KR101572898B1 - Ultrasonic module and helmet type stimulating apparatus using low intensity ultrasonic focused having the same - Google Patents
Ultrasonic module and helmet type stimulating apparatus using low intensity ultrasonic focused having the same Download PDFInfo
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- KR101572898B1 KR101572898B1 KR1020140029189A KR20140029189A KR101572898B1 KR 101572898 B1 KR101572898 B1 KR 101572898B1 KR 1020140029189 A KR1020140029189 A KR 1020140029189A KR 20140029189 A KR20140029189 A KR 20140029189A KR 101572898 B1 KR101572898 B1 KR 101572898B1
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Abstract
[0001] The present invention relates to an ultrasonic module and a helmet type low-intensity ultrasound focusing and stimulating device having the same. More particularly, the ultrasonic module according to the present invention comprises a module supporting part; A rotating part rotatably fixed to the module supporting part; And at least one transducer disposed on the rotating part, wherein one of the transducers is arranged in an operating position capable of irradiating ultrasonic waves to the head of the patient or detecting ultrasonic waves reflected from the head of the patient , The transducers are circulated to the operating position as the rotating part rotates.
According to the present invention, since a plurality of transducers are provided with an ultrasonic module having a rotary-circulation interchangeable structure, it is easy to easily exchange between the transducers.
Description
[0001] The present invention relates to an ultrasonic module and a helmet type low intensity ultrasound focusing apparatus having the same, and more particularly, to an ultrasound module including a plurality of transducers for irradiating ultrasonic waves of various frequencies and sensing reflected ultrasonic waves, To a stimulation apparatus using focused ultrasound.
In order to control the brain function, there are a brain cell activation method through a drug, an electrical stimulation method using a probe, and a transcranial magnetic stimulation method.
However, in the case of a brain cell activation method using drugs, there is a problem that it is impossible to control only a desired specific site as a drug. In the case of electrical stimulation using a probe, an electrocardiogram or deep brain stimulation : DBS) can implant or insert a probe at a specific location in the brain to provide electrical stimulation to temporarily or permanently convert brain function, but the risk is invariably followed by an invasive approach. In addition, the transthoracic magnetic stimulation system is a non-humidifying system that controls the brain function. It generates a strong magnetic field outside the skull to induce an induced current in the brain cortex to adjust brain function. However, (2 ㎝ ~ 3 ㎝). In addition, it is possible to stimulate only the surface of the cortex and the brain cortex of 1 ㎝ ~ 2 ㎝ deep. In the region located in the deeper brain, the size of the magnetic field And it is difficult to precisely control it.
The present invention provides an ultrasonic module in which a plurality of transducers can be easily replaced, and a helmet type low intensity ultrasound focusing and stimulating apparatus having the same.
The present invention also provides an ultrasonic module capable of improving the focusing accuracy of ultrasonic waves through a plurality of transducers and a helmet type low intensity ultrasound focusing and stimulating apparatus having the same.
The ultrasonic module according to the present invention includes a module supporting part; A rotating part rotatably fixed to the module supporting part; And at least one transducer disposed on the rotating part, wherein one of the transducers is arranged in an operating position capable of irradiating ultrasonic waves to the head of the patient or detecting ultrasonic waves reflected from the head of the patient , The transducers are circulated to the operating position as the rotating part rotates.
Further, the transducers may be arranged so as to be positioned on the same path of the ultrasonic wave when the transducers are placed in the operating position.
The transducer may further include: a first transducer for irradiating high intensity focused ultrasound (HIFU); A second transducer for acquiring an image of the head of the user; And a third transducer for illuminating low intensity focused ultrasound (LIFU).
In addition, the end portions of the first transducer, the second transducer, and the third transducer may be provided with a transfer portion for storing an ultrasonic wave mediator inside and mediating ultrasonic waves to the head portion of the user.
According to another aspect of the present invention, there is provided a helmet-type low-intensity ultrasound focusing apparatus, comprising: a support unit mounted on a head of a user; An ultrasonic module including a module supporting part, a rotation part rotatably fixed to the module supporting part, and a transducer provided at least in the rotation part; And a position controller connected to the supporter and configured to move the position of the ultrasonic module, wherein one of the transducers irradiates ultrasonic waves to the head of the patient or detects ultrasonic waves reflected from the head of the patient And the transducers are arranged in a circulating manner in the operating position as the rotating part rotates.
