005/002033 2004-01-23 2005-01-21 Appareil et procede de deplacement de micro-gouttelettes au moyen de gradients thermiques induits par laser WO2005069964A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US10/597,372 US7582858B2 (en) 2004-01-23 2005-01-21 Apparatus and method of moving micro-droplets using laser-induced thermal gradients

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53895104P 2004-01-23 2004-01-23
US60/538,951 2004-01-23

Publications (2)

Publication Number Publication Date
WO2005069964A2 WO2005069964A2 (fr) 2005-08-04
WO2005069964A3 true WO2005069964A3 (fr) 2005-09-22

Family

ID=34807245

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/002033 WO2005069964A2 (fr) 2004-01-23 2005-01-21 Appareil et procede de deplacement de micro-gouttelettes au moyen de gradients thermiques induits par laser

Country Status (1)

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WO (1) WO2005069964A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2901717A1 (fr) * 2006-05-30 2007-12-07 Centre Nat Rech Scient Procede de traitement de gouttes dans un circuit microfluidique.
EP1936369A1 (fr) * 2006-12-20 2008-06-25 Agilent Technologies, Inc. Excitation sélective de solvants contenant des radicaux OH
US8293339B2 (en) * 2007-09-17 2012-10-23 Sri International, Inc. Droplet bilayers

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5275787A (en) * 1989-10-04 1994-01-04 Canon Kabushiki Kaisha Apparatus for separating or measuring particles to be examined in a sample fluid
US5856200A (en) * 1993-09-08 1999-01-05 Boehringer Mannheim Gmbh Method and device for metering liquids
US20020001544A1 (en) * 1997-08-28 2002-01-03 Robert Hess System and method for high throughput processing of droplets
US20030086824A1 (en) * 2001-09-25 2003-05-08 Hitachi, Ltd. Flat cell and an analyzer using the same
US6620620B1 (en) * 1998-04-27 2003-09-16 Era Systems, Inc. Micro liquid evaporator
US20040191127A1 (en) * 2003-03-31 2004-09-30 Avinoam Kornblit Method and apparatus for controlling the movement of a liquid on a nanostructured or microstructured surface

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5275787A (en) * 1989-10-04 1994-01-04 Canon Kabushiki Kaisha Apparatus for separating or measuring particles to be examined in a sample fluid
US5856200A (en) * 1993-09-08 1999-01-05 Boehringer Mannheim Gmbh Method and device for metering liquids
US20020001544A1 (en) * 1997-08-28 2002-01-03 Robert Hess System and method for high throughput processing of droplets
US6620620B1 (en) * 1998-04-27 2003-09-16 Era Systems, Inc. Micro liquid evaporator
US20030086824A1 (en) * 2001-09-25 2003-05-08 Hitachi, Ltd. Flat cell and an analyzer using the same
US20040191127A1 (en) * 2003-03-31 2004-09-30 Avinoam Kornblit Method and apparatus for controlling the movement of a liquid on a nanostructured or microstructured surface

Also Published As

Publication number Publication date
WO2005069964A2 (fr) 2005-08-04

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