WO2005065409A2 - Ultrasound therapy head with movement control - Google Patents

Ultrasound therapy head with movement control Download PDF

Info

Publication number
WO2005065409A2
WO2005065409A2 PCT/US2004/044046 US2004044046W WO2005065409A2 WO 2005065409 A2 WO2005065409 A2 WO 2005065409A2 US 2004044046 W US2004044046 W US 2004044046W WO 2005065409 A2 WO2005065409 A2 WO 2005065409A2
Authority
WO
WIPO (PCT)
Prior art keywords
enclosure
energy applicator
therapy head
energy
window
Prior art date
Application number
PCT/US2004/044046
Other languages
French (fr)
Other versions
WO2005065409A3 (en
Inventor
Jens U. Quistgaard
Tim Etchells
Gregory Paul Darlington
Charles S. Desilets
Original Assignee
Liposonix, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Liposonix, Inc. filed Critical Liposonix, Inc.
Priority to EP04816028A priority Critical patent/EP1699407A4/en
Priority to JP2006547594A priority patent/JP2007516810A/en
Priority to CA002551348A priority patent/CA2551348A1/en
Priority to KR1020067013272A priority patent/KR101188930B1/en
Priority to AU2004311459A priority patent/AU2004311459B2/en
Priority to CN2004800390469A priority patent/CN1897907B/en
Priority to BRPI0417907-2A priority patent/BRPI0417907A/en
Publication of WO2005065409A2 publication Critical patent/WO2005065409A2/en
Publication of WO2005065409A3 publication Critical patent/WO2005065409A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
    • A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
    • A61B8/4461—Features of the scanning mechanism, e.g. for moving the transducer within the housing of the probe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H1/00—Apparatus for passive exercising; Vibrating apparatus; Chiropractic devices, e.g. body impacting devices, external devices for briefly extending or aligning unbroken bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/70—Manipulators specially adapted for use in surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0082—Scanning transducers

Definitions

  • the present invention relates to a handheld medical device for delivering energy in precise locations into the human body.
  • the device is principally for non-invasive therapies.
  • a general problem in the application of high intensity focused ultrasound (HIFU) for therapeutic purposes is that it is often necessary to hold the therapeutic means stationary for some significant amount of time over the tissue to be treated. Alternatively, it may be necessary to scan the therapy beam at a slow, constant rate through the tissue to be treated. Both of these requirements present a barrier to a handheld therapeutic device, as it is often difficult or impossible for a person to either hold the device steady, or to scan at an acceptably slow and steady rate for the desired therapeutic effect.
  • a HIFU procedure may require that the ultrasound beam be scanned over the treatment volume at a constant rate (e.g. 5mm/sec +/- lmm/sec) to achieve the desired therapeutic effect.
  • the treatment volume must be scanned so that there is never more than a 2mm spacing between adjacent focal lines of treatment. These requirements are beyond the capabilities of human beings.
  • the solution in the past has been to incorporate a computer controlled motion device rigidly mounted to something that is stationary with respect to the patient (e.g. the floor, wall or bed). Such a device is either absolutely stationary, or is able to scan at a precise rate in a precise pattern without any human intervention. Such an arrangement has the disadvantages of size and bulk, complexity and reliability of the overall device.
  • an ultrasound therapy head comprising an enclosure having a window, at least one energy applicator suspended within the enclosure and a means for maneuvering the energy applicator within the enclosure such that the energy applicator radiates energy through the window.
  • the energy applicator is an ultrasound transducer however a variety of other energy applicator may be used in combination with an ultrasound transducer.
  • the means for maneuvering the energy applicator preferably includes a means for determining the position of the energy applicator within the enclosure.
  • Figure 1 illustrates a therapy head.
  • Figure 2 shows a therapy head on an articulating arm with external control elements.
  • Figures 3 A-3B show internal views of actuators and motors in the therapy head.
  • Figure 4 provides a schematic of the elements of the present invention.
  • a therapy head having an enclosure with a window.
  • the enclosure contains one or more energy applicators, and a means of moving the energy applicators within the enclosure.
  • the energy applicators are positioned so the radiant energy passes through the window to a patient.
  • the enclosure is preferably small enough to be manipulated by hand. It can be operated by itself with a physician carrying the load of the therapy head, or it can be supported by an articulating arm or other mechanical device.
  • the enclosure has a window that is oriented toward a patient.
  • the window may be made from any material so long as it is essentially transparent to the energy applicator.
  • the window may be incorporated into the enclosure, or it may be a removable device. If the window is a removable device, then the window will cover an access port through which the interior components of the enclosure may be accessed.
  • the window may also be a disposable device, such as a disposable transducer seal.
  • At least one energy applicator within the enclosure is at least one energy applicator.
  • this energy applicator is an ultrasound transducer. More preferably the ultrasound transducer is a high intensity focused ultrasound transducer.
  • the transducer may be a component transducer assembly, or a device that incorporates multiple energy applicators, some of which may not be ultrasound transducers.
  • the means for maneuvering the energy applicator requires two components.
  • a first component is one or more actuators.
  • the energy applicator is attached to the actuators.
  • the attachment may be a slidable engagement, rotational engagement or through a series of traveler rods.
  • the actuators are driven by a force generating device, like an electric motor or the equivalent. Electric motors are preferred for their small size and reliability.
  • One or more position sensing devices such as rotational or optical encoders, are built into either the motor assembly, or the actuators, so the movement of the energy applicator within the enclosure is known.
  • the energy applicator may also contain a miniature location device (e.g. like mini-GPS system) that an external sensor can identify to determine the location of the energy applicator within the enclosure.
  • the second component of the maneuvering means is a driver or controller.
  • the driver or controller directs the movement of the motors, and thus the movement of the actuators and the maneuvering of the energy applicator.
  • the controller may be a medical appliance, a computer, or a specialized medical procedure controller.
  • the controller may be positioned within the enclosure, or it may be a device outside the enclosure providing signal to the motors.
  • the controller has a library of data used to coordinate the movement of the energy applicator and the dosage of the radiant energy into the patient. By controlling the movement of the energy applicator while radiant energy is emitted through the window, a precise energy dosage may be delivered into the patient.
  • the controller can be programmed with the parameters needed to perform the task. Parameters may include the type of therapy to be administered and the maximum safe dosage that may be applied to a patient for a given area, volume or mass of tissue.
  • a physician can place the therapy head on a patient.
  • the therapy head can move the energy applicator within the enclosure to treat the patient according to the procedure parameters programmed into the controller. If the procedure area is small, then the controller can move and activate the energy emitter without any additional input from a user.
  • the therapy head must be moved to cover as much area as needed. Movement of the therapy head can be done manually, or through a mechanical device. Data from the encoders is relayed to the controller so that the controller can identify the position of the energy applicator within the confines of the enclosure. This position information can be combined with a Position Tracking Device (Co- pending application, serial number unassigned), and an Articulating Arm (Co-pending application, serial number un-assigned).
  • a Position Tracking Device Co- pending application, serial number unassigned
  • an Articulating Arm Co-pending application, serial number un-assigned
  • the controller can utilize position data from the present invention, combined with the data derived from the two aforementioned co-pending applications, to produce precise position data for the energy applicator with respect to the enclosure, the patient and a fixed external reference point.
  • the controller can use the means for maneuvering the applicator, to correct the energy applicator's position.
  • the controller can identify the dosage of energy delivered with great precision to any particular area.
  • the controller can track the amount of energy transmitted into the patient through out the treatment area and can cause the energy applicator to radiate or not radiate depending on the amount of energy already deposited into the patient at the particular place in the procedure.
  • FIG. 1 there is a therapy head 50 having an energy applicator 600 within an enclosure 500.
  • the enclosure has a window 590 for allowing radiant energy to pass from the enclosure to a patient.
  • the therapy head 50 is preferably small and light enough for a physician to move it comfortably with one hand.
  • the therapy head 50 may increase in both size and weight if the physician is assisted by an articulating arm 200 in bearing the weight of the therapy head 50.
  • There is a data link 572 extending between the therapy head 50 and an external computer 400 or a therapy controller 450.
  • the therapy head 50 may be mounted (Fig. 2) on an articulated arm 200 supported by a base 100.
  • the articulating arm 200 would also have its movements and functions monitored or controlled by a computer 400 or therapy controller 450.
  • the enclosure 500 contains motor drives 508, 510 for moving the energy applicator 600 within the enclosure (Fig. 3 A).
  • the motor drives are connected directly, or through a gear assembly, to a pair of traveler rods 520, 528.
  • the traveler rods in turn move a pair of slotted actuators 520', 528'.
  • the slotted actuators travel along the traveler rods carrying the energy applicator at the intersection of the two slotted actuators.
  • the slotted actuators carry the energy applicator throughout the range of motion of the slotted traveler rods.
  • Rotational encoders 530 are positioned on the traveler rods 520, 528 so that the movement of the energy applicator can be accurately measured.
  • the motor drives 508, 510 can directly drive rotational actuators 514, 516 to move the energy applicator 600 within the enclosure (Fig 3B).
  • the motor drives 508, 510 can directly drive rotational actuators 514, 516 to move the energy applicator 600 within the enclosure (Fig 3B).
  • the actuators 514, 516 move in direct correlation to the motors.
  • the sensitivity of the positioning of the energy applicator can be controlled through the motor drives, or the actuators used in response to the energy applicator.
  • Three motors (not shown) may also be used to drive three articulating arms.
  • FIG. 4 illustrates a schematic of the present invention.
  • the therapy head 50 is shown in cross section with a partition 504 separating an upper enclosure from a lower enclosure.
  • the partition is water tight so that fluid in the lower partition does not seep into the upper enclosure.
  • the motor drive units pass rotational energy to the energy applicator 600 through a series of mechanical actuators 514, 516, 518.
  • the actuators extend through the water tight partition 504 and are themselves water resistant.
  • An acoustic window 590 is displaced at the bottom of the enclosure.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rehabilitation Therapy (AREA)
  • Surgical Instruments (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)