The ultrasonic module may further include: a first transducer for irradiating high intensity focused ultrasound (HIFU); A second transducer for acquiring an image of the head of the user; And a third transducer for illuminating low intensity focused ultrasound (LIFU).
The first transducer controls the high-intensity focusing ultrasonic wave to irradiate a predetermined destination point of the user's head for a predetermined period of time. The second transducer controls the second transducer And position setting means for controlling the transducer to compare the data of the predetermined destination point with the image data acquired by the second transducer and reflecting the calculated error to the initial position setting of the transducer .
The position control unit may include a first guide unit formed in an arc shape and provided and fixed to the support unit in the longitudinal direction; A second guide part formed in an arc shape and laterally connected to the support part so as to be perpendicular to the first guide part and supporting the ultrasonic module; One end of the second guide part is guided along the first guide part and rotates in the longitudinal direction, and the ultrasonic module is movable in the lateral direction along the second guide part.
Further, the ultrasonic module may include a distance adjusting unit for moving the transducer in the direction of travel of the ultrasonic wave or in the opposite direction.
And a transfer part for storing the ultrasonic wave mediating material inside and mediating ultrasound transmission interposed between the head of the user and the transducer.
In addition, the transfer unit may be provided separately on the end sides of the transducers.
The intermediate material may also be de-gas water.
According to the present invention, since a plurality of transducers are provided with an ultrasonic module having a rotary-circulation interchangeable structure, it is easy to easily exchange between the transducers.
Also, according to the present invention, it is possible to efficiently perform marking, image acquisition, and ultrasound focusing stimulation on a target while easily replacing a plurality of transducers.
1 is a perspective view showing a helmet type low intensity ultrasound focusing apparatus according to an embodiment of the present invention.
2 is a front view showing a helmet type low intensity ultrasound focusing apparatus according to an embodiment of the present invention.
3 is a side view showing a helmet type low intensity ultrasound focusing apparatus according to an embodiment of the present invention.
FIG. 4 is a partially cutaway perspective view showing an incision of a part of a helmet type low intensity ultrasound focusing apparatus according to an embodiment.
5 is a longitudinal sectional view taken along the line AA in Fig.
6 is a longitudinal sectional view for explaining the ultrasonic module.
FIG. 7 is a side view showing the helmet type low intensity ultrasound focusing apparatus of FIG. 6; FIG.
FIG. 8 is a perspective view illustrating a longitudinal position control of the helmet type low intensity ultrasound focusing apparatus according to the embodiment.
FIG. 9 is a perspective view showing a state of lateral position control of the helmet type low intensity ultrasound focusing apparatus according to an embodiment.
10 is a schematic view showing a state of distance control of an ultrasonic module according to an embodiment.
11 is a perspective view showing a state of distance control of an ultrasonic module according to an embodiment.
FIG. 12 is a perspective view illustrating a helmet type low intensity ultrasound focusing and stimulating apparatus having an ultrasonic module according to another embodiment.
13 is a cross-sectional view illustrating an ultrasonic module according to the embodiment of FIG.
FIG. 14 is a block diagram illustrating a helmet type low intensity ultrasound focusing system according to an embodiment of the present invention. Referring to FIG.
15 and 16 are schematic views showing attachment positions of the first marker according to one embodiment.
17 is a schematic view showing a state of the goggles to which the third marker is attached.
18 is a schematic view showing a state in which a patient wears the goggles of Fig.
19 and 20 are schematic views showing a state in which the third marker on the front side and the side face are photographed.
Figs. 21 and 22 are schematic diagrams showing an example of a continuous frame photographed with the third marker. Fig.
23 and 24 are a perspective view and a side view showing a helmet type low-intensity ultrasound focusing apparatus having an ultrasonic module according to another embodiment.
25 is a schematic side view showing the ultrasonic module of Fig.
26 and 27 are a perspective view and a side view showing a helmet type low intensity ultrasound focusing apparatus having an ultrasound module according to another embodiment of the present invention.
