KR20200049241A - Ultrasound apparatus for treating brain disease - Google Patents

Abstract

The present invention relates to an ultrasound apparatus for treating brain diseases such as Alzheimer′s disease. The present invention is composed of a medium having acoustic impedance similar to water as a space medium between an ultrasonic transducer generating ultrasonic waves and a head of a patient. Ultrasound is irradiated to the head of the patient in an underwater atmosphere, so that ultrasonic energy can be transmitted substantially in a single medium, thereby minimizing energy transmission loss and effectively transmitting ultrasonic energy to an irradiation target area.

Description

Ultrasound apparatus for treating brain disease

The present invention relates to an ultrasonic device for the treatment of brain diseases such as Alzheimer's disease, and to an ultrasonic device capable of effectively transmitting ultrasonic energy by minimizing transmission loss of ultrasonic energy to the head.

Alzheimer's disease (AD) is a degenerative brain disease that is characterized by slowly progressing cognitive decline and behavioral disorders.

The exact mechanism and cause of Alzheimer's disease are unknown, and it is known that the over-generated amyloid beta protein is deposited on the brain and has harmful effects on brain cells, leading to the development of brain cells. It is thought that overphosphorylation, inflammatory reaction, and oxidative damage of tau protein, which play an important role, also cause brain cell damage and affect onset.

Symptom relief agents for Alzheimer's disease have been shown, and further development of therapeutic drugs, such as drugs with amyloid antibody components, has been made. However, these drugs do not have a great effect, and the reason is presumed to be caused by a blood-brain barrier (BBB) that blocks blood vessels and brain nerves.

BBB is a single layer of cells surrounding the endothelium of the capillaries that lead to the central nervous system. It acts to protect the brain by regulating the movement of substances between the brain and the blood. It can't go and acts as a natural defense line to protect the weak brain from pathogens and toxic substances. BBB sends nutrients and oxygen into the brain and discharges waste products out of the brain, while strictly restricting the passage of macromolecules, so often the necessary drug molecules may not enter the brain. Therefore, BBB has long been regarded as the most difficult obstacle to developing a treatment for brain diseases.

Recently, the use of focused ultrasound (Focused ultrasound) as a method for improving this problem has been studied. Focused ultrasound is irradiated to the brain and temporarily forms a small hole in the BBB, and it is expected that the drug can be administered through the hole. In addition, in order to maximize focused ultrasound cavitation in a specific brain tissue area, research is also being conducted to investigate focused ultrasound after injecting micro bubbles into the brain tissue.

In addition, it is detected that there is an effect of improving the memory by focusing ultrasound without administering a drug to the treatment of Alzheimer's disease, and improving memory.

Whole-brain low-intensity pulsed ultrasound therapy markedly improves cognitive dysfunctions in mouse models of dementia-Crucial roles of endothelial nitric oxide synthase; Eguchi, Kumiko et al .; Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, Volume 11, Issue 5, 959-973; Sep. 2018.

Accordingly, the present invention is to provide an ultrasound device capable of effectively transmitting ultrasound without loss to the head of a patient for the treatment of brain diseases including Alzheimer's disease.

In addition, the present invention is to provide an ultrasound device that can shorten the treatment time by efficiently performing ultrasound irradiation over a wide range of the head of the patient.

An ultrasonic device according to an embodiment of the present invention, a vertically fixed guide member; A storage tank guided by the guide member, capable of adjusting height up and down, and having a boundary membrane at the lower opening to store water at a certain level; A robot arm provided on the guide member and capable of three-dimensional driving; It includes an ultrasonic transducer provided on the tip of the robot arm to generate ultrasonic waves.

An ultrasonic device according to another embodiment of the present invention, the main body provided with a pump for supplying water; A helmet-shaped frame supported on the main body and provided to surround the head; A guide rail disposed on an inner circumferential surface of the helmet-shaped frame; An ultrasonic transducer for generating ultrasonic waves in the water by the water supplied by the pump is provided, and includes a plurality of ultrasonic generator modules supported on the guide rail.

An ultrasonic device according to another embodiment of the present invention, a helmet-shaped frame provided to surround the head; A guide rail disposed on an inner circumferential surface of the helmet-shaped frame; An ultrasonic transducer for generating ultrasonic waves in water is provided, and includes a plurality of ultrasonic generator modules supported on the guide rail.