Abstract

A therapy head for use in HIFU procedures is described. The therapy head has an enclosure with a window, an energy applicator and a means of moving the energy applicator within the enclosure. The therapy head uses motors and actuators to move the energy applicator, usually an ultrasound transducer, inside the enclosure. A controller is provided either internally or externally that allows the therapy head to identify and distinguish locations where the therapy head should be to radiate energy into a patient. The controller uses the motors and actuators to move the energy applicator into the desired locations.

Description

Attorney Docket No.: 021356-001110PC
ULTRASOUND THERAPY HEAD WITH MOVEMENT CONTROL
CROSS-REFERENCES TO RELATED APPLICATIONS [0001] This application claims the benefit of provisional application no. 60/534,036 (Attorney Docket No. 021356-001100US), filed on December 30, 2003, the full disclosure of which is incorporated herein by reference.
[0002] The subject matter of the present application is related to that of the following applications: 10/750,370, entitled "Medical Device Inline Degasser" (Attorney Docket No. 02356-000500US); 10/751,344, entitled "Articulating Arm for Medical Procedures" (Attorney Docket No. 02356-000600US); 10/750,369, entitled "Disposable Transducer Seal" (Attorney Docket No. 02356-000700US); 60/533,528, entitled "Position Tracking Device" (Attorney Docket No. 021356-000900US); 60/533,988, entitled "Method for Planning and Performing Ultrasound Therapy" (Attorney Docket No. 021356-001000US); 60/533,958, entitled "Systems and Methods for the Destruction of Adipose Tissue" (Attorney Docket No. 021356-001200US); 60/534,034, entitled "Component Ultrasound Transducer" (Attorney Docket No. 021356-001300US); the full disclosure of each of these applications are incorporated herein by reference.
BACKGROUND OF THE INVENTION [0003] 1. Field of the Invention. The present invention relates to a handheld medical device for delivering energy in precise locations into the human body. The device is principally for non-invasive therapies.
[0004] 2. Background of the present invention. A general problem in the application of high intensity focused ultrasound (HIFU) for therapeutic purposes is that it is often necessary to hold the therapeutic means stationary for some significant amount of time over the tissue to be treated. Alternatively, it may be necessary to scan the therapy beam at a slow, constant rate through the tissue to be treated. Both of these requirements present a barrier to a handheld therapeutic device, as it is often difficult or impossible for a person to either hold the device steady, or to scan at an acceptably slow and steady rate for the desired therapeutic effect. [0005] A HIFU procedure may require that the ultrasound beam be scanned over the treatment volume at a constant rate (e.g. 5mm/sec +/- lmm/sec) to achieve the desired therapeutic effect. Additionally, the treatment volume must be scanned so that there is never more than a 2mm spacing between adjacent focal lines of treatment. These requirements are beyond the capabilities of human beings. The solution in the past has been to incorporate a computer controlled motion device rigidly mounted to something that is stationary with respect to the patient (e.g. the floor, wall or bed). Such a device is either absolutely stationary, or is able to scan at a precise rate in a precise pattern without any human intervention. Such an arrangement has the disadvantages of size and bulk, complexity and reliability of the overall device.
[0006] Thus there remains a need in the art for a HIFU applicator that can be easily manipulated by a user while still providing reliable and uniform treatment.
[0007] There is also a need for a HIFU transducer that can keep track of the tissue volumes treated so as to prevent re-treatment of those same volumes.
[0008] There is still further a need for a therapy device that can assist the operator in identifying regions of tissue to be treated.
BRIEF SUMMARY OF THE INVENTION [0009] It is an objective of the present invention to provide for a therapy head usable in HIFU procedures that can be easily manipulated and provide reliable and uniform treatment.
[0010] It is another object of the presenting invention to track tissue in a library or map of the tissue to be treated.
[0011] It is still further an objective of the present invention to provide a means for alerting a physician to any problems or difficulties associated with a procedure using a HIFU generator of the present invention.
[0012] At least some of the objectives of the present invention are realized through an ultrasound therapy head comprising an enclosure having a window, at least one energy applicator suspended within the enclosure and a means for maneuvering the energy applicator within the enclosure such that the energy applicator radiates energy through the window.
[0013] Preferably the energy applicator is an ultrasound transducer however a variety of other energy applicator may be used in combination with an ultrasound transducer. [0014] The means for maneuvering the energy applicator preferably includes a means for determining the position of the energy applicator within the enclosure.
BRIEF DESCRIPTION OF THE DRAWINGS [0015] Figure 1 illustrates a therapy head.
[0016] Figure 2 shows a therapy head on an articulating arm with external control elements.
[0017] Figures 3 A-3B show internal views of actuators and motors in the therapy head.
[0018] Figure 4 provides a schematic of the elements of the present invention.
DETAILED DESCRIPTION OF THE INVENTION [0019] Described herein is a device for use primarily in high intensity ultrasound procedures. A therapy head is disclosed having an enclosure with a window. The enclosure contains one or more energy applicators, and a means of moving the energy applicators within the enclosure. The energy applicators are positioned so the radiant energy passes through the window to a patient.
[0020] The enclosure is preferably small enough to be manipulated by hand. It can be operated by itself with a physician carrying the load of the therapy head, or it can be supported by an articulating arm or other mechanical device. The enclosure has a window that is oriented toward a patient. The window may be made from any material so long as it is essentially transparent to the energy applicator. The window may be incorporated into the enclosure, or it may be a removable device. If the window is a removable device, then the window will cover an access port through which the interior components of the enclosure may be accessed. The window may also be a disposable device, such as a disposable transducer seal.
[0021] Within the enclosure is at least one energy applicator. Preferably this energy applicator is an ultrasound transducer. More preferably the ultrasound transducer is a high intensity focused ultrasound transducer. However the transducer may be a component transducer assembly, or a device that incorporates multiple energy applicators, some of which may not be ultrasound transducers. [0022] There is a means for maneuvering the energy applicator within the enclosure. The means for maneuvering the energy applicator requires two components. A first component is one or more actuators. The energy applicator is attached to the actuators. The attachment may be a slidable engagement, rotational engagement or through a series of traveler rods. The actuators are driven by a force generating device, like an electric motor or the equivalent. Electric motors are preferred for their small size and reliability. One or more position sensing devices, such as rotational or optical encoders, are built into either the motor assembly, or the actuators, so the movement of the energy applicator within the enclosure is known. Alternatively the energy applicator may also contain a miniature location device (e.g. like mini-GPS system) that an external sensor can identify to determine the location of the energy applicator within the enclosure.
[0023] The second component of the maneuvering means is a driver or controller. The driver or controller directs the movement of the motors, and thus the movement of the actuators and the maneuvering of the energy applicator. The controller may be a medical appliance, a computer, or a specialized medical procedure controller. The controller may be positioned within the enclosure, or it may be a device outside the enclosure providing signal to the motors.
[0024] In operation, the controller has a library of data used to coordinate the movement of the energy applicator and the dosage of the radiant energy into the patient. By controlling the movement of the energy applicator while radiant energy is emitted through the window, a precise energy dosage may be delivered into the patient. The controller can be programmed with the parameters needed to perform the task. Parameters may include the type of therapy to be administered and the maximum safe dosage that may be applied to a patient for a given area, volume or mass of tissue.
[0025] Once the therapy head has been completely prepared for a procedure, a physician can place the therapy head on a patient. The therapy head can move the energy applicator within the enclosure to treat the patient according to the procedure parameters programmed into the controller. If the procedure area is small, then the controller can move and activate the energy emitter without any additional input from a user.
[0026] If the treatment area exceeds the window of the enclosure, or exceeds the range of motion of the energy applicator within the enclosure, the therapy head must be moved to cover as much area as needed. Movement of the therapy head can be done manually, or through a mechanical device. Data from the encoders is relayed to the controller so that the controller can identify the position of the energy applicator within the confines of the enclosure. This position information can be combined with a Position Tracking Device (Co- pending application, serial number unassigned), and an Articulating Arm (Co-pending application, serial number un-assigned). The controller can utilize position data from the present invention, combined with the data derived from the two aforementioned co-pending applications, to produce precise position data for the energy applicator with respect to the enclosure, the patient and a fixed external reference point. During the procedure if the controller reads the position or motion information from the encoders and other sensors and determines the energy applicator is not in the proper position, the controller can use the means for maneuvering the applicator, to correct the energy applicator's position.
[0027] Similarly the controller can identify the dosage of energy delivered with great precision to any particular area. The controller can track the amount of energy transmitted into the patient through out the treatment area and can cause the energy applicator to radiate or not radiate depending on the amount of energy already deposited into the patient at the particular place in the procedure.
[0028] Turning now to the drawings, in Figure 1 there is a therapy head 50 having an energy applicator 600 within an enclosure 500. The enclosure has a window 590 for allowing radiant energy to pass from the enclosure to a patient. The therapy head 50 is preferably small and light enough for a physician to move it comfortably with one hand. The therapy head 50 may increase in both size and weight if the physician is assisted by an articulating arm 200 in bearing the weight of the therapy head 50. There is a data link 572 extending between the therapy head 50 and an external computer 400 or a therapy controller 450.
[0029] The therapy head 50 may be mounted (Fig. 2) on an articulated arm 200 supported by a base 100. The articulating arm 200 would also have its movements and functions monitored or controlled by a computer 400 or therapy controller 450.
[0030] The enclosure 500 contains motor drives 508, 510 for moving the energy applicator 600 within the enclosure (Fig. 3 A). The motor drives are connected directly, or through a gear assembly, to a pair of traveler rods 520, 528. The traveler rods in turn move a pair of slotted actuators 520', 528'. The slotted actuators travel along the traveler rods carrying the energy applicator at the intersection of the two slotted actuators. As the traveler rods rotate in response to movement from the motors, the slotted actuators carry the energy applicator throughout the range of motion of the slotted traveler rods. Rotational encoders 530 are positioned on the traveler rods 520, 528 so that the movement of the energy applicator can be accurately measured.
[0031] Alternatively, the motor drives 508, 510 can directly drive rotational actuators 514, 516 to move the energy applicator 600 within the enclosure (Fig 3B). In this embodiment there is no need for a gear mechanism. As the motor drives move the axis of the motor assemblies back and forth, the actuators 514, 516 move in direct correlation to the motors. The sensitivity of the positioning of the energy applicator can be controlled through the motor drives, or the actuators used in response to the energy applicator. Three motors (not shown) may also be used to drive three articulating arms.
[0032] Figure 4 illustrates a schematic of the present invention. The therapy head 50 is shown in cross section with a partition 504 separating an upper enclosure from a lower enclosure. The partition is water tight so that fluid in the lower partition does not seep into the upper enclosure. There are a pair of motor drive units 508, 510 within the upper enclosure. The motor drive units pass rotational energy to the energy applicator 600 through a series of mechanical actuators 514, 516, 518. The actuators extend through the water tight partition 504 and are themselves water resistant. An acoustic window 590 is displaced at the bottom of the enclosure.