28 is a schematic side view showing the ultrasonic module of Fig. 26;
29 is a block diagram showing a helmet type low intensity ultrasound focusing system according to another embodiment.
BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings. In the absence of special definitions or references, the terms used in this description are based on the conditions indicated in the drawings. The same reference numerals denote the same members throughout the embodiments. For the sake of convenience, the thicknesses and dimensions of the structures shown in the drawings may be exaggerated, and they do not mean that the dimensions and the proportions of the structures should be actually set.
1 to 6, a helmet type low intensity ultrasound focusing and stimulating apparatus according to an embodiment of the present invention will be described. FIG. 1 is a perspective view showing a helmet type low intensity ultrasound focusing apparatus according to an embodiment of the present invention, FIG. 2 is a front view showing a helmet type low intensity ultrasound focusing apparatus according to an embodiment, 3 is a side view showing a state of a helmet type low intensity ultrasound focusing apparatus according to an embodiment. 4 is a partially cutaway perspective view showing a part of the helmet type low-intensity ultrasound focusing and stimulating apparatus according to the embodiment of the present invention, FIG. 5 is a vertical sectional view cut along the line AA in FIG. 1, Fig.
The helmet type low intensity
Referring to Figs. 1 to 3, the
The
The
An extension part (33) is formed at the center of the upper surface of the second guide part (30). The
Referring to FIGS. 4 and 5, an
The first
That is, when the first motor in the extended
The inner structure of the
Referring to FIG. 6, the
For convenience of explanation, the fixing
As described above, in the
The
The
The position control method of the transducer will be described with reference to Figs. 7 to 11. Fig. FIG. 7 is a side view showing a helmet type low intensity ultrasound focusing apparatus of FIG. 6, FIG. 8 is a perspective view showing a longitudinal position control of a helmet type low intensity ultrasound focusing apparatus according to an embodiment, Is a perspective view showing a state of lateral position control of the helmet type low intensity ultrasound focusing apparatus according to an embodiment of the present invention. 10 is a schematic view showing a distance control state of an ultrasonic module according to an embodiment, and FIG. 11 is a perspective view showing a state of distance control of an ultrasonic module according to an embodiment.
As shown in FIGS. 7 and 8, in order to move the
Thereafter, as shown in FIG. 9, the
10 and 11, the
Ultrasonic waves generated from the
12 and 13, a helmet type low intensity ultrasound focusing and stimulating apparatus according to another embodiment will be described. FIG. 12 is a perspective view showing a helmet type low intensity ultrasound focusing apparatus with an ultrasonic module according to another embodiment, and FIG. 13 is a sectional view showing an ultrasonic module according to the embodiment of FIG.
As shown in FIGS. 12 and 13, the helmet type low intensity ultrasound focusing apparatus of this embodiment differs from the above-described embodiment in the construction of the transmitting
Specifically, in the state in which the
The transmitting
In addition, the ultrasonic waves generated from the
Referring to FIG. 14, a helmet type low intensity ultrasound focusing stimulation system according to an embodiment will be described. FIG. 14 is a block diagram illustrating a helmet type low intensity ultrasound focusing system according to an embodiment of the present invention. Referring to FIG.
The
The
The
For example, sequence data stored in a sequence database is processed three times in a manner of irradiating a first-intensity ultrasound at a first position of the brain for about 3 seconds and putting a resting period of 1 second in order to treat a blush phenomenon, 2 < / RTI > sites of the second-intensity ultrasound for about 2 seconds and a 2 second pause for the second time can be stored as a series of treatment sequences.
The control unit 800 includes a
The
Since the human brain structure differs in size and shape from individual to individual, reliability is lowered when ultrasonic waves are irradiated using the relative coordinates of a standard human body as it is. Accordingly, the head relative image of the standard human body stored in the
The sequence control means 820 selects any one of the sequence data to control the position of the transducer described above according to the relative coordinates and the stimulus method corresponding to the corresponding sequence data stored in the sequence database, . At this time, selection of any one of the sequence data may be performed in various ways. For example, when the identification number of a specific patient is inputted, it is possible to automatically select specific sequence data by inquiring the patient's medical record or directly select a specific sequence according to the operation of the manager.