The present invention is composed of water, a medium having an acoustic impedance similar to water, and a space medium between an ultrasonic transducer that generates ultrasonic waves and the head of a patient, and transmits ultrasonic energy to the head of a patient in an underwater atmosphere to transmit ultrasonic energy. It can minimize and effectively transmit ultrasonic energy.

In addition, the present invention can shorten the ultrasound treatment time for a wide range of heads by including an ultrasonic generating means capable of actively driving according to the shape of the patient's head or a plurality of ultrasound generating modules arranged widely according to the shape of the head of the patient. have.

1 is a configuration diagram of an ultrasonic device according to a first embodiment of the present invention.
2 is a side configuration diagram of an ultrasonic device according to a first embodiment of the present invention.
3 is a plan view of the boundary film in the ultrasound device according to the first embodiment of the present invention.
4 is a block diagram of a control unit in an ultrasonic device according to a first embodiment of the present invention.
5A to 5E are views schematically showing an ultrasound procedure using an ultrasound device according to a first embodiment of the present invention.
6 is a configuration diagram of an ultrasonic device according to a second embodiment of the present invention.
7 is a bottom view of a helmet-shaped frame in an ultrasonic device according to a second embodiment of the present invention.
8 to 10 are configuration diagrams showing different embodiments of the ultrasound generating module in the ultrasound apparatus according to the second embodiment of the present invention.
11 is a configuration diagram of an ultrasonic device according to a third embodiment of the present invention.

The specific structure or functional descriptions presented in the embodiments of the present invention are exemplified for the purpose of explaining the embodiments according to the concept of the present invention, and the embodiments according to the concept of the present invention may be implemented in various forms. In addition, it should not be construed as being limited to the embodiments described herein, and should be understood to include all modifications, equivalents, and substitutes included in the spirit and scope of the present invention.

Embodiments of the present invention relates to a device capable of effectively irradiating ultrasound to the head of a patient for the treatment of brain diseases including Alzheimer's disease, which has high reflectance at the interface of the medium and energy in a medium having a different acoustic impedance. There is a large loss. Accordingly, the present invention is to provide an ultrasonic device capable of delivering ultrasonic waves without loss to the head of a patient so as to be suitable for ultrasonic treatment of brain diseases. Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings. .

Example 1

1 is a configuration diagram of an ultrasonic device according to a first embodiment of the present invention, and FIG. 2 is a side configuration diagram thereof.

1 and 2, the ultrasonic device of the present embodiment is guided by the guide member 110 and the guide member 110, height adjustment is possible, and a boundary membrane 120 is provided in the lower opening A reservoir 130 capable of storing water at a certain level, a robot arm 140 provided in the guide member 110 and driven, and an ultrasonic transducer 152 provided at the tip of the robot arm 130 to generate ultrasonic waves It includes.

Reservoir 130 is provided with a boundary membrane 120 in the lower opening to store a certain level of water, preferably, the entire head or part of the patient's head (HD) is located inside the reservoir 130 to scan ultrasound In the process, sufficient water is stored in the water storage tank 130 so that the ultrasonic transducer 152 is operated underwater.

Preferably, the boundary film 120 is provided by a high-elasticity elastic film to seal the lower opening of the reservoir 130, and preferably, a latex, silicone, or kenton film having an acoustic impedance similar to water may be used. have. Preferably, the boundary film 120 may be provided with a marker for location recognition on the surface.

As illustrated in FIG. 3, the boundary layer 120 has a circular planar structure, and a plurality of markers 121 are appropriately distributed on the surface. Each marker 121 may have a different shape depending on the location, and the marker 121 is used as a reference point for location recognition.

Referring back to FIGS. 1 and 2, the reservoir 130 is provided with a first guide arm 131 on which one side is raised and lowered along the guide member 110, and the reservoir 110 is adjusted up and down along the guide member 110. This is possible.

The reservoir 130 may be provided with an inlet 132 and an outlet 133, and the inlet 132 and the outlet 133 are connected to the temperature control unit 160 by piping or a flexible hose to store the reservoir 130. Water stored in the circulation may be made by the temperature control unit 160.

The temperature control unit 160 includes a pump 161 for supplying water in circulation, and a heat source supply unit 162 provided on a circulation system in which water is circulated by the pump 161 to control water temperature by heat exchange. Can be. The heat source supply unit 162 may be a chiller for cooling and / or a heater for heating. In addition, the temperature control unit 160 may be provided on a circulation system, and a separate water tank 163 for storing water may be added.