Claims

WHAT IS CLAIMED IS: 1. An ultrasound head comprising: an enclosure having a window; at least one directional energy applicator suspended within said enclosure; and a positioner within said enclosure for maneuvering the energy applicator such that said energy applicator radiates energy through said window.
2. The therapy head of claim 1 , wherein said window is a transmissible window for said energy applicator.
3. The therapy head of claim 1 , wherein said energy applicator is an ultrasound transducer.
4. The energy applicator of claim 3, wherein said ultrasound transducer is an imaging transducer.
5. The energy applicator of claim 3, wherein said ultrasound transducer is a high intensity focused ultrasound transducer.
6. The therapy head of claim 1, wherein the energy applicator is a component ultrasound transducer.
7. The therapy head of claim 1, wherein the means for maneuvering said energy applicator includes a one or more position sensors.
8. The therapy head of claim 1 , wherein said window is a disposable transducer seal.
9. The therapy head of claim 1, wherein said positioner comprises a plurality of actuators driven by one or more motors, wherein said energy applicator is movably attached to said actuators.
10. The means for maneuvering said energy applicator as described in claim 9, further comprising a plurality of encoders for measuring movement within said enclosure.
11. The means for maneuvering said energy applicator as described in claim 10, wherein said motors are electrical motors.
12. The therapy head of claim 1 , wherein said energy applicator is removable and interchangeable within the enclosure.
13. The therapy head of claim 1 , wherein said positioner further comprises a plurality of encoders.
14. The therapy head of claim 1, wherein said enclosure further comprises a horizontal water tight partition defining an upper enclosure and a lower enclosure, said upper enclosure containing said means for maneuvering and said lower enclosure containing said energy applicator, said window being in said lower enclosure.
15. The therapy head of claim 14, further comprising a fluid circulation system for circulating a coupling fluid through said lower enclosure.
16. A method for delivering ultrasound energy to a body surface, said method comprising: engaging an enclosure against the body structure; and positioning and activating an ultrasound transducer within the enclosure so that ultrasound energy is scanned over the body surface through a window in the enclosure which remains stationary relative to the body surface.
PCT/US2004/044046 2003-12-30 2004-12-29 Ultrasound therapy head with movement control WO2005065409A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP04816028A EP1699407A4 (en) 2003-12-30 2004-12-29 Ultrasound therapy head with movement control
JP2006547594A JP2007516810A (en) 2003-12-30 2004-12-29 Ultrasonic therapy head with motion control
CA002551348A CA2551348A1 (en) 2003-12-30 2004-12-29 Ultrasound therapy head with movement control
KR1020067013272A KR101188930B1 (en) 2003-12-30 2004-12-29 Ultrasound therapy head with movement control
AU2004311459A AU2004311459B2 (en) 2003-12-30 2004-12-29 Ultrasound therapy head with movement control
CN2004800390469A CN1897907B (en) 2003-12-30 2004-12-29 Ultrasound therapy head with movement control
BRPI0417907-2A BRPI0417907A (en) 2003-12-30 2004-12-29 ultrasound head, energy applicator, means for maneuvering it, and method for distributing ultrasound energy to a body surface

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53403603P 2003-12-30 2003-12-30
US60/534,036 2003-12-30

Publications (2)

Publication Number Publication Date
WO2005065409A2 true WO2005065409A2 (en) 2005-07-21
WO2005065409A3 WO2005065409A3 (en) 2006-04-20

Family

ID=34748986

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/044046 WO2005065409A2 (en) 2003-12-30 2004-12-29 Ultrasound therapy head with movement control

Country Status (9)

Country Link
US (2) US7695437B2 (en)
EP (1) EP1699407A4 (en)
JP (1) JP2007516810A (en)
KR (1) KR101188930B1 (en)
CN (1) CN1897907B (en)
AU (1) AU2004311459B2 (en)
BR (1) BRPI0417907A (en)
CA (1) CA2551348A1 (en)
WO (1) WO2005065409A2 (en)