The sequence control means 820 controls the position control unit 300 such as the
The position correcting means 830 obtains the position change information of the helmet type low intensity ultrasound focusing apparatus on the head of the patient based on the positional change of the third marker on the image photographed by the
The position setting means 840 sets the initial coordinates of the
The
On the other hand, there is no limitation on the position where the
15 to 22, a method for controlling the position of the transducer using markers and markers according to the present invention will be described in detail. FIGS. 15 and 16 are schematic views showing attachment positions of the first marker according to one embodiment, and FIG. 17 is a schematic view showing a state of the goggles to which the third marker is attached. 19 and 20 are schematic views showing a state in which a third marker on the front side and a side face are photographed, and Figs. 21 and 22 are schematic views showing a state in which the third marker FIG. 2 is a block diagram showing an example of a continuous frame photographed.
The second marker M2 may be formed of a light reflective material reflecting the light used by the corresponding optical camera. For example, the second marker M2 may be formed of a material reflecting infrared rays so that the infrared camera can detect the infrared ray reflected from the infrared camera. Generally, a marker used for motion capture or the like uses a spherical marker so that uniform reflection is possible in any direction. However, in this embodiment, since the positional change between the optical camera and the marker is not large, a uniform curved surface A marker having a shape protruding from the surface can be used.
The second marker M2 may be provided on the forehead of the patient as shown in Fig. 15, for example, and may be attached to the back of both ears, i.e., the occiput side adjacent to the ear, as shown in Fig.
On the other hand, the second marker M2 should be attached to the position of the first marker which was attached when capturing the head image of the patient by using medical equipment such as CT, MRI and fMRI described above. In the case of this embodiment, the first marker should also be attached at a position including the attachment position of the second marker M2 shown in Figs. 15 and 16. Since the first marker is preferably attached to the parietal region of the patient, the forehead, and the occiput adjacent to the ear, the second marker may also be attached to the position of the parietal region, the forehead, and the occipital region adjacent to the ear according to the position of the first marker, Since it is easy to take a picture by the optical camera according to the present embodiment, it is preferable that the top of the head is excluded.
As described above, the coordinates of the patient's brain and the coordinate system for controlling the transducer should be linked to each other based on a specific point. At this time, the first marker and the second marker function as specific points connecting the two coordinate systems.
On the other hand, the third marker is used for position correction. As the third marker, the second marker described above can be used. In addition, the third marker may be a separate marker attached to the patient, and the marker M3-1, M3-2 attached on the
Also, as shown in FIG. 18, the third markers M3-1 and M3-2 newly attached together with the second marker M2 may be used together for the purpose of position correction.
On the other hand, the optical cameras 900-1 and 900-2 can be attached to the front surface and both side surfaces of the
At least two markers shall be used as the third marker. One of the third markers M3-1 is used as a reference marker for calculating the movement distance of a specific point and the remaining third markers M3-2 are used for calculating the rotation angle about the reference marker .
As described above, the position correcting unit continuously measures the third marker and detects the movement of the third marker, thereby correcting the error caused by the twisting of the helmet type low intensity ultrasound focusing apparatus. Specifically, as shown in FIGS. 21 and 22, the third marker determines whether there is a change in the position of the third marker between consecutively photographed frames. If there is a change, the third marker has the reference marker M3-1 (A1, a2) of the third marker M3-2 and the angle q of the third marker M3-2 rotated about the reference marker are calculated to calculate an error caused by the motion of the helmet have.
In general, when the motion of the markers is large based on the camera, the swapping of the markers may occur. That is, if the position of the marker is reversed between consecutive frames, identification of the two markers may be difficult. However, in the case of this embodiment, since the positional change in the state of wearing the helmet type low-intensity ultrasound focusing apparatus is not so severe as to change the positions of the markers, it is also possible to use only two markers, Is not required.
The position correcting means may be configured so that the movement distance of the calculated reference marker and the rotation angle around the reference marker are transmitted to the position setting means to reset the initial coordinates of the transducer, Can be transmitted to the sequence control means so as to reflect the error calculated during the position control of the transducer.