The temperature control unit 160 maintains the water level of the water storage tank 130 by supplying circulating water, and also serves to control the water temperature. Although not shown, the water tank has a separate water level sensor and a water temperature sensor for detecting the water level, and controls the driving of the pump 161 by the detection signals of the water level sensor and the water temperature sensor to control the water level and water temperature of the water tank within an appropriate range. Can be maintained.

The robot arm 140 is attached to the guide member 110, has a multi-joint structure, and manipulates the position and posture of the end effector provided at the tip by multi-dimensional three-dimensional driving in three dimensions. Can be provided by

The robot arm 140 is provided with a second guide arm 141 that is moved up and down along the guide member 110 so that the height of the robot arm 140 can be adjusted up and down.

An end unit 150 including an ultrasonic transducer 152 is provided at the tip of the robot arm 140. Meanwhile, the ultrasonic transducer 152 may be a focused or planar transducer for focusing ultrasound locally.

The end unit 150 includes a housing 151 and an ultrasonic transducer 152 fixed to the housing 151 to generate ultrasonic waves.

Preferably, the end unit 150 further includes an ultrasonic sensing sensor unit 153 for detecting reflected ultrasonic waves. The ultrasonic sensor unit 153 detects reverberant ultrasonic waves reflected by the ultrasonic transducer 152 when irradiated with ultrasonic waves, and detects reverberated ultrasonic waves to monitor whether or not the transmitted ultrasonic waves are normally transmitted.

Preferably, the end unit 150 further includes a camera 154 for obtaining image information and a distance measurement sensor unit 155 for measuring the distance.

The camera 154 is fixed to the housing 151 to obtain image information on an ultrasound irradiation site, and the marker of the boundary membrane 120 mentioned above can be used as a reference point for a location on the image information of the camera 154 have. A plurality of cameras 154 may be disposed in the housing 151.

The distance measurement sensor unit 155 is provided by a known distance detection means, such as a laser range finder or a high-frequency oscillation type proximity sensor, to be used to detect the shape of the head HD by detecting a distance from the end unit 150. Can be.

A control unit that controls each driving element including an ultrasonic transducer by receiving a detection signal by the plurality of sensors may be added.

Specifically, referring to FIG. 4, the control unit 170 controls the height of the reservoir and the robot arm by controlling the first guide arm 131 and the second guide arm 141, and also controls the robot arm. The position or posture of the end unit 150 is controlled.

In addition, the control unit 170 may control the ultrasonic transducer 152 to adjust the ultrasonic irradiation depth. At this time, whether the normal transmission of ultrasonic waves irradiated to the head of the patient using the echo detection signal of the ultrasonic sensing sensor unit 153 Can be judged.

In addition, the control unit 170 may scan the shape of the head of the patient using the camera 154 and the distance measurement sensor unit 155 in a step before irradiation of ultrasound to determine the depth of irradiation of ultrasound according to the position of the head.

The control unit 170 may include an input device 171 through which a user can input a command, and a display 172 through which various information generated in a procedure is output.

5A to 5E are views schematically showing an ultrasound procedure using an ultrasound device according to a first embodiment of the present invention.

As illustrated in (a) of FIG. 5, the patient is seated in a seat in which the reservoir 130 is located at the top, and at this time, to separate the head (HD) to prevent movement of the head (HD) during the procedure The fixing mechanism 1 may be used. In addition, a gel for ultrasound may be applied to the head of the patient to prevent transmission loss of ultrasound.

Next, as shown in Figure 5 (b), the reservoir 130 is lowered, the boundary membrane 120 is in close contact with the head (HD) and substantially the target portion of the ultrasound irradiation of the head (HD) is the reservoir 130 It is located inside. Thereafter, the reservoir 130 is filled with water to a certain level, and the water stored in the reservoir 130 by the temperature controller can be adjusted to a constant water temperature.

FIG. 5 (c) shows a process of calculating the position and depth of ultrasound irradiation by scanning the shape of the patient's head (HD) before the ultrasound irradiation. The robot arm 140 is driven to scan the end unit 150 as it moves along the shape of the head (HD), and this scanning process is made through the camera and the distance sensor provided in the end unit 150, Parameters for ultrasound irradiation, such as irradiation position and depth of ultrasound, may be determined according to the shape of the head (HD) of the patient.