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1967232A1 (en) * 2005-12-27 2008-09-10 Chongqing Ronghai Medical Ultrasound Industry Ltd. Swinging high intensity focused ultrasound therapeutic apparatus and mri guided high intensity focused ultrasound therapeutic system thereof
EP2043584A2 (en) * 2006-07-13 2009-04-08 Misonix, Inc. High intensity focused ultrasound method and associated apparatus
WO2009051656A1 (en) * 2007-10-12 2009-04-23 Ushifu, Llc High-intensity focused ultrasound probe movement control device
US8932238B2 (en) 2009-09-29 2015-01-13 Liposonix, Inc. Medical ultrasound device with liquid dispensing device coupled to a therapy head
US10010721B2 (en) 2004-10-06 2018-07-03 Guided Therapy Systems, L.L.C. Energy based fat reduction
US10010726B2 (en) 2004-10-06 2018-07-03 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
US10010724B2 (en) 2004-10-06 2018-07-03 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
US10010725B2 (en) 2004-10-06 2018-07-03 Guided Therapy Systems, Llc Ultrasound probe for fat and cellulite reduction
US10046181B2 (en) 2004-10-06 2018-08-14 Guided Therapy Systems, Llc Energy based hyperhidrosis treatment
US10046182B2 (en) 2004-10-06 2018-08-14 Guided Therapy Systems, Llc Methods for face and neck lifts
US10420960B2 (en) 2013-03-08 2019-09-24 Ulthera, Inc. Devices and methods for multi-focus ultrasound therapy
US10525288B2 (en) 2004-10-06 2020-01-07 Guided Therapy Systems, Llc System and method for noninvasive skin tightening
US10537304B2 (en) 2008-06-06 2020-01-21 Ulthera, Inc. Hand wand for ultrasonic cosmetic treatment and imaging
US10603521B2 (en) 2014-04-18 2020-03-31 Ulthera, Inc. Band transducer ultrasound therapy
US10864385B2 (en) 2004-09-24 2020-12-15 Guided Therapy Systems, Llc Rejuvenating skin by heating tissue for cosmetic treatment of the face and body
ES2850083A1 (en) * 2020-02-21 2021-08-25 Consejo Superior Investigacion DEVICE TO APPLY FOCUSED PHYSIOTHERAPEUTIC ULTRASOUNDS AND POSITIONING METHOD OF THE SAME (Machine-translation by Google Translate, not legally binding)
US11207548B2 (en) 2004-10-07 2021-12-28 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
US11224895B2 (en) 2016-01-18 2022-01-18 Ulthera, Inc. Compact ultrasound device having annular ultrasound array peripherally electrically connected to flexible printed circuit board and method of assembly thereof
US11235179B2 (en) 2004-10-06 2022-02-01 Guided Therapy Systems, Llc Energy based skin gland treatment
US11241218B2 (en) 2016-08-16 2022-02-08 Ulthera, Inc. Systems and methods for cosmetic ultrasound treatment of skin
US11338156B2 (en) 2004-10-06 2022-05-24 Guided Therapy Systems, Llc Noninvasive tissue tightening system
US11724133B2 (en) 2004-10-07 2023-08-15 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
US11883688B2 (en) 2004-10-06 2024-01-30 Guided Therapy Systems, Llc Energy based fat reduction
US11944849B2 (en) 2018-02-20 2024-04-02 Ulthera, Inc. Systems and methods for combined cosmetic treatment of cellulite with ultrasound
US12076591B2 (en) 2018-01-26 2024-09-03 Ulthera, Inc. Systems and methods for simultaneous multi-focus ultrasound therapy in multiple dimensions
US12102473B2 (en) 2008-06-06 2024-10-01 Ulthera, Inc. Systems for ultrasound treatment