23 to 25, an ultrasonic module according to another embodiment will be described. FIGS. 23 and 24 are a perspective view and a side view showing a helmet type low intensity ultrasound focusing apparatus with an ultrasonic module according to another embodiment, and FIG. 25 is a schematic side view showing the ultrasonic module of FIG.
The helmet type low-intensity ultrasound focusing apparatus of this embodiment differs from the above-described embodiment in the configuration of the
Specifically, the
25, the
The
At this time, the
The
A method of displaying image information using ultrasound is classified into A mode, B mode, M mode, and D mode. The A mode is the most basic form of displaying the intensity of the reflected wave by the magnitude of the amplitude, and there is a limit to providing all the information of the reflected wave with one beam. The B mode is a method of converting the brightness of the point into brightness, that is, brightness, in comparison with the echo intensity in the A mode. The brightness of each point is proportional to the amplitude of the reflected signal, and the difference from a small reflection to a large reflection is divided into 256 different luminances Level. B mode is currently used in most ultrasonic equipment. The M mode is a modified form of the A mode, which displays the distance of the moving reflector in terms of time and shows the reflected wave from the moving organs together with the B mode. However, it is used to record the motion of the aorta and the heart sound of the fetus during the heart valve or abdominal scan, and is not suitable for acquiring image data of the human head that does not move the internal tissues. The D mode is used to measure the velocity and direction of blood flow using the Doppler effect. That is, the D mode is used to diagnose the backflow of the blood flow in the heart valve, the stenosis of the valve, and the heart disease. In this embodiment, a variety of image display methods can be used, but it is preferable to use the B mode.
The
The
The
As shown in Fig. 25, the
Meanwhile, the
On the other hand, the
26 to 28, an ultrasonic module according to another embodiment will be described. FIGS. 26 and 27 are a perspective view and a side view showing a helmet type low intensity ultrasound focusing apparatus with an ultrasonic module according to another embodiment, and FIG. 28 is a schematic side view showing the ultrasonic module of FIG.
The
As an intermediate material provided inside the
A helmet type low intensity ultrasound focusing system according to another embodiment will be described with reference to FIG. 29 is a block diagram showing a helmet type low intensity ultrasound focusing system according to another embodiment.
The control unit 800 according to the present embodiment differs from the control unit 800 described above in terms of the function of the
The position setting means 840 sets the initial coordinates of the
In this case, in the embodiment described above, the image data of a specific patient is received from medical imaging equipment such as CT, MRI, and fMRI, and matched with the head relative coordinate value of the standard human body stored in the
That is, the image information acquired through the
The position setting means 840 controls the
The position setting means 840 controls the second transducer so as to acquire an image of the target point whose body temperature has been raised by the ultrasonic wave irradiation of the
The circulation arrangement of the
While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims. have.
10: Support
20: first guide portion
30: second guide portion
40, 40a: ultrasonic module
47, 47a, 47b: transducer
100: helmet type low intensity ultrasound focusing stimulator
1000: helmet type low intensity ultrasound focusing stimulus system
Claims (12)
An ultrasonic module including a module supporting part, a rotation part rotatably fixed to the module supporting part, and a transducer provided at least in the rotation part; And
And a position control unit connected to the support unit and configured to move the position of the ultrasonic module,
Wherein one of the transducers is arranged in an operating position capable of irradiating ultrasonic waves to the head of the patient or detecting ultrasonic waves reflected from the head of the patient,
The transducers are circulated in the operating position as the rotating part rotates,
The position control unit,
A first guide portion formed in an arc shape and provided and fixed to the support portion in the longitudinal direction;
A second guide part formed in an arc shape and laterally connected to the support part so as to be perpendicular to the first guide part and supporting the ultrasonic module;
The second guide portion is guided along the first guide portion at one point and rotates in the longitudinal direction,
And the ultrasonic module is movable in the lateral direction along the second guide unit.
The ultrasonic module includes:
A first transducer for irradiating high intensity focused ultrasound (HIFU);
A second transducer for acquiring an image of the head of the user; And
And a third transducer for illuminating low intensity focused ultrasound (LIFU).