5 (d) shows the irradiation process of the ultrasound, the robot arm 140 is operated, the end unit 150 is positioned at the irradiation position determined by the shape of the head (HD) of the patient, and the end unit ( The ultrasonic transducer of 150) irradiates ultrasonic waves to the determined irradiation depth. During the irradiation process of ultrasonic waves, the ultrasonic sensor may detect echo ultrasonic waves and monitor whether normal transmission occurs.

During the irradiation process of ultrasonic waves, the ultrasonic transducer is placed in the water to perform work. In this way, by irradiating ultrasound to the head (HD) through a boundary film in close contact with the head (HD) in the water, the ultrasound is irradiated in a single medium to minimize transmission loss due to mismatching of acoustic impedance.

Next, as shown in (e) of FIG. 5, after the ultrasonic irradiation is completed, the water stored in the reservoir 130 is recovered and the reservoir 130 and the robot arm 140 move upward to end the procedure.

Example 2

6 is a configuration diagram of an ultrasonic device according to a second embodiment of the present invention.

Referring to FIG. 6, the present exemplary embodiment includes a main body 210 provided with a pump 211 for supplying water, a helmet-shaped frame 220 supported by the main body 210 and wrapped around the head, and a helmet type It includes a guide rail 230 disposed on the inner circumferential surface of the frame 220 and a plurality of ultrasonic generating modules 240 supported on the guide rail 230 to generate ultrasonic waves.

The main body 210 is provided with a pump 211 capable of supplying water, and serves to support the helmet-shaped frame 220 by a support arm 212. In addition, the main body 210 may include a power supply unit for driving the ultrasonic generator module 240 and a control unit for control.

The support arm 212 may be rotated vertically and horizontally with respect to the main body 210, and the support arm 212 has a hollow structure and has a helmet-shaped frame 220 from the main body 210 therein. A pipe for supplying water circulation to be connected and a cable for power or control may be received.

The helmet-shaped frame 220 has a generally semi-spherical shape so that the head of the patient is located inside, and a guide rail 230 is provided on the inner circumferential surface.

The guide rail 230 is provided with a plurality of ultrasonic generating modules 240 capable of generating ultrasonic waves, and each ultrasonic generating module 240 generates ultrasonic waves in the water by water supplied by the pump 211. It includes a transducer, and specific embodiments thereof will be described again with reference to related drawings.

7 is a bottom view of the helmet-shaped frame in the ultrasonic device according to the second embodiment of the present invention, and illustrates the guide rail 230 arranged in the form of a square grid on the inner circumferential surface of the helmet-shaped frame 220. Without limitation, the guide rail may have various arrangements or structures in consideration of the number and location of the ultrasonic generating modules.

In this embodiment, the ultrasonic generating modules 240A and 240B are fixed ultrasonic generating modules 240A fixed to the guide rail 230 and movable ultrasonic generating modules 240B movable along the guide rail 230 Can be configured. As another modified example, the plurality of ultrasonic generating modules provided on the guide rail may be entirely fixed or entirely movable.

8 to 10 are configuration diagrams showing different embodiments of the ultrasonic generating module in the ultrasonic device according to the second embodiment of the present invention.

Referring to FIG. 8, the ultrasonic generator module 240 of the present embodiment includes a driving driver 241 movable along the guide rail 230 and a shock absorbing portion 242 elastically supported and connected to the driving driver 241, A module body 243 and 244 having a sealed structure and receiving the ultrasonic transducer 245 and supported by the shock absorber 242, and a water supply unit for supplying water to the module body 243 and 244 ( 249).

The driving driver 241 is for forward and backward movement along the guide rail 230, and may include a driving wheel or a driving gear capable of driving forward or reverse along the guide rail, but is not limited thereto.

The buffer portion 242 elastically supports the module body 243 and 244, so that the lower portion of the module body 243 and 244 can maintain a state in close contact with the head.

The module body 243 and 244 may be composed of a first module body 243 and a second module body 244 in which a cartridge type fitting assembly is performed with the first module body 243, and the first body module The body 243 and the second module body 244 may be inserted into an assembly site, and a known packing (not shown) for airtightness may be added. The ultrasonic transducer 245 is fixed to the first module body 243 by a fixed rod 245a, separating the second module body 244 from the first module body 243, and Replacement can be made.