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6050943A (en) 1997-10-14 2000-04-18 Guided Therapy Systems, Inc. Imaging, therapy, and temperature monitoring ultrasonic system
US7914453B2 (en) 2000-12-28 2011-03-29 Ardent Sound, Inc. Visual imaging system for ultrasonic probe
CN1897907B (en) * 2003-12-30 2012-06-20 麦迪斯技术公司 Ultrasound therapy head with movement control
BRPI0417022A (en) * 2003-12-30 2007-02-21 Liposonix Inc systems for applying energy to a body region, for producing a topographic subcutaneous tissue map, and for positioning a medical device, apparatus for guiding the movement of an energy emitter over a patient's body, methods for applying energy to a patient's body. body region, to perform a lipoplasty therapy procedure, to destroy fat tissue, to create a 3d body map with the locations of fat tissue volumes, to body sculpture using a 3d body map, and to position a head space ultrasound therapy
CN1901837B (en) * 2003-12-30 2010-05-12 利普索尼克斯股份有限公司 Component ultrasound transducer
US7857773B2 (en) * 2003-12-30 2010-12-28 Medicis Technologies Corporation Apparatus and methods for the destruction of adipose tissue
US8235909B2 (en) 2004-05-12 2012-08-07 Guided Therapy Systems, L.L.C. Method and system for controlled scanning, imaging and/or therapy
US7824348B2 (en) 2004-09-16 2010-11-02 Guided Therapy Systems, L.L.C. System and method for variable depth ultrasound treatment
US9011336B2 (en) 2004-09-16 2015-04-21 Guided Therapy Systems, Llc Method and system for combined energy therapy profile
US7393325B2 (en) 2004-09-16 2008-07-01 Guided Therapy Systems, L.L.C. Method and system for ultrasound treatment with a multi-directional transducer
US7758524B2 (en) 2004-10-06 2010-07-20 Guided Therapy Systems, L.L.C. Method and system for ultra-high frequency ultrasound treatment
CA2583600A1 (en) 2004-10-06 2006-04-20 Guided Therapy Systems, L.L.C. Method and system for noninvasive cosmetic enhancement
EP2409729A1 (en) 2004-10-06 2012-01-25 Guided Therapy Systems, L.L.C. Method and system for ultrasound tissue treatment
US20060122509A1 (en) * 2004-11-24 2006-06-08 Liposonix, Inc. System and methods for destroying adipose tissue
US8218477B2 (en) * 2005-03-31 2012-07-10 Alcatel Lucent Method of detecting wireless network faults
US7571336B2 (en) 2005-04-25 2009-08-04 Guided Therapy Systems, L.L.C. Method and system for enhancing safety with medical peripheral device by monitoring if host computer is AC powered
US10219815B2 (en) 2005-09-22 2019-03-05 The Regents Of The University Of Michigan Histotripsy for thrombolysis
US8155729B1 (en) * 2006-02-17 2012-04-10 General Electric Company Method and apparatus to compensate imaging data with simultaneously acquired motion data
US9107798B2 (en) * 2006-03-09 2015-08-18 Slender Medical Ltd. Method and system for lipolysis and body contouring
US20090048514A1 (en) * 2006-03-09 2009-02-19 Slender Medical Ltd. Device for ultrasound monitored tissue treatment
US7828734B2 (en) * 2006-03-09 2010-11-09 Slender Medical Ltd. Device for ultrasound monitored tissue treatment
JP4703724B2 (en) 2006-04-28 2011-06-15 ゼルティック エステティックス インコーポレイテッド Antifreeze for use in therapeutic devices with improved cooling of subcutaneous lipid-rich cells
US9566454B2 (en) 2006-09-18 2017-02-14 Guided Therapy Systems, Llc Method and sysem for non-ablative acne treatment and prevention
US20080077201A1 (en) 2006-09-26 2008-03-27 Juniper Medical, Inc. Cooling devices with flexible sensors
US8192474B2 (en) 2006-09-26 2012-06-05 Zeltiq Aesthetics, Inc. Tissue treatment methods
US9132031B2 (en) 2006-09-26 2015-09-15 Zeltiq Aesthetics, Inc. Cooling device having a plurality of controllable cooling elements to provide a predetermined cooling profile
US9241683B2 (en) 2006-10-04 2016-01-26 Ardent Sound Inc. Ultrasound system and method for imaging and/or measuring displacement of moving tissue and fluid
US8038622B2 (en) * 2007-08-03 2011-10-18 Innoscion, Llc Wired and wireless remotely controlled ultrasonic transducer and imaging apparatus
US8142200B2 (en) * 2007-03-26 2012-03-27 Liposonix, Inc. Slip ring spacer and method for its use
JP4892732B2 (en) * 2007-03-28 2012-03-07 国立大学法人岐阜大学 Blood vessel imaging method, blood vessel imaging system, and blood vessel imaging program
CN101274124B (en) * 2007-03-29 2010-06-23 重庆融海超声医学工程研究中心有限公司 Ultrasonic medical treating gun
US9216276B2 (en) * 2007-05-07 2015-12-22 Guided Therapy Systems, Llc Methods and systems for modulating medicants using acoustic energy
WO2008137944A1 (en) 2007-05-07 2008-11-13 Guided Therapy Systems, Llc. Methods and systems for coupling and focusing acoustic energy using a coupler member
US20150174388A1 (en) 2007-05-07 2015-06-25 Guided Therapy Systems, Llc Methods and Systems for Ultrasound Assisted Delivery of a Medicant to Tissue
US20080287839A1 (en) 2007-05-18 2008-11-20 Juniper Medical, Inc. Method of enhanced removal of heat from subcutaneous lipid-rich cells and treatment apparatus having an actuator
US8523927B2 (en) 2007-07-13 2013-09-03 Zeltiq Aesthetics, Inc. System for treating lipid-rich regions
US8285390B2 (en) 2007-08-21 2012-10-09 Zeltiq Aesthetics, Inc. Monitoring the cooling of subcutaneous lipid-rich cells, such as the cooling of adipose tissue
JP4831534B2 (en) * 2007-09-28 2011-12-07 株式会社テクノリンク Biological stimulator
WO2009050719A2 (en) * 2007-10-15 2009-04-23 Slender Medical, Ltd. Implosion techniques for ultrasound
US20090240146A1 (en) * 2007-10-26 2009-09-24 Liposonix, Inc. Mechanical arm
CN101861186B (en) * 2007-11-15 2014-03-05 皇家飞利浦电子股份有限公司 Method and apparatus for positional tracking of therapeutic ultrasound transducer
AU2009208982B2 (en) * 2008-02-01 2013-07-04 Solta Medical, Inc. Therapy head for use with an ultrasound system
CN101614596B (en) * 2008-06-24 2011-11-09 北京奥麦特科技有限公司 Temperature detecting device for HIFU radiation treatment area
US20110178541A1 (en) * 2008-09-12 2011-07-21 Slender Medical, Ltd. Virtual ultrasonic scissors
US8275442B2 (en) 2008-09-25 2012-09-25 Zeltiq Aesthetics, Inc. Treatment planning systems and methods for body contouring applications
US9757595B2 (en) * 2008-10-14 2017-09-12 Theraclion Sa Systems and methods for synchronizing ultrasound treatment of thryoid and parathyroid with movements of patients
US8353832B2 (en) * 2008-10-14 2013-01-15 Theraclion Systems and methods for ultrasound treatment of thyroid and parathyroid
US8603073B2 (en) 2008-12-17 2013-12-10 Zeltiq Aesthetics, Inc. Systems and methods with interrupt/resume capabilities for treating subcutaneous lipid-rich cells
AR076081A1 (en) * 2009-03-04 2011-05-18 Medicis Technologies Corp PROVISION FOR THE TREATMENT BY ULTRASOUND OF TISSUE ADIPOSE TO MULTIPLE DEPTHS
US8208346B2 (en) * 2009-03-23 2012-06-26 Liposonix, Inc. Selectable tuning transformer
BRPI1014623B1 (en) 2009-04-30 2020-01-07 Zeltiq Aesthetics, Inc. SYSTEM FOR TREATING SUBCUTANEOUS CELLS RICH IN LIPIDS IN A TARGET AREA
US8298163B1 (en) 2009-05-01 2012-10-30 Body Beam Research Inc. Non-invasive ultrasonic soft-tissue treatment apparatus
US8715186B2 (en) 2009-11-24 2014-05-06 Guided Therapy Systems, Llc Methods and systems for generating thermal bubbles for improved ultrasound imaging and therapy