Wherein the first transducer controls the high intensity focused ultrasonic wave to irradiate a predetermined destination point of the user's head for a predetermined period of time and controls the second transducer to acquire an image of the target point whose body temperature has been raised by the ultrasonic irradiation of the first transducer, And a position setting means for controlling the ducer and comparing the calculated data with the image data obtained by the second transducer and reflecting the calculated error to the initial position setting of the transducer. Strength Ultrasonic Focusing Stimulation Device.
Wherein the ultrasonic module includes a distance adjusting unit for moving the transducer in the direction of travel of the ultrasonic wave or in a direction opposite to that of the ultrasonic wave.
And a transmission part interposed between the head part of the user and the transducer for mediating ultrasonic wave transmission.
Wherein the transducer is separately provided on an end side of the transducers.
The helmet type low intensity ultrasound focusing apparatus of claim 1, wherein the mediator is de-gas water.
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KR1020140029189A KR101572898B1 (en) | 2014-03-12 | 2014-03-12 | Ultrasonic module and helmet type stimulating apparatus using low intensity ultrasonic focused having the same |
PCT/KR2015/002411 WO2015137749A1 (en) | 2014-03-12 | 2015-03-12 | Ultrasonic module and helmet-type low-intensity ultrasound focusing stimulation device comprising same |
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KR1020140029189A KR101572898B1 (en) | 2014-03-12 | 2014-03-12 | Ultrasonic module and helmet type stimulating apparatus using low intensity ultrasonic focused having the same |
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KR101572898B1 true KR101572898B1 (en) | 2015-11-30 |
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Families Citing this family (9)
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KR101850801B1 (en) | 2016-09-05 | 2018-04-23 | 한국과학기술연구원 | Ultrasonic stimulation device used in MRI Device |
KR101972570B1 (en) * | 2017-03-16 | 2019-08-26 | 주식회사 뉴로소나 | Medical head gear and Transcranial ultrasound delivery device comprising the same |
KR101861963B1 (en) | 2017-06-30 | 2018-05-28 | 한국과학기술원 | Method for stimulating, and apparatuses performing the same |
KR102094328B1 (en) * | 2018-02-06 | 2020-03-27 | 재단법인 대구경북첨단의료산업진흥재단 | Method for delivering drug efficiently in brain using additional focused ultrasound stimulation |
KR102148854B1 (en) * | 2018-10-31 | 2020-08-28 | (주)클래시스 | Ultrasound apparatus for treating brain disease |
KR102247568B1 (en) * | 2019-10-11 | 2021-05-04 | 재단법인 대구경북첨단의료산업진흥재단 | Focused ultrasound irradiation system and the method for adjusting the degree of opening of the blood brain barrier using the same |
CN111013029A (en) * | 2019-12-05 | 2020-04-17 | 重庆医科大学 | Mechanical focusing ultrasonic therapeutic head |
KR102148853B1 (en) * | 2020-07-02 | 2020-08-28 | (주)클래시스 | Ultrasound apparatus for treating brain disease |
KR102537398B1 (en) * | 2022-09-07 | 2023-05-30 | 주식회사 딥슨바이오 | Movable ultrasonic stimulator band |
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US20090171185A1 (en) * | 2007-12-26 | 2009-07-02 | National Health Research Institutes | Positioning system for thermal therapy |
US20110218598A1 (en) * | 2004-02-04 | 2011-09-08 | Erchonia Corporation | Stand-Alone Scanning Laser Device |
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KR101143645B1 (en) * | 2009-07-29 | 2012-05-09 | 주세은 | Transcranial low-intensity ultrasound delivery device and non-invasive modulation of brain function |
CN103479403B (en) * | 2012-06-08 | 2016-06-22 | 长庚大学 | System and the method thereof that focusing ultrasound wave releases energy is guided with operation guiding system |
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2014
- 2014-03-12 KR KR1020140029189A patent/KR101572898B1/en not_active IP Right Cessation
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US20110218598A1 (en) * | 2004-02-04 | 2011-09-08 | Erchonia Corporation | Stand-Alone Scanning Laser Device |
US20090171185A1 (en) * | 2007-12-26 | 2009-07-02 | National Health Research Institutes | Positioning system for thermal therapy |
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