The ultrasonic transducer 235 may be a focused or planar transducer for focusing ultrasound locally.

The second module body 244 has a thin flexible material such as natural rubber, silicone rubber, or the like, or a latex film having an acoustic impedance similar to water is attached to the bottom of the second module body 244 to minimize ultrasonic transmission loss while being in close contact with the head. Can be.

A touch detection sensor 248 capable of detecting whether the head is in close contact with the head may be added to the bottom of the second module body 244.

The water supply unit 249 may be provided by an inlet pipe and an outlet pipe that are positioned through the module body 243 and 244, and water supplied by driving the pump 211 (see FIG. 6) is a water supply unit. It is circulated through the module body 243 and 244 through 249.

9 is a block diagram of a ultrasonic generating module according to another embodiment of the present invention, and shows a fixed ultrasonic generating module, and a duplicate description of the same configuration as in the previous embodiment will be omitted and will be mainly described with respect to differences.

Referring to FIG. 9, in this embodiment, the buffer part 251 that elastically supports the module body 253 and 254 is directly fixed to the guide rail 230, and the first module body 253 is a transducer ( It includes a rotation drive unit 256 that can drive the rotation 255). The rotation driving unit 256 may be provided by a well-known small motor.

10 is a configuration diagram of an ultrasonic generation module according to another embodiment of the present invention, and a duplicate description of the same configuration as the previous embodiment will be omitted and the description will be mainly focused on differences.

Referring to FIG. 10, in this embodiment, the module bodies 263 and 264 are fixed to the guide rail 230 through a telescopic drive unit 261 that is adjustable in length, and thus, is driven to drive the telescopic drive unit 261. Thereby, the vertical height of the module bodies 263 and 264 can be actively adjusted.

Meanwhile, a driving driver (not shown) capable of driving back and forth along the guide rail 230 may be added to the expansion and contraction driving unit 261, so that the module body 263 and 264 may be moved back and forth or adjusted in height.

Although the ultrasonic generation module of each of these embodiments has been described separately as a separate embodiment to help understanding, it should be understood that the configurations of each embodiment can be combined with each other. In addition, each ultrasonic generating module disposed in the helmet-type frame is not limited to the same type, and ultrasonic generating modules of different embodiments may be combined and disposed.

Referring back to FIGS. 6 and 7, the patient installs the helmet-shaped frame 220 to cover the head of the patient by adjusting the position of the helmet-shaped frame 220 while seated in the seat, and then each ultrasound generating module In operation 240, ultrasound is performed by irradiating ultrasound to the affected area at a plurality of locations while in close contact with the head. During the ultrasound procedure, the ultrasound transducer of each ultrasound generating module 240 irradiates ultrasound in an underwater atmosphere, thereby minimizing transmission loss due to echo ultrasound.

Third embodiment

11 is a configuration diagram of an ultrasonic device according to a third embodiment of the present invention, which is a modified embodiment of the second embodiment. Hereinafter, the description overlapping with the second embodiment will be omitted and the description will be mainly focused on the differences.

Referring to FIG. 11, the ultrasonic device 300 according to the present embodiment includes a helmet-shaped frame 310 provided to surround a head, a guide rail 330 disposed on an inner circumferential surface of the helmet-shaped frame 310, and a guide rail It includes a plurality of ultrasonic generating module 340 is supported on 330 to generate ultrasonic waves.

The ultrasonic generator module 340 is provided with an ultrasonic transducer that generates ultrasonic waves in water, as described in the second embodiment, wherein the underwater condition in the ultrasonic generator module 340 is a separate circulation supply from the outside It can be provided by self-stored water without any need, and thus, no additional equipment such as a pump for circulating water supply or a cooling device for controlling water temperature is required.

Meanwhile, in the present embodiment, a temperature detecting means capable of sensing the water temperature of the ultrasonic generating module 340 is added, and a control means for stopping ultrasonic irradiation when rising above a certain temperature during operation may be added, or a timer It is provided that the ultrasonic irradiation can be made only for a set time.

In addition, in the present embodiment, the ultrasonic generating module 340 disposed on the guide rail 330 may be configured as a fixed type to exclude a driving unit required for displacement driving of the ultrasonic generating module 340.