AU2011207506A1 (en) 2010-01-25 2012-08-09 Zeltiq Aesthetics, Inc. Home-use applicators for non-invasively removing heat from subcutaneous lipid-rich cells via phase change coolants, and associated devices, systems and methods
US8676338B2 (en) 2010-07-20 2014-03-18 Zeltiq Aesthetics, Inc. Combined modality treatment systems, methods and apparatus for body contouring applications
CA2802481A1 (en) 2010-07-24 2012-02-09 Liposonix, Inc. Apparatus and methods for non-invasive body contouring
WO2012018390A2 (en) 2010-08-02 2012-02-09 Guided Therapy Systems, Llc Systems and methods for treating acute and/or chronic injuries in soft tissue
US9504446B2 (en) 2010-08-02 2016-11-29 Guided Therapy Systems, Llc Systems and methods for coupling an ultrasound source to tissue
KR101977130B1 (en) * 2010-08-18 2019-08-28 미라빌리스 메디카 인코포레이티드 Hifu applicator
US8857438B2 (en) 2010-11-08 2014-10-14 Ulthera, Inc. Devices and methods for acoustic shielding
US20130281737A1 (en) 2010-12-29 2013-10-24 Rohm And Haas Company Method for reducing equipment fouling in (meth)acrylic acid production process
EP2739357B1 (en) 2011-07-10 2023-09-06 Guided Therapy Systems, L.L.C. Systems for improving an outside appearance of skin using ultrasound as an energy source
US9011337B2 (en) 2011-07-11 2015-04-21 Guided Therapy Systems, Llc Systems and methods for monitoring and controlling ultrasound power output and stability
US9263663B2 (en) 2012-04-13 2016-02-16 Ardent Sound, Inc. Method of making thick film transducer arrays
US20130296743A1 (en) * 2012-05-02 2013-11-07 Siemens Medical Solutions Usa, Inc. Ultrasound for Therapy Control or Monitoring
US9510802B2 (en) 2012-09-21 2016-12-06 Guided Therapy Systems, Llc Reflective ultrasound technology for dermatological treatments
WO2014055708A1 (en) * 2012-10-02 2014-04-10 Ardent Sound, Inc. Motion mechanisms for ultrasound transducer modules
US20140100459A1 (en) 2012-10-05 2014-04-10 The Regents Of The University Of Michigan Bubble-induced color doppler feedback during histotripsy
EP2722012B1 (en) 2012-10-18 2015-06-03 Storz Medical AG Device for shock wave treatment of the human brain
CN103961806B (en) * 2013-01-29 2017-11-07 重庆海扶医疗科技股份有限公司 Ultrasonic therapeutic head and ultrasonic therapeutic apparatus
US9844460B2 (en) 2013-03-14 2017-12-19 Zeltiq Aesthetics, Inc. Treatment systems with fluid mixing systems and fluid-cooled applicators and methods of using the same
US9545523B2 (en) 2013-03-14 2017-01-17 Zeltiq Aesthetics, Inc. Multi-modality treatment systems, methods and apparatus for altering subcutaneous lipid-rich tissue
US10561862B2 (en) 2013-03-15 2020-02-18 Guided Therapy Systems, Llc Ultrasound treatment device and methods of use
KR101307551B1 (en) * 2013-03-26 2013-09-12 (주)클래시스 Handpiece of ultrasonic apparatus
WO2015003154A1 (en) 2013-07-03 2015-01-08 Histosonics, Inc. Articulating arm limiter for cavitational ultrasound therapy system
US10780298B2 (en) 2013-08-22 2020-09-22 The Regents Of The University Of Michigan Histotripsy using very short monopolar ultrasound pulses
KR101808835B1 (en) * 2013-09-12 2017-12-13 알피니언메디칼시스템 주식회사 High strength focused ultrasonic wave treatment head having improved sealing characteristic
ES2974899T3 (en) 2014-01-31 2024-07-02 Zeltiq Aesthetics Inc Compositions and treatment systems for enhanced cooling of lipid-rich tissue
US10675176B1 (en) 2014-03-19 2020-06-09 Zeltiq Aesthetics, Inc. Treatment systems, devices, and methods for cooling targeted tissue
USD777338S1 (en) 2014-03-20 2017-01-24 Zeltiq Aesthetics, Inc. Cryotherapy applicator for cooling tissue
US10952891B1 (en) 2014-05-13 2021-03-23 Zeltiq Aesthetics, Inc. Treatment systems with adjustable gap applicators and methods for cooling tissue
US10935174B2 (en) 2014-08-19 2021-03-02 Zeltiq Aesthetics, Inc. Stress relief couplings for cryotherapy apparatuses
US10568759B2 (en) 2014-08-19 2020-02-25 Zeltiq Aesthetics, Inc. Treatment systems, small volume applicators, and methods for treating submental tissue
WO2016064016A1 (en) 2014-10-24 2016-04-28 (주)클래시스 Ultrasonic cartridge and ultrasonic treatment head using same
RU2613431C2 (en) * 2015-06-17 2017-03-16 федеральное государственное автономное образовательное учреждение высшего образования "Санкт-Петербургский политехнический университет Петра Великого" ФГАОУ ВО СПбПУ" Device for energy impact on anatomical structures
EP4230262A3 (en) 2015-06-24 2023-11-22 The Regents Of The University Of Michigan Histotripsy therapy systems for the treatment of brain tissue
WO2017070112A1 (en) 2015-10-19 2017-04-27 Zeltiq Aesthetics, Inc. Vascular treatment systems, cooling devices, and methods for cooling vascular structures
KR20170051979A (en) * 2015-11-03 2017-05-12 이일권 Method And Apparatus for Detecting Abnormal Operation of Oscillator
KR101649519B1 (en) 2015-12-03 2016-08-19 (주)클래시스 Head of ultrasonic therapy system for treatment
KR101643885B1 (en) 2015-12-14 2016-07-29 (주)클래시스 Ultrasonic cartridge
US10524956B2 (en) 2016-01-07 2020-01-07 Zeltiq Aesthetics, Inc. Temperature-dependent adhesion between applicator and skin during cooling of tissue
US10765552B2 (en) 2016-02-18 2020-09-08 Zeltiq Aesthetics, Inc. Cooling cup applicators with contoured heads and liner assemblies
WO2017176009A1 (en) * 2016-04-05 2017-10-12 (주)클래시스 Ultrasonic transducer exercise apparatus and ultrasonic therapeutic head using same
US10555831B2 (en) 2016-05-10 2020-02-11 Zeltiq Aesthetics, Inc. Hydrogel substances and methods of cryotherapy
US10682297B2 (en) 2016-05-10 2020-06-16 Zeltiq Aesthetics, Inc. Liposomes, emulsions, and methods for cryotherapy
US11382790B2 (en) 2016-05-10 2022-07-12 Zeltiq Aesthetics, Inc. Skin freezing systems for treating acne and skin conditions
KR101677903B1 (en) * 2016-05-16 2016-11-21 정성재 Ultrasonic cartridge and head of ultrasonic therapy system for treatment
US11076879B2 (en) 2017-04-26 2021-08-03 Zeltiq Aesthetics, Inc. Shallow surface cryotherapy applicators and related technology
EP3829496A1 (en) 2018-07-31 2021-06-09 Zeltiq Aesthetics, Inc. Methods, devices, and systems for improving skin characteristics
TWI692349B (en) * 2018-08-20 2020-05-01 美康生物科技有限公司 Focused ultrasound probe
JP2022510654A (en) 2018-11-28 2022-01-27 ヒストソニックス，インコーポレーテッド Tissue disruption system and method
CA3169465A1 (en) 2020-01-28 2021-08-05 The Regents Of The University Of Michigan Systems and methods for histotripsy immunosensitization
JP2023553142A (en) * 2020-12-11 2023-12-20 ヴィオル カンパニー リミテッド Ultrasonic device that uses a two-row transducer movement system
KR102553256B1 (en) * 2020-12-11 2023-07-07 (주)비올 Ultrasound apparatus with reciprocating transfer way of transducer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3227624A1 (en) 1982-07-23 1984-01-26 Siemens AG, 1000 Berlin und 8000 München Device for examining the female breast using ultrasound
DE19745400C1 (en) 1997-10-14 1999-04-15 Siemens Ag Ultrasonic breast tumour therapy process
US20020042574A1 (en) 1998-11-18 2002-04-11 Biosonix Ltd. Dual ultrasonic transducer probe for blood flow measurment, and blood vessel diameter determination method
WO2003059434A2 (en) 2002-01-21 2003-07-24 Nanyang Technological University Ultrasonic treatment of breast cancer

