WO2005062938A3 - Chemical agents and methods for optical clearing of skin and mucous membranes to improve light-based diagnostics and therapeutics - Google Patents

Chemical agents and methods for optical clearing of skin and mucous membranes to improve light-based diagnostics and therapeutics Download PDF

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Publication number
WO2005062938A3
WO2005062938A3 PCT/US2004/043365 US2004043365W WO2005062938A3 WO 2005062938 A3 WO2005062938 A3 WO 2005062938A3 US 2004043365 W US2004043365 W US 2004043365W WO 2005062938 A3 WO2005062938 A3 WO 2005062938A3
Authority
WO
WIPO (PCT)
Prior art keywords
skin
methods
light
therapeutics
mucous membranes
Prior art date
Application number
PCT/US2004/043365
Other languages
French (fr)
Other versions
WO2005062938A2 (en
Inventor
Misbah Huzaira Khan
Stuart J Nelson
Samuel Chess
Original Assignee
Univ California
Misbah Huzaira Khan
Stuart J Nelson
Samuel Chess
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Misbah Huzaira Khan, Stuart J Nelson, Samuel Chess filed Critical Univ California
Publication of WO2005062938A2 publication Critical patent/WO2005062938A2/en
Publication of WO2005062938A3 publication Critical patent/WO2005062938A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72—Polyisocyanates or polyisothiocyanates
    • C08G18/74—Polyisocyanates or polyisothiocyanates cyclic
    • C08G18/75—Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic
    • C08G18/758—Polyisocyanates or polyisothiocyanates cyclic cycloaliphatic containing two or more cycloaliphatic rings
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4833—Polyethers containing oxyethylene units

Abstract

Compositions comprising polyurethane prepolymers, methods for preparing such compositions and methods for using such compositions to improve the transmissibility of light into or through tissues (e.g., skin, mucous membrane, epithelium, other tissue) and to enhance or modify the effects of light-based therapies (e.g., therapies where laser light, white light, UV light, infrared light and/or other light is cast into or through skin, mucous membrane, epithelium or other tissue).
PCT/US2004/043365 2003-12-23 2004-12-22 Chemical agents and methods for optical clearing of skin and mucous membranes to improve light-based diagnostics and therapeutics WO2005062938A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53281803P 2003-12-23 2003-12-23
US60/532,818 2003-12-23
US55939604P 2004-04-02 2004-04-02
US60/559,396 2004-04-02

Publications (2)

Publication Number Publication Date
WO2005062938A2 WO2005062938A2 (en) 2005-07-14
WO2005062938A3 true WO2005062938A3 (en) 2006-08-10

Family

ID=34743026

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/043365 WO2005062938A2 (en) 2003-12-23 2004-12-22 Chemical agents and methods for optical clearing of skin and mucous membranes to improve light-based diagnostics and therapeutics

Country Status (1)

Country Link
WO (1) WO2005062938A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8545517B2 (en) 2008-06-06 2013-10-01 Restoration Robotics, Inc. Systems and methods for improving follicular unit harvesting
EP2210590A1 (en) 2009-01-26 2010-07-28 Academisch Medisch Centrum Drug delivery system for use in the treatment of vascular and vessel-related pathologies
IN2014DN09073A (en) 2012-08-09 2015-05-22 Univ Leland Stanford Junior
HU230989B1 (en) 2013-01-17 2019-08-28 Gd Photonics Kft. Composition for improving the efficiency of uvb light therapy, process for their preparation and use thereof
AU2015266894A1 (en) 2014-05-30 2016-08-25 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for imaging large intact tissue samples
WO2017139501A1 (en) 2016-02-10 2017-08-17 The Board Of Trustees Of The Leland Stanford Junior University Rna fixation and detection in clarity-based hydrogel tissue

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6275726B1 (en) * 1997-05-15 2001-08-14 Board Of Regents, The University Of Texas System Methods of enhanced light transmission through turbid biological media

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6275726B1 (en) * 1997-05-15 2001-08-14 Board Of Regents, The University Of Texas System Methods of enhanced light transmission through turbid biological media

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
VARGAS ET AL.: "Morphological Changes in Blood Vessels Produced by Hyperosmotic Agents and Measured by Optical Coherence Tomography", PHOTOCHEM. PHOTOBIOL., vol. 77, no. 5, May 2003 (2003-05-01), pages 541 - 549, XP003002649 *
VARGAS ET AL.: "Use of an Agent to Reduce Scattering in Skin", LASERS SURG. MED., vol. 24, no. 2, 1999, pages 133 - 141, XP000847219 *
VIATOR ET AL.: "Specta from 2.5-15 Micron of Tissue Phantom Materials, Optical Clearing Agents and ex vivo Human Skin: Implications for Depth Profiling of Human Skin", PHYS. MED. BIOL., vol. 48, no. 2, 21 January 2003 (2003-01-21), pages N15 - N24, XP003002648 *

Also Published As

Publication number Publication date
WO2005062938A2 (en) 2005-07-14

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