The ultrasonic device 300 according to the present embodiment excludes the helmet-type frame 310 and the physically separated auxiliary equipment, and arranges all the components for ultrasonic irradiation on the head to be disposed and handled on the helmet-type frame 310 itself. And convenient operation.

The present invention described above is not limited by the above-described embodiments and accompanying drawings, and various substitutions, modifications, and changes are possible within the scope of the present invention without departing from the technical spirit of the present invention. It will be obvious to those who have the knowledge of.

110: guide member 120: boundary membrane
130: reservoir 131: second guide arm
140: robot arm 141: second guide arm
150: end unit 151: housing
152: ultrasonic transducer 153: ultrasonic detection sensor unit
154: camera 155: distance sensor
160: temperature control unit 170: control unit
171; Input device 172: display
210: main body 220, 310: helmet-shaped frame
230, 330: guide rail
240, 250, 260, 340: ultrasonic generation module
241: drive driver 242: shock absorber
243, 244, 253, 254, 263, 264: module body
245: ultrasonic transducer 247: film
248: contact detection sensor 249: water supply
256: rotation drive unit 261: telescopic drive unit

Claims (18)

A vertically fixed guide member;
A storage tank guided by the guide member, capable of adjusting height up and down, and having a boundary membrane at the lower opening to store water at a certain level;
A robot arm provided on the guide member and capable of three-dimensional driving;
An ultrasonic device including an ultrasonic transducer provided at the tip of the robot arm to generate ultrasonic waves. The ultrasonic device according to claim 1, wherein the boundary film is an elastic film having elasticity. 3. The ultrasonic device according to claim 2, wherein the elastic film is any one of latex, silicone, or ketone film. According to claim 1,
The storage tank is an ultrasonic device further comprising a temperature control unit for controlling the temperature of the stored water. According to claim 4, The temperature control unit,
A pump for circulating supply of water stored in the water storage tank;
An ultrasonic device including a heat source supply unit provided on a circulation system where circulation is performed by the pump to control water temperature by heat exchange. According to claim 1, The robot arm is provided at the tip of the ultrasonic device further comprises an ultrasonic sensing sensor for detecting the reflected ultrasound. The ultrasound device of claim 1, wherein the robot arm further comprises a camera for obtaining image information. The ultrasonic device of claim 1, wherein the robot arm further comprises a distance measurement sensor unit for measuring a distance at the tip. The ultrasound apparatus according to claim 1, wherein the boundary film is provided with a marker displayed to enable the camera to recognize a position. A body provided with a pump for supplying water;
A helmet-shaped frame supported on the main body and provided to surround the head;
A guide rail disposed on an inner circumferential surface of the helmet-shaped frame;
An ultrasonic device including a plurality of ultrasonic generating modules which are provided with an ultrasonic transducer for generating ultrasonic waves in water by the water supplied by the pump and supported on the guide rail. The method of claim 10, wherein the ultrasonic generating module,
A buffer part elastically connected to the guide rail;
A module body having a closed structure and receiving the ultrasonic transducer and supported by the buffer unit;
An ultrasonic device including a water supply unit for supplying water to the module body. 12. The ultrasonic device of claim 11, further comprising a drive driver capable of moving back and forth along the guide rail, wherein the shock absorber is connected to the guide rail via the drive driver. The method of claim 10, wherein the ultrasonic generating module,
A telescopic drive unit provided on the guide rail and capable of adjusting length;
A module body having a closed structure and receiving the ultrasonic transducer and supported by the telescopic drive unit;
An ultrasonic device including a water supply unit for supplying water to the module body. The method of claim 11 or 13,
The module body is an ultrasonic device including a first module body to which the ultrasonic transducer is fixed, and a second module body that is fitted with the first module body. The method of claim 11 or 13,
The module body is an ultrasonic device further comprising a rotation drive for rotating the ultrasonic transducer. The method of claim 11 or 13,
The module body is an ultrasonic device characterized in that a film of a thin film is attached to the lower opening that is in close contact with the human body. The method of claim 11 or 13,
The module body is an ultrasonic device further comprising a contact detection sensor that can detect whether the head and the close contact. A helmet-shaped frame provided to cover the head;
A guide rail disposed on an inner circumferential surface of the helmet-shaped frame;
An ultrasonic device including a plurality of ultrasonic generating modules that are supported on the guide rail by being provided with an ultrasonic transducer for generating ultrasonic waves in water.

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