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB820814A (en) 1955-12-22 1959-09-30 Univ Illinois Apparatus for treating living tissue
US3454923A (en) * 1968-02-01 1969-07-08 Honeywell Inc Transducer control apparatus
US4002221A (en) * 1972-09-19 1977-01-11 Gilbert Buchalter Method of transmitting ultrasonic impulses to surface using transducer coupling agent
US4059098A (en) * 1975-07-21 1977-11-22 Stanford Research Institute Flexible ultrasound coupling system
DE2826277C2 (en) * 1978-06-15 1980-07-17 Siemens Ag, 1000 Berlin Und 8000 Muenchen Device for ultrasonic scanning of objects
US4211949A (en) * 1978-11-08 1980-07-08 General Electric Company Wear plate for piezoelectric ultrasonic transducer arrays
US4326418A (en) * 1980-04-07 1982-04-27 North American Philips Corporation Acoustic impedance matching device
DE3021449A1 (en) * 1980-06-06 1981-12-24 Siemens AG, 1000 Berlin und 8000 München ULTRASONIC TRANSDUCER ARRANGEMENT AND METHOD FOR THE PRODUCTION THEREOF
US4368410A (en) * 1980-10-14 1983-01-11 Dynawave Corporation Ultrasound therapy device
US4459854A (en) 1981-07-24 1984-07-17 National Research Development Corporation Ultrasonic transducer coupling member
US4459845A (en) * 1982-06-25 1984-07-17 United Technologies Corporation Methods for determining rate of fuel flow to an engine
JPS595947A (en) * 1982-07-02 1984-01-12 Toshiba Corp Ultrasonic scanning apparatus
JPS6015212Y2 (en) * 1982-07-26 1985-05-14 株式会社モリタ製作所 Light arm balance mechanism
US4593699A (en) * 1983-06-13 1986-06-10 Poncy Richard P Sterile cover for intraoperative ultrasonic diagnostic devices and method and kit for providing same
US4556066A (en) * 1983-11-04 1985-12-03 The Kendall Company Ultrasound acoustical coupling pad
US4567895A (en) * 1984-04-02 1986-02-04 Advanced Technology Laboratories, Inc. Fully wetted mechanical ultrasound scanhead
US4572200A (en) * 1984-04-13 1986-02-25 Indianapolis Center For Advanced Research Intraoperative scanner
US4865042A (en) * 1985-08-16 1989-09-12 Hitachi, Ltd. Ultrasonic irradiation system
EP0253268B1 (en) * 1986-07-07 1992-12-30 Matsushita Electric Industrial Co., Ltd. Ultrasonic probe
US4756313A (en) * 1986-11-05 1988-07-12 Advanced Diagnostic Medical Systems, Inc. Ultrasonic probe
JPS63164944A (en) * 1986-12-26 1988-07-08 株式会社東芝 Ultrasonic remedy apparatus
DE3888273T3 (en) * 1987-09-30 1997-06-05 Toshiba Kawasaki Kk Medical apparatus for treatment with ultrasound.
US4936303A (en) * 1987-11-20 1990-06-26 Ultrathermics Ultrasonic heating apparatus and method
US4955365A (en) * 1988-03-02 1990-09-11 Laboratory Equipment, Corp. Localization and therapy system for treatment of spatially oriented focal disease
US4930515A (en) * 1988-10-04 1990-06-05 Diasonics, Inc. Ultrasound probe with multi-orientation tip-mounted transducer
DE9012429U1 (en) * 1990-08-30 1990-10-31 Johnson & Johnson Medical GmbH, 2000 Norderstedt Sterile ultrasound cover tube
US5253648A (en) * 1991-10-11 1993-10-19 Spacelabs Medical, Inc. Method and apparatus for excluding artifacts from automatic blood pressure measurements
US5871446A (en) * 1992-01-10 1999-02-16 Wilk; Peter J. Ultrasonic medical system and associated method
AU3727993A (en) * 1992-02-21 1993-09-13 Diasonics Inc. Ultrasound intracavity system for imaging therapy planning and treatment of focal disease
DE4207463C2 (en) * 1992-03-10 1996-03-28 Siemens Ag Arrangement for the therapy of tissue with ultrasound
DE4212809C2 (en) * 1992-04-16 1996-08-14 Siemens Ag Therapy device for treating a living being with focused acoustic waves
US5434208A (en) * 1992-07-10 1995-07-18 Akzo Nobel N.V. Optically non-linear active waveguiding material comprising a dopant having multiple donor-n-acceptor systems
CA2074424A1 (en) * 1992-07-22 1994-01-23 Bryce L. Fanning Acoustic gel
JP2825403B2 (en) * 1992-10-20 1998-11-18 株式会社日立製作所 Method, apparatus and reagents for measuring catecholamines and their metabolites
US5352301A (en) * 1992-11-20 1994-10-04 General Motors Corporation Hot pressed magnets formed from anisotropic powders
DE4241161C2 (en) * 1992-12-07 1995-04-13 Siemens Ag Acoustic therapy facility
US5262554A (en) * 1992-12-30 1993-11-16 Dow Corning Corporation Process for preparation of beta-cyanoalkylsilanes
US5738635A (en) 1993-01-22 1998-04-14 Technomed Medical Systems Adjustable focusing therapeutic apparatus with no secondary focusing
DE4302538C1 (en) * 1993-01-29 1994-04-07 Siemens Ag Ultrasonic therapy device for tumour treatment lithotripsy or osteorestoration - with ultrasonic imaging and ultrasonic treatment modes using respective acoustic wave frequencies
US6535794B1 (en) * 1993-02-23 2003-03-18 Faro Technologoies Inc. Method of generating an error map for calibration of a robot or multi-axis machining center
DE4408110A1 (en) * 1993-03-11 1994-09-15 Zentralinstitut Fuer Biomedizi Method and device for neuromagnetic stimulation
DE69431741T2 (en) * 1993-03-12 2003-09-11 Kabushiki Kaisha Toshiba, Kawasaki Device for medical treatment with ultrasound
CN2162257Y (en) * 1993-03-22 1994-04-20 刘晓东 Treating headache by ultrasonic
US5331962A (en) * 1993-04-16 1994-07-26 Cornell Research Foundation Inc. Ultrasound system for corneal biometry
AU682510B2 (en) * 1993-07-01 1997-10-09 Pfizer Japan Inc. 2-(1-(1,3-thiazolin-2-yl)azetidin-3-yl)thio-carbapenem derivatives
US5477736A (en) * 1994-03-14 1995-12-26 General Electric Company Ultrasonic transducer with lens having electrorheological fluid therein for dynamically focusing and steering ultrasound energy
US5623928A (en) * 1994-08-05 1997-04-29 Acuson Corporation Method and apparatus for coherent image formation
US5695501A (en) * 1994-09-30 1997-12-09 Ohio Medical Instrument Company, Inc. Apparatus for neurosurgical stereotactic procedures
US6152137A (en) * 1995-01-23 2000-11-28 Schwartz; Alan N. Pliable and resilient sealing pad
US5626554A (en) 1995-02-21 1997-05-06 Exogen, Inc. Gel containment structure
DE19507478C1 (en) * 1995-03-03 1996-05-15 Siemens Ag Therapy device for treatment with focused ultrasound
US5755753A (en) * 1995-05-05 1998-05-26 Thermage, Inc. Method for controlled contraction of collagen tissue
DE19681395T1 (en) * 1995-05-16 1998-04-16 Brown & Sharpe Mfg Coordinate measuring machine with articulated arm
WO1997000649A1 (en) * 1995-06-20 1997-01-09 Wan Sing Ng Articulated arm for medical procedures
US5738098A (en) * 1995-07-21 1998-04-14 Hewlett-Packard Company Multi-focus ultrasound lens
US5568810A (en) * 1995-11-28 1996-10-29 General Electric Company Ultrasound coupling medium warmer and storage means
US6085749A (en) * 1996-02-26 2000-07-11 Ethicon Endo-Surgery, Inc. Articulating guide arm for medical applications
US5769790A (en) 1996-10-25 1998-06-23 General Electric Company Focused ultrasound surgery system guided by ultrasound imaging
US5676159A (en) * 1996-11-05 1997-10-14 Janin Group Ultrasound cover
US5938922A (en) * 1997-08-19 1999-08-17 Celgard Llc Contactor for degassing liquids
US6113558A (en) * 1997-09-29 2000-09-05 Angiosonics Inc. Pulsed mode lysis method
US6007499A (en) * 1997-10-31 1999-12-28 University Of Washington Method and apparatus for medical procedures using high-intensity focused ultrasound
US6325769B1 (en) * 1998-12-29 2001-12-04 Collapeutics, Llc Method and apparatus for therapeutic treatment of skin
US6102853A (en) * 1998-01-23 2000-08-15 United States Surgical Corporation Surgical instrument
US6039689A (en) * 1998-03-11 2000-03-21 Riverside Research Institute Stripe electrode transducer for use with therapeutic ultrasonic radiation treatment
US6261249B1 (en) * 1998-03-17 2001-07-17 Exogen Inc. Ultrasonic treatment controller including gel sensing circuit
FR2778573B1 (en) * 1998-05-13 2000-09-22 Technomed Medical Systems FREQUENCY ADJUSTMENT IN A HIGH INTENSITY FOCUSED ULTRASOUND TREATMENT APPARATUS
US6039694A (en) * 1998-06-25 2000-03-21 Sonotech, Inc. Coupling sheath for ultrasound transducers
JP3321103B2 (en) * 1998-09-04 2002-09-03 ジーイー横河メディカルシステム株式会社 Image display method and ultrasonic diagnostic apparatus
US6302848B1 (en) * 1999-07-01 2001-10-16 Sonotech, Inc. In vivo biocompatible acoustic coupling media
JP2000237199A (en) * 1999-02-25 2000-09-05 Toshiba Corp Ultrasonic therapeutic device
US6350245B1 (en) * 1998-12-22 2002-02-26 William W. Cimino Transdermal ultrasonic device and method
CN1338909A (en) 1999-02-02 2002-03-06 外科器械股份有限公司 Intrabody HIFU applicator
US6233476B1 (en) * 1999-05-18 2001-05-15 Mediguide Ltd. Medical positioning system
US6142748A (en) * 1999-08-18 2000-11-07 Eastman Chemical Company Degas piping for pumps
US6361531B1 (en) * 2000-01-21 2002-03-26 Medtronic Xomed, Inc. Focused ultrasound ablation devices having malleable handle shafts and methods of using the same
US6306146B1 (en) * 2000-04-06 2001-10-23 Ohio Medical Instrument Company, Inc. Surgical instrument support and method
US6554826B1 (en) * 2000-04-21 2003-04-29 Txsonics-Ltd Electro-dynamic phased array lens for controlling acoustic wave propagation
US6613004B1 (en) * 2000-04-21 2003-09-02 Insightec-Txsonics, Ltd. Systems and methods for creating longer necrosed volumes using a phased array focused ultrasound system
US6419648B1 (en) * 2000-04-21 2002-07-16 Insightec-Txsonics Ltd. Systems and methods for reducing secondary hot spots in a phased array focused ultrasound system
JP2001327495A (en) * 2000-05-19 2001-11-27 Shimadzu Corp Ultrasonic apparatus
US6506171B1 (en) * 2000-07-27 2003-01-14 Insightec-Txsonics, Ltd System and methods for controlling distribution of acoustic energy around a focal point using a focused ultrasound system
US6679855B2 (en) * 2000-11-07 2004-01-20 Gerald Horn Method and apparatus for the correction of presbyopia using high intensity focused ultrasound
US6618620B1 (en) * 2000-11-28 2003-09-09 Txsonics Ltd. Apparatus for controlling thermal dosing in an thermal treatment system
US7347855B2 (en) * 2001-10-29 2008-03-25 Ultrashape Ltd. Non-invasive ultrasonic body contouring
US6607498B2 (en) * 2001-01-03 2003-08-19 Uitra Shape, Inc. Method and apparatus for non-invasive body contouring by lysing adipose tissue
AU2002217412B2 (en) * 2001-01-03 2006-09-14 Ultrashape Ltd. Non-invasive ultrasonic body contouring
US6575906B1 (en) * 2001-04-19 2003-06-10 Acuson Corporation Rapid-heating ultrasound gel warmer
US6561389B1 (en) * 2001-07-31 2003-05-13 Walter R. Earle Dispenser apparatus for medical grade ultrasound gel
US6709397B2 (en) * 2001-10-16 2004-03-23 Envisioneering, L.L.C. Scanning probe
WO2004034694A2 (en) * 2002-10-10 2004-04-22 Visualsonics Inc. High frequency high frame-rate ultrasound imaging system
CN1897907B (en) * 2003-12-30 2012-06-20 麦迪斯技术公司 Ultrasound therapy head with movement control
BRPI0417022A (en) * 2003-12-30 2007-02-21 Liposonix Inc systems for applying energy to a body region, for producing a topographic subcutaneous tissue map, and for positioning a medical device, apparatus for guiding the movement of an energy emitter over a patient's body, methods for applying energy to a patient's body. body region, to perform a lipoplasty therapy procedure, to destroy fat tissue, to create a 3d body map with the locations of fat tissue volumes, to body sculpture using a 3d body map, and to position a head space ultrasound therapy
US20060111744A1 (en) * 2004-10-13 2006-05-25 Guided Therapy Systems, L.L.C. Method and system for treatment of sweat glands
US20060122509A1 (en) * 2004-11-24 2006-06-08 Liposonix, Inc. System and methods for destroying adipose tissue
AU2009208982B2 (en) * 2008-02-01 2013-07-04 Solta Medical, Inc. Therapy head for use with an ultrasound system

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3227624A1 (en) 1982-07-23 1984-01-26 Siemens AG, 1000 Berlin und 8000 München Device for examining the female breast using ultrasound
DE19745400C1 (en) 1997-10-14 1999-04-15 Siemens Ag Ultrasonic breast tumour therapy process
US20020042574A1 (en) 1998-11-18 2002-04-11 Biosonix Ltd. Dual ultrasonic transducer probe for blood flow measurment, and blood vessel diameter determination method
WO2003059434A2 (en) 2002-01-21 2003-07-24 Nanyang Technological University Ultrasonic treatment of breast cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1699407A4

Cited By (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10328289B2 (en) 2004-09-24 2019-06-25 Guided Therapy Systems, Llc Rejuvenating skin by heating tissue for cosmetic treatment of the face and body
US10864385B2 (en) 2004-09-24 2020-12-15 Guided Therapy Systems, Llc Rejuvenating skin by heating tissue for cosmetic treatment of the face and body
US10888718B2 (en) 2004-10-06 2021-01-12 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
US11338156B2 (en) 2004-10-06 2022-05-24 Guided Therapy Systems, Llc Noninvasive tissue tightening system
US10888717B2 (en) 2004-10-06 2021-01-12 Guided Therapy Systems, Llc Probe for ultrasound tissue treatment
US11717707B2 (en) 2004-10-06 2023-08-08 Guided Therapy Systems, Llc System and method for noninvasive skin tightening
US11697033B2 (en) 2004-10-06 2023-07-11 Guided Therapy Systems, Llc Methods for lifting skin tissue
US10010721B2 (en) 2004-10-06 2018-07-03 Guided Therapy Systems, L.L.C. Energy based fat reduction
US10010726B2 (en) 2004-10-06 2018-07-03 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
US10010724B2 (en) 2004-10-06 2018-07-03 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
US10010725B2 (en) 2004-10-06 2018-07-03 Guided Therapy Systems, Llc Ultrasound probe for fat and cellulite reduction
US10046181B2 (en) 2004-10-06 2018-08-14 Guided Therapy Systems, Llc Energy based hyperhidrosis treatment
US10046182B2 (en) 2004-10-06 2018-08-14 Guided Therapy Systems, Llc Methods for face and neck lifts
US10238894B2 (en) 2004-10-06 2019-03-26 Guided Therapy Systems, L.L.C. Energy based fat reduction
US10245450B2 (en) 2004-10-06 2019-04-02 Guided Therapy Systems, Llc Ultrasound probe for fat and cellulite reduction
US10252086B2 (en) 2004-10-06 2019-04-09 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
US10265550B2 (en) 2004-10-06 2019-04-23 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
US10888716B2 (en) 2004-10-06 2021-01-12 Guided Therapy Systems, Llc Energy based fat reduction
US11400319B2 (en) 2004-10-06 2022-08-02 Guided Therapy Systems, Llc Methods for lifting skin tissue
US10525288B2 (en) 2004-10-06 2020-01-07 Guided Therapy Systems, Llc System and method for noninvasive skin tightening
US10532230B2 (en) 2004-10-06 2020-01-14 Guided Therapy Systems, Llc Methods for face and neck lifts
US11235179B2 (en) 2004-10-06 2022-02-01 Guided Therapy Systems, Llc Energy based skin gland treatment
US10603519B2 (en) 2004-10-06 2020-03-31 Guided Therapy Systems, Llc Energy based fat reduction
US11235180B2 (en) 2004-10-06 2022-02-01 Guided Therapy Systems, Llc System and method for noninvasive skin tightening
US10603523B2 (en) 2004-10-06 2020-03-31 Guided Therapy Systems, Llc Ultrasound probe for tissue treatment
US10610706B2 (en) 2004-10-06 2020-04-07 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
US10610705B2 (en) 2004-10-06 2020-04-07 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
US11207547B2 (en) 2004-10-06 2021-12-28 Guided Therapy Systems, Llc Probe for ultrasound tissue treatment
US11179580B2 (en) 2004-10-06 2021-11-23 Guided Therapy Systems, Llc Energy based fat reduction
US11883688B2 (en) 2004-10-06 2024-01-30 Guided Therapy Systems, Llc Energy based fat reduction
US11167155B2 (en) 2004-10-06 2021-11-09 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
US10960236B2 (en) 2004-10-06 2021-03-30 Guided Therapy Systems, Llc System and method for noninvasive skin tightening
US11724133B2 (en) 2004-10-07 2023-08-15 Guided Therapy Systems, Llc Ultrasound probe for treatment of skin
US11207548B2 (en) 2004-10-07 2021-12-28 Guided Therapy Systems, L.L.C. Ultrasound probe for treating skin laxity
EP1967232A4 (en) * 2005-12-27 2009-02-25 Chongqing Ronghai Medical Ultrasound Industry Ltd Swinging high intensity focused ultrasound therapeutic apparatus and mri guided high intensity focused ultrasound therapeutic system thereof
EP1967232A1 (en) * 2005-12-27 2008-09-10 Chongqing Ronghai Medical Ultrasound Industry Ltd. Swinging high intensity focused ultrasound therapeutic apparatus and mri guided high intensity focused ultrasound therapeutic system thereof
EP2043584A2 (en) * 2006-07-13 2009-04-08 Misonix, Inc. High intensity focused ultrasound method and associated apparatus
EP2043584A4 (en) * 2006-07-13 2010-12-29 Misonix Inc High intensity focused ultrasound method and associated apparatus
WO2009051656A1 (en) * 2007-10-12 2009-04-23 Ushifu, Llc High-intensity focused ultrasound probe movement control device
US12102473B2 (en) 2008-06-06 2024-10-01 Ulthera, Inc. Systems for ultrasound treatment
US11723622B2 (en) 2008-06-06 2023-08-15 Ulthera, Inc. Systems for ultrasound treatment
US10537304B2 (en) 2008-06-06 2020-01-21 Ulthera, Inc. Hand wand for ultrasonic cosmetic treatment and imaging
US11123039B2 (en) 2008-06-06 2021-09-21 Ulthera, Inc. System and method for ultrasound treatment
US8932238B2 (en) 2009-09-29 2015-01-13 Liposonix, Inc. Medical ultrasound device with liquid dispensing device coupled to a therapy head
US10010722B2 (en) 2009-09-29 2018-07-03 Liposonix, Inc. Transducer cartridge for an ultrasound therapy head
US10420960B2 (en) 2013-03-08 2019-09-24 Ulthera, Inc. Devices and methods for multi-focus ultrasound therapy
US11517772B2 (en) 2013-03-08 2022-12-06 Ulthera, Inc. Devices and methods for multi-focus ultrasound therapy
US11969609B2 (en) 2013-03-08 2024-04-30 Ulthera, Inc. Devices and methods for multi-focus ultrasound therapy
US10603521B2 (en) 2014-04-18 2020-03-31 Ulthera, Inc. Band transducer ultrasound therapy
US11351401B2 (en) 2014-04-18 2022-06-07 Ulthera, Inc. Band transducer ultrasound therapy
US11224895B2 (en) 2016-01-18 2022-01-18 Ulthera, Inc. Compact ultrasound device having annular ultrasound array peripherally electrically connected to flexible printed circuit board and method of assembly thereof
US11241218B2 (en) 2016-08-16 2022-02-08 Ulthera, Inc. Systems and methods for cosmetic ultrasound treatment of skin
US12076591B2 (en) 2018-01-26 2024-09-03 Ulthera, Inc. Systems and methods for simultaneous multi-focus ultrasound therapy in multiple dimensions
US11944849B2 (en) 2018-02-20 2024-04-02 Ulthera, Inc. Systems and methods for combined cosmetic treatment of cellulite with ultrasound
WO2021165562A1 (en) * 2020-02-21 2021-08-26 Consejo Superior De Investigaciones Cientificas (Csic) Device for the application of focalised physiotherapeutic ultrasound, and method for the positioning of the same
ES2850083A1 (en) * 2020-02-21 2021-08-25 Consejo Superior Investigacion DEVICE TO APPLY FOCUSED PHYSIOTHERAPEUTIC ULTRASOUNDS AND POSITIONING METHOD OF THE SAME (Machine-translation by Google Translate, not legally binding)

Also Published As

Publication number Publication date
US7695437B2 (en) 2010-04-13
JP2007516810A (en) 2007-06-28
CN1897907B (en) 2012-06-20
WO2005065409A3 (en) 2006-04-20
KR20060121267A (en) 2006-11-28
BRPI0417907A (en) 2007-04-10
CA2551348A1 (en) 2005-07-21
US20110077559A1 (en) 2011-03-31
EP1699407A4 (en) 2010-12-01
AU2004311459A1 (en) 2005-07-21
CN1897907A (en) 2007-01-17
EP1699407A2 (en) 2006-09-13
AU2004311459B2 (en) 2011-07-14
US20050187495A1 (en) 2005-08-25
KR101188930B1 (en) 2012-10-08

Similar Documents

Publication Publication Date Title
AU2004311459B2 (en) Ultrasound therapy head with movement control
JP7531542B2 (en) Ultrasound-guided opening of the blood-brain barrier
TWI414330B (en) A guided positioning module and a treatment system having the positioning module
KR101177691B1 (en) 3 axis control head of therapy system for treatment of fatness using hifu
US7993289B2 (en) Systems and methods for the destruction of adipose tissue
US20180333595A1 (en) Energy based hyperhidrosis treatment
CA2743158C (en) Focused ultrasound system
JP3578217B2 (en) Treatment device for treating heart disease and blood vessels near the heart
EP1913974B1 (en) Mri-guided focusing ultrasound therapeutic system with high intensity
US20210228914A1 (en) Energy based skin gland treatment
KR102148853B1 (en) Ultrasound apparatus for treating brain disease
JP2009542416A (en) High-density focused ultrasound therapy and related equipment
KR20200049241A (en) Ultrasound apparatus for treating brain disease
EP0514051B1 (en) Ultrasonic therapy apparatus
JPH04236953A (en) Shock wave therapeutic device

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200480039046.9

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2006547594

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2004816028

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2551348

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2004311459

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: PA/a/2006/007452

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 1020067013272

Country of ref document: KR

NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Ref document number: DE

ENP Entry into the national phase

Ref document number: 2004311459

Country of ref document: AU

Date of ref document: 20041229

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2004311459

Country of ref document: AU

WWP Wipo information: published in national office

Ref document number: 2004816028

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1020067013272

Country of ref document: KR

ENP Entry into the national phase

Ref document number: PI0417907

Country of ref document: BR